Preparation and bioevaluation of 99mTc nitrido radiopharmaceuticals with pyrazolo[1,5-a]pyrimidine as tumor imaging agents

Medicinal Chemistry Research

Volumn 21, Issue 4, 2012, Pages 523-530

  Ding, Rui ^a   He, Yong ^a   Xu, Jingli ^a   Liu, Hang ^a   Wang, Xiao ^a   Feng, Man ^a   Qi, Chuanmin ^a   Zhang, Junbo ^a   Peng, Cheng ^b  

^a BEIJING NORMAL UNIVERSITY   (China)

^b CAPITAL MEDICAL UNIVERSITY   (China)

Author keywords

Pyrazolo 1,5 a pyrimidine; Tumor imaging

Indexed keywords

2 (ETHOXYMETHYLENE)MALONONITRILE; 3 AMINO 4 CYANOPYRAZOLE; 5 METHYL 3 CYANO 7 CHLOROPYRAZOLO[1,5 A]PYRIMIDINE; 5 METHYL 3 CYANO 7 HYDROXYPYRAZOLO[1,5 A]PYRIMIDINE; 7 (2 AMINOETHYLAMINO) 5 METHYL 3 CYANOPYRAZOLO[1,5 A]PYRIMIDINE; N MERCAPTOACETYLGLYCINE; N MERCAPTOACETYLPHENYLALANINE; N MERCAPTOACETYLVALINE; N [(TRITYLMERCAPTO)ACETYL]GLYCINE; N [(TRITYLMERCAPTO)ACETYL]PHENYLALANINE; N [(TRITYLMERCAPTO)ACETYL]VALINE; NITRIDOCADE TECHNETIUM TC 99M; PYRAZOLO[1,5 A]PYRIMIDINE DERIVATIVE; RADIOPHARMACEUTICAL AGENT; TRITYLMERCAPTOACETIC ACID; TRITYLMERCAPTOACETIC ACID N HYDROXYSUCCINIMIDO ESTER; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; DRUG CLEARANCE; DRUG CONJUGATION; DRUG SCREENING; DRUG SYNTHESIS; FEMALE; MOUSE; NONHUMAN;

EID: 85027948893     PISSN: 10542523     EISSN: 15548120     Source Type: Journal    
DOI: 10.1007/s00044-011-9558-8     Document Type: Article

References (17)

1. Arora A, Scholar EM (2005) Role of tyrosine kinase inhibitors in cancer therapy. J Pharmacol Exp Ther 315(3):971-979 (Pubitemid 41635382)
2. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE (2000) The protein data bank. Nucleic Acids Res 28(1):235-242 (Pubitemid 30047768)
3. De bondt HL, Rosenblatt J, Jancarik J, Jones HD, Morgan DO, Kim SH (1993) Crystal structure of cyclin-dependent kinase 2. Nature 363:595-602 (Pubitemid 23227617)
4. Fraley ME, Hoffman WF, Rubino RS, Hungate RW, Tebben AJ, Rutledge RZ, McFall RC, Huckle WR, Kendall RL, Coll KE, Thomas KA (2002) Synthesis and initial SAR studies of 3, 6-disubstituted pyrazolo[1,5-a]pyrimidines: a new class of KDR kinase inhibitors. Bioorg Med Chem Lett 12:2767-2770 (Pubitemid 35247634)
5. 99mTc labeling. Bioorg Med Chem 14:2904-2909
6. Havlicek L, Fuksova K, Krystof V, Orsag M, Vojtesek B, Strnad M (2005) 8-Azapurines as new inhibitors of cyclin-dependent kinases. Bioorg Med Chem 13:5399-5407 (Pubitemid 41132618)
7. Knockaert M, Greengard P, Meijer L (2002) Pharmacological inhibitors of cyclin-dependent kinases. Trends Pharmacol Sci 23:417-425 (Pubitemid 35247771)
8. Lane ME, Yu B, Rice A, Lipson KE, Liang C, Sun L, Tang C, McMahon G, Pestell RG, Wadler S (2001) A novel cdk2- selective inhibitor, SU9516, induces apoptosis in colon carcinoma cells. Cancer Res 61:6170-6177 (Pubitemid 32762555)
9. Lawrie AM, Noble MEM, Tunnah P, Brown NR, Johnson LM, Endicott JA (1997) Protein kinase inhibition by staurosporine revealed in details of the molecular interaction with CDK2. Nat Struct Biol 4(10):796-801
10. Li J, Zhao YF, Zhao XL, Yuan XY, Gong P (2006) Synthesis and anti-tumor activities of novel pyrazolo[1,5-a]pyrimidines. Arch Pharm Chem Life Sci 339:593-597 (Pubitemid 44831694)
11. 99mTc-labeled small peptides as diagnostic radiopharmaceuticals. Chem Rev 99(9):2235-2268
12. Meijer L, Raymond AE (2003) Roscovitine and other purines as kinase inhibitors. From starfish oocytes to clinical trials. Acc Chem Res 36:417-425
13. 99mTc-pseudo-peptide complexes in mice. Med Chem Res 11(6): 345-359 (Pubitemid 36693679)
14. Richardson CM, Williamson DS, Paratt MJ, Borgognoni J, Cansfield AD, Dokurno P, Fracis GL, Howes R, Moore JD, Murray JB, Robertson A, Surgenor AE, Torrance CJ (2006) Triazolo[1,5- a]pyrimidines as novel CDK2 inhibitors: protein structureguided design and SAR. Bioorg Med Chem 16:1353-1357 (Pubitemid 43143021)
15. Sielecki TM, Boylan JF, Benfield PA, Trainor GL (2000) Cyclindependent kinase inhibitors: useful targets in cell cycle regulation. J Med Chem 43:1-18 (Pubitemid 30055758)
16. Williamson DS, Paratt MJ, Bower JF, Moore JD, Richardson CM, Dokurno P, Cansfield AD, Fracis GL, Hebdon RJ, Howes R, Jackson PS, Lockie AM, Murray JB, Nunns CL, Powles J, Robertson A, Surgenor AE, Torrance CJ (2005) Structure-guided design of pyrazolo[1,5-a]pyrimidines as inhibitors of human cyclin-dependent kinase 2. Bioorg Med Chem Lett 15:863-867 (Pubitemid 40467433)
17. Wu Z, Fraley ME, Bilodeau MT, Kaufman ML, Tasber ES, Balitza AE, Hartman GD, Coll KE, Rickert K, Shipman J, Shi B, Sepp- Lorenzino L, Thomas KA (2004) Design and synthesis of 3, 7-diarylimidazopyridines as inhibitors of the VEGF-receptor KDR. Bioorg Med Chem Lett 14:909-912 (Pubitemid 38167613)