메뉴 건너뛰기




Volumn 19, Issue 10, 2012, Pages 1311-1317

Correlation between anti-interferon-β binding and neutralizing antibodies in interferon-β-treated multiple sclerosis patients

Author keywords

Antibodies; ELISA; Interferon beta; Luciferase; Multiple sclerosis; MxA; Neutralizing; RT PCR

Indexed keywords

BETA1A INTERFERON; BINDING ANTIBODY; INTERFERON ANTIBODY; INTERFERON BETA SERINE; LUCIFERASE; MESSENGER RNA; NEUTRALIZING ANTIBODY; UNCLASSIFIED DRUG;

EID: 85027953762     PISSN: 13515101     EISSN: 14681331     Source Type: Journal    
DOI: 10.1111/j.1468-1331.2012.03721.x     Document Type: Article
Times cited : (17)

References (39)
  • 1
    • 9644262469 scopus 로고    scopus 로고
    • Interferons, interferon-like cytokines, and their receptors
    • Pestka S, Karuse CD, Walter MR. Interferons, interferon-like cytokines, and their receptors. Immunol Rev 2004; 202: 8-32.
    • (2004) Immunol Rev , vol.202 , pp. 8-32
    • Pestka, S.1    Karuse, C.D.2    Walter, M.R.3
  • 2
    • 10744225329 scopus 로고    scopus 로고
    • Clinical importance of neutralising antibodies against interferon beta in patients with relapsing-remitting multiple sclerosis
    • Sorensen PS, Ross C, Clemmesen KM, et al. Clinical importance of neutralising antibodies against interferon beta in patients with relapsing-remitting multiple sclerosis. Lancet 2003; 362: 1184-1191.
    • (2003) Lancet , vol.362 , pp. 1184-1191
    • Sorensen, P.S.1    Ross, C.2    Clemmesen, K.M.3
  • 3
    • 0027418515 scopus 로고
    • Interferon beta-1b is effective in relapsing-remitting multiple sclerosis: I. Clinical results of a multicenter, randomized, double-blind, placebo-controlled trial
    • The IFNB Multiple Sclerosis Study Group
    • The IFNB Multiple Sclerosis Study Group. Interferon beta-1b is effective in relapsing-remitting multiple sclerosis: I. Clinical results of a multicenter, randomized, double-blind, placebo-controlled trial. Neurology 1993; 43: 655-661.
    • (1993) Neurology , vol.43 , pp. 655-661
  • 4
    • 0029161628 scopus 로고
    • Interferon beta-1b in the treatment of multiple sclerosis: final outcome of the randomized controlled trial
    • The IFNB Multiple Sclerosis Study Group and the University of British Columbia MS/MRI analysis Group
    • The IFNB Multiple Sclerosis Study Group and the University of British Columbia MS/MRI analysis Group. Interferon beta-1b in the treatment of multiple sclerosis: final outcome of the randomized controlled trial Neurology 1995; 45: 1277-1285.
    • (1995) Neurology , vol.45 , pp. 1277-1285
  • 5
    • 0008678962 scopus 로고    scopus 로고
    • Intramuscular interferon beta-1a for disease progression in relapsing multiple sclerosis. The Multiple Sclerosis Collaborative Research Group (MSCRG)
    • Jacobs LD, Cookfair DL, Rudick RA, et al. Intramuscular interferon beta-1a for disease progression in relapsing multiple sclerosis. The Multiple Sclerosis Collaborative Research Group (MSCRG). Ann Neurol 1996; 39: 285-294.
    • (1996) Ann Neurol , vol.39 , pp. 285-294
    • Jacobs, L.D.1    Cookfair, D.L.2    Rudick, R.A.3
  • 6
    • 0345601517 scopus 로고    scopus 로고
    • Randomised double-blind placebo-controlled study of interferon beta-1a in relapsing/remitting multiple sclerosis
    • PRISMS Study Group
    • PRISMS Study Group. Randomised double-blind placebo-controlled study of interferon beta-1a in relapsing/remitting multiple sclerosis. Lancet 1998; 352: 1498-1504.
    • (1998) Lancet , vol.352 , pp. 1498-1504
  • 7
    • 0035012959 scopus 로고    scopus 로고
    • Study of binding and neutralizing antibodies to interferon-b in two groups of relapsing-remitting multiple sclerosis patients
    • Fernandez O, Mayorga C, Luque G, et al. Study of binding and neutralizing antibodies to interferon-b in two groups of relapsing-remitting multiple sclerosis patients. J Neurol 2001; 248: 383-388.
    • (2001) J Neurol , vol.248 , pp. 383-388
    • Fernandez, O.1    Mayorga, C.2    Luque, G.3
  • 8
    • 27744509228 scopus 로고    scopus 로고
    • Guidelines on use of anti-IFN-b antibody measurement in multiple sclerosis: report of an EFSN Task Force on IFN-b antibodies in multiple sclerosis
    • Sorensen PS, Deisenhammer F, Duda P, et al. Guidelines on use of anti-IFN-b antibody measurement in multiple sclerosis: report of an EFSN Task Force on IFN-b antibodies in multiple sclerosis. Eur J Neurol 2005; 12: 817-827.
    • (2005) Eur J Neurol , vol.12 , pp. 817-827
    • Sorensen, P.S.1    Deisenhammer, F.2    Duda, P.3
  • 9
    • 65349183493 scopus 로고    scopus 로고
    • The clinical effect of neutralizing antibodies against interferon-beta is independent of the type of interferon-beta used for patients with relapsing-remitting multiple sclerosis
    • Koch-Henriksen N, Sorensen P, Bendtzen K, Flachs E. The clinical effect of neutralizing antibodies against interferon-beta is independent of the type of interferon-beta used for patients with relapsing-remitting multiple sclerosis. Mult Scler J 2009; 15: 601-605.
    • (2009) Mult Scler J , vol.15 , pp. 601-605
    • Koch-Henriksen, N.1    Sorensen, P.2    Bendtzen, K.3    Flachs, E.4
  • 10
    • 0037075272 scopus 로고    scopus 로고
    • Pure red-cell aplasia and antierythropoietin in patients treated with recombinant erythropoietin
    • Casadevall N, Nataf J, Viron B, et al. Pure red-cell aplasia and antierythropoietin in patients treated with recombinant erythropoietin. N Engl J Med 2002; 346: 469-475.
    • (2002) N Engl J Med , vol.346 , pp. 469-475
    • Casadevall, N.1    Nataf, J.2    Viron, B.3
  • 11
    • 77957367160 scopus 로고    scopus 로고
    • On the role of aggregates in the immunogenicity of recombinant human interferon beta in patients with multiple sclerosis
    • van Beers MMC, Jiskoot W, Schellekens H. On the role of aggregates in the immunogenicity of recombinant human interferon beta in patients with multiple sclerosis. J Interferon Cytokine Res 2010; 30: 767-775.
    • (2010) J Interferon Cytokine Res , vol.30 , pp. 767-775
    • van Beers, M.M.C.1    Jiskoot, W.2    Schellekens, H.3
  • 12
    • 48349093740 scopus 로고    scopus 로고
    • HLA-DRB1 0401 and HLA-DRB1 0408 are strongly associated with the development of antibodies against interferon-beta therapy in multiple sclerosis
    • Hoffmann S, Cepok S, Grummel V, et al. HLA-DRB1 0401 and HLA-DRB1 0408 are strongly associated with the development of antibodies against interferon-beta therapy in multiple sclerosis. Am J Hum Genet 2008; 83: 219-227.
    • (2008) Am J Hum Genet , vol.83 , pp. 219-227
    • Hoffmann, S.1    Cepok, S.2    Grummel, V.3
  • 13
    • 20444490479 scopus 로고    scopus 로고
    • Appearance and disappearance of neutralizing antibodies during interferon-beta therapy
    • Sorensen PS, Koch-Henriksen N, Ross C, Clemmesen KM, Bendtzen K. Appearance and disappearance of neutralizing antibodies during interferon-beta therapy. Neurology 2005; 65: 33-39.
    • (2005) Neurology , vol.65 , pp. 33-39
    • Sorensen, P.S.1    Koch-Henriksen, N.2    Ross, C.3    Clemmesen, K.M.4    Bendtzen, K.5
  • 14
    • 4444348797 scopus 로고    scopus 로고
    • Interferon-beta: the neutralizing antibody (Nab) titres predicts reversion to Nab negativity
    • Gneiss C, Reindl M, Lutterotte A, et al. Interferon-beta: the neutralizing antibody (Nab) titres predicts reversion to Nab negativity. Mult Scler J 2004; 10: 507-510.
    • (2004) Mult Scler J , vol.10 , pp. 507-510
    • Gneiss, C.1    Reindl, M.2    Lutterotte, A.3
  • 15
    • 43149085573 scopus 로고    scopus 로고
    • Neutralizing anti-interferon beta antibodies are associated with reduced side effects and delayed impact on efficacy of Interferon-beta
    • Farrell R, Kapoor R, Leary S, et al. Neutralizing anti-interferon beta antibodies are associated with reduced side effects and delayed impact on efficacy of Interferon-beta. Mult Scler J 2008; 14: 212-218.
    • (2008) Mult Scler J , vol.14 , pp. 212-218
    • Farrell, R.1    Kapoor, R.2    Leary, S.3
  • 16
    • 84993748625 scopus 로고    scopus 로고
    • Neutralizing antibodies against interferon-beta
    • Sorensen PS. Neutralizing antibodies against interferon-beta. Ther Adv Neurol Dis 2008; 1: 62-78.
    • (2008) Ther Adv Neurol Dis , vol.1 , pp. 62-78
    • Sorensen, P.S.1
  • 17
    • 48349122841 scopus 로고    scopus 로고
    • Is the treatment effect of IFN-beta restored after the disappearance of neutralizing antibodies?
    • Sorensen PS, Koch-Henriksen N, Flachs E, Bendtzen K. Is the treatment effect of IFN-beta restored after the disappearance of neutralizing antibodies? Mult Scler J 2008; 14: 837-842.
    • (2008) Mult Scler J , vol.14 , pp. 837-842
    • Sorensen, P.S.1    Koch-Henriksen, N.2    Flachs, E.3    Bendtzen, K.4
  • 18
    • 0242489120 scopus 로고    scopus 로고
    • An improved ELISA for screening for neutralizing anti-IFN-beta antibodies in MS-patients
    • Pachner AR. An improved ELISA for screening for neutralizing anti-IFN-beta antibodies in MS-patients. Neurology 2003; 61: 1444-1446.
    • (2003) Neurology , vol.61 , pp. 1444-1446
    • Pachner, A.R.1
  • 19
    • 34547661898 scopus 로고    scopus 로고
    • Neutralising antibodies to interferon b in multiple sclerosis. Expert panel report
    • Hartung HP, Polman C, Bertolotto A, et al. Neutralising antibodies to interferon b in multiple sclerosis. Expert panel report. J Neurol 2007; 254: 827-837.
    • (2007) J Neurol , vol.254 , pp. 827-837
    • Hartung, H.P.1    Polman, C.2    Bertolotto, A.3
  • 20
    • 3242880075 scopus 로고    scopus 로고
    • Measurements of neutralizing antibodies to interferon beta in patients with multiple sclerosis
    • Deisenhammer F, Schellekens H, Bertolotto A. Measurements of neutralizing antibodies to interferon beta in patients with multiple sclerosis. J Neurol 2004; 251(Suppl. 2): II/31-II/39.
    • (2004) J Neurol , vol.251 , Issue.SUPPL. 2
    • Deisenhammer, F.1    Schellekens, H.2    Bertolotto, A.3
  • 21
    • 77957352554 scopus 로고    scopus 로고
    • Critical Review: assessment of Interferon-b Immunogenicity on Multiple Sclerosis
    • Bendtzen K. Critical Review: assessment of Interferon-b Immunogenicity on Multiple Sclerosis. J Interferon Cytokine Res 2010; 30: 759-766.
    • (2010) J Interferon Cytokine Res , vol.30 , pp. 759-766
    • Bendtzen, K.1
  • 22
    • 0034081983 scopus 로고    scopus 로고
    • The Danish National Project of interferon-beta treatment in relapsing-remitting multiple sclerosis. The Danish Multiple Sclerosis Group
    • Koch-Henriksen N, Sorensen PS. The Danish National Project of interferon-beta treatment in relapsing-remitting multiple sclerosis. The Danish Multiple Sclerosis Group. Multiple Sclerosis 2000; 6: 172-175.
    • (2000) Multiple Sclerosis , vol.6 , pp. 172-175
    • Koch-Henriksen, N.1    Sorensen, P.S.2
  • 23
    • 0032818106 scopus 로고    scopus 로고
    • ELISA methods for the analysis of antibody responses induced in multiple sclerosis patients treated with recombinant interferon-beta
    • Brickelmaier M, Hochman PS, Baciu R, Chao B, Cuervo JH, Whitty A. ELISA methods for the analysis of antibody responses induced in multiple sclerosis patients treated with recombinant interferon-beta. J Immunol Methods 1999; 227: 121-135.
    • (1999) J Immunol Methods , vol.227 , pp. 121-135
    • Brickelmaier, M.1    Hochman, P.S.2    Baciu, R.3    Chao, B.4    Cuervo, J.H.5    Whitty, A.6
  • 24
    • 0037465461 scopus 로고    scopus 로고
    • Persistent neutralizing antibodies abolish the interferon beta bioavailability in MS patients
    • Bertolotto A, Gilli F, Sala A, et al. Persistent neutralizing antibodies abolish the interferon beta bioavailability in MS patients. Neurology 2003; 60: 634-639.
    • (2003) Neurology , vol.60 , pp. 634-639
    • Bertolotto, A.1    Gilli, F.2    Sala, A.3
  • 25
    • 0242333124 scopus 로고    scopus 로고
    • MxA gene expression analysis as an interferon-b bioactivity measurement in patients with multiple sclerosis and the identification of antibody-mediated decreased bioactivity
    • Pachner AR, Narayan K, Price N, Hurd M, Dail D. MxA gene expression analysis as an interferon-b bioactivity measurement in patients with multiple sclerosis and the identification of antibody-mediated decreased bioactivity. Mol Diagn 2003; 7: 17-25.
    • (2003) Mol Diagn , vol.7 , pp. 17-25
    • Pachner, A.R.1    Narayan, K.2    Price, N.3    Hurd, M.4    Dail, D.5
  • 26
    • 70450162691 scopus 로고    scopus 로고
    • Identification of new sensitive biomarkers for the in vivo response to interferon-β treatment in multiple sclerosis using DNA-array evaluation
    • Sellebjerg F, Krakauer M, Hesse D, et al. Identification of new sensitive biomarkers for the in vivo response to interferon-β treatment in multiple sclerosis using DNA-array evaluation. Eur J Neurol 2009; 16: 1291-1298.
    • (2009) Eur J Neurol , vol.16 , pp. 1291-1298
    • Sellebjerg, F.1    Krakauer, M.2    Hesse, D.3
  • 27
    • 70449449076 scopus 로고    scopus 로고
    • Effect of neutralizing antibodies on biomarker responses to interferon beta. The INSIGHT study
    • Pachner AR, Warth JD, Pace A, Goelz S. Effect of neutralizing antibodies on biomarker responses to interferon beta. The INSIGHT study. Neurology 2009; 73: 1493-1500.
    • (2009) Neurology , vol.73 , pp. 1493-1500
    • Pachner, A.R.1    Warth, J.D.2    Pace, A.3    Goelz, S.4
  • 28
    • 33750990488 scopus 로고    scopus 로고
    • Neutralizing antibodies hamper IFNbeta bioactivity and treatment effect on MRI in patients with MS
    • Sorensen PS, Tscherning T, Mathiesen HK, et al. Neutralizing antibodies hamper IFNbeta bioactivity and treatment effect on MRI in patients with MS. Neurology 2006; 67: 1681-1683.
    • (2006) Neurology , vol.67 , pp. 1681-1683
    • Sorensen, P.S.1    Tscherning, T.2    Mathiesen, H.K.3
  • 29
    • 0025856601 scopus 로고
    • Kinetic maturation of an immune response
    • Foote J, Milstein C. Kinetic maturation of an immune response. Nature 1991; 352: 530-532.
    • (1991) Nature , vol.352 , pp. 530-532
    • Foote, J.1    Milstein, C.2
  • 30
    • 0032893144 scopus 로고    scopus 로고
    • The evolution of neutralizing antibodies in multiple sclerosis patients treated with interferon beta-1b
    • Rice GP, Paszner B, Oger J, Lesaux J, Paty D, Ebers G. The evolution of neutralizing antibodies in multiple sclerosis patients treated with interferon beta-1b. Neurology 1999; 52: 1277-1279.
    • (1999) Neurology , vol.52 , pp. 1277-1279
    • Rice, G.P.1    Paszner, B.2    Oger, J.3    Lesaux, J.4    Paty, D.5    Ebers, G.6
  • 31
    • 31644438194 scopus 로고    scopus 로고
    • Measuring and evaluating interferon-beta-induced antibodies in patients with multiple sclerosis
    • Ross C, Clemmensen KM, Sorensen PS, Koch-Henriksen N, Bendtzen K. Measuring and evaluating interferon-beta-induced antibodies in patients with multiple sclerosis. Mult Scler J 2006; 12: 39-46.
    • (2006) Mult Scler J , vol.12 , pp. 39-46
    • Ross, C.1    Clemmensen, K.M.2    Sorensen, P.S.3    Koch-Henriksen, N.4    Bendtzen, K.5
  • 32
    • 0036158851 scopus 로고    scopus 로고
    • Monthly corticosteroids decrease neutralizing antibodies to IFNbeta1 b: a randomized trial in multiple sclerosis
    • Pozzilli C, Antonini G, Bagnato F, et al. Monthly corticosteroids decrease neutralizing antibodies to IFNbeta1 b: a randomized trial in multiple sclerosis. J Neurol 2002; 249: 50-56.
    • (2002) J Neurol , vol.249 , pp. 50-56
    • Pozzilli, C.1    Antonini, G.2    Bagnato, F.3
  • 33
    • 23644433705 scopus 로고    scopus 로고
    • Significance of neutralizing antibodies to interferon beta during treatment of multiple sclerosis: expert opinions based on the Proceedings of an International Consus Conference
    • Hartung HP, Munschauer F, Schellekens H. Significance of neutralizing antibodies to interferon beta during treatment of multiple sclerosis: expert opinions based on the Proceedings of an International Consus Conference. Eur J Neurol 2005; 12: 588-601.
    • (2005) Eur J Neurol , vol.12 , pp. 588-601
    • Hartung, H.P.1    Munschauer, F.2    Schellekens, H.3
  • 34
    • 33646189628 scopus 로고    scopus 로고
    • Multiplex analysis of expression of three IFNb-induced genes in antibody-positive MS patients
    • Pachner AR, Narayan K, Pak E. Multiplex analysis of expression of three IFNb-induced genes in antibody-positive MS patients. Neurology 2006; 66: 444-446.
    • (2006) Neurology , vol.66 , pp. 444-446
    • Pachner, A.R.1    Narayan, K.2    Pak, E.3
  • 35
    • 77953454473 scopus 로고    scopus 로고
    • Recommendations for clinical use of data on neutralising antibodies to interferon-beta therapy in multiple sclerosis
    • Polman CH, Bertolotto A, Deisenhammer F, et al. Recommendations for clinical use of data on neutralising antibodies to interferon-beta therapy in multiple sclerosis. Lancet Neurol 2010; 9: 740-750.
    • (2010) Lancet Neurol , vol.9 , pp. 740-750
    • Polman, C.H.1    Bertolotto, A.2    Deisenhammer, F.3
  • 36
    • 46249089511 scopus 로고    scopus 로고
    • Validating parameters of a luciferase reporter gene assay to measure neutralizing antibodies to IFNbeta in multiple sclerosis patients
    • Lam R, Farrell R, Aziz T, et al. Validating parameters of a luciferase reporter gene assay to measure neutralizing antibodies to IFNbeta in multiple sclerosis patients. J Immunol Methods 2008; 336: 113-118.
    • (2008) J Immunol Methods , vol.336 , pp. 113-118
    • Lam, R.1    Farrell, R.2    Aziz, T.3
  • 37
    • 2442743850 scopus 로고    scopus 로고
    • A novel bioassay for the determination of neutralizing antibodies to IFN-beta1b
    • Pungor E Jr, Files JG, Gabe JD, et al. A novel bioassay for the determination of neutralizing antibodies to IFN-beta1b. J Interferon Cytokine Res 1998; 18: 1025-1030.
    • (1998) J Interferon Cytokine Res , vol.18 , pp. 1025-1030
    • Pungor Jr., E.1    Files, J.G.2    Gabe, J.D.3
  • 38
    • 35448967388 scopus 로고    scopus 로고
    • Identification of interferon-beta antibodies in a reference laboratory setting: findings for 1144 consecutive sera
    • Prince HE, Lapé-Nixon M, Audette C, et al. Identification of interferon-beta antibodies in a reference laboratory setting: findings for 1144 consecutive sera. J Neuroimmunol 2007; 190: 165-169.
    • (2007) J Neuroimmunol , vol.190 , pp. 165-169
    • Prince, H.E.1    Lapé-Nixon, M.2    Audette, C.3
  • 39
    • 0005489101 scopus 로고    scopus 로고
    • Neutralizing antibodies during treatment of multiple sclerosis with interferon beta-1b: experience during the first three years
    • The IFNB Multiple Sclerosis Study Group and the University of British Columbia MS/MRI Analysis Group
    • The IFNB Multiple Sclerosis Study Group and the University of British Columbia MS/MRI Analysis Group. Neutralizing antibodies during treatment of multiple sclerosis with interferon beta-1b: experience during the first three years. Neurology 1996; 47: 889-894.
    • (1996) Neurology , vol.47 , pp. 889-894


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.