Hesperidin reverses perivascular adipose-mediated aortic stiffness with aging

Experimental Gerontology

Volumn 97, Issue , 2017, Pages 68-72

  Ouyang, An ^a   Garner, Tyler B ^a   Fleenor, Bradley S ^a  

^a UNIVERSITY OF KENTUCKY   (United States)

Author keywords

Advanced glycation end products; Age; Artery; Fat

Indexed keywords

AMINOGUANIDINE; HESPERIDIN; TRANSCRIPTION FACTOR RELA; ADVANCED GLYCATION END PRODUCT;

AGING; ANIMAL EXPERIMENT; ANIMAL TISSUE; AORTIC PRESSURE; ARTERIAL STIFFNESS; ARTICLE; CARDIOVASCULAR DISEASE; CONTROLLED STUDY; FUNCTIONAL ASSESSMENT; HEART FUNCTION; HEART RATE; MOUSE; NONHUMAN; OXIDATIVE STRESS; PERIVASCULAR ADIPOSE TISSUE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PULSE WAVE; ADIPOSE TISSUE; ANIMAL; AORTA; C57BL MOUSE; DRUG EFFECT; METABOLISM; PATHOLOGY;

ADIPOSE TISSUE; AGING; ANIMALS; AORTA; GLYCATION END PRODUCTS, ADVANCED; HESPERIDIN; MICE; MICE, INBRED C57BL; OXIDATIVE STRESS; PULSE WAVE ANALYSIS; VASCULAR STIFFNESS;

EID: 85026917360     PISSN: 05315565     EISSN: 18736815     Source Type: Journal    
DOI: 10.1016/j.exger.2017.08.003     Document Type: Article

References (20)

1. Britton, K.A., Massaro, J.M., Murabito, J.M., Kreger, B.E., Hoffmann, U., Fox, C.S., Body fat distribution, incident cardiovascular disease, cancer, and all-cause mortality. J. Am. Coll. Cardiol. 62:10 (2013), 921–925, 10.1016/j.jacc.2013.06.027.
2. Britton, K.A., Wang, N., Palmisano, J., Corsini, E., Schlett, C.L., Hoffmann, U., Fox, C.S., Thoracic periaortic and visceral adipose tissue and their cross-sectional associations with measures of vascular function. Obesity (Silver Spring) 21:7 (2013), 1496–1503, 10.1002/oby.20166.
3. Cassidy, A., Rimm, E.B., O'Reilly, E.J., Logroscino, G., Kay, C., Chiuve, S.E., Rexrode, K.M., Dietary flavonoids and risk of stroke in women. Stroke 43:4 (2012), 946–951, 10.1161/STROKEAHA.111.637835.
4. Du, B., Ouyang, A., Eng, J.S., Fleenor, B.S., Aortic perivascular adipose-derived interleukin-6 contributes to arterial stiffness in low-density lipoprotein receptor deficient mice. Am. J. Physiol. Heart Circ. Physiol. 308:11 (2015), H1382–1390, 10.1152/ajpheart.00712.2014.
5. Fleenor, B.S., Sindler, A.L., Eng, J.S., Nair, D.P., Dodson, R.B., Seals, D.R., Sodium nitrite de-stiffening of large elastic arteries with aging: role of normalization of advanced glycation end-products. Exp. Gerontol. 47:8 (2012), 588–594.
6. Fleenor, B.S., Eng, J.S., Sindler, A.L., Pham, B.T., Kloor, J.D., Seals, D.R., Superoxide-signaling in perivascular adipose tissue promotes age-related artery stiffness. Aging Cell 13 (2014), 576–578, 10.1111/acel.12196.
7. Kakadiya, J., Mulani, H., Shah, N., Protective effect of hesperidin on cardiovascular complication in experimentally induced myocardial infarction in diabetes in rats. Journal of basic and clinical pharmacy, 1(2), 2010, 85.
8. Kamel, K.M., Abd El-Raouf, O.M., Metwally, S.A., Abd El-Latif, H.A., El-Sayed, M.E., Hesperidin and rutin, antioxidant citrus flavonoids, attenuate cisplatin-induced nephrotoxicity in rats. J. Biochem. Mol. Toxicol., 2014, 10.1002/jbt.21567.
9. Lakatta, E.G., Levy, D., Arterial and cardiac aging: major shareholders in cardiovascular disease enterprises: part i: aging arteries: a “set up” for vascular disease. Circulation 107:1 (2003), 139–146, 10.1161/01.cir.0000048892.83521.58.
10. Mitchell, G.F., Hwang, S.-J., Vasan, R.S., Larson, M.G., Pencina, M.J., Hamburg, N.M., Benjamin, E.J., Arterial stiffness and cardiovascular events: the Framingham heart study. Circulation 121:4 (2010), 505–511, 10.1161/circulationaha.109.886655.
11. Morand, C., Dubray, C., Milenkovic, D., Lioger, D., Martin, J.F., Scalbert, A., Mazur, A., Hesperidin contributes to the vascular protective effects of orange juice: a randomized crossover study in healthy volunteers. Am. J. Clin. Nutr. 93:1 (2011), 73–80.
12. Prasad, A., Bekker, P., Tsimikas, S., Advanced glycation end products and diabetic cardiovascular disease. Cardiol. Rev. 20:4 (2012), 177–183, 10.1097/CRD.0b013e318244e57c.
13. Rizza, S., Muniyappa, R., Iantorno, M., Kim, J.A., Chen, H., Pullikotil, P., Quon, M.J., Citrus polyphenol hesperidin stimulates production of nitric oxide in endothelial cells while improving endothelial function and reducing inflammatory markers in patients with metabolic syndrome. J. Clin. Endocrinol. Metab. 96:5 (2011), E782–792, 10.1210/jc.2010-2879.
14. Schmidt, A.M., Hori, O., Brett, J., Yan, S., Wautier, J.-L., Stern, D., Cellular receptors for advanced glycation end products. Implications for induction of oxidant stress and cellular dysfunction in the pathogenesis of vascular lesions. Arterioscler. Thromb. Vasc. Biol. 14:10 (1994), 1521–1528.
15. Shi, X., Liao, S., Mi, H., Guo, C., Qi, D., Li, F., Yang, Z., Hesperidin prevents retinal and plasma abnormalities in streptozotocin-induced diabetic rats. Molecules 17:11 (2012), 12868–12881, 10.3390/molecules171112868.
16. Steppan, J., Tran, H., Benjo, A.M., Pellakuru, L., Barodka, V., Ryoo, S., Berkowitz, D.E., Alagebrium in combination with exercise ameliorates age-associated ventricular and vascular stiffness. Exp. Gerontol. 47:8 (2012), 565–572, 10.1016/j.exger.2012.04.006.
17. Wells-Knecht, K.J., Brinkmann, E., Wells-Knecht, M.C., Litchfield, J.E., Ahmed, M.U., Reddy, S., Baynes, J.W., New biomarkers of Maillard reaction damage to proteins. Nephrol. Dial. Transplant. 11:supp5 (1996), 41–47.
18. Wilmsen, P.K., Spada, D.S., Salvador, M., Antioxidant activity of the flavonoid hesperidin in chemical and biological systems. J. Agric. Food Chem. 53:12 (2005), 4757–4761.
19. Writing Group, M, Mozaffarian, D., Benjamin, E.J., Go, A.S., Arnett, D.K., Blaha, M.J., Stroke Statistics, S, Heart disease and stroke statistics-2016 update: a report from the American Heart Association. Circulation 133:4 (2016), e38–360, 10.1161/CIR.0000000000000350.
20. Yan, S.D., Schmidt, A.M., Anderson, G.M., Zhang, J., Brett, J., Zou, Y.S., Stern, D., Enhanced cellular oxidant stress by the interaction of advanced glycation end products with their receptors/binding proteins. J. Biol. Chem. 269:13 (1994), 9889–9897.