메뉴 건너뛰기




Volumn 14, Issue 6, 2008, Pages 837-842

Is the treatment effect of IFN-β restored after the disappearance of neutralizing antibodies?

(15)  Sorensen, Per Soelberg a   Koch Henriksen, Nils a,b   Flachs, E M c   Bendtzen, K a,d   Sellebjerg, Finn a   Frederiksen, Jette Lautrup e   Jensen, Kai f   Heltberg, Anne g   Kristensen, Ole h   Deth, Sven i   Madsen, Claus j   Stenager, Egon k   Petersen, Thor l   Sivertsen, Bjarne m   Torring, Jesper n  


Author keywords

Interferon beta; Interferon beta antibodies; Multiple sclerosis; Neutralizing antibodies; Therapy; Treatment effect

Indexed keywords

BETA INTERFERON; BETA1 INTERFERON; NEUTRALIZING ANTIBODY;

EID: 48349122841     PISSN: 13524585     EISSN: None     Source Type: Journal    
DOI: 10.1177/1352458508088942     Document Type: Article
Times cited : (25)

References (30)
  • 1
    • 0033763507 scopus 로고    scopus 로고
    • Immunogenicity of interferon-beta in multiple sclerosis patients: Influence of preparation, dosage, dose frequency, and route of administration
    • for the Danish Multiple Sclerosis Study Group
    • Ross, C, Clemmesen, KM, Svensor, M, Sorensen, PS, Koch-Henriksen, N, Skovgaard, GL, et al. for the Danish Multiple Sclerosis Study Group. Immunogenicity of interferon-beta in multiple sclerosis patients: influence of preparation, dosage, dose frequency, and route of administration. Ann Neurol 2000; 48 706-712.
    • (2000) Ann Neurol , vol.48 , pp. 706-712
    • Ross, C.1    Clemmesen, K.M.2    Svensor, M.3    Sorensen, P.S.4    Koch-Henriksen, N.5    Skovgaard, G.L.6
  • 2
    • 0034744952 scopus 로고    scopus 로고
    • Interferon-beta (INF-beta) antibodies in interferon-beta1a- and interferon-beta1b-treated multiple sclerosis patients. Prevalence, kinetics, crossreactivity, and factors enhancing interferon-beta immunogenicity in vivo
    • Perini, P, Facchinetti, A, Bulian, P, Massaro, AR, Pascalis, DD, Bertolotto, A, et al. Interferon-beta (INF-beta) antibodies in interferon-beta1a- and interferon-beta1b-treated multiple sclerosis patients. Prevalence, kinetics, crossreactivity, and factors enhancing interferon-beta immunogenicity in vivo. Eur Cytokine Netw 2001; 12: 56-61.
    • (2001) Eur Cytokine Netw , vol.12 , pp. 56-61
    • Perini, P.1    Facchinetti, A.2    Bulian, P.3    Massaro, A.R.4    Pascalis, D.D.5    Bertolotto, A.6
  • 3
    • 0027418515 scopus 로고
    • Interferon beta-1b is effective in relapsing-remitting multiple sclerosis. I. Clinical results of a multicenter, randomized, double-blind, placebo-controlled trial
    • The IFNB Multiple Sclerosis Study Group
    • The IFNB Multiple Sclerosis Study Group. Interferon beta-1b is effective in relapsing-remitting multiple sclerosis. I. Clinical results of a multicenter, randomized, double-blind, placebo-controlled trial. Neurology 1993; 43: 655-661.
    • (1993) Neurology , vol.43 , pp. 655-661
  • 4
    • 0005489101 scopus 로고    scopus 로고
    • Columbia MS/MRI Analysis Group. Neutralizing antibodies during treatment of multiple sclerosis with interferon beta-1b: Experience during the first three years
    • The IFNB Multiple Sclerosis Study Group and The University of British
    • The IFNB Multiple Sclerosis Study Group and The University of British. Columbia MS/MRI Analysis Group. Neutralizing antibodies during treatment of multiple sclerosis with interferon beta-1b: experience during the first three years. Neurology 1996; 47: 889-894.
    • (1996) Neurology , vol.47 , pp. 889-894
  • 5
    • 0035954361 scopus 로고    scopus 로고
    • PRISMS-4: Long-term efficacy of interferon-beta-1a in relapsing MS
    • PRISMS Study Group
    • PRISMS Study Group. PRISMS-4: Long-term efficacy of interferon-beta-1a in relapsing MS. Neurology 2001; 56: 1628-1636.
    • (2001) Neurology , vol.56 , pp. 1628-1636
  • 6
    • 22044436956 scopus 로고    scopus 로고
    • Interferon beta-1a in MS: Results following development of neutralizing antibodies in PRISMS
    • Francis, GS, Rice, GP, Alsop, JC. Interferon beta-1a in MS: results following development of neutralizing antibodies in PRISMS. Neurology 2005; 65: 48-55.
    • (2005) Neurology , vol.65 , pp. 48-55
    • Francis, G.S.1    Rice, G.P.2    Alsop, J.C.3
  • 7
    • 0037435532 scopus 로고    scopus 로고
    • Neutralizing antibodies during treatment of secondary progressive MS with in erferon beta-1b
    • Polman, C, Kappos, L, White, R, Dahlke, F, Beckmann, K, Pozzilli, C, et al. Neutralizing antibodies during treatment of secondary progressive MS with in erferon beta-1b. Neurology 2003; 60: 37-43.
    • (2003) Neurology , vol.60 , pp. 37-43
    • Polman, C.1    Kappos, L.2    White, R.3    Dahlke, F.4    Beckmann, K.5    Pozzilli, C.6
  • 8
    • 8844222623 scopus 로고    scopus 로고
    • Interferon beta-1b in secondary progressive MS: Results from a 3-year controlled study
    • Panitch, H, Miller, A, Paty, D, Weinshenker, B. Interferon beta-1b in secondary progressive MS: results from a 3-year controlled study. Neurology 2004; 63: 1788-1795.
    • (2004) Neurology , vol.63 , pp. 1788-1795
    • Panitch, H.1    Miller, A.2    Paty, D.3    Weinshenker, B.4
  • 9
    • 10744225329 scopus 로고    scopus 로고
    • Clinical importance of neutralising antibodies against interferon beta in patients with relapsing-remitting multiple clerosis
    • Sorensen, PS, Ross, C, Clemmesen, KM, Bendtzen, K, Frederiksen, JL, Jensen, K, et al. Clinical importance of neutralising antibodies against interferon beta in patients with relapsing-remitting multiple clerosis. Lancet 2003; 362: 1184-1191.
    • (2003) Lancet , vol.362 , pp. 1184-1191
    • Sorensen, P.S.1    Ross, C.2    Clemmesen, K.M.3    Bendtzen, K.4    Frederiksen, J.L.5    Jensen, K.6
  • 11
    • 20444490479 scopus 로고    scopus 로고
    • Appearance and disappearance of neutralizing antibodies during interferon-beta therapy
    • Sorensen, PS, Koch-Henriksen, N, Ross, C, Clemmesen, KM, Bendtzen, K. Appearance and disappearance of neutralizing antibodies during interferon-beta therapy. Neurology 2005; 65: 33-39.
    • (2005) Neurology , vol.65 , pp. 33-39
    • Sorensen, P.S.1    Koch-Henriksen, N.2    Ross, C.3    Clemmesen, K.M.4    Bendtzen, K.5
  • 12
    • 0242658889 scopus 로고    scopus 로고
    • Anti-IFN BAb and NAb antibodies: A minireview
    • Bendtzen, K. Anti-IFN BAb and NAb antibodies: a minireview. Neurology 2003; 61: S6-10.
    • (2003) Neurology , vol.61
    • Bendtzen, K.1
  • 13
    • 0035480227 scopus 로고    scopus 로고
    • Evaluation of bioavailability of three types of IFNbeta in multiple sclerosis patients by a new quantitative-competitive-PCR method for MxA quantification
    • Bertolotto, A, Gilli, F, Sala, A, Audano, L, Castello, A, Magliola, U, et al. Evaluation of bioavailability of three types of IFNbeta in multiple sclerosis patients by a new quantitative-competitive-PCR method for MxA quantification. J Immunol Methods 2001; 256: 141-452.
    • (2001) J Immunol Methods , vol.256 , pp. 141-452
    • Bertolotto, A.1    Gilli, F.2    Sala, A.3    Audano, L.4    Castello, A.5    Magliola, U.6
  • 14
    • 0037465461 scopus 로고    scopus 로고
    • Persistent neutralizing antibodies abolish the interferon beta bioavailability in MS patients
    • Bertolotto, A, Gilli, F, Sala, A, Capobianco, M, Malucchi, S, Milano, E, et al. Persistent neutralizing antibodies abolish the interferon beta bioavailability in MS patients. Neurology 2003; 60: 634-639.
    • (2003) Neurology , vol.60 , pp. 634-639
    • Bertolotto, A.1    Gilli, F.2    Sala, A.3    Capobianco, M.4    Malucchi, S.5    Milano, E.6
  • 15
    • 4344660973 scopus 로고    scopus 로고
    • Biological activity of interferon betas in patients with multiple sclerosis is affected by treatment regimen and neutralising antibodies
    • Bertolotto, A, Sala, A, Malucchi, S. Marnetto, F, Caldano, M, Di Sapio, A, et al. Biological activity of interferon betas in patients with multiple sclerosis is affected by treatment regimen and neutralising antibodies. J Neurol Neurosurg Psychiatry 2004; 75: 1294-1299.
    • (2004) J Neurol Neurosurg Psychiatry , vol.75 , pp. 1294-1299
    • Bertolotto, A.1    Sala, A.2    Malucchi, S.3    Marnetto, F.4    Caldano, M.5    Di Sapio, A.6
  • 16
    • 0035949741 scopus 로고    scopus 로고
    • Serum IFN neutralizing antibodies and neopterin levels in a cross- section of MS patients
    • Cook, SD, Quinless, JR, Jotkowitz, A, Beaton, P. Serum IFN neutralizing antibodies and neopterin levels in a cross- section of MS patients. Neurology 2001; 57: 1080-1084.
    • (2001) Neurology , vol.57 , pp. 1080-1084
    • Cook, S.D.1    Quinless, J.R.2    Jotkowitz, A.3    Beaton, P.4
  • 17
    • 0032893876 scopus 로고    scopus 로고
    • Bioavailability of interferon beta 1b in MS patients with and without neutralizing antibodies
    • Deisenhammer, F, Reindl, M, Harvey, J. Gasse, T, Dilitz, E, Berger, T. Bioavailability of interferon beta 1b in MS patients with and without neutralizing antibodies. Neurology 1999; 52: 1239-1243.
    • (1999) Neurology , vol.52 , pp. 1239-1243
    • Deisenhammer, F.1    Reindl, M.2    Harvey, J.3    Gasse, T.4    Dilitz, E.5    Berger, T.6
  • 18
    • 0242404144 scopus 로고    scopus 로고
    • Measurement of MxA mRNA or protein as a biomarker of IFNbeta bioactivity: Detection of antibody-mediated decreased bioactivity (ADB)
    • Pachner, AR, Bertolotto, A, Deisenhammmer, F. Measurement of MxA mRNA or protein as a biomarker of IFNbeta bioactivity: detection of antibody-mediated decreased bioactivity (ADB). Neurology 2003; 61: S24-S26.
    • (2003) Neurology , vol.61
    • Pachner, A.R.1    Bertolotto, A.2    Deisenhammmer, F.3
  • 19
    • 23144458935 scopus 로고    scopus 로고
    • The importance of measuring IFNbeta bioactivity: Monitoring in MS patients and the effect of anti-IFNbeta antibodies
    • Pachner, AR, Dail, D, Pak, E, Narayan, K. The importance of measuring IFNbeta bioactivity: monitoring in MS patients and the effect of anti-IFNbeta antibodies. J Neuroimmunol 2005; 166: 180-188.
    • (2005) J Neuroimmunol , vol.166 , pp. 180-188
    • Pachner, A.R.1    Dail, D.2    Pak, E.3    Narayan, K.4
  • 20
    • 0031841745 scopus 로고    scopus 로고
    • Incidence and significance of neutralizing antibodies to interferon beta-1a in multiple sclerosis. Multiple Sclerosis Collaborative Research Group (MSCRG)
    • Rudick, RA, Simonian, NA, Alam, JA, Campion, M, Scaramucci, JO, Jones, W, et al. Incidence and significance of neutralizing antibodies to interferon beta-1a in multiple sclerosis. Multiple Sclerosis Collaborative Research Group (MSCRG). Neurology 1998; 50: 1266-1272.
    • (1998) Neurology , vol.50 , pp. 1266-1272
    • Rudick, R.A.1    Simonian, N.A.2    Alam, J.A.3    Campion, M.4    Scaramucci, J.O.5    Jones, W.6
  • 21
    • 33750990488 scopus 로고    scopus 로고
    • Neutralizing antibodies hamper IFNbeta bioactivity and treatment effect on MRI in patients with MS
    • Sorensen, PS, Tscherning T, Mathiesen, HK, Langkilde, AR, Ross, C, Ravnborg, M, et al. Neutralizing antibodies hamper IFNbeta bioactivity and treatment effect on MRI in patients with MS, Neurology 2006; 67: 1681-1683.
    • (2006) Neurology , vol.67 , pp. 1681-1683
    • Sorensen, P.S.1    Tscherning, T.2    Mathiesen, H.K.3    Langkilde, A.R.4    Ross, C.5    Ravnborg, M.6
  • 22
    • 0041850097 scopus 로고    scopus 로고
    • Neutralising antibodies to interferon beta during the treatment of multiple sclerolis
    • Polman, CH, Kappos, L, Petkau, J, Thompson, A. Neutralising antibodies to interferon beta during the treatment of multiple sclerolis. J. Neurol Neurosurg Pscyhiatry 74: 1162-11611
    • J. Neurol Neurosurg Pscyhiatry , vol.74 , pp. 1162-11611
    • Polman, C.H.1    Kappos, L.2    Petkau, J.3    Thompson, A.4
  • 23
    • 27744509228 scopus 로고    scopus 로고
    • Guidelines on use of anti-interferon-beta antibody measurements in multiple sclerosis - report of an EFM Task Force on IFN-beta antibodies in multiple sclerosis
    • Sorensen, PS, Delsenhammer, F, Duda, P, Hohlfeld, R, Myhr, KM, Palace, J, et al. Guidelines on use of anti-interferon-beta antibody measurements in multiple sclerosis - report of an EFM Task Force on IFN-beta antibodies in multiple sclerosis. Eur J Neurol 2005; 12: 817-827.
    • (2005) Eur J Neurol , vol.12 , pp. 817-827
    • Sorensen, P.S.1    Delsenhammer, F.2    Duda, P.3    Hohlfeld, R.4    Myhr, K.M.5    Palace, J.6
  • 24
    • 30644457182 scopus 로고    scopus 로고
    • Fate of multiple sclerosis patients positive for neutralising antibodies towards interferon beta shifted to alternative treatments
    • Malucchi, S, Capobianco, M, Gilli, F, Marnetto, F, Caldano, M, Sala, A, et al. Fate of multiple sclerosis patients positive for neutralising antibodies towards interferon beta shifted to alternative treatments. Neurol Sci 2005; 26: S213-S214.
    • (2005) Neurol Sci , vol.26
    • Malucchi, S.1    Capobianco, M.2    Gilli, F.3    Marnetto, F.4    Caldano, M.5    Sala, A.6
  • 25
    • 0242655956 scopus 로고    scopus 로고
    • Statistical approaches to assessing the effects of neutralizing antibodies IFNbeta-1b in the pivotal trial of relapsing-remitting multiple. sclerosis
    • Petkau, AJ, White, R. Statistical approaches to assessing the effects of neutralizing antibodies IFNbeta-1b in the pivotal trial of relapsing-remitting multiple. sclerosis. Neurology 2003; 61: S35-S37.
    • (2003) Neurology , vol.61
    • Petkau, A.J.1    White, R.2
  • 26
    • 3042526220 scopus 로고    scopus 로고
    • Longitudinal analyses of the effects of neutralizing antibodies on interferon beta-1b in relapsing-remitting multiple sclerosis
    • Petkau, AJ, White, RA, Ebers, GC, Reder, AT, Sibley, WA, Lublin, FP, et al. Longitudinal analyses of the effects of neutralizing antibodies on interferon beta-1b in relapsing-remitting multiple sclerosis. Mult Scler 2004; 10: 126-138.
    • (2004) Mult Scler , vol.10 , pp. 126-138
    • Petkau, A.J.1    White, R.A.2    Ebers, G.C.3    Reder, A.T.4    Sibley, W.A.5    Lublin, F.P.6
  • 28
    • 0142121383 scopus 로고    scopus 로고
    • Fate of neutralizing and binding antibodies to IFN beta in MS patients treated with IFN beta for 6 years
    • Bellomi, F, Scagnolari, C, Tomassini, V, Gasperini, C, Paolillo, A, Pozzilli, C, et al. Fate of neutralizing and binding antibodies to IFN beta in MS patients treated with IFN beta for 6 years. J Neurol Sci 2003; 215: 3-8.
    • (2003) J Neurol Sci , vol.215 , pp. 3-8
    • Bellomi, F.1    Scagnolari, C.2    Tomassini, V.3    Gasperini, C.4    Paolillo, A.5    Pozzilli, C.6
  • 29
    • 4444348797 scopus 로고    scopus 로고
    • Interferon-beta the neutralizing antibody (NAb) titre predicts reversion to NAb negativity
    • Gneiss C, Reindl, M, Lutterotti, A, Ihling, R, Egg, R, Khalil, M, et al. Interferon-beta the neutralizing antibody (NAb) titre predicts reversion to NAb negativity. Mult Scler 2004; 10: 507-510.
    • (2004) Mult Scler , vol.10 , pp. 507-510
    • Gneiss, C.1    Reindl, M.2    Lutterotti, A.3    Ihling, R.4    Egg, R.5    Khalil, M.6
  • 30
    • 34250660946 scopus 로고    scopus 로고
    • ex Vivo neutralising antibodies against IFN-β always detrimental to therapeutic efficacy in multiple sclerosis?
    • Sorensen, PS, Koch-Henriksen, N, Bendtzen, K. Are ex Vivo neutralising antibodies against IFN-β always detrimental to therapeutic efficacy in multiple sclerosis? Mult Scler 2007; 13: 616-621.
    • (2007) Mult Scler , vol.13 , pp. 616-621
    • Sorensen, P.S.1    Koch-Henriksen, N.2    Bendtzen, K.A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.