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Volumn 16, Issue 12, 2009, Pages 1291-1298

Identification of new sensitive biomarkers for the in vivo response to interferon-β treatment in multiple sclerosis using DNA-array evaluation

Author keywords

Biomarkers; Gene expression; Interferon ; Multiple sclerosis; Neutralizing antibodies

Indexed keywords

BETA INTERFERON; BIOLOGICAL MARKER; COMPLEMENTARY DNA; DNA; GAMMA INTERFERON INDUCIBLE PROTEIN 10; INTERFERON ALPHA INDUCED PROTEIN 27; MONOCYTE CHEMOTACTIC PROTEIN 1; MYXOVIRUS RESISTANCE PROTEIN A; NEUTRALIZING ANTIBODY; RNA; UNCLASSIFIED DRUG;

EID: 70450162691     PISSN: 13515101     EISSN: 14681331     Source Type: Journal    
DOI: 10.1111/j.1468-1331.2009.02716.x     Document Type: Article
Times cited : (54)

References (35)
  • 1
    • 33645324079 scopus 로고    scopus 로고
    • Drug insight: Interferon treatment in multiple sclerosis
    • Marrie RA, Rudick RA. Drug insight: interferon treatment in multiple sclerosis. Nat Clin Pract Neurol 2006 2 : 34 44.
    • (2006) Nat Clin Pract Neurol , vol.2 , pp. 34-44
    • Marrie, R.A.1    Rudick, R.A.2
  • 2
    • 34547092660 scopus 로고    scopus 로고
    • Using measurements of neutralizing antibodies: The challenge of IFN-beta therapy
    • Hesse D, Sorensen PS. Using measurements of neutralizing antibodies: the challenge of IFN-beta therapy. Eur J Neurol 2007 14 : 850 859.
    • (2007) Eur J Neurol , vol.14 , pp. 850-859
    • Hesse, D.1    Sorensen, P.S.2
  • 3
    • 27744509228 scopus 로고    scopus 로고
    • Guidelines on use of anti-IFN-beta antibody measurements in multiple sclerosis: Report of an EFNS Task Force on IFN-beta antibodies in multiple sclerosis
    • Sorensen PS, Deisenhammer F, Duda P, et al. Guidelines on use of anti-IFN-beta antibody measurements in multiple sclerosis: report of an EFNS Task Force on IFN-beta antibodies in multiple sclerosis. Eur J Neurol 2005 12 : 817 827.
    • (2005) Eur J Neurol , vol.12 , pp. 817-827
    • Sorensen, P.S.1    Deisenhammer, F.2    Duda, P.3
  • 4
    • 34147161297 scopus 로고    scopus 로고
    • Neutralizing antibodies to interferon beta: Assessment of their clinical and radiographic impact: An evidence report: Report of the Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology
    • DOI 10.1212/01.wnl.0000258545.73854.cf, PII 0000611420070327000006
    • Goodin DS, Frohman EM, Hurwitz B, et al. Neutralizing antibodies to interferon beta: assessment of their clinical and radiographic impact: an evidence report: report of the Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology. Neurology 2007 68 : 977 984. (Pubitemid 46569129)
    • (2007) Neurology , vol.68 , Issue.13 , pp. 977-984
    • Goodin, D.S.1    Frohman, E.M.2    Hurwitz, B.3    O'Connor, P.W.4    Oger, J.J.5    Reder, A.T.6    Stevens, J.C.7
  • 5
    • 34250660946 scopus 로고    scopus 로고
    • Are ex vivo neutralising antibodies against IFN-beta always detrimental to therapeutic efficacy in multiple sclerosis?
    • Sorensen PS, Koch-Henriksen N, Bendtzen K. Are ex vivo neutralising antibodies against IFN-beta always detrimental to therapeutic efficacy in multiple sclerosis? Mult Scler 2007 13 : 616 621.
    • (2007) Mult Scler , vol.13 , pp. 616-621
    • Sorensen, P.S.1    Koch-Henriksen, N.2    Bendtzen, K.3
  • 6
    • 20444490479 scopus 로고    scopus 로고
    • Appearance and disappearance of neutralizing antibodies during interferon-beta therapy
    • Sorensen PS, Koch-Henriksen N, Ross C, Clemmesen KM, Bendtzen K. Appearance and disappearance of neutralizing antibodies during interferon-beta therapy. Neurology 2005 65 : 33 39.
    • (2005) Neurology , vol.65 , pp. 33-39
    • Sorensen, P.S.1    Koch-Henriksen, N.2    Ross, C.3    Clemmesen, K.M.4    Bendtzen, K.5
  • 7
    • 33744781321 scopus 로고    scopus 로고
    • Persistence of neutralizing antibodies after discontinuation of IFNbeta therapy in patients with relapsing-remitting multiple sclerosis
    • Petersen B, Bendtzen K, Koch-Henriksen N, Ravnborg M, Ross C, Sorensen PS. Persistence of neutralizing antibodies after discontinuation of IFNbeta therapy in patients with relapsing-remitting multiple sclerosis. Mult Scler 2006 12 : 247 252.
    • (2006) Mult Scler , vol.12 , pp. 247-252
    • Petersen, B.1    Bendtzen, K.2    Koch-Henriksen, N.3    Ravnborg, M.4    Ross, C.5    Sorensen, P.S.6
  • 8
    • 0032893144 scopus 로고    scopus 로고
    • The evolution of neutralizing antibodies in multiple sclerosis patients treated with interferon beta-1b
    • Rice GP, Paszner B, Oger J, Lesaux J, Paty D, Ebers G. The evolution of neutralizing antibodies in multiple sclerosis patients treated with interferon beta-1b. Neurology 1999 52 : 1277 1279.
    • (1999) Neurology , vol.52 , pp. 1277-1279
    • Rice, G.P.1    Paszner, B.2    Oger, J.3    Lesaux, J.4    Paty, D.5    Ebers, G.6
  • 9
    • 0142121383 scopus 로고    scopus 로고
    • Fate of neutralizing and binding antibodies to IFN beta in MS patients treated with IFN beta for 6 years
    • Bellomi F, Scagnolari C, Tomassini V, et al. Fate of neutralizing and binding antibodies to IFN beta in MS patients treated with IFN beta for 6 years. J Neurol Sci 2003 215 : 3 8.
    • (2003) J Neurol Sci , vol.215 , pp. 3-8
    • Bellomi, F.1    Scagnolari, C.2    Tomassini, V.3
  • 10
    • 4444348797 scopus 로고    scopus 로고
    • Interferon-beta: The neutralizing antibody (NAb) titre predicts reversion to NAb negativity
    • Gneiss C, Reindl M, Lutterotti A, et al. Interferon-beta: the neutralizing antibody (NAb) titre predicts reversion to NAb negativity. Mult Scler 2004 10 : 507 510.
    • (2004) Mult Scler , vol.10 , pp. 507-510
    • Gneiss, C.1    Reindl, M.2    Lutterotti, A.3
  • 11
    • 48349122841 scopus 로고    scopus 로고
    • Is the treatment effect of IFN-beta restored after the disappearance of neutralizing antibodies?
    • Sorensen PS, Koch-Henriksen N, Flachs EM, Bendtzen K. Is the treatment effect of IFN-beta restored after the disappearance of neutralizing antibodies? Mult Scler 2008 14 : 837 842.
    • (2008) Mult Scler , vol.14 , pp. 837-842
    • Sorensen, P.S.1    Koch-Henriksen, N.2    Flachs, E.M.3    Bendtzen, K.4
  • 12
    • 0034796419 scopus 로고    scopus 로고
    • The neutralization of interferons by antibody. II. Neutralizing antibody unitage and its relationship to bioassay sensitivity: The tenfold reduction unit
    • Grossberg SE, Kawade Y, Kohase M, Klein JP. The neutralization of interferons by antibody. II. Neutralizing antibody unitage and its relationship to bioassay sensitivity: the tenfold reduction unit. J Interferon Cytokine Res 2001 21 : 743 755.
    • (2001) J Interferon Cytokine Res , vol.21 , pp. 743-755
    • Grossberg, S.E.1    Kawade, Y.2    Kohase, M.3    Klein, J.P.4
  • 13
    • 0034798067 scopus 로고    scopus 로고
    • The neutralization of interferons by antibody. I. Quantitative and theoretical analyses of the neutralization reaction in different bioassay systems
    • Grossberg SE, Kawade Y, Kohase M, Yokoyama H, Finter N. The neutralization of interferons by antibody. I. Quantitative and theoretical analyses of the neutralization reaction in different bioassay systems. J Interferon Cytokine Res 2001 21 : 729 742.
    • (2001) J Interferon Cytokine Res , vol.21 , pp. 729-742
    • Grossberg, S.E.1    Kawade, Y.2    Kohase, M.3    Yokoyama, H.4    Finter, N.5
  • 14
    • 0031841745 scopus 로고    scopus 로고
    • Incidence and significance of neutralizing antibodies to interferon beta-1a in multiple sclerosis. Multiple sclerosis collaborative research group (MSCRG)
    • Rudick RA, Simonian NA, Alam JA, et al. Incidence and significance of neutralizing antibodies to interferon beta-1a in multiple sclerosis. Multiple Sclerosis Collaborative Research Group (MSCRG). Neurology 1998 50 : 1266 1272.
    • (1998) Neurology , vol.50 , pp. 1266-1272
    • Rudick, R.A.1    Simonian, N.A.2    Alam, J.A.3
  • 15
    • 0032893876 scopus 로고    scopus 로고
    • Bioavailability of interferon beta 1b in MS patients with and without neutralizing antibodies
    • Deisenhammer F, Reindl M, Harvey J, Gasse T, Dilitz E, Berger T. Bioavailability of interferon beta 1b in MS patients with and without neutralizing antibodies. Neurology 1999 52 : 1239 1243.
    • (1999) Neurology , vol.52 , pp. 1239-1243
    • Deisenhammer, F.1    Reindl, M.2    Harvey, J.3    Gasse, T.4    Dilitz, E.5    Berger, T.6
  • 16
    • 33750990488 scopus 로고    scopus 로고
    • Neutralizing antibodies hamper IFNbeta bioactivity and treatment effect on MRI in patients with MS
    • Sorensen PS, Tscherning T, Mathiesen HK, et al. Neutralizing antibodies hamper IFNbeta bioactivity and treatment effect on MRI in patients with MS. Neurology 2006 67 : 1681 1683.
    • (2006) Neurology , vol.67 , pp. 1681-1683
    • Sorensen, P.S.1    Tscherning, T.2    Mathiesen, H.K.3
  • 17
    • 0035480227 scopus 로고    scopus 로고
    • Evaluation of bioavailability of three types of IFNbeta in multiple sclerosis patients by a new quantitative-competitive-PCR method for MxA quantification
    • Bertolotto A, Gilli F, Sala A, et al. Evaluation of bioavailability of three types of IFNbeta in multiple sclerosis patients by a new quantitative-competitive-PCR method for MxA quantification. J Immunol Methods 2001 256 : 141 152.
    • (2001) J Immunol Methods , vol.256 , pp. 141-152
    • Bertolotto, A.1    Gilli, F.2    Sala, A.3
  • 18
    • 0037465461 scopus 로고    scopus 로고
    • Persistent neutralizing antibodies abolish the interferon beta bioavailability in MS patients
    • Bertolotto A, Gilli F, Sala A, et al. Persistent neutralizing antibodies abolish the interferon beta bioavailability in MS patients. Neurology 2003 60 : 634 639.
    • (2003) Neurology , vol.60 , pp. 634-639
    • Bertolotto, A.1    Gilli, F.2    Sala, A.3
  • 19
    • 0242333124 scopus 로고    scopus 로고
    • MxA gene expression analysis as an interferon-beta bioactivity measurement in patients with multiple sclerosis and the identification of antibody-mediated decreased bioactivity
    • Pachner A, Narayan K, Price N, Hurd M, Dail D. MxA gene expression analysis as an interferon-beta bioactivity measurement in patients with multiple sclerosis and the identification of antibody-mediated decreased bioactivity. Mol Diagn 2003 7 : 17 25.
    • (2003) Mol Diagn , vol.7 , pp. 17-25
    • Pachner, A.1    Narayan, K.2    Price, N.3    Hurd, M.4    Dail, D.5
  • 20
    • 23144458935 scopus 로고    scopus 로고
    • The importance of measuring IFNbeta bioactivity: Monitoring in MS patients and the effect of anti-IFNbeta antibodies
    • Pachner AR, Dail D, Pak E, Narayan K. The importance of measuring IFNbeta bioactivity: monitoring in MS patients and the effect of anti-IFNbeta antibodies. J Neuroimmunol 2005 166 : 180 188.
    • (2005) J Neuroimmunol , vol.166 , pp. 180-188
    • Pachner, A.R.1    Dail, D.2    Pak, E.3    Narayan, K.4
  • 21
    • 33746078848 scopus 로고    scopus 로고
    • Dynamics of interferon-beta modulated mRNA biomarkers in multiple sclerosis patients with anti-interferon-beta neutralizing antibodies
    • Santos R, Weinstock-Guttman B, Tamano-Blanco M, et al. Dynamics of interferon-beta modulated mRNA biomarkers in multiple sclerosis patients with anti-interferon-beta neutralizing antibodies. J Neuroimmunol 2006 176 : 125 133.
    • (2006) J Neuroimmunol , vol.176 , pp. 125-133
    • Santos, R.1    Weinstock-Guttman, B.2    Tamano-Blanco, M.3
  • 22
    • 37749040878 scopus 로고    scopus 로고
    • In vivo bioactivity of interferon-beta in multiple sclerosis patients with neutralising antibodies is titre-dependent
    • Sominanda A, Hillert J, Fogdell-Hahn A. In vivo bioactivity of interferon-beta in multiple sclerosis patients with neutralising antibodies is titre-dependent. J Neurol Neurosurg Psychiatry 2008 79 : 57 62.
    • (2008) J Neurol Neurosurg Psychiatry , vol.79 , pp. 57-62
    • Sominanda, A.1    Hillert, J.2    Fogdell-Hahn, A.3
  • 23
    • 31644440262 scopus 로고    scopus 로고
    • Biological markers of interferon-beta therapy: Comparison among interferon-stimulated genes MxA, TRAIL and XAF-1
    • Gilli F, Marnetto F, Caldano M, et al. Biological markers of interferon-beta therapy: comparison among interferon-stimulated genes MxA, TRAIL and XAF-1. Mult Scler 2006 12 : 47 57.
    • (2006) Mult Scler , vol.12 , pp. 47-57
    • Gilli, F.1    Marnetto, F.2    Caldano, M.3
  • 24
    • 33646189628 scopus 로고    scopus 로고
    • Multiplex analysis of expression of three IFNbeta-induced genes in antibody-positive MS patients
    • Pachner AR, Narayan K, Pak E. Multiplex analysis of expression of three IFNbeta-induced genes in antibody-positive MS patients. Neurology 2006 66 : 444 446.
    • (2006) Neurology , vol.66 , pp. 444-446
    • Pachner, A.R.1    Narayan, K.2    Pak, E.3
  • 25
    • 46849085156 scopus 로고    scopus 로고
    • Gene expression analysis of interferon-beta treatment in multiple sclerosis
    • Sellebjerg F, Datta P, Larsen J, et al. Gene expression analysis of interferon-beta treatment in multiple sclerosis. Mult Scler 2008 14 : 615 621.
    • (2008) Mult Scler , vol.14 , pp. 615-621
    • Sellebjerg, F.1    Datta, P.2    Larsen, J.3
  • 26
    • 31644438194 scopus 로고    scopus 로고
    • Measuring and evaluating interferon beta-induced antibodies in patients with multiple sclerosis
    • Ross C, Clemmesen KM, Sorensen PS, Koch-Henriksen N, Bendtzen K. Measuring and evaluating interferon beta-induced antibodies in patients with multiple sclerosis. Mult Scler 2006 12 : 39 46.
    • (2006) Mult Scler , vol.12 , pp. 39-46
    • Ross, C.1    Clemmesen, K.M.2    Sorensen, P.S.3    Koch-Henriksen, N.4    Bendtzen, K.5
  • 27
    • 0001677717 scopus 로고
    • Controlling the false discovery rate: A practical and powerful approach to multiple testing
    • Benjamini Y, Hoffmann F. Controlling the false discovery rate: a practical and powerful approach to multiple testing. J R Stat Soc Series B (Methodol) 1995 57 : 289 300.
    • (1995) J R Stat Soc Series B (Methodol) , vol.57 , pp. 289-300
    • Benjamini, Y.1    Hoffmann, F.2
  • 28
    • 0042930859 scopus 로고    scopus 로고
    • Genomic effects of IFN-beta in multiple sclerosis patients
    • Weinstock-Guttman B, Badgett D, Patrick K, et al. Genomic effects of IFN-beta in multiple sclerosis patients. J Immunol 2003 171 : 2694 2702.
    • (2003) J Immunol , vol.171 , pp. 2694-2702
    • Weinstock-Guttman, B.1    Badgett, D.2    Patrick, K.3
  • 29
    • 44249102808 scopus 로고    scopus 로고
    • IFN-beta1b induces transient and variable gene expression in relapsing-remitting multiple sclerosis patients independent of neutralizing antibodies or changes in IFN receptor RNA expression
    • Reder AT, Velichko S, Yamaguchi KD, et al. IFN-beta1b induces transient and variable gene expression in relapsing-remitting multiple sclerosis patients independent of neutralizing antibodies or changes in IFN receptor RNA expression. J Interferon Cytokine Res 2008 28 : 317 331.
    • (2008) J Interferon Cytokine Res , vol.28 , pp. 317-331
    • Reder, A.T.1    Velichko, S.2    Yamaguchi, K.D.3
  • 30
    • 10344243508 scopus 로고    scopus 로고
    • Biological responsiveness to first injections of interferon-beta in patients with multiple sclerosis
    • Gilli F, Marnetto F, Caldano M, et al. Biological responsiveness to first injections of interferon-beta in patients with multiple sclerosis. J Neuroimmunol 2005 158 : 195 203.
    • (2005) J Neuroimmunol , vol.158 , pp. 195-203
    • Gilli, F.1    Marnetto, F.2    Caldano, M.3
  • 31
    • 0027197664 scopus 로고
    • Identification of a new interferon-alpha-inducible gene (p27) on human chromosome 14q32 and its expression in breast carcinoma
    • Rasmussen UB, Wolf C, Mattei MG, et al. Identification of a new interferon-alpha-inducible gene (p27) on human chromosome 14q32 and its expression in breast carcinoma. Cancer Res 1993 53 : 4096 4101.
    • (1993) Cancer Res , vol.53 , pp. 4096-4101
    • Rasmussen, U.B.1    Wolf, C.2    Mattei, M.G.3
  • 32
    • 34948870976 scopus 로고    scopus 로고
    • G1P3, an IFN-induced survival factor, antagonizes TRAIL-induced apoptosis in human myeloma cells
    • Cheriyath V, Glaser KB, Waring JF, Baz R, Hussein MA, Borden EC. G1P3, an IFN-induced survival factor, antagonizes TRAIL-induced apoptosis in human myeloma cells. J Clin Invest 2007 117 : 3107 3117.
    • (2007) J Clin Invest , vol.117 , pp. 3107-3117
    • Cheriyath, V.1    Glaser, K.B.2    Waring, J.F.3    Baz, R.4    Hussein, M.A.5    Borden, E.C.6
  • 33
    • 4644279369 scopus 로고    scopus 로고
    • Interferon-beta induces transient systemic IP-10/CXCL10 chemokine release in patients with multiple sclerosis
    • Buttmann M, Merzyn C, Rieckmann P. Interferon-beta induces transient systemic IP-10/CXCL10 chemokine release in patients with multiple sclerosis. J Neuroimmunol 2004 156 : 195 203.
    • (2004) J Neuroimmunol , vol.156 , pp. 195-203
    • Buttmann, M.1    Merzyn, C.2    Rieckmann, P.3
  • 34
    • 33745868391 scopus 로고    scopus 로고
    • Dynamic T-lymphocyte chemokine receptor expression induced by interferon-beta therapy in multiple sclerosis
    • Krakauer M, Sorensen PS, Khademi M, Olsson T, Sellebjerg F. Dynamic T-lymphocyte chemokine receptor expression induced by interferon-beta therapy in multiple sclerosis. Scand J Immunol 2006 64 : 155 163.
    • (2006) Scand J Immunol , vol.64 , pp. 155-163
    • Krakauer, M.1    Sorensen, P.S.2    Khademi, M.3    Olsson, T.4    Sellebjerg, F.5
  • 35
    • 41549122387 scopus 로고    scopus 로고
    • Predictive markers for response to interferon therapy in patients with multiple sclerosis
    • Malucchi S, Gilli F, Caldano M, et al. Predictive markers for response to interferon therapy in patients with multiple sclerosis. Neurology 2008 70 : 1119 1127.
    • (2008) Neurology , vol.70 , pp. 1119-1127
    • Malucchi, S.1    Gilli, F.2    Caldano, M.3


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