Determination of Nicotine, Cotinine and Trans-3′-Hydroxycotinine using LC/MS/MS in Forensic Samples of a Nicotine Fatal Case by Oral Ingestion of e-cigarette Liquid,

Journal of Forensic Sciences

Volumn 61, Issue 4, 2016, Pages 1149-1154

  You, Gundong ^a   Rhee, Jongsook ^a   Park, Yuran ^a   Park, Sunhye ^a  

^a National Forensic Service   (South Korea)

Author keywords

cotinine; e cigarette liquid; fatal; forensic science; liquid chromatography with tandem mass spectrometry; nicotine; trans 3 hydroxycotinine

Indexed keywords

EID: 85027954848     PISSN: 00221198     EISSN: 15564029     Source Type: Journal    
DOI: 10.1111/1556-4029.13083     Document Type: Article

References (33)

1. Moriya F, Hashimoto Y. A fatal poisoning caused by methomyl and nicotine. Forensic Sci Int 2005;149:167–70.
2. Corkery JM, Button J, Vento AE, Schifano F. Two UK suicides using nicotine extracted from tobacco employing instructions available on the Internet. Forensic Sci Int 2010;199:e9–13.
3. Solarino B, Rosenbaum F, RieBelmann B, Buschmann CT, Tsokos M. Death due to ingestion of nicotine-containing solution: case report and review of the literature. Forensic Sci Int 2010;195:e19–22.
4. Baselt RC. Disposition of toxic drugs and chemicals in man, 9th edn. Seal Beach, CA: Biomedical Publications, 2011;1193–6.
5. Schneider S, Diederich N, Appenzeller B, Schartz A, Lorang C, Wennig R. Internet suicide guidelines: report of a life-threatening poisoning using tobacco extract. J Emerg Med 2010;38(5):610–3.
6. Thornton SL, Oller L, Sawyer T. Fatal intravenous injection of electronic nicotine delivery system refilling solution. J Med Toxicol 2014;10:202–4.
7. Mayer B. How much nicotine kills a human? Tracing back the generally accepted lethal dose to dubious self-experiments in the nineteenth century. Arch Toxicol 2014;88:5–7.
8. True BL, Dreisbach RH. Dreisbach's handbook of poisoning, prevention, diagnosis and treatment, 13th edn. London, U.K.: The Parthenon Publishing Group, 2002;138–40.
9. Doctor PB, Gokani VN, Kulkarni PK, Parikh JR, Saiyed HN. Determination of nicotine and cotinine in tobacco harvesters' urine by solid-phase extraction and liquid chromatography. J Chromatogr B 2004;802:323–8.
10. Miller EI, Norris HRK, Rollins DE, Tiffany ST, Wilkins DG. A novel validated procedure for the determination of nicotine, eight nicotine metabolites and two minor tobacco alkaloids in human plasma or urine by solid-phase extraction coupled with liquid chromatography-electrospray ionization-tandem mass spectrometry. J Chromatogr B 2010;878:725–37.
11. Park SW. Distribution of nicotine and toluene in teenagers' urine. Annual Report of NISI 1997;29:217–23.
12. Grana R, Benowitz N, Glantz SA. E-cigarettes: a scientific review. Circulation 2014;129:1972–86.
13. Grana R, Benowitz N, Glantz SA, Background Paper on E-cigarettes (Electronic Nicotine Delivery Systems). Center for Tobacco Control Research and Education, UC San Francisco, WHO Tobacco Control Papers, Winter 2013; http://escholarship.org/uc/item/13p2b72n (accessed June 8, 2015).
14. Etter JF, Bullen C, Flouris AD, Laugesen M, Eissenberg T. Electronic nicotine delivery systems: a research agenda. Tob Control 2011;20(3):243–8.
15. Lee SK, Grana RA, Glantz A. Electronic cigarette use among Korean adolescents: a cross-sectional study of market penetration, dual use, and relationship to quit attempts and former smoking. J Adolesc Health 2014;54:684–90.
16. Etter JF, Zather E, Svensson S. Analysis of refill for electronic cigarettes. Addiction 2013;108:1671–9.
17. Goniewicz ML, Kuma T, Gawron M, Knysak J, Kosmider L. Nicotine levels in electronic cigarettes. Nicotine Tob Res 2013;15(1):158–66.
18. Dawkins L, Coreoran O. Acute electronic cigarette use: nicotine delivery and subjective effects in regular users. Psychopharmacology 2014;231(2):401–7.
19. Kudo K, Ishida T, Hikiji W, Usumoto Y, Umehara T, Nagamatsu K, et al. Pattern of poisoning in Japan: selection of drugs and poisons for systematic toxicological analysis. Forensic Toxicol 2010;28:25–32.
20. Moriya F, Hashimoto Y. Nicotine and cotinine levels in blood and urine from forensic autopsy cases. Leg Med 2014;6:164–9.
21. Moriya F, Hashimoto Y, Furumiya J. Nicotine and cotinine levels in body fluids of smokers who committed suicide. Forensic Sci Int 2007;168:102–5.
22. Goniewicz ML, Hajek P, McRobbie H. Nicotine content of electronic cigarettes, its release in vapour and its consistency across batches: regulatory implications. Addiction 2014;109:500–7.
23. Chang YL, Tsai PL, Chou YC, Tien JH, Tsai TH. Simultaneous determination of nicotine and its metabolite, cotinine in rat blood and brain tissue using microdialysis coupled with liquid chromatography: pharmacokinetic application. J Chromatogr A 2005;1088:152–7.
24. Kim IS, Darwin WD, Huestis MA. Simultaneous determination of nicotine, cotinine, norcotinine, and trans-3′-hydroxycotinine in human oral liquid using solid phase extraction and gas chromatography-mass spectrometry. J Chromatogr B 2005;814:233–40.
25. Shakleya D, Huestis M. Simultaneous and sensitive measurement of nicotine, cotinine, trans-3′-hydroxycotinine and norcotinine in human plasma by liquid chromatography-tandem mass spectrometry. J Chromatogr B 2009;877:3537–42.
26. Baumann F, Regenthal R, Burgos-Guerrero IL, Hegerl U, Preiss R. Determination of nicotine and cotinine in human serum by means of LC/MS. J Chromatogr B 2010;878:107–11.
27. Piller M, Gilch G, Scherer G, Scherer M. Simple, fast and sensitive LC-MS/MS analysis for the simultaneous quantification of nicotine and 10 of its major metabolites. J Chromatogr B 2014;951–952:7–15.
28. SOFT/AAFS forensic laboratory guidelines. 2006; http://www.soft-tox.org/files/Guidelines_2006_Final.pdf (accessed June 8, 2015).
29. Lardi C, Vogt S, Pollak S, Thierauf A. Complex suicide with homemade nicotine patches. Forensic Sci Int 2014;236:e14–8.
30. Baselt RC, Cravey RH. A compendium of therapeutic and toxic concentrations of toxicologically significant drugs in human biofluids. J Anal Tox 1977;1:81–103.
31. Cervelline G, Luci M, Bellini C, Lippi G. Bad news about an old poison. A case of nicotine poisoning due to both ingestion and injection of the content of an electronic cigarette refill. Emerg Care J 2013;9:e18.
32. Christensen LB, Veen TV, Bang J. Three cases of attempted suicide by ingestion of nicotine liquid used in e-cigarettes. Clin Toxicol 2013;51(4):290.
33. Molina DK. Handbook of forensic toxicology for medical examiners. Boca Raton, FL: Taylor and Francis Group, CRC Press, 2010;212.