Suicidal behavior during lithium and valproate treatment: A within-individual 8-year prospective study of 50,000 patients with bipolar disorder

American Journal of Psychiatry

Volumn 174, Issue 8, 2017, Pages 795-802

  Song, Jie ^a   Sjölander, Arvid ^a   Joas, Erik ^a   Bergen, Sarah E ^a   Runeson, Bo ^a   Larsson, Henrik ^a   Landén, Mikael ^a   Lichtenstein, Paul ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

LITHIUM; VALPROIC ACID; LITHIUM DERIVATIVE; LITHIUM SULFATE; SULFATE; TRANQUILIZER;

ADOLESCENT; ADULT; AGED; ARTICLE; BIPOLAR DISORDER; BIPOLAR I DISORDER; BIPOLAR II DISORDER; COHORT ANALYSIS; CONFIDENCE INTERVAL; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE SEVERITY; FEMALE; HAZARD RATIO; HUMAN; INCIDENCE; LONGITUDINAL STUDY; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROPENSITY SCORE; PROPORTIONAL HAZARDS MODEL; PROSPECTIVE STUDY; PUBLIC HEALTH; SENSITIVITY ANALYSIS; SUICIDAL BEHAVIOR; SWEDISH CITIZEN; VERY ELDERLY; COMPARATIVE STUDY; INFORMATION RETRIEVAL; MIDDLE AGED; PSYCHOLOGY; REGISTER; RISK; STATISTICS AND NUMERICAL DATA; SUICIDE; SUICIDE, ATTEMPTED; SWEDEN; YOUNG ADULT;

ADOLESCENT; ADULT; AGED; ANTIMANIC AGENTS; BIPOLAR DISORDER; FEMALE; HUMANS; INFORMATION STORAGE AND RETRIEVAL; LITHIUM COMPOUNDS; LONGITUDINAL STUDIES; MALE; MIDDLE AGED; PROPORTIONAL HAZARDS MODELS; REGISTRIES; RISK; SUICIDE; SUICIDE, ATTEMPTED; SULFATES; SWEDEN; VALPROIC ACID; YOUNG ADULT;

EID: 85026757876     PISSN: 0002953X     EISSN: 15357228     Source Type: Journal    
DOI: 10.1176/appi.ajp.2017.16050542     Document Type: Article

References (38)

1. Nordentoft M, Mortensen PB, Pedersen CB: Absolute risk of suicide after first hospital contact in mental disorder. Arch Gen Psychiatry 2011; 68:1058-1064
2. Chen YW, Dilsaver SC: Lifetime rates of suicide attempts among subjects with bipolar and unipolar disorders relative to subjects with other axis I disorders. Biol Psychiatry 1996; 39:896-899
3. Webb RT, Lichtenstein P, Larsson H, et al: Suicide, hospitalpresenting suicide attempts, and criminality in bipolar disorder: examination of risk for multiple adverse outcomes. J Clin Psychiatry 2014; 75:e809-e816
4. Latalova K, Kamaradova D, Prasko J: Suicide in bipolar disorder: a review. Psychiatr Danub 2014; 26:108-114
5. Cipriani A, Reid K, Young AH, et al: Valproic acid, valproate and divalproex in the maintenance treatment of bipolar disorder. Cochrane Database Syst Rev 2013; 10:CD003196
6. Tondo L, Baldessarini RJ: Suicidal behavior in mood disorders: response to pharmacological treatment. Curr Psychiatry Rep 2016; 18:88
7. Kessing LV, Søndergord L, Kvist K, et al: Suicide risk in patients treated with lithium. Arch Gen Psychiatry 2005; 62:860-866
8. Baldessarini RJ, Tondo L, Davis P, et al: Decreased risk of suicides and attempts during long-term lithium treatment: a meta-analytic review. Bipolar Disord 2006; 8:625-639
9. Tondo L, Hennen J, Baldessarini RJ: Lower suicide risk with longterm lithium treatment in major affective illness: a meta-analysis. Acta Psychiatr Scand 2001; 104:163-172
10. Goodwin FK, Fireman B, Simon GE, et al: Suicide risk in bipolar disorder during treatment with lithium and divalproex.JAMA2003; 290:1467-1473
11. Smith EG, Søndergord L, Lopez AG, et al: Association between consistent purchase of anticonvulsants or lithium and suicide risk: a longitudinal cohort study from Denmark, 1995-2001. J Affect Disord 2009; 117:162-167
12. Søndergord L, Lopez AG, Andersen PK, et al: Mood-stabilizing pharmacological treatment in bipolar disorders and risk of suicide. Bipolar Disord 2008; 10:87-94
13. Ahearn EP, Chen P, HertzbergM, et al: Suicide attempts in veterans with bipolar disorder during treatment with lithium, divalproex, and atypical antipsychotics. J Affect Disord 2013; 145:77-82
14. Hayes JF, Pitman A, MarstonL, et al: Self-harm, unintentional injury, and suicide in bipolar disorder during maintenance mood stabilizer treatment: a UK population-based electronic health records study. JAMA Psychiatry 2016; 73:630-637
15. Baldessarini RJ, Tondo L: Lithium and suicidal risk. Bipolar Disord 2008; 10:114-115
16. Baldessarini RJ, Tondo L: Suicidal risks during treatment of bipolar disorder patients with lithium versus anticonvulsants. Pharmacopsychiatry 2009; 42:72-75
17. Cipriani A, Hawton K, Stockton S, et al: Lithium in the prevention of suicide in mood disorders: updated systematic review and metaanalysis. BMJ 2013; 346:f3646
18. Oquendo MA, Galfalvy HC, Currier D, et al: Treatment of suicide attempters with bipolar disorder: a randomized clinical trial comparing lithium and valproate in the prevention of suicidal behavior. Am J Psychiatry 2011; 168:1050-1056
19. Schaffer A, Isomets ET, Tondo L, et al: Epidemiology, neurobiology and pharmacological interventions related to suicide deaths and suicide attempts in bipolar disorder: part I of a report of the International Society for Bipolar Disorders Task Force on Suicide in Bipolar Disorder. Aust N Z J Psychiatry 2015; 49:785-802
20. Freeman TW, Clothier JL, Pazzaglia P, et al: A double-blind comparison of valproate and lithium in the treatment of acute mania.Am J Psychiatry 1992; 149:108-111
21. Lichtenstein P, Halldner L, Zetterqvist J, et al: Medication for attention deficit-hyperactivity disorder and criminality. N Engl J Med 2012; 367:2006-2014
22. Ludvigsson JF, Otterblad-Olausson P, Pettersson BU, et al: The Swedish personal identity number: possibilities and pitfalls in healthcare and medical research. Eur J Epidemiol 2009; 24:659-667
23. Wettermark B, Hammar N, Fored CM, et al: The new Swedish Prescribed Drug Register-opportunities for pharmacoepidemiological research and experience from the first six months. Pharmacoepidemiol Drug Saf 2007; 16:726-735; correction, 2008; 17:533
24. Sellgren C, Landén M, Lichtenstein P, et al: Validity of bipolar disorder hospital discharge diagnoses: file review and multiple register linkage in Sweden. Acta Psychiatr Scand 2011; 124:447-453
25. Molero Y, Lichtenstein P, Zetterqvist J, et al: Selective serotonin reuptake inhibitors and violent crime: a cohort study. PLoS Med 2015; 12:e1001875
26. Allison PD: Fixed Effects Regression Models. Thousand Oaks, Calif, SAGE Publications, 2009
27. Chang Z, Lichtenstein P, D'Onofrio BM, et al: Serious transport accidents in adults with attention-deficit/hyperactivity disorder and the effect of medication: a population-based study.JAMAPsychiatry 2014; 71:319-325
28. Chen Q, Sjolander A, Runeson B, et al: Drug treatment for attentiondeficit/ hyperactivity disorder and suicidal behaviour: register based study. BMJ 2014; 348:g3769
29. Bruzzi P, Green SB, Byar DP, et al: Estimating the population attributable risk for multiple risk factors using case-control data.AmJ Epidemiol 1985; 122:904-914
30. Scheen L, Brandt L, Bodén R, et al: Predictors for initiation of pharmacological prophylaxis in patients with newly diagnosed bipolar disorder-a nationwide cohort study. J Affect Disord 2015; 172: 204-210
31. BALANCE investigators and collaborators, Geddes JR, Goodwin GM, et al:Lithiumplus valproate combinationtherapy versusmonotherapy for relapse prevention in bipolar I disorder (BALANCE): a randomised open-label trial. Lancet 2010; 375: 385-395
32. Smith EG, Austin KL, Kim HM, et al: Suicide risk in Veterans Health Administration patients with mental health diagnoses initiating lithium or valproate: a historical prospective cohort study. BMC Psychiatry 2014; 14:357
33. StataCorp: Stata: Release 13. College Station, Tex, StataCorp, 2013
34. Nery-Fernandes F, Quarantini LC, Guimarães JL, et al: Is there an association between suicide attempt and delay of initiation of mood stabilizers in bipolar I disorder? J Affect Disord 2012; 136:1082-1087
35. Collins JC, McFarland BH: Divalproex, lithium and suicide among Medicaid patients with bipolar disorder. J Affect Disord 2008; 107: 23-28
36. Wasserman D, Rihmer Z, Rujescu D, et al: The European Psychiatric Association (EPA) guidance on suicide treatment and prevention. Eur Psychiatry 2012; 27:129-141
37. Karanti A, Kardell M, Lundberg U, et al: Changes in mood stabilizer prescription patterns in bipolar disorder. J Affect Disord 2016; 195: 50-56
38. Schaffer A, Isomets ET, Azorin JM, et al: A review of factors associated with greater likelihood of suicide attempts and suicide deaths in bipolar disorder: part II of a report of the International Society for Bipolar Disorders Task Force on Suicide in Bipolar Disorder. Aust N Z J Psychiatry 2015; 49:1006-1020