Developmental and genetic components explain enhanced pulmonary volumes of female peruvian quechua

American Journal of Physical Anthropology

Volumn 148, Issue 4, 2012, Pages 534-542

  Kiyamu, Melisa ^a   Bigham, Abigail ^b   Parra, Esteban ^c   Leõn Velarde, Fabiola ^d   Rivera Chira, María ^d   Brutsaert, Tom D ^e  

^a STATE UNIVERSITY OF NEW YORK   (United States)

^b UNIVERSITY OF MICHIGAN   (United States)

^c UNIVERSITY OF TORONTO   (Canada)

^d UNIVERSIDAD PERUANA CAYETANO HEREDIA   (Peru)

^e SYRACUSE UNIVERSITY   (United States)

Author keywords

adaptation; development; genetics; hypoxia

Indexed keywords

ADULT; AGED; ALTITUDE; ARTICLE; BODY SIZE; DEVELOPMENTAL GENETICS; FEMALE; FORCED VITAL CAPACITY; HUMAN; LUNG VOLUME; PERU; RESIDUAL VOLUME; TOTAL LUNG CAPACITY;

EID: 85027951657     PISSN: 00029483     EISSN: 10968644     Source Type: Journal    
DOI: 10.1002/ajpa.22069     Document Type: Article

References (70)

1. Barker DJ,. 1995. Fetal origins of coronary heart disease. BMJ 311: 171-174.
2. Barker DJ, Bull AR, Osmond C, Simmonds SJ,. 1990. Fetal and placental size and risk of hypertension in adult life. BMJ 301: 259-262. (Pubitemid 20241224)
3. Barker DJ, Hales CN, Fall CH, Osmond C, Phipps K, Clark PM,. 1993. Type 2 (non-insulin-dependent) diabetes mellitus, hypertension and hyperlipidaemia (syndrome X): relation to reduced fetal growth. Diabetologia 36: 62-67. (Pubitemid 23018337)
4. Bartlett D Jr, Remmers JE,. 1971. Effects of high altitude exposure on the lungs of young rats. Respir Physiol 13: 116-125.
5. Beall CM,. 2000. Tibetan and Andean contrasts in adaptation to high-altitude hypoxia. Adv Exp Med Biol 475: 63-74. (Pubitemid 32197714)
6. Beall CM, Cavalleri GL, Deng L, Elston RC, Gao Y, Knight J, Li C, Li JC, Liang Y, McCormack M, Montgomery HE, Pan H, Robbins PA, Shianna KV, Tam SC, Tsering N, Veeramah KR, Wang W, Wangdui P, Weale ME, Xu Y, Xu Z, Yang L, Zaman MJ, Zeng C, Zhang L, Zhang X, Zhaxi P, Zheng YT, et al. 2010. Natural selection on EPAS1 (HIF2alpha) associated with low hemoglobin concentration in Tibetan highlanders. Proc Natl Acad Sci USA 107: 11459-11464.
7. Beall CM, Song K, Elston RC, Goldstein MC,. 2004. Higher offspring survival among Tibetan women with high oxygen saturation genotypes residing at 4,000 m. Proc Natl Acad Sci USA 101: 14300-14304. (Pubitemid 39305069)
8. Bigham A, Bauchet M, Pinto D, Mao X, Akey JM, Mei R, Scherer SW, Julian CG, Wilson MJ, Lõpez Herráez D, Brutsaert T, Parra EJ, Moore LG, Shriver MD,. 2010. Identifying signatures of natural selection in Tibetan and Andean populations using dense genome scan data. PLoS Genet 6. p ii: e1001116.
9. Bigham AW, Kiyamu M, Leõn-Velarde F, Parra EJ, Rivera-Ch M, Shriver MD, Brutsaert TD,. 2008. Angiotensin-converting enzyme genotype and arterial oxygen saturation at high altitude in Peruvian Quechua. High Alt Med Biol 9: 167-178. (Pubitemid 351913536)
10. Bonilla C, Parra EJ, Pfaff CL, Dios S, Marshall JA, Hamman RF, Ferrell RE, Hoggart CL, McKeigue PM, Shriver MD,. 2004. Admixture in the Hispanics of the San Luis Valley, Colorado, and its implications for complex trait gene mapping. Ann Hum Genet 68: 139-153. (Pubitemid 38379845)
11. Boyce AJ, Haight JS, Rimmer DB, Harrison GA,. 1974. Respiratory function in Peruvian Quechua Indians. Ann Hum Biol 1: 137-148.
12. Brutsaert T, Parra E, Shriver M, Gamboa A, Palacios J, Rivera M, Rodriguez I, Leõn-Velarde F,. 2003. Spanish genetic admixture is associated with larger V(O2) max decrement from sea level to 4338 m in Peruvian Quechua. J Appl Physiol 92: 519-528. (Pubitemid 36944272)
13. Brutsaert T, Parra E, Shriver M, Gamboa A, Rivera-Ch M, Leõn-Velarde F,. 2005. Ancestry explains the blunted ventilatory response to sustained hypoxia and lower exercise ventilation of Quechua altitude natives. Am J Physiol Regul Integr Comp Physiol 289: R225-R234. (Pubitemid 40874979)
14. Brutsaert TD, Parra E, Shriver M, Gamboa A, Palacios JA, Rivera M, Rodriguez I, Leõn-Velarde F,. 2004. Effects of birthplace and individual genetic admixture on lung volume and exercise phenotypes of Peruvian Quechua. Am J Phys Anthropol 123: 390-398. (Pubitemid 38524550)
15. Brutsaert TD, Soria R, Caceres E, Spielvogel H, Haas JD,. 1999. Effect of developmental and ancestral high altitude exposure on chest morphology and pulmonary function in Andean and European/North American natives. Am J Hum Biol 11: 383-395. (Pubitemid 129726308)
16. Burri PH, Weibel ER,. 1971. Morphometric estimation of pulmonary diffusion capacity. II. Effect of PO2 on the growing lung. Adaption of the growing rat lung to hypoxia and hyperoxia. Respir Physiol 1971: 247-264.
17. Canoy D, Pekkanen J, Elliott P, Pouta A, Laitinen J, Hartikainen A-L, Zitting P, Patel S, Little MP, Jarvelin M-J,. 2007. Early growth and adult respiratory function in men and women followed from the fetal period to adulthood. Thorax 62: 396-402. (Pubitemid 46698387)
18. Chakraborty R, Barton SA, Ferrell RE, Schull WJ,. 1989. Ethnicity determination by names among the Aymara of Chile and Bolivia. Hum Biol 61: 159-177. (Pubitemid 19193390)
19. Copland I, Post M,. 2004. Lung development and fetal lung growth. Paediatr Respir Rev 5 Suppl A: S259-64.
20. Cunningham EL, Brody JS, Jain BP,. 1974. Lung growth induced by hypoxia. J Appl Physiol 37: 362-366.
21. DeGraff AC Jr, Grover RF, Johnson RL Jr, Hammond JW Jr, Miller JM,. 1970. Diffusing capacity of the lung in Caucasians native to 3,100 m. J Appl Physiol 29: 71-76.
22. Dempsey JA, Reddan WG, Birnbaum ML, Forster HV, Thoden JS, Grover RF, Rankin J,. 1971. Effects of acute through life-long hypoxic exposure on exercise pulmonary gas-exchange. Respir Physiol 13: 62-89.
23. Droma T, McCullough RG, McCullough RE, Zhuang JG, Cymerman A, Sun SF, Sutton JR, Moore LG,. 1991. Increased vital and total lung capacities in Tibetan compared to Han residents of Lhasa (3,658 m). Am J Phys Anthropol 86: 341-351.
24. Durnin JV, Womersley J,. 1974. Body fat assessed from total body density and its estimation from skinfold thickness: measurements on 481 men and women aged from 16 to 72 years. Br J Nutr 32: 77-97.
25. Fall CH, Osmond C, Barker DJ, Clark PM, Hales CN, Stirling Y, Meade TW,. 1995. Fetal and infant growth and cardiovascular risk factors in women. BMJ 310: 428-432.
26. Faridy EE, Sanii MR, Thiveris JA,. 1988. Fetal lung growth: influence of maternal hypoxia and hyperoxia in rats. Respir Physiol 73: 225-242.
27. Frisancho AR, Frisancho HG, Albalak R, Villain M, Vargas E, Soria R,. 1997. Developmental, genetic and environmental components of lung volumes at high altitude. Am J Hum Biol 9: 191-203. (Pubitemid 127466797)
28. Frisancho AR, Velásquez T, Sanchez J,. 1973. Influence of developmental adaptation on lung function at high altitude. Hum Biol 45: 583-594.
29. Frisancho AR,. 1969. Human growth and pulmonary function of a high altitude Peruvian Quechua population. Hum Biol 91: 365-379.
30. Frisancho R,. 1983. The high altitude native. In:, Sutton JR, Houston CS, Jones NL, editors. Hypoxia, exercise and altitude. New York: Alan R. Liss. p 383-407.
31. Frisancho AR,. 2009. Developmental adaptation: where we go from here. Am J Hum Biol 21: 694-703.
32. Greksa LP,. 1986. Growth patterns of European and Amerindian high altitude natives. Curr Anthropol 22: 72-73.
33. Greksa LP,. 1990. Developmental responses to high-altitude hypoxia in Bolivian children of European ancestry: a test of the developmental adaptation hypothesis. Am J Hum Biol 2: 603-612.
34. Greksa LP,. 1996. Evidence for a genetic basis to the enhanced total lung capacity of Andean highlanders. Hum Biol 68: 119-129. (Pubitemid 126612006)
35. Greksa LP, Spielvogel H, Caceres E,. 1994. Total lung capacity in young highlanders of Aymara ancestry. Am J Phys Anthropol 94: 477-486. (Pubitemid 24237404)
36. Greksa LP, Spielvogel H, Caceres E, Paredes-Fernandez L,. 1987. Lung function of young Aymara highlanders. Ann Hum Biol 14: 533-542. (Pubitemid 17166990)
37. Guleria JS, Pande JN, Sethi PK, Roy SB,. 1971. Pulmonary diffusing capacity at high altitude. J Appl Physiol 31: 536-543.
38. Hanis CL, Chakraborty R, Ferrell RE, Schull WJ,. 1986. Individual admixture estimates: disease associations and individual risk of diabetes and gallbladder disease among Mexican-Americans in Starr County, Texas. Am J Phys Anthropol 70: 433-441. (Pubitemid 16041403)
39. Harrison GA,. 1966. Human adaptability with reference to the IBP proposals for high altitude research. In:, Baker PT, Weiner JS, editors. The biology of human adaptability. Oxford: Clarendon Press. p 509-519.
40. Harrison GA, Kuchemann CF, Moore MAS, Boyce AJ, Baju T, Mourant AE, Godber MJ, Glasgow BG, Kopec AC, Tills D, Clegg EJ,. 1969. The effects of altitudinal variation in Ethiopian populations. Philos Trans R Soc Lond 256: 147-182.
41. Hochachka PW, Rupert JL, Monge C,. 1999. Adaptation and conservation of physiological systems in the evolution of human hypoxia tolerance. Comp Biochem Physiol A Mol Integr Physiol 124: 1-17. (Pubitemid 29452938)
42. Johnson RL Jr., Cassidy SS, Grover RF, Schutte JE, Epstein RH,. 1985. Functional capacities of lungs and thorax in beagles after prolonged residence at 3,100 m. J Appl Physiol 59: 1773-1782. (Pubitemid 16158251)
43. Julian CG, Wilson MJ, Lopez M, Yamashiro H, Tellez W, Rodriguez A, Bigham AW, Shriver MD, Rodriguez C, Vargas E, Moore LG,. 2009. Augmented uterine artery blood flow and oxygen delivery protect Andeans from altitude-associated reductions in fetal growth. Am J Physiol Regul Integr Comp Physiol 296: R1564-R1575.
44. Kotecha SJ, Watkins WJ, Heron J, Henderson J, Dunstan FD, Kotecha S,. 2010. Spirometric lung function in school-aged children: effect of intrauterine growth retardation and catch-up growth. Am J Respir Crit Care Med 181: 969-974.
45. Lawlor DA, Ebrahim S, Davey Smith G,. 2005. Association of birth weight with adult lung function: findings from the British women's heart and health study and a meta-analysis. Thorax 60: 851-858. (Pubitemid 41475214)
46. Lechner AJ, Banchero N,. 1980. Lung morphometry in guinea pigs acclimated to hypoxia during growth. Respir Physiol 42: 155-169. (Pubitemid 11192701)
47. Monge MC,. 1948. Acclimatization in the Andes. Baltimore, MD: John Hopkins University Press.
48. Moore LG,. 2001. Human genetic adaptation to high altitude. High Alt Med Biol 2: 257-279. (Pubitemid 32677861)
49. Moore LG, Brodeur P, Chumbe O, D'Brot J, Hofmeister S, Monge C,. 1986. Maternal hypoxic ventilatory response, ventilation, and infant birth weight at 4,300 m. J Appl Physiol 60: 1401-1406. (Pubitemid 16028444)
50. Mortola JP, Frappell PB, Frappell DE, Villena-Cabrera N, Villena-Cabrera M, Peña F,. 1992. Ventilation and gaseous metabolism in infants born at high altitude, and their responses to hyperoxia. Am Rev Respir Dis 146: 1206-1209.
51. Mueller WH, Yen F, Rothhammer F, Schull WJ,. 1978. A multinational Andean genetic and health program. VI. Physiological measurements of lung function in a hypoxic environment. Hum Biol 50: 489-513. (Pubitemid 9121903)
52. Parra EJ, Kittles RA, Shriver MD,. 2004. Implications of correlations between skin color and genetic ancestry for biomedical research. Nat Genet 36: S54-S60. (Pubitemid 41103839)
53. Phillips DI, Barker DJ, Hales CN, Hirst S, Osmond C,. 1994. Thinness at birth and insulin resistance in adult life. Diabetologia 37: 150-154. (Pubitemid 24042883)
54. Polgar G, Weng TR,. 1979. The functional development of the respiratory system from the period of gestation to adulthood. Am Rev Respir Dis 120: 625-695. (Pubitemid 10230205)
55. Rupert JL, Hochachka PW,. 2001. The evidence for hereditary factors contributing to high altitude adaptation in Andean natives: a review. High Alt Med Biol 2: 235-256. (Pubitemid 32680870)
56. Schoene RB, Roach RC, Lahiri S, Peters Jr. RM, Hackett PH, Santolaya R,. 1990. Increased diffusion capacity maintains arterial saturation during exercise in the Quechua Indians of Chilean Altiplano. Am J Hum Biol 2: 663-668.
57. Sekhon H, Thurlbeck W,. 1996a. Lung morphometric changes after exposure to hypobaria and/or hypoxia and undernutrition. Respir Physiol 106: 99-107. (Pubitemid 26376079)
58. Sekhon HS, Thurlbeck WM,. 1996b. Time course of lung growth following exposure to hypobaria and/or hypoxia in rats. Respir Physiol 105: 241-252. (Pubitemid 26356875)
59. Shriver M, Parra E, Dios S, Bonilla C, Norton H, Jovel C, Pfaff C, Jones C, Massac A, Cameron N, Baron A, Jackson T, Argyropoulos G, Jin L, Hoggart CJ, McKeigue PM, Kittles RA,. 2003. Skin pigmentation, biogeographical ancestry and admixture mapping. Hum Genet 112: 387-399. (Pubitemid 36869067)
60. Simonson TS, Yang Y, Huff CD, Yun H, Qin G, Witherspoon DJ, Bai Z, Lorenzo FR, Xing J, Jorde LB, Prchal JT, Ge R,. 2010. Genetic evidence for high-altitude adaptation in Tibet. Science 329: 72-75.
61. Siri W,. 1956. The gross composition of the body. Adv Biol Med Phys 4: 239-280.
62. Sun SF, Droma TS, Zhang JG, Tao JX, Huang SY, McCullough RG, McCullough RE, Reeves CS, Reeves JT, Moore LG,. 1990. Greater maximal O2 uptakes and vital capacities in Tibetan than Han residents of Lhasa. Respir Physiol 79: 151-161. (Pubitemid 20059874)
63. Vargas E, Beard J, Haas J, Cudkowicz L,. 1982. Pulmonary diffusing capacity in young Andean highland children. Respiration 43: 330-335. (Pubitemid 12024408)
64. Velasquez T, Martinez C, Pezzia W, Gallardo N,. 1968. Ventilatory effects of oxygen in high altitude natives. Resp Physiol 5:211- 220.
65. Wagner PD, Araoz M, Boushel R, Calbet JA, Jessen B, Radergran G, Spielvogel H, Sondegaard H, Wagner H, Saltin B,. 2002. Pulmonary gas exchange and acid-base state at 5,260m in high-altitude Bolivians and acclimatized lowlanders. J Appl Physiol 92: 1393-400. (Pubitemid 34670891)
66. Weitz CA, Garruto RM, Chin C-T, Liu J-C, Liu R-L, He X,. 2002. Lung function of Han Chinese born and raised near sea level and at high altitude in Western China. Am J Hum Biol 14: 494-510. (Pubitemid 34704706)
67. Wilmore JH, Vodak PA, Parr RB, Girandola RN, Billing JE,. 1980. Further simplification of a method for determination of residual lung volume. Med Sci Sports Exerc 12: 216-218. (Pubitemid 10002286)
68. Wilson MJ, Lopez M, Vargas M, Julian C, Tellez W, Rodriguez A, Bigham A, Armaza F, Niermeyer S, Shriver M, Vargas E, Moore LG,. 2007. Greater uterine artery blood flow during pregnancy in multigenerational (Andean) than shorter-term (European) high-altitude residents. Am J Physiol Regul Integr Comp Physiol 293: R1313-R1324. (Pubitemid 47358956)
69. Yi X, Liang Y, Huerta-Sanchez E, Jin X, Cuo ZX, Pool JE, Xu X, Jiang H, Vinckenbosch N, Korneliussen TS, Zheng H, Liu T, He W, Li K, Luo R, Nie X, Wu H, Zhao M, Cao H, Zou J, Shan Y, Li S, Yang Q, Asan Ni P, Tian G, Xu J, Liu X, Jiang T, Wu R, Zhou G, Tang M, Qin J, Wang T, Feng S, Li G, Huasang, Luosang J, Wang W, Chen F, Wang Y, Zheng X, Li Z, Bianba Z, Yang G, Wang X, Tang S, Gao G, Chen Y, Luo Z, Gusang L, Cao Z, Zhang Q, Ouyang W, Ren X, Liang H, Zheng H, Huang Y, Li J, Bolund L, Kristiansen K, Li Y, Zhang Y, Zhang X, Li R, Li S, Yang H, Nielsen R, Wang J, Wang J,. et al. 2010. Sequencing of 50 human exomes reveals adaptation to high altitude. Science 329: 75-78.
70. Zhuang J, Droma T, Sutton JR, Groves BM, McCullough RE, McCullough RG, Sun S, Moore LG,. 1996. Smaller alveolar-arterial O2 gradients in Tibetan than Han residents of Lhasa (3658 m). Respir Physiol 103: 75-82. (Pubitemid 26049037)