-
1
-
-
84944937210
-
Nivolumab versus docetaxel in advanced nonsquamous non–small cell lung cancer
-
Borghaei H, Paz-Ares L, Horn L, Spigel DR, Steins M, Ready NE, et al. Nivolumab versus docetaxel in advanced nonsquamous non–small cell lung cancer. N Engl J Med 2015;373:1627–39.
-
(2015)
N Engl J Med
, vol.373
, pp. 1627-1639
-
-
Borghaei, H.1
Paz-Ares, L.2
Horn, L.3
Spigel, D.R.4
Steins, M.5
Ready, N.E.6
-
2
-
-
84950117835
-
Pembrolizumab versus docetaxel for previously treated, PD-L1-positive, advanced non-small-cell lung cancer (KEYNOTE-010): A randomised controlled trial
-
Herbst RS, Baas P, Kim DW, Felip E, Perez-Gracia JL, Han JY, et al. Pembrolizumab versus docetaxel for previously treated, PD-L1-positive, advanced non-small-cell lung cancer (KEYNOTE-010): a randomised controlled trial. Lancet 2016;387:1540–50.
-
(2016)
Lancet
, vol.387
, pp. 1540-1550
-
-
Herbst, R.S.1
Baas, P.2
Kim, D.W.3
Felip, E.4
Perez-Gracia, J.L.5
Han, J.Y.6
-
3
-
-
84925222119
-
Nivolumab in previously untreated melanoma without BRAF mutation
-
Robert C, Long GV, Brady B, Dutriaux C, Maio M, Mortier L, et al. Nivolumab in previously untreated melanoma without BRAF mutation. N Engl J Med 2015;372:320–30.
-
(2015)
N Engl J Med
, vol.372
, pp. 320-330
-
-
Robert, C.1
Long, G.V.2
Brady, B.3
Dutriaux, C.4
Maio, M.5
Mortier, L.6
-
4
-
-
84994120928
-
PD-1-PD-L1 immune-checkpoint blockade in B-cell lymphomas
-
Goodman A, Patel SP, Kurzrock R. PD-1-PD-L1 immune-checkpoint blockade in B-cell lymphomas. Nat Rev Clin Oncol 2016;14:203–220.
-
(2016)
Nat Rev Clin Oncol
, vol.14
, pp. 203-220
-
-
Goodman, A.1
Patel, S.P.2
Kurzrock, R.3
-
5
-
-
84932628341
-
PD-1 blockade in tumors with mismatch-repair deficiency
-
Le DT, Uram JN, Wang H, Bartlett BR, Kemberling H, Eyring AD, et al. PD-1 blockade in tumors with mismatch-repair deficiency. N Engl J Med. 2015;372:2509–20.
-
(2015)
N Engl J Med
, vol.372
, pp. 2509-2520
-
-
Le, D.T.1
Uram, J.N.2
Wang, H.3
Bartlett, B.R.4
Kemberling, H.5
Eyring, A.D.6
-
6
-
-
84935474357
-
PD-L1 expression as a predictive biomarker in cancer immunotherapy
-
Patel SP, Kurzrock R. PD-L1 expression as a predictive biomarker in cancer immunotherapy. Mol Cancer Ther 2015;14:847–56.
-
(2015)
Mol Cancer Ther
, vol.14
, pp. 847-856
-
-
Patel, S.P.1
Kurzrock, R.2
-
7
-
-
84983216790
-
Mutations associated with acquired resistance to PD-1 blockade in melanoma
-
Zaretsky JM, Garcia-Diaz A, Shin DS, Escuin-Ordinas H, Hugo W, Hu-Lieskovan S, et al. Mutations associated with acquired resistance to PD-1 blockade in melanoma. N Engl J Med 2016;375:819–29.
-
(2016)
N Engl J Med
, vol.375
, pp. 819-829
-
-
Zaretsky, J.M.1
Garcia-Diaz, A.2
Shin, D.S.3
Escuin-Ordinas, H.4
Hugo, W.5
Hu-Lieskovan, S.6
-
8
-
-
84947248057
-
Pseudoprogression and immune-related response in solid tumors
-
Chiou VL, Burotto M. Pseudoprogression and immune-related response in solid tumors. J Clin Oncol 2015;33:3541–3.
-
(2015)
J Clin Oncol
, vol.33
, pp. 3541-3543
-
-
Chiou, V.L.1
Burotto, M.2
-
9
-
-
85018847861
-
Hyperprogressive disease (HPD) is a new pattern of progression in cancer patients treated by anti-PD-1/PD-L1
-
Champiat S, Dercle L, Ammari S, Massard C, Hollebecque A, Postel-Vinay S, et al. Hyperprogressive disease (HPD) is a new pattern of progression in cancer patients treated by anti-PD-1/PD-L1. Clin Cancer Res 2017; 23:1920–8.
-
(2017)
Clin Cancer Res
, vol.23
, pp. 1920-1928
-
-
Champiat, S.1
Dercle, L.2
Ammari, S.3
Massard, C.4
Hollebecque, A.5
Postel-Vinay, S.6
-
10
-
-
84959577118
-
Atezolizumab in patients with locally advanced and metastatic urothelial carcinoma who have progressed following treatment with platinum-based chemotherapy: A single-arm, multicentre, phase 2 trial
-
Rosenberg JE, Hoffman-Censits J, Powles T, van der Heijden MS, Balar AV, Necchi A, et al. Atezolizumab in patients with locally advanced and metastatic urothelial carcinoma who have progressed following treatment with platinum-based chemotherapy: a single-arm, multicentre, phase 2 trial. Lancet 2016;387:1909–20.
-
(2016)
Lancet
, vol.387
, pp. 1909-1920
-
-
Rosenberg, J.E.1
Hoffman-Censits, J.2
Powles, T.3
Van Der Heijden, M.S.4
Balar, A.V.5
Necchi, A.6
-
11
-
-
66749124176
-
Prospective validation of a prognostic score to improve patient selection for oncology phase I trials
-
Arkenau HT, Barriuso J, Olmos D, Ang JE, de Bono J, Judson I, et al. Prospective validation of a prognostic score to improve patient selection for oncology phase I trials. J Clin Oncol 2009;27:2692–6.
-
(2009)
J Clin Oncol
, vol.27
, pp. 2692-2696
-
-
Arkenau, H.T.1
Barriuso, J.2
Olmos, D.3
Ang, J.E.4
De Bono, J.5
Judson, I.6
-
12
-
-
84861133847
-
Survival of 1,181 patients in a phase I clinic: The MD Anderson Clinical Center for targeted therapy experience
-
Wheler J, Tsimberidou AM, Hong D, Naing A, Falchook G, Piha-Paul S, et al. Survival of 1,181 patients in a phase I clinic: the MD Anderson Clinical Center for targeted therapy experience. Clin Cancer Res 2012;18:2922–9.
-
(2012)
Clin Cancer Res
, vol.18
, pp. 2922-2929
-
-
Wheler, J.1
Tsimberidou, A.M.2
Hong, D.3
Naing, A.4
Falchook, G.5
Piha-Paul, S.6
-
13
-
-
84887491073
-
Development and validation of a clinical cancer genomic profiling test based on massively parallel DNA sequencing
-
Frampton GM, Fichtenholtz A, Otto GA, Wang K, Downing SR, He J, et al. Development and validation of a clinical cancer genomic profiling test based on massively parallel DNA sequencing. Nat Biotechnol 2013; 31:1023–31.
-
(2013)
Nat Biotechnol
, vol.31
, pp. 1023-1031
-
-
Frampton, G.M.1
Fichtenholtz, A.2
Otto, G.A.3
Wang, K.4
Downing, S.R.5
He, J.6
-
14
-
-
33745926178
-
Sensitive mutation detection in heterogeneous cancer specimens by massively parallel picoliter reactor sequencing
-
Thomas RK, Nickerson E, Simons JF, Janne PA, Tengs T, Yuza Y, et al. Sensitive mutation detection in heterogeneous cancer specimens by massively parallel picoliter reactor sequencing. Nat Med 2006;12:852–5.
-
(2006)
Nat Med
, vol.12
, pp. 852-855
-
-
Thomas, R.K.1
Nickerson, E.2
Simons, J.F.3
Janne, P.A.4
Tengs, T.5
Yuza, Y.6
-
15
-
-
84865833740
-
High-throughput detection of actionable genomic alterations in clinical tumor samples by targeted, massively parallel sequencing
-
Wagle N, Berger MF, Davis MJ, Blumenstiel B, Defelice M, Pochanard P, et al. High-throughput detection of actionable genomic alterations in clinical tumor samples by targeted, massively parallel sequencing. Cancer Discov 2012;2:82–93.
-
(2012)
Cancer Discov
, vol.2
, pp. 82-93
-
-
Wagle, N.1
Berger, M.F.2
Davis, M.J.3
Blumenstiel, B.4
Defelice, M.5
Pochanard, P.6
-
16
-
-
0002390737
-
Exact stratified linear rank tests for ordered categorical and binary data
-
Mehta CR, Patel N, Senchaudhuri P. Exact stratified linear rank tests for ordered categorical and binary data. J Comput Graphical Stat 1992;1: 21–40.
-
(1992)
J Comput Graphical Stat
, vol.1
, pp. 21-40
-
-
Mehta, C.R.1
Patel, N.2
Senchaudhuri, P.3
-
17
-
-
0034906866
-
Internal validation of predictive models: Efficiency of some procedures for logistic regression analysis
-
Steyerberg EW, Harrell FE Jr, Borsboom GJ, Eijkemans MJ, Vergouwe Y, Habbema JD. Internal validation of predictive models: efficiency of some procedures for logistic regression analysis. J Clin Epidemiol 2001;54: 774–81.
-
(2001)
J Clin Epidemiol
, vol.54
, pp. 774-781
-
-
Steyerberg, E.W.1
Harrell, F.E.2
Borsboom, G.J.3
Eijkemans, M.J.4
Vergouwe, Y.5
Habbema, J.D.6
-
18
-
-
73149092567
-
Guidelines for the evaluation of immune therapy activity in solid tumors: Immune-related response criteria
-
Wolchok JD, Hoos A, O'Day S, Weber JS, Hamid O, Lebbe C, et al. Guidelines for the evaluation of immune therapy activity in solid tumors: immune-related response criteria. Clin Cancer Res 2009;15:7412–20.
-
(2009)
Clin Cancer Res
, vol.15
, pp. 7412-7420
-
-
Wolchok, J.D.1
Hoos, A.2
O'Day, S.3
Weber, J.S.4
Hamid, O.5
Lebbe, C.6
-
19
-
-
84992103934
-
Effect of tumor growth rate (TGR) on response patterns of checkpoint inhibitors in non-small cell lung cancer (NSCLC)
-
Lahmar J, Facchinetti F, Koscielny S, Ferte C, Mezquita L, Bluthgen MV. Effect of tumor growth rate (TGR) on response patterns of checkpoint inhibitors in non-small cell lung cancer (NSCLC). J Clin Oncol 2016;34: abstr 9034.
-
(2016)
J Clin Oncol
, vol.34
-
-
Lahmar, J.1
Facchinetti, F.2
Koscielny, S.3
Ferte, C.4
Mezquita, L.5
Bluthgen, M.V.6
-
20
-
-
85006767479
-
Tumor's flare-up and patterns of recurrence in patients (pts) with recurrent and/or metastatic (R/M) head and neck squamous cell carcinoma (HNSCC) treated with anti-PD-1/PD-L1 inhibitors
-
Saada-Bouzid E, Defaucheux C, Karabajakian A, Palomar Coloma V, Servois V, Paoletti X. Tumor's flare-up and patterns of recurrence in patients (pts) with recurrent and/or metastatic (R/M) head and neck squamous cell carcinoma (HNSCC) treated with anti-PD-1/PD-L1 inhibitors. J Clin Oncol 2016;34:suppl; abstr 6072.
-
(2016)
J Clin Oncol
, vol.34
-
-
Saada-Bouzid, E.1
Defaucheux, C.2
Karabajakian, A.3
Palomar Coloma, V.4
Servois, V.5
Paoletti, X.6
-
21
-
-
84873055344
-
MDM2, MDMX and p53 in oncogenesis and cancer therapy
-
Wade M, Li YC, Wahl GM. MDM2, MDMX and p53 in oncogenesis and cancer therapy. Nat Rev Cancer 2013;13:83–96.
-
(2013)
Nat Rev Cancer
, vol.13
, pp. 83-96
-
-
Wade, M.1
Li, Y.C.2
Wahl, G.M.3
-
22
-
-
84867544962
-
PD-1 blockade enhances T-cell migration to tumors by elevating IFN-gamma inducible chemokines
-
Peng W, Liu C, Xu C, Lou Y, Chen J, Yang Y, et al. PD-1 blockade enhances T-cell migration to tumors by elevating IFN-gamma inducible chemokines. Cancer Res 2012;72:5209–18.
-
(2012)
Cancer Res
, vol.72
, pp. 5209-5218
-
-
Peng, W.1
Liu, C.2
Xu, C.3
Lou, Y.4
Chen, J.5
Yang, Y.6
-
23
-
-
34547108380
-
JAK-STAT signaling: From interferons to cytokines
-
Schindler C, Levy DE, Decker T. JAK-STAT signaling: from interferons to cytokines. J Biol Chem 2007;282:20059–63.
-
(2007)
J Biol Chem
, vol.282
, pp. 20059-20063
-
-
Schindler, C.1
Levy, D.E.2
Decker, T.3
-
24
-
-
84885029080
-
Myeloid-derived suppressor cell development is regulated by a STAT/IRF-8 axis
-
Waight JD, Netherby C, Hensen ML, Miller A, Hu Q, Liu S, et al. Myeloid-derived suppressor cell development is regulated by a STAT/IRF-8 axis. J Clin Invest 2013;123:4464–78.
-
(2013)
J Clin Invest
, vol.123
, pp. 4464-4478
-
-
Waight, J.D.1
Netherby, C.2
Hensen, M.L.3
Miller, A.4
Hu, Q.5
Liu, S.6
-
25
-
-
84897710994
-
The regulation of MDM2 oncogene and its impact on human cancers
-
Zhao Y, Yu H, Hu W. The regulation of MDM2 oncogene and its impact on human cancers. Acta Biochim Biophys Sin 2014;46:180–9.
-
(2014)
Acta Biochim Biophys Sin
, vol.46
, pp. 180-189
-
-
Zhao, Y.1
Yu, H.2
Hu, W.3
-
26
-
-
70349251460
-
IFN regulatory factor 8 regulates MDM2 in germinal center B cells
-
Zhou JX, Lee CH, Qi CF, Wang H, Naghashfar Z, Abbasi S, et al. IFN regulatory factor 8 regulates MDM2 in germinal center B cells. J Immunol 2009;183:3188–94.
-
(2009)
J Immunol
, vol.183
, pp. 3188-3194
-
-
Zhou, J.X.1
Lee, C.H.2
Qi, C.F.3
Wang, H.4
Naghashfar, Z.5
Abbasi, S.6
-
27
-
-
84958152593
-
Clinical overview of MDM2/X-targeted therapies
-
Burgess A, Chia KM, Haupt S, Thomas D, Haupt Y, Lim E. Clinical overview of MDM2/X-targeted therapies. Front Oncol 2016;6:7.
-
(2016)
Front Oncol
, vol.6
, pp. 7
-
-
Burgess, A.1
Chia, K.M.2
Haupt, S.3
Thomas, D.4
Haupt, Y.5
Lim, E.6
-
28
-
-
84890020587
-
Activation of the PD-1 pathway contributes to immune escape in EGFR-driven lung tumors
-
Akbay EA, Koyama S, Carretero J, Altabef A, Tchaicha JH, Christensen CL, et al. Activation of the PD-1 pathway contributes to immune escape in EGFR-driven lung tumors. Cancer Discov 2013;3:1355–63.
-
(2013)
Cancer Discov
, vol.3
, pp. 1355-1363
-
-
Akbay, E.A.1
Koyama, S.2
Carretero, J.3
Altabef, A.4
Tchaicha, J.H.5
Christensen, C.L.6
-
29
-
-
85012048135
-
Safety and efficacy of PD-1 blockade using pembrolizumab in patients with advanced soft tissue (STS) and bone sarcomas (BS): Results of SARC028–a multicenter phase II study
-
Tawbi HA-H, Burgess MA, Crowley J, Van Tine BA, Hu J, Schuetze S, et al. Safety and efficacy of PD-1 blockade using pembrolizumab in patients with advanced soft tissue (STS) and bone sarcomas (BS): results of SARC028–a multicenter phase II study. ASCO Annual Meeting Proc 2016;2016:11006.
-
(2016)
ASCO Annual Meeting Proc
, vol.2016
, pp. 11006
-
-
Tawbi, H.A.-H.1
Burgess, M.A.2
Crowley, J.3
Van Tine, B.A.4
Hu, J.5
Schuetze, S.6
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