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75149126765
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Merck & Co Inc. Diciembre [citado 28 Ene 2008] Disponible en:
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Merck & Co Inc. Isentress® Prescribing Information. Diciembre 2007 [citado 28 Ene 2008]. Agencia Europea del Medicamento (EMEA). Disponible en: http://emea.europa.eu/humandocs/PDFs/EPAR/isentress/H-860-PI-es.pdf
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(2007)
Isentress® Prescribing Information
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2
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33845192798
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Biochemical and antiviral activity of MK-0518, a potent HIV integrase inhibitor
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Abstract THAA0302
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M.D. Miller, W. Witmer, K. Stillmock, P. Felock, L. Ecto, J. Flynn, et al. Biochemical and antiviral activity of MK-0518, a potent HIV integrase inhibitor 16th International AIDS Conference Toronto, Canada. August 13-18 2006 Abstract THAA0302
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16th International AIDS Conference. Toronto, Canada. August 13-18, 2006
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Miller, M.D.1
Witmer, W.2
Stillmock, K.3
Felock, P.4
Ecto, L.5
Flynn, J.6
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3
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75149194314
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Raltegravir dose proportionality and effect of food
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Abstract H-1046
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L. Wenning, M. Anderson, A. Petry, E. Friedman, J. Kost, S. James, et al. Raltegravir dose proportionality and effect of food 47th Interscience Conference on Antimicrobial Agents and Chemotherapy Chicago, IL. September 17-20 2007 Abstract H-1046
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47th Interscience Conference on Antimicrobial Agents and Chemotherapy. Chicago, IL. September 17-20, 2007
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Wenning, L.1
Anderson, M.2
Petry, A.3
Friedman, E.4
Kost, J.5
James, S.6
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4
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38349194563
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Safety, tolerability, and pharmacokinetics of raltegravir after single and multiple doses in healthy subjects
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M. Iwamoto, L.A. Wenning, A.S. Petry, M. Laethem, M. De Smet, J.T. Kost, et al. Safety, tolerability, and pharmacokinetics of raltegravir after single and multiple doses in healthy subjects Clin Pharmacol Ther 83 2008 293 299
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(2008)
Clin Pharmacol Ther
, vol.83
, pp. 293-299
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Iwamoto, M.1
Wenning, L.A.2
Petry, A.S.3
Laethem, M.4
De Smet, M.5
Kost, J.T.6
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5
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75149193434
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Safety, tolerability, and pharmacokinetics after single and multiple doses of MK-0518 in healthy subjects
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Abstract A-376
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A. Petry, L.A. Wenning, T. Laethem, M. De Smet, J.T. Kost, S. Merschman, et al. Safety, tolerability, and pharmacokinetics after single and multiple doses of MK-0518 in healthy subjects 46th Interscience Conference on Antimicrobial Agents and Chemotherapy San Francisco, CA. September 27-30 2006 Abstract A-376
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46th Interscience Conference on Antimicrobial Agents and Chemotherapy. San Francisco, CA. September 27-30, 2006
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Petry, A.1
Wenning, L.A.2
Laethem, T.3
De Smet, M.4
Kost, J.T.5
Merschman, S.6
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6
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33845366857
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Antiretroviral activity, pharmacokinetics, and tolerability of MK-0518, a novel inhibitor of HIV-1 integrase, dosed as monotherapy for 10 days in treatment-naive HIV-1-infected individuals
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DOI 10.1097/QAI.0b013e31802b4956, PII 0012633420061215000002
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M. Markowitz, J.O. Morales-Ramírez, B.Y. Nguyen, C.M. Kovacs, R.T. Steigbigel, and D.A. Cooper Antiretroviral activity, pharmacokinetics, and tolerability of MK-0518, a novel inhibitor of HIV-1 integrase, dosed as monotherapy for 10 days in treatment-naive HIV-1-infected individuals J Acquir Immune Defic Syndr 43 2006 509 515 (Pubitemid 44885615)
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(2006)
Journal of Acquired Immune Deficiency Syndromes
, vol.43
, Issue.5
, pp. 509-515
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Markowitz, M.1
Morales-Ramirez, J.O.2
Nguyen, B.-Y.3
Kovacs, C.M.4
Steigbigel, R.T.5
Cooper, D.A.6
Liporace, R.7
Schwartz, R.8
Isaacs, R.9
Gilde, L.R.10
Wenning, L.11
Zhao, J.12
Teppler, H.13
Tsoukas, C.14
Galpin, J.15
Hicks, C.16
Brown, S.17
Chen, J.18
Miller, M.19
Hazuda, D.20
Vacca, J.21
Iwamoto, M.22
Rowley, M.23
Summa, V.24
more..
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7
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34548065793
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Metabolism and disposition in humans of raltegravir (MK-0518), an anti-AIDS drug targeting the human immunodeficiency virus 1 integrase enzyme
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DOI 10.1124/dmd.107.016196
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K. Kassahun, I. McIntosh, D. Cui, D. Hreniuk, M. Merschman, and K. Lasseter Metabolism and disposition in humans of raltegravir (MK-0518), an anti-AIDS drug targeting the human immunodeficiency virus 1 integrase enzyme Drug Metab Dispos 35 2007 1657 1663 (Pubitemid 47296061)
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(2007)
Drug Metabolism and Disposition
, vol.35
, Issue.9
, pp. 1657-1663
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Kassahun, K.1
McIntosh, I.2
Cui, D.3
Hreniuk, D.4
Merschman, S.5
Lasseter, K.6
Azrolan, N.7
Iwamoto, M.8
Wagner, J.A.9
Wenning, L.A.10
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9
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75149191862
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Effect of severe renal insufficiency on raltegravir pharmacokinetics
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Abstract A-1424
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A.S. Petry, W.D. Hanley, G. Silk, J.T. Kost, S.A. Merschman, R. Robson, et al. Effect of severe renal insufficiency on raltegravir pharmacokinetics 47th Interscience Conference on Antimicrobial Agents and Chemotherapy Chicago, IL. September 17-20 2007 Abstract A-1424
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47th Interscience Conference on Antimicrobial Agents and Chemotherapy. Chicago, IL. September 17-20, 2007
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Petry, A.S.1
Hanley, W.D.2
Silk, G.3
Kost, J.T.4
Merschman, S.A.5
Robson, R.6
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11
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38349182976
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Lack of a pharmacokinetic effect of raltegravir on midazolam: In vitro/in vivo correlation
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M. Iwamoto, K. Kassahun, M.D. Troyer, W.D. Hanley, P. Lu, A. Rhoton, et al. Lack of a pharmacokinetic effect of raltegravir on midazolam: in vitro/in vivo correlation J Clin Pharmacol 48 2008 209 214
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(2008)
J Clin Pharmacol
, vol.48
, pp. 209-214
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Iwamoto, M.1
Kassahun, K.2
Troyer, M.D.3
Hanley, W.D.4
Lu, P.5
Rhoton, A.6
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12
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67651111369
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Lack of a significant drug interaction between MK-0518 and tenofovir disoproxil fumarate (TDF)
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Abstract A-375
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L.A. Wenning, E. Friedman, J.T. Kost, S. Merschman, K. Lasseter, N. Azrolan, et al. Lack of a significant drug interaction between MK-0518 and tenofovir disoproxil fumarate (TDF) 46th Interscience Conference on Antimicrobial Agents and Chemotherapy San Francisco, CA. September 27-30 2006 Abstract A-375
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46th Interscience Conference on Antimicrobial Agents and Chemotherapy. San Francisco, CA. September 27-30, 2006
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Wenning, L.A.1
Friedman, E.2
Kost, J.T.3
Merschman, S.4
Lasseter, K.5
Azrolan, N.6
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13
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34748860363
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Rapid and durable antiretroviral effect of the HIV-1 integrase inhibitor raltegravir as part of combination therapy in treatment-naive patients with HIV-1 infection: Results of a 48-week controlled study
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DOI 10.1097/QAI.0b013e318157131c, PII 0012633420071001000001
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M. Markowitz, B.Y. Nguyen, E. Gotuzzo, F. Mendo, W. Ratanasuwan, and C. Kovacs Rapid and durable antiretroviral effect of the HIV-1 integrase inhibitor raltegravir as part of combination therapy in treatment-naïve patients with HIV-1 infection. Results of a 48-week controlled study J Acquir Immune Defic Syndr 46 2007 125 133 (Pubitemid 47482607)
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(2007)
Journal of Acquired Immune Deficiency Syndromes
, vol.46
, Issue.2
, pp. 125-133
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Markowitz, M.1
Nguyen, B.-Y.2
Gotuzzo, E.3
Mendo, F.4
Ratanasuwan, W.5
Kovacs, C.6
Prada, G.7
Morales-Ramirez, J.O.8
Crumpacker, C.S.9
Isaacs, R.D.10
Gilde, L.R.11
Wan, H.12
Miller, M.D.13
Wenning, L.A.14
Teppler, H.15
Baker, D.16
Bloch, M.17
Bodsworth, N.18
Cooper, D.19
Workman, C.20
Kovacs, C.21
Tsoukas, C.22
Afani, A.23
Perez, J.24
Cortes, J.25
Prada, G.26
Gotuzzo, E.27
Mendo, F.28
Ratanasuwan, W.29
Thitivichianlert, S.30
Brown, S.31
Crumpacker, C.32
Galpin, J.33
Hicks, C.34
Kumar, P.35
Lichtenstein, K.36
Little, S.37
Liporace, R.38
Markowitz, M.39
Morales-Ramirez, J.40
Santana-Bagur, J.41
Schwartz, R.42
Steigbigel, R.43
Tashima, K.44
more..
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14
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77953659589
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Minimal effect of ritonavir (RTV) and efavirenz (EFV) on the pharmacokinetics (PK) of MK-0518
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Abstract A-373
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M. Iwamoto, L.A. Wenning, A.S. Petry, T. Laethem, M. Desmet, J.T. Kost, et al. Minimal effect of ritonavir (RTV) and efavirenz (EFV) on the pharmacokinetics (PK) of MK-0518 46th Interscience Conference on Antimicrobial Agents and Chemotherapy San Francisco, CA. September 27-30 2006 Abstract A-373
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46th Interscience Conference on Antimicrobial Agents and Chemotherapy. San Francisco, CA. September 27-30, 2006
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Iwamoto, M.1
Wenning, L.A.2
Petry, A.S.3
Laethem, T.4
Desmet, M.5
Kost, J.T.6
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15
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75149167449
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Pharmacokinetic evaluation of non-nucleoside reverse transcriptase inhibitor and integrase inhibitor raltegravir in healthy subjects
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Abstract TUPDB02
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M.S. Anderson, T.N. Kakuda, J.L. Miller, M. Simonts, D. Miller, W. Hanley, et al. Pharmacokinetic evaluation of non-nucleoside reverse transcriptase inhibitor and integrase inhibitor raltegravir in healthy subjects 4th IAS Conference on HIV Pathogenesis, Treatment and Prevention Sydney, Australia. July 22-25 2007 Abstract TUPDB02
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4th IAS Conference on HIV Pathogenesis, Treatment and Prevention. Sydney, Australia. July 22-25, 2007
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Anderson, M.S.1
Kakuda, T.N.2
Miller, J.L.3
Simonts, M.4
Miller, D.5
Hanley, W.6
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16
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75149179069
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Monitoring of raltegravir (MK-0518) in experienced HIV patients
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Abstract PS4/6
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K. Long, C. Soulié, L. Schneider, J. Ghosn, C. Piketty, F. Boué, et al. Monitoring of raltegravir (MK-0518) in experienced HIV patients 11th European AIDS Conference Madrid, Spain. October 22-24 2007 Abstract PS4/6
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11th European AIDS Conference. Madrid, Spain. October 22-24, 2007
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Long, K.1
Soulié, C.2
Schneider, L.3
Ghosn, J.4
Piketty, C.5
Boué, F.6
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17
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75149161912
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Atazanavir and ritonavir increase plasma levels of MK-0518
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Abstract P291
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G.C. Mistry, L.A. Wenning, S. Merschman, J.T. Kost, W.E. Bridson, J.A. Stone, et al. Atazanavir and ritonavir increase plasma levels of MK-0518 8th International Congress on Drug Therapy in HIV Infection Glasgow, UK. November 12-16 2006 Abstract P291
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8th International Congress on Drug Therapy in HIV Infection. Glasgow, UK. November 12-16, 2006
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Mistry, G.C.1
Wenning, L.A.2
Merschman, S.3
Kost, J.T.4
Bridson, W.E.5
Stone, J.A.6
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18
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34147136222
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Safety and efficacy of the HIV-1 integrase inhibitor raltegravir (MK-0518) in treatment-experienced patients with multidrug-resistant virus: A phase II randomised controlled trial
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DOI 10.1016/S0140-6736(07)60597-2, PII S0140673607605972
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B. Grinsztejn, B.Y. Nguyen, C. Katlama, J.M. Gatell, A. Lazzarin, and D. Vittecoq Safety and efficacy of the HIV-1 integrase inhibitor raltegravir (MK-0518) in treatment-experienced patients with multidrug-resistant virus: a phase II randomized controlled trial Lancet 369 2007 1261 1269 (Pubitemid 46553846)
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(2007)
Lancet
, vol.369
, Issue.9569
, pp. 1261-1269
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Grinsztejn, B.1
Nguyen, B.-Y.2
Katlama, C.3
Gatell, J.M.4
Lazzarin, A.5
Vittecoq, D.6
Gonzalez, C.J.7
Chen, J.8
Harvey, C.M.9
Isaacs, R.D.10
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20
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67651121226
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Effect of tipranavir + ritonavir (TPV + RTV) on pharmacokinetics of MK-0518
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Abstract A-374
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L.A. Wenning, H. Hanley, J. Stone, A. Moreau, J.T. Kost, E. Mangin, et al. Effect of tipranavir + ritonavir (TPV + RTV) on pharmacokinetics of MK-0518 46th Interscience Conference on Antimicrobial Agents and Chemotherapy San Francisco, CA. September 27-30 2006 Abstract A-374
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46th Interscience Conference on Antimicrobial Agents and Chemotherapy. San Francisco, CA. September 27-30, 2006
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Wenning, L.A.1
Hanley, H.2
Stone, J.3
Moreau, A.4
Kost, J.T.5
Mangin, E.6
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21
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75149136052
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Efficacy of raltegravir, an HIV integrase inhibitor, in combination with regimens containing enfuvirtide, darunavir, or tipranavir in patients with triple-class resistant virus: Combined results from Benchmrk-1 and Benchmrk-2
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Abstract P7
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P. Kumar, D. Cooper, R. Steigbigel, J. Zhao, H. Teppler, and B.Y. Nguyen Efficacy of raltegravir, an HIV integrase inhibitor, in combination with regimens containing enfuvirtide, darunavir, or tipranavir in patients with triple-class resistant virus: combined results from Benchmrk-1 and Benchmrk-2 European AIDS Conference Madrid. October 24-27 2007 Abstract P7
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European AIDS Conference. Madrid. October 24-27, 2007
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Kumar, P.1
Cooper, D.2
Steigbigel, R.3
Zhao, J.4
Teppler, H.5
Nguyen, B.Y.6
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22
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70349527751
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Rifampin modestly reduces plasma levels of MK-0518
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Abstract P299
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M. Iwamoto, L.A. Wenning, S.Y. Liou, J.T. Kost, E. Mangin, K.M. Strohmaier, et al. Rifampin modestly reduces plasma levels of MK-0518 8th International Congress on Drug Therapy in HIV Infection Glasgow, UK. November 12-16 2006 Abstract P299
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8th International Congress on Drug Therapy in HIV Infection. Glasgow, UK. November 12-16, 2006
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Iwamoto, M.1
Wenning, L.A.2
Liou, S.Y.3
Kost, J.T.4
Mangin, E.5
Strohmaier, K.M.6
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24
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70349535921
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Effect of raltegravir on the pharmacokinetics of oral contraceptives
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Abstract A-1425
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M.S. Anderson, L.A. Wenning, A. Moreau, J.T. Kost, F.A. Bieberdorf, J.A. Stone, et al. Effect of raltegravir on the pharmacokinetics of oral contraceptives 47th Interscience Conference on Antimicrobial Agents and Chemotherapy Chicago, IL. September 17-20 2007 Abstract A-1425
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47th Interscience Conference on Antimicrobial Agents and Chemotherapy. Chicago, IL. September 17-20, 2007
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Anderson, M.S.1
Wenning, L.A.2
Moreau, A.3
Kost, J.T.4
Bieberdorf, F.A.5
Stone, J.A.6
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