Spanish genetic admixture is associated with larger V̇O2 max decrement from sea level to 4,338 m in Peruvian Quechua

Journal of Applied Physiology

Volumn 95, Issue 2, 2003, Pages 519-528

  Brutsaert, Tom D ^a   Parra, Esteban J ^b   Shriver, Mark D ^c   Gamboa, Alfredo ^d   Palacios, Jose Antonio ^d   Rivera, Maria ^d   Rodriguez, Ivette ^c,e   León Velarde, Fabiola ^d  

^a STATE UNIVERSITY OF NEW YORK   (United States)

^b UNIVERSITY OF TORONTO   (Canada)

^c PENNSYLVANIA STATE UNIVERSITY   (United States)

^d UNIVERSIDAD PERUANA CAYETANO HEREDIA   (Peru)

^e Instituto Boliviano de Biologia de Altura   (Bolivia)

Author keywords

Aerobic performance; Altitude; Andes; Deoxyribonucleic acid; Genetic markers; Hypoxia

Indexed keywords

DNA MARKER;

ADULT; ARTICLE; BOLIVIA; CONTROLLED STUDY; COVARIANCE; EVOLUTION; GENE INTERACTION; GENETIC ANALYSIS; GENETICS; HUMAN; HUMAN EXPERIMENT; HYPOTHESIS; LUNG FUNCTION TEST; OXYGEN CONSUMPTION; OXYGEN SATURATION; PREDICTION; PRIORITY JOURNAL; SEA LEVEL;

EID: 0041627923     PISSN: 87507587     EISSN: None     Source Type: Journal    
DOI: 10.1152/japplphysiol.01088.2002     Document Type: Article

References (52)

1. Akey JM, Sosnoski D, Parra E, Dios S, Hiester K, Su B, Bonilla C, Jin L, and Shriver MD. Melting curve analysis of SNPs (McSNP): a gel-free and inexpensive approach for SNP genotyping. Biotechniques 30: 358-367, 2001.
2. Baker PT. Human adaptation to high altitude. Science 163: 1149-1156, 1969.
3. Baker PT. Work performance of highland natives. In: Man in the Andes: A Multidisciplinary Study of High-Altitude Quechua Natives, edited by Baker PT and Little MA. Stroudsburg, PA: Wowden, Hutchinson, and Ross, 1976.
4. Brutsaert TD. Limits on inferring genetic adaptation to high altitude in Himalayan and Andean populations. High Alt Med Biol 2: 211-225, 2001.
5. Brutsaert TD, Araoz M, Soria R, Spielvogel H, and Haas JD. Higher arterial oxygen saturation during submaximal exercise in Bolivian Aymara compared with European sojourners and Europeans born and raised at high altitude. Am J Phys Anthropol 113: 169-181, 2000.
6. Brutsaert TD, Soria R, Caceres E, Spielvogel H, and Haas JD. Effect of developmental and ancestral high altitude exposure on chest morphology and pulmonary function in Andean and European/North American natives. Am J Human Biol 11: 383-395, 1999.
7. Caiozzo VJ, Davis JA, Ellis JF, Azus JL, Vandagriff R, Prietto CA, and McMaster WC. A comparison of gas exchange indices used to detect the anaerobic threshold. J Appl Physiol 53: 1184-1189, 1982.
8. Chakraborty R and Weiss KM. Admixture as a tool for finding linked genes and detecting that difference from allelic association between loci. Proc Natl Acad Sci USA 85: 9119-9123, 1988.
9. Dempsey JA, Hanson PG, and Henderson KS. Exercise-induced arterial hypoxaemia in healthy human subjects at sea level. J Physiol 355: 161-175, 1984.
10. Durnin JV and Womersley J. Body fat assessed from total body density and its estimation from skinfold thickness: measurements on 481 men and women aged from 16 to 72 years. Br J Nutr 32: 77-97, 1974.
11. Elsner RW, Blostad A, and Forno C. Maximum oxygen consumption of Peruvian Indians native to high altitude. In: The Physiological Effects of High Altitude, edited by Weihe WH. New York: Pergamon, 1964, p. 217-223.
12. Ferretti G, Moia C, Thomet JM, and Kayser B. The decrease of maximal oxygen consumption during hypoxia in man: a mirror image of the oxygen equilibrium curve. J Physiol 498: 231-237, 1997.
13. Frisancho AR, Frisancho HG, Albalak R, Villena M, Vargas E, and Soria R. Developmental, genetic and environmental components of lung volumes at high altitude. Am J Human Biol 9:191-203, 1997.
14. Frisancho AR, Martinez C, Velasquez T, Sanchez J, and Montoye H. Influence of developmental adaptation on aerobic capacity at high altitude. J Appl Physiol 34: 176-180, 1973.
15. Gale GE, Torre-Bueno JR, Moon RE, Saltzman HA, and Wagner PD. Ventilation-perfusion inequality in normal humans during exercise at sea level and simulated altitude. J Appl Physiol 58: 978-988, 1985.
16. Garland T Jr and Carter PA. Evolutionary physiology. Annu Rev Physiol 56: 579-621, 1994.
17. Gore CJ, Hahn AG, Scroop GC, Watson DB, Norton KI, Wood RJ, Campbell DP, and Emonson DL. Increased arterial desaturation in trained cyclists during maximal exercise at 580 m altitude. J Appl Physiol 80: 2204-2210, 1996.
18. Greksa LP. Evidence for a genetic basis to the enhanced total lung capacity of Andean highlanders. Hum Biol 68: 119-129, 1996.
19. Hammond MD, Gale GE, Kapitan KS, Ries A, and Wagner PD. Pulmonary gas exchange in humans during exercise at sea level. J Appl Physiol 60: 1590-1598, 1986.
20. Hannhart B, Haberer JP, Saunier C, and Laxenaire MC. Accuracy and precision of fourteen pulse oximeters. Eur Respir J 4: 115-119, 1991.
21. Hewett JE, Anderson SK, and Minor MA. Statistical analyses for research in arthritis when assessing change. Arthritis Care Res 5: 74-80, 1992.
22. Hochachka PW, Gunga HC, and Kirsch K. Our ancestral physiological phenotype: an adaptation for hypoxia tolerance and for endurance performance? Proc Natl Acad Sci USA 95: 1915-1920, 1998.
23. Hochachka PW, Stanley C, Matheson GO, McKenzie DC, Allen PS, and Parkhouse WS. Metabolic and work efficiencies during exercise in Andean natives. J Appl Physiol 70: 1720-1730, 1991.
24. Hurtado A. Animals in high altitudes: resident man. In: Handbook of Physiology. Adaptation to the Environment. Washington, DC: Am. Physiol. Soc., 1964, sect. 4, chapt. 54, p. 843-860.
25. Kaiser L. Adjusting for baseline: change or percentage change? Stat Med 8: 1183-1190, 1989.
26. Kashiwazaki H, Dejima Y, Orias-Rivera J, and Coward W. Validity of published prediction equations for body composition in high altitude Bolivian Aymara as evaluated by doubly labeled water. Am J Hum Biol 10: 371-384, 1998.
27. Katz A and Sahlin K. Role of oxygen in regulation of glycolysis and lactate production in human skeletal muscle. Exerc Sport Sci Rev 18: 1-28, 1990.
28. Koistinen P, Takala T, Martikkala V, and Leppaluoto J. Aerobic fitness influences the response of maximal oxygen uptake and lactate threshold in acute hypobaric hypoxia. Int J Sports Med 16: 78-81, 1995.
29. Kollias J, Buskirk ER, Akers RF, Prokop EK, Baker PT, and Picon-Reategui E. Work capacity of long-time residents and newcomers to altitude. J Appl Physiol 24: 792-799, 1968.
30. O2 max decrement during exposure to acute hypoxia. J Appl Physiol 64: 1486-1492, 1988.
31. Lynch TF. Glacial-age man in South America? A critical review. Am Antiq 55: 12-36, 1990.
32. O2 max of trained and untrained subjects. J Sports Sci 11: 37-42, 1993.
33. Martinez P, Haberer JP, Hannhart B, Saunier C, and Laxenaire MC. [Comparative evaluation of 13 pulse oximeters]. Ann Fr Anesth Reanim 8, Suppl: R225, 1989.
34. Mazess RB. Exercise performance at high altitude in Peru. Fed Proc 28: 1301-1306, 1969.
35. Mazess RB. Exercise performance of Indian and white high altitude residents. Hum Biol 41: 494-518, 1969.
36. Molokhia M, Hoggart C, Patrick AL, Shriver M, Parra E, Ye J, Silman AJ, and McKeigue PM. Relation of risk of systemic lupus erythematosus to west African admixture in a Caribbean population. Hum Genet 112: 310-318, 2003.
37. Plummer JL, Zakaria AZ, Ilsley AH, Fronsko RR, and Owen H. Evaluation of the influence of movement on saturation readings from pulse oximeters. Anaesthesia 50: 423-426, 1995.
38. Pritchard JK, Stephens M, and Donnelly P. Inference of population structure using multilocus genotype data. Genetics 155:945-959, 2000.
39. Remmers JE and Mithoefer JC. The carbon monoxide diffusing capacity in permanent residents at high altitude. Respir Physiol 6: 233-244, 1969.
40. Rice AJ, Thornton AT, Gore CJ, Scroop GC, Greville HW, Wagner H, Wagner PD, and Hopkins SR. Pulmonary gas exchange during exercise in highly trained cyclists with arterial hypoxemia. J Appl Physiol 87: 1802-1812, 1999.
41. O2 max during acute hypobaric hypoxia. Med Sci Sports Exerc 30:869-879, 1998.
42. Shephard RJ, Bouhlel E, Vandewalle H, and Monod H. Peak oxygen intake and hypoxia: influence of physical fitness. Int J Sports Med 9: 279-283, 1988.
43. Shriver MD, Parra EJ, Dios S, Bonilla C, Norton H, Jovel C, Pfaff C, Jones C, Massac A, Cameron N, Baron A, Jackson T, Argyropoulos G, Jin L, Hoggart CJ, McKeigue PM, and Kittles RA. Skin pigmentation, biogeographical ancestry and admixture mapping. Hum Genet 11: 387-399, 2003.
44. Terrados N, Mizuno M, and Andersen H. Reduction in maximal oxygen uptake at low altitudes; role of training status and lung function. Clin Physiol 5: 75-79, 1985.
45. Velasquez T. Acquired acclimatization to sea-level. In: Life at High Altitudes. Washington, DC: Pan American Health Organiztion, Scientific Publications, 1966, p. 58-63.
46. Vincent J, Hellot MF, Vargas E, Gautier H, Pasquis P, and Lefrancois R. Pulmonary gas exchange, diffusing capacity in natives and newcomers at high altitude. Respir Physiol 34: 219-231, 1978.
47. Vogel JA, Hartley LH, and Cruz JC. Cardiac output during exercise in altitude natives at sea level and high altitude. J Appl Physiol 36: 173-176, 1974.
48. Wagner PD. Determinants of maximal oxygen uptake and utilization. Annu Rev Physiol 58: 21-50, 1996.
49. Way AB. Exercise capacity of high altitude peruvian Quechua Indians migrant to low altitude. Hum Biol 48: 175-191, 1976.
50. West JB. Highest permanent human habitation. High Alt Med Biol 3: 401-407, 2002.
51. Wood RJ, Gore CJ, Hahn AG, Norton KI, Scroop GC, Campbell DP, Watson DB, and Emonson DL. Accuracy of two pulse oximeters during maximal cycling exercise. Aust J Sci Med Sport 29: 47-50, 1997.
52. Yamaya Y, Bogaard HJ, Wagner PD, Niizeki K, and Hopkins SR. Validity of pulse oximetry during maximal exercise in normoxia, hypoxia, and hyperoxia. J Appl Physiol 92: 162-168, 2002.