Anoectochilus roxburghii: A review of its phytochemistry, pharmacology, and clinical applications

Journal of Ethnopharmacology

Volumn 209, Issue , 2017, Pages 184-202

  Ye, Shenyi ^a   Shao, Qingsong ^a,b   Zhang, Ailian ^a  

^a ZHEJIANG A F UNIVERSITY   (China)

^b Zhejiang Province Key Laboratory of Plant Secondary Metabolism and Regulation   (China)

Author keywords

Anoectochilus roxburghii; Clinical applications; Pharmacology; Phytochemistry

Indexed keywords

ALKALOID DERIVATIVE; ANOECTOCHILUS ROXBURGHII EXTRACT; ANTIDIABETIC AGENT; ANTIINFLAMMATORY AGENT; ANTILIPEMIC AGENT; ANTINEOPLASTIC AGENT; ANTIVIRUS AGENT; CARBOXYLIC ACID; FLAVONOID; GLYCOSIDE; HYPNOTIC AGENT; IMMUNOMODULATING AGENT; LIVER PROTECTIVE AGENT; NUCLEOSIDE DERIVATIVE; PLANT EXTRACT; POLYSACCHARIDE; STEROID; TRITERPENE DERIVATIVE; UNCLASSIFIED DRUG; VOLATILE AGENT; HERBACEOUS AGENT; PHYTOCHEMICAL;

ANOECTOCHILUS ROXBURGHII; ANTIDIABETIC ACTIVITY; ANTIINFLAMMATORY ACTIVITY; ANTINEOPLASTIC ACTIVITY; ANTIVIRAL ACTIVITY; ASTHMA; CHINESE MEDICINE; CHRONIC HEPATITIS B; COUGH VARIANT ASTHMA; DRUG EFFICACY; HAND FOOT AND MOUTH DISEASE; HELICOBACTER INFECTION; HUMAN; HYPERURICEMIA; IMMUNOMODULATION; LIVER PROTECTION; MENTAL DISEASE; NON INSULIN DEPENDENT DIABETES MELLITUS; ORCHIDACEAE; PHYTOCHEMISTRY; RENAL PROTECTION; REVIEW; TIC COPROLALIA SYNDROME; CHEMISTRY; ETHNOPHARMACOLOGY; PHYTOTHERAPY;

DRUGS, CHINESE HERBAL; ETHNOPHARMACOLOGY; HUMANS; ORCHIDACEAE; PHYTOCHEMICALS; PHYTOTHERAPY;

EID: 85026442981     PISSN: 03788741     EISSN: 18727573     Source Type: Journal    
DOI: 10.1016/j.jep.2017.07.032     Document Type: Review

References (85)

1. An, Y.F., Zhang, Y.Q., Feng, D.Q., Pharmacological effects and clinical use advances of Anoectochilus roxburghii. Mod. Chin. Med. 16 (2014), 685–687.
2. Cai, J.Y., Gong, L.M., Zhang, Y.H., Ruan, H.L., Pi, H.F., Wu, J.Z., Studies on chemical constituents from Anoectochilus roxburghii. J. Chin. Med. Mater. 31 (2008), 370–372.
3. Chen, C.X., Li, S.S., Study on the activity and structure of Isoselagine. Taiwan Pharm. J. 36 (1984), 1–3.
4. Chen, J.F., Zhang, X.C., Hypoglycemic Effect of n-butyl alcohol extraction from Anoectochilus roxburghii. Herald. Med. 34 (2015), 1454–1457.
5. Chen, W.J., Wu, S.H., Miao, C.X., Ke, H.Z., Study of volatile oil extracted by different solvents from whole plants of wild Anoectochilus roxburghii(wall.)Lindl.by GC-MS. J. Liaoning Univ. Tradit. Chin. Med. 12 (2010), 42–45.
6. Chen, X.X., Xia, X.N., Zhang, D.F., Huang, M., Xiao, Z.G., Treatment of 36 cases of hyperuricemia in elderly patients with Anoectochilus roxburghii capsule. Mil. Med. J. Southeast China 12 (2010), 331–332.
7. Chen, Z., Experimental Studies on the Hypoglycemic effect of Herba Anoectochili and Its active ingredient. J. Fujian Med. Univ., 2000 (Fujian).
8. Chen, Z., Huang, Z.Q., Studies on the hypoglycemic effect of the aqueous extractive of Anoectochilus roxburghii. Pharmacol. Clin. Chin. Mater. Med. 16 (2000), 23–24.
9. Chinese Herbalism Editorial Board, Chinese Materia Medica. 1999, Shanghai Scientific and Technical Publishers, Shanghai.
10. Cui, S.C., Yu, J., Zhang, X.H., Cheng, M.Z., Yang, L.W., Xu, J.Y., Antihyperglycemic and antioxidant activity of water extract from Anoectochilus roxburghii in experimental diabetes. Exp. Toxicol. Pathol., 65, 2013, 485 (Official Journal of the Gesellschaft Fur Toxikologische Pathologie).
11. Deng, Y.Q., Wei, L.I., Zhang, X.H., Jie, Y.U., Effects of polysaccharides from Anoectochilus roxburghii on α-glucosidase activity and blood glucose in diabetic mice. J. Shantou Univ. 29 (2014), 41–45.
12. Du, X., Sun, N., Tamura, T., Mohri, A., Sugiura, M., Yoshizawa, T., Irino, N., Hayashi, J., Shoyama, Y., Higher yielding isolation of kinsenoside in Anoectochilus and its antihyperliposis effect. Biol. Pharm. Bull., 24, 2001, 65.
13. Du, X.M., Irino, N., Furusho, N., Hayashi, J., Shoyama, Y., Pharmacologically active compounds in the Anoectochilus and Goodyera species. J. Nat. Med. 62 (2008), 132–148.
14. Fujian Forestry Science Research Institute, Fujian Wild Medicinal Plants. 1960, Fujian People 's Publishing House, Fujian.
15. Fujian Institute of Traditional Chinese Medicine, Fujian Drug Records. 1994, FujianScience and Technology Press, Fujian.
16. Gong, X.H., Xu, M., Dong, H.Z., Lin, Z.C., Zhang, Y.J., Zhao, P., Comparative study of the chemical constituents of Anoectochilus spp.from different origins. J. Anhui Agric. Sci., 17530–17531, 2012, 17607.
17. Guan, J., Wang, C.L., Guo, S.X., Isolation and structural elucidation of flavonoids from Ancecotochilus roxburghii. Chin. Tradit. Herbal. Drugs 36 (2005), 1450–1453.
18. Guo, W.J., Guo, S.X., Studies on the chemical constituents of endophytic fungi Epulorhiza sp. with potential anti-HIV activity. Chinese traditional and herbal. Drugs 41 (2010), 1773–1775.
19. Gupta, S., Sharma, S.B., Bansal, S.K., Prabhu, K.M., Antihyperglycemic and hypolipidemic activity of aqueous extract of Cassia auriculata L. leaves in experimental diabetes. J. Ethnopharmacol., 123, 2009, 499.
20. Han, M.H., Yang, X.W., Jin, Y.P., Chemical constituents of the essential oil from the whole plants of Anoectochilus roxburghii(wall) Lindl. Nat. Product. Res. Dev. 18 (2006), 65–68.
21. Han, M.H., Yang, X.W., Jin, Y.P., Novel triterpenoid acyl esters and alkaloids from Anoectochilus roxburghii. Phytochem. Anal., 19, 2008, 438.
22. He, C.N., Wang, C.L., Guo, S.X., Yang, J.S., Xiao, P.G., Study on chemical constituents in herbs of Anoectochilus roxburghii II. China. J. Chin. Mater. Med. 30 (2005), 761–763.
23. He, C.N., Wang, C.L., Guo, S.X., Yang, J.S., Xiao, P.G., Study on chemical constituents of Anoectochilus roxburghii(III). Nat. Product. Res. Dev. 17 (2005), 259–262.
24. He, C.N., Wang, C.L., Guo, S.X., Yang, J.S., Xiao, P.G., Study on chemical constiuent of Anoectochilus roxburghii. Chin. Pharm. J. 40 (2005), 581–583.
25. He, C.N., Wang, C.L., Guo, S.X., Yang, J.S., Xiao, P.G., A novel flavonoid glucoside from Anoectochilus roxburghii (Wall.) Lindl. J. Integr. Plant Biol. 48 (2006), 359–363.
26. He, X., Fang, J., Wang, X., Zhao, Z., Chang, Y., Guo, H., Huang, L., Bletilla striata: medicinal uses, phytochemistry and pharmacological activities. J. Ethnopharmacol. 195 (2016), 20–38.
27. Hong, L., Shao, Q.S., zhou, A.C., Wang, H.Z., Zhang, A., Xu, J., Huang, Y., Current status and sustainable development countermeasures of Anoectochilus roxburghii. China J. Chin. Mater. Med. 41 (2016), 553–558.
28. Hsiao, H.B., Wu, J.B., Lin, H., Lin, W.C., Kinsenoside isolated from Anoectochilus Formosanus suppresses LPS-stimulated inflammatory reactions in macrophages and endotoxin shock in mice. Shock 35 (2011), 184–190.
29. Hu, G.H., 2009. Study on the Activity of Kinsenoside and Its Synthesis of Complete Acetylation. Huazhong University of Science and Technology, Hubei.
30. Huang, L., Chen, T., Ye, Z., Chen, G., Use of liquid chromatography-atmospheric pressure chemical ionization-ion trap mass spectrometry for identification of oleanolic acid and ursolic acid in Anoectochilus roxburghii (wall.) Lindl. J. Mass Spectrom., 42, 2007, 910.
31. Huang, L., Cao, Y., Xu, H., Chen, G., Separation and purification of ergosterol and stigmasterol in Anoectochilus roxburghii (wall) Lindl by high-speed counter-current chromatography. J. Sep. Sci., 34, 2011, 385.
32. Huang, L.F., Lu, R.Y., Su, Z.M., Fan, S.T., Yu, X.Q., Effect of Herba anoectochili extracts on acutely and chronically damaged livers induced by CCl_4 in mice. Pharm. J. Chin. Peoples Lib. Army 23 (2007), 278–281.
33. Huang, W., Huang, J.Q., Reversion of malignant phenotypes of human lung cancer cells and suppression of its invasive ability by cinnamic acid. Chin. J. Clin. Oncol. 24 (1997), 456–460.
34. Ito, A., Kasai, R., Yamasaki, K., Sugimoto, H., Aliphatic and aromatic glucosides from Anoectochilus koshunesis. Phytochemistry 33 (1993), 1133–1137.
35. Jiang, Y.B., 2012. Dynamic Change of Main Active Ingredients in A.roxburghii (Wall) Lindl and A.formosanus Hayata in Different growth stages. Fujian Agriculture and Forestry University, Fujian.
36. Jiangsu Institute of Botany, Xinhua Compendium of Materia Medica. 1990, Shanghai Scientific and Technical Publishers, Shanghai.
37. Jiangsu new medical college, The Dictionary of Medicinal Plant. 1977, Shanghai Scientific and Technical Publishers, Shanghai.
38. Jie, Y.U., Wei, L.I., Zhang, X.H., Research of antidiabetic activites of polysaccharides from Anoectochilus roxburghii. Strait Pharm. J. 25 (2013), 37–40.
39. Jue, W.C., 2011. The extraction of volatile oil in Anoectochilus and its inhibition effect in lung cancer cell NCI-H446. Fujian Medical University, Fujian.
40. Li, L., Li, Y.M., Liu, Z.L., Zhang, J.G., Liu, Q., Yi, L.T., The renal protective effects of Anoectochilus roxburghii polysaccharose on diabetic mice induced by high-fat diet and streptozotocin. J. Ethnopharmacol., 178, 2015, 58.
41. Li, M., Zou, D., Three different sources of Anoectochilus roxburghii pharmacological studies. Strait Pharm. J. 4 (1995), 12–14.
42. Li, Q., Zhou, W., Liu, L., Zheng, L., Guan, S.C., Clinical Observation on the treatment of hand-foot-mouth disease with Anoectochilus roxburghii spray. Fujian J. TCM 43 (2012), 9–10.
43. Li, Q., Huang, W., Zhou, W., Li, J., Chen, Z.S., Clinical study of Anoectochilus roxburghii liquid in treating oral ulcer due to chemotherapy for childhood leukemia. J. Nanjing Univ. Tradit. Chin. Med. 32 (2016), 422–424.
44. Lin, W.C., Shih, C.C., Wu, Y.W., Effects of crude aqueous extracts of Anoectochilus formosanus Hayata Adminstered to Pregenant and Lacting rats on their offspring. J. Chin. Med 11 (1999), 1–13.
45. Lin, W.C., Shih, C.C., Wu, Y.W., Chen, I.J., Chang, H.L., Hsu, C.T., Ninety-day oral toxicity study of crude aqueous extracts of Anoectochilus formosanus Hayata in rats. J. Chin. Med 11 (2000), 1–22.
46. Liu, H.H., Shen, L., Mao, B.Z., Chemical composition research Progress of Pharmacological action and vitro culture in Shorthairy Antenoron (Anoectochilus roxburghii). Pharm. Biotechnol. 22 (2015), 553–556.
47. Liu, Q., Wei, H., Liu, Z., Xu, J., Tian, Y., Zhou, X., Mu, X., 3-Hydroxybutanolide derivatives and flavonoid glucosides from Anoectochilus roxburghii. Phytochem. Lett. 8 (2014), 109–115.
48. Liu, S.Y., Chang, T.W., Wang, J.Y., Chang, A.H., Wang, S.C., Studies on the Varietal characters and acute toxicity of Anoectochilus spp. J. Agric. Res. China 47 (1998), 242–258.
49. Liu, Z.F., Li, Q., Clinical Observation on 30 cases of chronic hepatitis B treated by compound Jinlianlian oral liquid combined with entecavir. Fujian J. TCM 39 (2008), 3–4.
50. Liu, Z.L., Liu, Q., Xiao, B., Zhou, J., Zhang, J.G., Li, Y., The vascular protective properties of kinsenoside isolated from Anoectochilus roxburghii under high glucose condition. Fitoterapia 86 (2013), 163–170.
51. Meng, Y.Q., Chen, Y., Wang, Z., Research advance of ursolic acid. Chin. J. New Drugs 16 (2007), 25–28.
52. National Compendium of Chinese Herbal Medicine, Editorial Board, 1978. National Compendium of Chinese Herbal Medicine. People's Medical Publishing House, Beijing.
53. New Compendium of South China Materia Medica, Editorial board, 1975. New Compendium of South China Materia Medica. Wenzhou Health Bureau, Zhejiang.
54. Peng, G.T., 2006. Studies on the tissue-cultured rare herbal medicine Anoectochilus roxburghii and Corynebacterium spp. ps-1. Zhongshan University, Taiwan.
55. Shao, Q.S., Wang, H.Z., Guo, H.P., Zhou, A.C., Huang, Y.Q., Sun, Y.L., Li, M.Y., Effects of shade treatments on photosynthetic characteristics, chloroplast ultrastructure, and physiology of Anoectochilus roxburghii. PLoS One, 9, 2013, e85996.
56. Shao, Q.S., Deng, Y.M., Liu, H.B., Zhang, A.L., Huang, Y.Q., Xu, G.Z., Li, M.Y., Essential oils extraction from Anoectochilus roxburghii using supercritical carbon dioxide and their antioxidant activity. Ind. Crops Prod. 60 (2014), 104–112.
57. Shao, Q.S., Zhou, A.C., Hu, R.H., Zhang, Y.Y., Liu, T.M., Li, M.Y., Influence of seedling grade on plant growth, yield and quality of Anoectochilus roxburghii. China J. Chin. Mater. Med. 39 (2014), 785–789.
58. Shao, Q.S., Ye, S.Y., Zhou, A.C., Wang, H.Z., Zhang, A.L., Xu, J.W., Current researches and prospects of seedling propagation and cultivation modes of Jinxianlian. China J. Chin. Mater. Med. 41 (2016), 43–49.
59. Shyur, L.F., Chen, C.H., Lo, C.P., Wang, S.Y., Kang, P.L., Sun, S.J., Chang, C.A., Tzeng, C.M., Yang, N.S., Induction of apoptosis in MCF-7 human breast cancer cells by phytochemicals from Anoectochilus formosanus. J. Biomed. Sci. 11 (2004), 928–939.
60. Su, B., Wang, L.E., Tseng, C.C., Hsu, C.C., Huang, H., June, C.P., Lin, C.M., Cheng, K.T., 2000. The effect of Anoectochilus formosanus on hepatic cytokeratin 18 of mice. Res Comraun Pharmacol Toxicol 5, pp. 194–204.
61. Tang, F., Zhang, X.Q., Xu, J.T., Cai, J.Y., Zhang, J.W., Zhang, Y.H., Screening on hypoglycemic effective part of Anoectochilus roxburghii. Chin. Tradit. Herbal. Drugs 42 (2011), 340–342.
62. Tang, J., Deng, Y.R., Zhuo, Y.R., Advances in pharmacological activity of Anoectochilus roxburghii. Strait Pharm. J. 20 (2008), 77–79.
63. Tseng, C.C., Shang, H.F., Wang, L.F., Su, B., Hsu, C.C., Kao, H.Y., Cheng, K.T., Antitumor and immunostimulating effects of Anoectochilus formosanus Hayata. Phytomedicine Int. J. Phytother. Phytopharm. 13 (2006), 366–370.
64. Wang, J.C., Research Progress on chemical components of Anoectochilus. Southeast Hortic., 2014, 68–74.
65. 1H NMR/RRLCMS parallel dynamic spectroscopy. Int. J. Mol. Sci. 12 (2011), 2556–2571.
66. Wang, Z., Analysis&determination of trace elements&amino acids in taiwanensis. J. Fujian Coll. Tradit. Chin. Med., 1993.
67. Weng, X.H., Wang, C.L., Yuan, X., Chen, W.J., Inhibitory effect of Anoectochilus formosanus polysaccharide on human prostate cancer PC-3 cell in vitro. Chin. J. Hosp. Pharm. 31 (2011), 1083–1087.
68. Wu, D.F., Zhang, H., Zhou, B.H., Cai, H.S., Studies on the mechanism of inhibitory action of sodium Ferulate on liver lipid peroxidation in mice. Chin. J. Chin. Mat. Med., 1996, 21–299.
69. Wu, J.B., Lin, W.L., Hsieh, C.C., Ho, H.Y., Tsay, H.S., Lin, W.C., The hepatoprotective activity of kinsenoside from Anoectochilus formosanus. Phytother. Res. PTR, 21, 2007, 58.
70. Wu, L.L., Liang, Y., Xu, G.H., Advances on investigation of chemical components,Pharmacological Activtties and clinical applications of Anocetochilus roxburghii. Strait Pharm. J., 2014, 34–37.
71. Wu, L.T., Wu, Y.W., Shih, C.C., Ko, Y.J., Lin, W.C., Primary studies on the Genotoxity of aqueous Extiracts from Anoectochilus formosanus and glycine Tomentella. J. Chin. Med 12 (2001), 173–178.
72. Wu, P.P., 2013. Analysis on Active Substances and Evaluation on Quality of A. Roxburghii (Wall.) Lindl. Fujian Medical University, Fujian.
73. Xiao, W., Treatment of 49 cases of infantile Tourette syndrome with Anoectochilus roxburghii oral liquid. J. Northwest Pharm. 20 (2005), 81–82.
74. Xiao, Z.W., Treatment of 60 cases of infantile cough variant asthma with Anoectochilus roxburghii mixture. Chin. Arch. Tradit. Chin. Med., 22, 2004, 2005.
75. Xu, W.J., Chen, Y., Huang, Z.Q., Yang, S.Y., Chen, J.Y., A preliminary study on the treatment of compound Herba anoectochili capsule on diabetes II. Subtrop. Plantence 29 (2000), 47–49.
76. Xu, J., 2008. Study on the Chemical Constituents of Anoectochilus roxburghii and Activity of Derivatives of Deoxypodophyllotoxin. Lanzhou University, Gansu.
77. Yan, Y.B., Clinical Observation on treatment of 60 cases of Hp infection with omeprazole and Anoectochilus roxburghii. Fujian J. TCM 39 (2008), 11–12.
78. Yang, X.W., Han, M.H., Jin, Y.P., Studies on the chemical constituents from herba Anoectochili. J. Chin. Med. Mater. 30 (2007), 797–800.
79. Yin, Z.N., Xu, K.X., Fan, J.J., Ma, Z.Q., Lin, R.C., Research progress on chemical constituents of Anoectochilus and pharmacological activities. Glob. Tradit. Chin. Med. 9 (2016), 1153–1160.
80. Zhang, S.N., Experimental study on immune function of Anoectochilus roxburghii polysaccharide oral liquid. J. Pract. Tradit. Chin. Med. 30 (2014), 987–988.
81. Zhang, S.Y., Li, Z., Progress in oleanolic acid research. Food Ferment. Technol. 46 (2010), 20–24.
82. Zhang, Y., Cai, J., H., Pi, H., Wu, J., Antihyperglycemic activity of kinsenoside, a high yielding constituent from Anoectochilus roxburghii in streptozotocin diabetic rats. J. Ethnopharmacol. 114 (2007), 141–145.
83. Zhang, X.H., 2008. Structural analysis and antidiabetic activities of ploysaccharides from Anoectochilus roxburghii. Shantou University, Guangdong.
84. Zhao, S.X., Traditional Chinese Medicine Citing, Vol. II, 1996, China Medical Science Press, Beijing.
85. Zhong, T.H., Huang, L.Y., Wang, Y., Extraction and determination of the alkaloids in Anoectochilus formosanus. Chem. Res. 17 (2006), 68–70.