Increased cathepsin S in Prdm1-/- dendritic cells alters the T FH cell repertoire and contributes to lupus

Nature Immunology

Volumn 18, Issue 9, 2017, Pages 1016-1024

  Kim, Sun Jung ^a   Schätzle, Sebastian ^b   Ahmed, S Sohail ^c   Haap, Wolfgang ^a   Jang, Su Hwa ^a   Gregersen, Peter K ^b   Georgiou, George ^b   Diamond, Betty ^a  

^a FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH   (United States)

^b The University of Texas at Austin   (United States)

^c F HOFFMANN LA ROCHE LTD   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINUCLEAR ANTIBODY; CATHEPSIN; CATHEPSIN S; DNA; LYMPHOCYTE ANTIGEN RECEPTOR; PRDM1 PROTEIN, MOUSE; TRANSCRIPTION FACTOR;

ANIMAL; ANTIGEN PRESENTATION; CD4+ T LYMPHOCYTE; CELL DIFFERENTIATION; CELL PROLIFERATION; DENDRITIC CELL; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; GENETICS; HELPER CELL; IMMUNOLOGY; KIDNEY; KNOCKOUT MOUSE; LYMPHOCYTE ACTIVATION; METABOLISM; MOUSE; PATHOLOGY; SYSTEMIC LUPUS ERYTHEMATOSUS;

ANIMALS; ANTIBODIES, ANTINUCLEAR; ANTIGEN PRESENTATION; CATHEPSINS; CD4-POSITIVE T-LYMPHOCYTES; CELL DIFFERENTIATION; CELL PROLIFERATION; DENDRITIC CELLS; DNA; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; KIDNEY; LUPUS ERYTHEMATOSUS, SYSTEMIC; LYMPHOCYTE ACTIVATION; MICE; MICE, KNOCKOUT; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; T-LYMPHOCYTES, HELPER-INDUCER; TRANSCRIPTION FACTORS;

EID: 85027849552     PISSN: 15292908     EISSN: 15292916     Source Type: Journal    
DOI: 10.1038/ni.3793     Document Type: Article

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