Vascular reactivity at rest and during exercise in middle-aged obese men: Effects of short-term, low-intensity, exercise training

International Journal of Obesity

Volumn 35, Issue 6, 2011, Pages 820-828

  Vinet, A ^a   Karpoff, L ^a   Walther, G ^a   Startun, A ^b,c   Obert, P ^a   Goret, L ^b,c   Dauzat, M ^b,c   Perez Martin, A ^b,c  

^a UNIVERSITY OF AVIGNON   (France)

^b UNIV MONTPELLIER   (France)

^c NÎMES UNIVERSITY HOSPITAL   (France)

Author keywords

blood flow; exercise; flow mediated dilation; training

Indexed keywords

ADULT; ARTERY BLOOD FLOW; ARTERY COMPLIANCE; ARTERY DILATATION; ARTICLE; BLOOD VESSEL REACTIVITY; BRACHIAL ARTERY; CAROTID ARTERY; CLINICAL ARTICLE; CONTROLLED STUDY; EXERCISE INTENSITY; HUMAN; INTIMA; MALE; MIDDLE AGED; OBESITY; PRIORITY JOURNAL; REST; THICKNESS; TUNICA MEDIA; VASCULAR ENDOTHELIUM;

EID: 85027932955     PISSN: 03070565     EISSN: 14765497     Source Type: Journal    
DOI: 10.1038/ijo.2010.206     Document Type: Article

References (39)

1. Van Guilder GP, Hoetzer GL, Dengel DR, Stauffer BL, DeSouza CA. Impaired endothelium-dependent vasodilation in normotensive and normoglycemic obese adult humans. J Cardiovasc Pharmacol 2006; 47: 310-313. (Pubitemid 44384071)
2. Acree LS, Comp PC, Whitsett TL, Montgomery PS, Nickel KJ, Fjeldstad AS et al. The influence of obesity on calf blood flow and vascular reactivity in older adults. Dyn Med 2007; 6: 4.
3. Chung WB, Hamburg NM, Holbrook M, Shenouda SM, Dohadwala MM, Terry DF et al. The brachial artery remodels to maintain local shear stress despite the presence of cardiovascular risk factors. Arterioscler Thromb Vasc Biol 2009; 29: 606-612.
4. De Filippis E, Cusi K, Ocampo G, Berria R, Buck S, Consoli A et al. Exercise-induced improvement in vasodilatory function accompanies increased insulin sensitivity in obesity and type 2 diabetes mellitus. J Clin Endocrinol Metab 2006; 91: 4903-4910. (Pubitemid 44917325)
5. Hashimoto M, Akishita M, Eto M, Kozaki K, Ako J, Sugimoto N et al. The impairment of flow-mediated vasodilatation in obese men with visceral fat accumulation. Int J Obes Relat Metab Disord 1998; 22: 477-484. (Pubitemid 28211977)
6. Corretti MC, Anderson TJ, Benjamin EJ, Celermajer D, Charbonneau F, Creager MA et al. Guidelines for the ultrasound assessment of endothelial-dependent flow-mediated vasodilation of the brachial artery: a report of the International Brachial Artery Reactivity Task Force. J Am Coll Cardiol 2002; 39: 257-265. (Pubitemid 34084631)
7. Brook RD, Bard RL, Rubenfire M, Ridker PM, Rajagopalan S. Usefulness of visceral obesity (waist/hip ratio) in predicting vascular endothelial function in healthy overweight adults. Am J Cardiol 2001; 88: 1264-1269. (Pubitemid 33132095)
8. Skilton MR, Sieveking DP, Harmer JA, Franklin J, Loughnan G, Nakhla S et al. The effects of obesity and non-pharmacological weight loss on vascular and ventricular function and structure. Diabetes Obes Metab 2008; 10: 874-884.
9. Pasimeni G, Ribaudo MC, Capoccia D, Rossi F, Bertone C, Leonetti F et al. Non-invasive evaluation of endothelial dysfunction in uncomplicated obesity: relationship with insulin resistance. Microvasc Res 2006; 71: 115-120. (Pubitemid 44316781)
10. Higashi Y, Sasaki S, Nakagawa K, Matsuura H, Chayama K, Oshima T. Effect of obesity on endothelium-dependent, nitric oxide-mediated vasodilation in normotensive individuals and patients with essential hypertension. Am J Hypertens 2001; 14: 1038-1045. (Pubitemid 32978077)
11. Sivitz WI, Wayson SM, Bayless ML, Sinkey CA, Haynes WG. Obesity impairs vascular relaxation in human subjects: hyperglycemia exaggerates adrenergic vasoconstriction arterial dysfunction in obesity and diabetes. J Diabetes Complications 2007; 21: 149-157. (Pubitemid 46687066)
12. Perticone F, Ceravolo R, Candigliota M, Ventura G, Iacopino S, Sinopoli F et al. Obesity and body fat distribution induce endothelial dysfunction by oxidative stress: protective effect of vitamin C. Diabetes 2001; 50: 159-165. (Pubitemid 32047995)
13. Vigili de Kreutzenberg S, Kiwanuka E, Tiengo A, Avogaro A. Visceral obesity is characterized by impaired nitric oxideindependent vasodilation. Eur Heart J 2003; 24: 1210-1215. (Pubitemid 36834637)
14. Saltin B, Ra°degran G, Koskolou MD, Roach RC. Skeletal muscle blood flow in humans and its regulation during exercise. Acta Physiol Scand 1998; 162: 421-436. (Pubitemid 28121421)
15. Karpoff L, Vinet A, Schuster I, Oudot C, Goret L, Dauzat M et al. Abnormal vascular reactivity at rest and exercise in obese boys. Eur J Clin Invest 2009; 39: 94-102.
16. Negrão CE, Trombetta IC, Batalha LT, Ribeiro MM, Rondon MU, Tinucci T et al. Muscle metaboreflex control is diminished in normotensive obese women. Am J Physiol Heart Circ Physiol 2001; 281: H469-H475.
17. Bijnen FC, Caspersen CJ, Feskens EJ, Saris WH, Mosterd WL, Kromhout D. Physical activity and 10-year mortality from cardiovascular diseases and all causes: The Zutphen Elderly Study. Arch Intern Med 1998; 158: 1499-1505. (Pubitemid 28340982)
18. Lavrencic A, Salobir BG, Keber I. Physical training improves flowmediated dilation in patients with the polymetabolic syndrome. Arterioscler Thromb Vasc Biol 2000; 20: 551-555. (Pubitemid 30086116)
19. Schjerve IE, Tyldum GA, Tjønna AE, Stølen T, Loennechen JP, Hansen HE et al. Both aerobic endurance and strength training programmes improve cardiovascular health in obese adults. Clin Sci (Lond) 2008; 115: 283-293.
20. Trombetta IC, Batalha LT, Rondon MU, Laterza MC, Kuniyoshi FH, Gowdak MM et al. Weight loss improves neurovascular and muscle metaboreflex control in obesity. Am J Physiol Heart Circ Physiol 2003; 285: H974-H982. (Pubitemid 37048150)
21. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment: insulin resistance and b-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 1985; 28: 412-419. (Pubitemid 15018832)
22. Walther G, Nottin S, Dauzat M, Obert P. Femoral and axillary ultrasound blood flow during exercise: a methodological study. Med Sci Sports Exerc 2006; 38: 1353-1361. (Pubitemid 44036709)
23. Touboul PJ, Hennerici MG, Meairs S, Adams H, Amarenco P, Bornstein N et al. Mannheim carotid intima-media thickness consensus (2004-2006). An update on behalf of the advisory board of the 3rd and 4th watching the risk symposium, 13th and 15th European Stroke Conferences, Mannheim, Germany, 2004, and Brussels, Belgium, 2006. Cerebrovasc Dis 2007; 23: 75-80.
24. Betik AC, Luckham VB, Hughson RL. Flow-mediated dilation in human brachial artery after different circulatory occlusion conditions. Am J Physiol Heart Circ Physiol 2004; 286: H442-H448. (Pubitemid 38049511)
25. Perez-Martin A, Dumortier M, Raynaud E, Brun JF, Fédou C, Bringer J et al. Balance of substrate oxidation during submaximal exercise in lean and obese people. Diabetes Metab 2001; 27: 466-474. (Pubitemid 32852455)
26. Peronnet F, Massicotte D. Table of nonprotein respiratory quotient: an update. Can J Sport Sci 1991; 16: 23-29.
27. MacRae HS, Noakes TD, Dennis SC. Role of decreased carbohydrate oxidation on slower rises in ventilation with increasing exercise intensity after training. Eur J Appl Physiol 1995; 71: 523-529. (Pubitemid 26002266)
28. Dumortier M, Brandou F, Perez-Martin A, Fedou C, Mercier J, Brun JF. Low intensity endurance exercise targeted for lipid oxidation improves body composition and insulin sensitivity in patients with the metabolic syndrome. Diabetes Metab 2003; 29: 509-518. (Pubitemid 37474263)
29. Kuboki K, Jiang ZY, Takahara N, Ha SW, Igarashi M, Yamauchi T et al. Regulation of endothelial constitutive nitric oxide synthase gene expression in endothelial cells and in vivo: a specific vascular action of insulin. Circulation 2000; 101: 676-681. (Pubitemid 30094740)
30. Vanhoutte PM. Endothelial control of vasomotor function: from health to coronary disease. Circ J 2003; 67: 572-575. (Pubitemid 36834382)
31. Higashi Y, Sasaki S, Nakagawa K, Matsuura H, Kajiyama G, Oshima T. A noninvasive measurement of reactive hyperemia that can be used to assess resistance artery endothelial function in humans. Am J Cardiol 2001; 87: 121-125. (Pubitemid 32013961)
32. Pierce GL, Beske SD, Lawson BR, Southall KL, Benay FJ, Donato AJ et al. Weight loss alone improves conduit and resistance artery endothelial function in young and older overweight/obese adults. Hypertension 2008; 52: 72-79.
33. Gavin TP, Stallings HW, Zwetsloot KA,Westerkamp LM, Ryan NA, Moore RA et al. Lower capillary density but no difference in VEGF expression in obese vs. lean young skeletal muscle in humans. J Appl Physiol 2005; 98: 315-321. (Pubitemid 40041262)
34. Hedman A, Andersson PE, Reneland R, Lithell HO. Insulinmediated changes in leg blood flow are coupled to capillary density in skeletal muscle in healthy 70-year-old men. Metabolism 2001; 50: 1078-1082. (Pubitemid 32904168)
35. Hamdy O, Ledbury S, Mullooly C, Jarema C, Porter S, Ovalle K et al. Lifestyle modification improves endothelial function in obese subjects with the insulin resistance syndrome. Diabetes Care 2003; 26: 2119-2125. (Pubitemid 41184262)
36. Joannides R, Bellien J, Thuillez C. Clinical methods for the evaluation of endothelial function- a focus on resistance arteries. Fundam Clin Pharmacol 2006; 20: 311-320.
37. Green DJ, Maiorana A, O'Driscoll G, Taylor R. Effect of exercise training on endothelium-derived nitric oxide function in humans. J Physiol 2004; 561: 1-25. (Pubitemid 39549463)
38. Green DJ, Walsh JH, Maiorana A, Burke V, Taylor RR, O'Driscoll JG. Comparison of resistance and conduit vessel nitric-oxidemediated vascular function in vivo: effects of exercise training. J Appl Physiol 2004; 97: 749-755. (Pubitemid 38963151)
39. Sciacqua A, Candigliota M, Ceravolo R, Scozzafava A, Sinopoli F, Corsonello A et al. Weight loss in combination with physical activity improves endothelial dysfunction in human obesity. Diabetes Care 2003; 26: 1673-1678. (Pubitemid 36929102)