Design, synthesis and preliminary evaluation of some novel [1,4]diazepino [5,6-b]pyrrolizine and 6-(2-oxopyrrolidino)-1Hpyrrolizine derivatives as anticonvulsant agents

Medicinal Chemistry Research

Volumn 20, Issue 7, 2011, Pages 1015-1023

  Abbas, Safinaz E ^a   Awadallah, Fadi Mohsen ^a   Ibrahim, Nashwa A ^b   Gouda, Ahmed M ^b   Shehata, Bassem A ^b  

^a CAIRO UNIVERSITY   (Egypt)

^b Beni Suef University   (Egypt)

Author keywords

6 (2 Oxopyrrolidino) 1H pyrrolizines; Anticonvulsant activity; 1,4 Diazepino 5,6 b pyrrolizines

Indexed keywords

1 METHYL 2,5 DIOXO 4 (4 CHLOROPHENYL) 1,2,3,4,5,7,8,9 OCTAOCTAHYDRO [1,4]DIAZEPINO [5,6 B]PYRROLIZINE 10 CARBONITRILE; 1 METHYL 2,5 DIOXO 4 (4 TOLYL) 1,2,3,4,5,7,8,9 OCTAHYDRO[1,4]DIAZEPINO[5,6 B] PYRROLIZINE 10 CARBONITRILE; 1 METHYL 2,5 DIOXO 4 PHENYL 1,2,3,4,5,7,8,9 OCTAHYDRO[1,4]DIAZEPINO[5,6-B]PYRROLIZINE 10 CARBONITRILE; 2,5 DIOXO 4 (4 CHLOROPHENYL) 1,2,3,4,5,7,8,9 OCTAHYDRO[1,4]DIAZEPINO[5,6 B]PYRROLIZINE 10 CARBONITRILE; 2,5 DIOXO 4 (4 TOLYL) 1,2,3,4,5,7,8,9 OCTAHYDRO[1,4]DIAZEPINO [5,6 B]PYRROLIZINE 10 CARBONITRILE; 2,5 DIOXO 4 (4 TOLYL) 1,2,3,4,5,7,8,9 OCTAHYDRO[1,4]DIAZEPINO[5,6 B]PYRROLIZINE 10 CARBONITRILE; 7 CYANO 6 (2 OXOPYRROLIDINO) N (4 CHLOROPHENYL) 2,3 DIHYDRO 1H PYRROLIZINE 5 CARBOXAMIDE; 7 CYANO 6 (2 OXOPYRROLIDINO) N (4 TOLYL) 2,3 DIHYDRO 1 PYRROLIZINE 5 CARBOXAMIDE; 7 CYANO 6 (2 OXOPYRROLIDINO) N PHENYL 2,3 DIHYDRO 1H PYRROLIZINE 5 CARBOXAMIDE; ANTICONVULSIVE AGENT; PHENOBARBITAL; PYRROLIZINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANTICONVULSANT ACTIVITY; ARTICLE; DRUG DESIGN; DRUG SYNTHESIS; MALE; MOUSE; NONHUMAN; SEIZURE; X RAY CRYSTALLOGRAPHY;

EID: 85027958207     PISSN: 10542523     EISSN: 15548120     Source Type: Journal    
DOI: 10.1007/s00044-010-9429-8     Document Type: Article

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