Cytokine-specific Neurograms in the Sensory Vagus Nerve

Bioelectronic Medicine

Volumn 3, Issue 1, 2016, Pages 7-17

  Steinberg, Benjamin E ^a,b   Silverman, Harold A ^a   Robbiati, Sergio ^a   Gunasekaran, Manoj K ^a   Tsaava, Téa ^a   Battinelli, Emily ^a   Stiegler, Andrew ^c   Bouton, Chad E ^a   Chavan, Sangeeta S ^a   Tracey, Kevin J ^a   Huerta, Patricio T ^a,d  

^a FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH   (United States)

^b UNIVERSITY OF TORONTO   (Canada)

^c Circulatory Technologies Inc ^*  (United States)

^d DONALD AND BARBARA ZUCKER SCHOOL OF MEDICINE AT HOFSTRA NORTHWELL   (United States)

Author keywords

Cervical Vagus; Compound Action Potential (CAP); Neurogram; Nodose Ganglion; Vagaries

Indexed keywords

ELECTROPHYSIOLOGY; IMMUNE SYSTEM; MACROPHAGES; MAMMALS; PHYSIOLOGICAL MODELS;

CERVICAL VAGUS; COMPOUND ACTION POTENTIAL; COMPOUND ACTION POTENTIALS; CYTOKINES; INTERLEUKIN 1Β; NEUROGRAM; NODOSE GANGLION; TUMOR NECROSIS FACTORS; VAGARY; VAGUS NERVE;

NEURONS;

EID: 85027283434     PISSN: None     EISSN: 23328886     Source Type: Journal    
DOI: 10.15424/bioelectronmed.2016.00007     Document Type: Article

References (27)

1. Tracey KJ. (2002) The inflammatory reflex. Nature. 420:853–59. DOI: 10.1038/nature01321
2. Rosas-Ballina M, Olofsson PS, Ochani M, et al. (2011) Acetylcholine-synthesizing T cells relay neural signals in a vagus nerve circuit. Science. 334:98–101. DOI: 10.1126/science.1209985
3. Reardon C, Duncan GS, Brüstle A, et al. (2013) Lymphocyte-derived ACh regulates local innate but not adaptive immunity. Proc. Natl. Acad. Sci. USA. 110:1410–15. DOI: 10.1073/pnas.1221655110
4. Hansen MK, O’Connor KA, Goehler LE, Watkins LR, Maier SF. (2001) The contribution of the vagus nerve in interleukin-1beta-induced fever is dependent on dose. Am. J. Physiol. Regul. Integr. Comp. Physiol. 280:R929–34. DOI: 10.1152/ajpregu.2001.280.4.R929
5. Watkins LR, Goehler LE, Relton JK, et al. (1995) Blockade of interleukin-1 induced hyperthermia by subdiaphragmatic vagotomy: evidence for vagal mediation of immune-brain communication. Neurosci. Lett. 183:27–31. DOI: 10.1016/0304-3940(94)11105-R
6. Niijima A, Hori T, Katafuchi T, Ichijo T. (1995) The effect of interleukin-1 beta on the efferent activity of the vagus nerve to the thymus. J. Auton. Nerv. Syst. 54:137–44. DOI: 10.1016/0165-1838(95)00003-G
7. Niijima A. (1996) The afferent discharges from sensors for interleukin 1 beta in the hepatoportal system in the anesthetized rat. J. Auton. Nerv. Syst. 61:287–91. DOI: 10.1016/S0165-1838(96)00098-7
8. Niijima A. (1992) Electrophysiological study on the vagal innervation of the adrenal gland in the rat. J. Auton. Nerv. Syst. 41:87–92. DOI: 10.1016/0165-1838(92)90130-9
9. Czeschik JC, Hagenacker T, Schäfers M, Büsselberg D. (2008) TNF-alpha differentially modulates ion channels of nociceptive neurons. Neurosci. Lett. 434:293–98. DOI: 10.1016/j.neulet.2008.01.070
10. Hagenacker T, Czeschik JC, Schäfers M, Büsselberg D. (2010) Sensitization of voltage activated calcium channel currents for capsaicin in nociceptive neurons by tumor-necrosis-factor-alpha. Brain Res. Bull. 81:157–63. DOI: 10.1016/j.brainresbull.2009.09.012
11. Binshtok AM, Wang H, Zimmermann K, et al. (2008) Nociceptors are interleukin-1beta sensors. J. Neurosci. 28:14062–73. DOI: 10.1523/JNEUROSCI.3795-08.2008
12. Kagan BL, Baldwin RL, Munoz D, Wisnieski BJ. (1992) Formation of ion-permeable channels by tumor necrosis factor-alpha. Science. 255:1427–30. DOI: 10.1126/science.1371890
13. Chiu IM, Heesters BA, Ghasemlou N, et al. (2013) Bacteria activate sensory neurons that modulate pain and inflammation. Nature. 501:52–57. DOI: 10.1038/nature12479
14. Muroi Y, Ru F, Kollarik M, et al. (2011) Selective silencing of NaV1.7 decreases excitability and conduction in vagal sensory neurons. J Physiol. 589:5663–76. DOI: 10.1113/jphysiol.2011.215384
15. Docherty RJ, Charlesworth G, Farrag K, Bhattacharjee A, Costa S. (2005) The use of the rat isolated vagus nerve for functional measurements of the effect of drugs in vitro. J. Pharmacol. Toxicol. Methods. 51:235–42. DOI: 10.1016/j.vascn.2004.08.011
16. Farrag KJ, Costa SK, Docherty RJ. (2002) Differential sensitivity to tetrodotoxin and lack of effect of prostaglandin E2 on the pharmacology and physiology of propagated action potentials. Br. J. Pharmacol. 135:1449–56. DOI: 10.1038/sj.bjp.0704607
17. Akopian AN, Sivilotti L, Wood JN. (1996) A tetrodotoxin-resistant voltage-gated sodium channel expressed by sensory neurons. Nature. 379:257–62. DOI: 10.1038/379257a0
18. Tate S, Benn S, Hick C, et al. (1998) Two sodium channels contribute to the TTX-R sodium current in primary sensory neurons. Nat. Neurosci. 1:653–55. DOI: 10.1038/3652
19. Chang EH, Huerta PT. (2012) Neurophysiological correlates of object recognition in the dorsal subiculum. Front. Behav. Neurosci. 6:46. DOI: 10.3389/fnbeh.2012.00046
20. Nácher V, Ledberg A, Deco G, Romo R. (2013) Coherent delta-band oscillations between cortical areas correlate with decision making. Proc. Natl. Acad. Sci. USA. 110:15085–90. DOI: 10.1073/pnas.1314681110
21. Kopell N, Kramer MA, Malerba P, Whittington MA. (2010) Are different rhythms good for different functions? Front. Hum. Neurosci. 4:187. DOI: 10.3389/fnhum.2010.00187
22. Famm K, Litt B, Tracey KJ, Boyden E, Slaoui M. (2013) Drug discovery: a jump-start for electroceuticals. Nature. 496:159–61. DOI: 10.1038/496159a
23. Birmingham K, Gradinaru V, Anikeeva P, et al. (2014) Bioelectronic medicines: a research roadmap. Nat. Rev. Drug. Discov. 13:399–400. DOI: 10.1038/nrd4351
24. Huerta PT, Olofsson PS. (2016) Bioelectronic medicine: Harnessing the electric patterns of neurons for therapy. Technical workshop W06 at the 10th Forum of Neuroscience, Copenhagen, Denmark. FENS; c.2016 [updated 2016 Jun 30; cited 2016 Dec 8]. Available from: https://doi.org/forum2016.fens.org/forum-programme/preliminary-programme/
25. Koopman FA, Schuurman PR, Vervoordeldonk MJ, Tak PP. (2014) Vagus nerve stimulation: a new bioelectronics approach to treat rheumatoid arthritis? Best Pract. Res. Clin. Rheumatol. 28:625–35. DOI: 10.1016/j.berh.2014.10.015
26. Koopman FA, Chavan SS, Miljko S, et al. (2016) Vagus nerve stimulation inhibits cytokine production and attenuates disease severity in rheumatoid arthritis. Proc. Natl. Acad. Sci. USA. 113:8284–89. DOI: 10.1073/pnas.1605635113
27. Simasko SM, Wiens J, Karpiel A, Covasa M, Ritter RC. (2002) Cholecystokinin increases cytosolic calcium in a subpopulation of cultured vagal afferent neurons. Am. J. Physiol. Regul. Integr. Comp. Physiol. 283:R1303–13. DOI: 10.1152/ajpregu.00050.2002