Daily supplementation with 15 mg vitamin D2 compared with vitamin D3 to increase wintertime 25-hydroxyvitamin D status in healthy South Asian and white European women: A 12-wk randomized, placebo-controlled food-fortification trial

American Journal of Clinical Nutrition

Volumn 106, Issue 2, 2017, Pages 481-490

  Tripkovic, Laura ^a   Wilson, Louise R ^a   Hart, Kathryn ^a   Johnsen, Sig ^b   De Lusignan, Simon ^a   Smith, Colin P ^c   Bucca, Giselda ^c   Penson, Simon ^d   Chope, Gemma ^d   Elliott, Ruan ^a   Hypponen, Elina ^e   Berry, Jacqueline L ^f   Lanham New, Susan A ^a  

^a UNIVERSITY OF SURREY   (United Kingdom)

^b UNIVERSITY OF SURREY   (United Kingdom)

^c UNIVERSITY OF BRIGHTON   (United Kingdom)

^d CAMPDEN BRI   (United Kingdom)

^e UNIVERSITY OF SOUTH AUSTRALIA   (Australia)

^f UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

25 hydroxyVitamin D; Food fortification; Healthy women; Randomized controlled trial; South Asian; Vitamin D; Vitamin D 2; Vitamin D 3; White European

Indexed keywords

25 HYDROXYVITAMIN D; CALCIUM; COLECALCIFEROL; ERGOCALCIFEROL; PARATHYROID HORMONE; PLACEBO; 25-HYDROXYVITAMIN D; VITAMIN; VITAMIN D;

ADULT; ARTICLE; BISCUIT; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; ETHNIC DIFFERENCE; EUROPEAN; FEMALE; FORTIFIED FOOD; HUMAN; LIQUID CHROMATOGRAPHY-MASS SPECTROMETRY; NORMAL HUMAN; RANDOMIZED CONTROLLED TRIAL; SOUTH ASIAN; UNITED KINGDOM; VITAMIN BLOOD LEVEL; VITAMIN SUPPLEMENTATION; WINTER; ANALOGS AND DERIVATIVES; ASIA; ASIAN CONTINENTAL ANCESTRY GROUP; BLOOD; CAUCASIAN; COMPARATIVE STUDY; DIETARY SUPPLEMENT; ETHNOLOGY; EUROPE; MALE; MIDDLE AGED; SEASON; VITAMIN D DEFICIENCY;

ADULT; ASIA; ASIAN CONTINENTAL ANCESTRY GROUP; CHOLECALCIFEROL; DIETARY SUPPLEMENTS; DOUBLE-BLIND METHOD; ERGOCALCIFEROLS; EUROPE; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; FOOD, FORTIFIED; HUMANS; MALE; MIDDLE AGED; SEASONS; UNITED KINGDOM; VITAMIN D; VITAMIN D DEFICIENCY; VITAMINS;

EID: 85026630134     PISSN: 00029165     EISSN: 19383207     Source Type: Journal    
DOI: 10.3945/ajcn.116.138693     Document Type: Article

References (30)

1. Ross CA, Taylor CL, Yaktime AL, Del Valle HB, editors. Institute of Medicine (US) Dietary Reference Intakes for calcium and vitamin D. Washington (DC): National Academies Press; 2011.
2. Holick MF. Vitamin D deficiency. N Engl J Med 2007;357:266-81.
3. Biancuzzo RM, Young A, Bibuld D, Cai MH, Winter MR, Klein EK, Ameri A, Reitz R, Salameh W, Chen TC, et al. Fortification of orange juice with vitamin D2 or vitamin D3 is as effective as an oral supplement in maintaining vitamin D status in adults. Am J Clin Nutr 2010; 91:1621-6.
4. Newberry SJ, Chung M, Shekelle PG, Booth MS, Liu JL, Maher AR, Motala A, Cui M, Perry T, Shanman R, et al. Vitamin D and calcium: A systematic review of health outcomes (update). Rockville (MD): Agency for Healthcare Research and Quality; 2014. Evidence Report/ Technology Assessment No. 217. (Prepared by the Southern California Evidence-based Practice Center under Contract No. 290-2012-00006-I.) AHRQ Publication No.: 14-E004-EF.
5. Lanham-New S, Vieth R, Heaney R. Vitamin D2 and vitamin D3 comparisons: Fundamentally flawed study methodology. Am J Clin Nutr 2010;92:999.
6. Biancuzzo RM, Holick MF. Response to authors re fundamentally flawed study methodology. Am J Clin Nutr 2010;92:1000.
7. Binkley N, Gemar D, Engelke J, Gangnon R, Ramamurthy R, Krueger D, Drezner MK. Evaluation of ergocalciferol or cholecalciferol dosing, 1, 600 IU daily or 50, 000 IU monthly in older adults. J Clin Endocrinol Metab 2011;96:981-8.
8. Heaney RP, Recker RR, Grote J, Horst RL, Armas LA. Vitamin D(3) is more potent than vitamin D(2) in humans. J Clin Endocrinol Metab 2011;96:E447-52.
9. Romagnoli E, Mascia ML, Cipriani C, Fassino V, Mazzei F, D'Erasmo E, Carnevale V, Scillitani A, Minisola S. Short and longterm variations in serum calciotropic hormones after a single very large dose of ergocalciferol (vitamin D2) or cholecalciferol (vitamin D3) in the elderly. J Clin Endocrinol Metab 2008;93:3015-20.
10. Trang HM, Cole DE, Rubin LA, Pierratos A, Siu S, Vieth R. Evidence that vitamin D3 increases serum 25-hydroxyvitamin D more efficiently than does vitamin D2. Am J Clin Nutr 1998;68:854-8.
11. Holick MF, Biancuzzo RM, Chen TC, Klein EK, Young A, Bibuld D, Reitz R, Salameh W, Ameri A, Tannenbaum AD. Vitamin D2 is as effective as vitamin D3 in maintaining circulating concentrations of 25-hydroxyvitamin D. J Clin Endocrinol Metab 2008;93:677-81.
12. Glendenning P, Chew GT, Seymour HM, Gillett MJ, Goldswain PR, Inderjeeth CA, Vasikaran SD, Taranto M, Musk AA, Fraser WD. Serum 25-hydroxyvitamin D levels in vitamin D-insufficient hip fracture patients after supplementation with ergocalciferol and cholecalciferol. Bone 2009;45:870-5.
13. Fisk CM, Theobald HE, Sanders TA. Fortified malted milk drinks containing low-dose ergocalciferol and cholecalciferol do not differ in their capacity to raise serum 25-hydroxyvitamin D concentrations in healthy men and women not exposed to UV-B. J Nutr 2012;142:1286-90.
14. Tripkovic L, Lambert H, Hart K, Smith CP, Bucca G, Penson S, Chope G, Hyppönen E, Berry J, Vieth R, et al. Comparison of vitamin D2 and vitamin D3 supplementation in raising serum 25-hydroxyvitamin D status: A systematic review and meta-analysis. Am J Clin Nutr 2012;95:1357-64.
15. Hyppönen E, Power C. Hypovitaminosis D in British adults at age 45 y: nationwide cohort study of dietary and lifestyle predictors. Am J Clin Nutr 2007;85:860-8.
16. Darling AL, Hart KH, Macdonald HM, Horton K, Kang'ombe AR, Berry JL, Lanham-New SA. Vitamin D deficiency in UK South Asian women of childbearing age: A comparative longitudinal investigation with UK European women. Osteoporos Int 2013;24:477-88.
17. Schulz KF, Altman DG, Moher D, Group C. CONSORT 2010 statement: Updated guidelines for reporting parallel group randomized trials. J Clin Epidemiol 2010;63:834-40.
18. Logan VF, Gray AR, Peddie MC, Harper MJ, Houghton LA. Longterm vitamin D3 supplementation is more effective than vitamin D2 in maintaining serum 25-hydroxyvitamin D status over the winter months. Br J Nutr 2013;109:1082-8.
19. Lehmann U, Hirche F, Stangl GI, Hinz K, Westphal S, Dierkes J. Bioavailability of vitamin D2 and D3 in healthy volunteers: A randomized placebo-controlled trial. J Clin Endocrinol Metab 2013;98:4339-45.
20. Itkonen ST, Skaffari E, Saaristo P, Saarnio EM, Erkkola M, Jakobsen J, Cashman KD, Lamberg-Allardt C. Effects of vitamin D 2-fortified bread v. supplementation with vitamin D2 or D3 on serum 25-hydroxyvitamin D metabolites: An 8-week randomised-controlled trial in young adult Finnish women. Br J Nutr 2016;115:1232-9.
21. Tjellesen L, Hummer L, Christiansen C, Rødbro P. Serum concentration of vitamin D metabolites during treatment with vitamin D2 and D3 in normal premenopausal women. Bone Miner 1986;1:407-13.
22. Oliveri B, Mastaglia SR, Brito GM, Seijo M, Keller GA, Somoza J, Diez RA, Di Girolamo G. Vitamin D3 seems more appropriate than D2 to sustain adequate levels of 25(OH)D: A pharmacokinetic approach. Eur J Clin Nutr 2015;69:697-702.
23. Jones KS, Assar S, Harnpanich D, Bouillon R, Lambrechts D, Prentice A, Schoenmakers I. 25(OH)D2 half-life is shorter than 25(OH)D3 half-life and is influenced by DBP concentration and genotype. J Clin Endocrinol Metab 2014;99:3373-81.
24. Bates B, Lennox A, Prentice A, Bates C, Page P, Nicholson S, Swan G. The National Diet and Nutrition Survey: Results from years 1, 2, 3 and 4 (combined) of the rolling programme (2008/2009 - 2011/2012). London: The Stationary Office; 2014.
25. Department of Health. Dietary reference values for food energy and nutrients for the United Kingdom: Report of the Panel on Dietary Reference Values of the Committee on Medical Aspects of Food Policy. London: The Stationary Office; 1991. Report of Health and Social Subjects No.: 41.
26. Scientific Advisory Committee on Nutrition. Vitamin D and health. London: The Stationary Office; 2016.
27. Buttriss JL. Vitamin D: Sunshine vs. diet vs. pills. Nutr Bull 2015;40: 279-85.
28. Lanham-New SA, Wilson LR. Vitamin D-has the new dawn for dietary recommendations arrived? J Hum Nutr Diet 2016;29:3-6.
29. Brown J, Sandmann A, Ignatius A, Amling M, Barvencik F. New perspectives on vitamin D food fortification based on a modeling of 25(OH)D concentrations. Nutr J 2013;12:151.
30. Allen RE, Dangour AD, Tedstone AE, Chalabi Z. Does fortification of staple foods improve vitamin D intakes and status of groups at risk of deficiency? A United Kingdom modeling study. Am J Clin Nutr 2015; 102:338-44.