Release of ATP by pre-Bötzinger complex astrocytes contributes to the hypoxic ventilatory response via a Ca2+-dependent P2Y1 receptor mechanism

Journal of Physiology

Volumn 596, Issue 15, 2018, Pages 3245-3269

  Rajani, Vishaal ^a,f   Zhang, Yong ^a   Jalubula, Venkatesh ^a   Rancic, Vladimir ^a   SheikhBahaei, Shahriar ^b,e   Zwicker, Jennifer D ^a   Pagliardini, Silvia ^a   Dickson, Clayton T ^c   Ballanyi, Klaus ^a   Kasparov, Sergey ^d   Gourine, Alexander V ^e   Funk, Gregory D ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

^b NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE   (United States)

^c Faculty of Science   (Canada)

^d UNIVERSITY OF BRISTOL   (United Kingdom)

^e UNIVERSITY COLLEGE LONDON   (United Kingdom)

^f HOSPITAL FOR SICK CHILDREN   (Canada)

Author keywords

ATP; glia; gliotransmission; hypoxia; hypoxic ventilatory response; P2Y1; preB tzinger complex; purinoceptor

Indexed keywords

ADENOSINE TRIPHOSPHATE; ADENOVIRUS VECTOR; CALCIUM ION; PURINERGIC P2Y1 RECEPTOR; PURINERGIC RECEPTOR AFFECTING AGENT; TETANUS TOXIN; CALCIUM;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; CONTROLLED STUDY; ENZYME RELEASE; EXOCYTOSIS; GLIA; HYPOXIA; HYPOXIC VENTILATORY RESPONSE; IN VITRO STUDY; INSPIRATORY CAPACITY; LIGHT CHAIN; MALE; NERVE CELL; NERVE CELL CULTURE; NONHUMAN; PRIORITY JOURNAL; PROTEIN SECRETION; RAT; RESPIRATION DEPRESSION; RESPIRATORY FUNCTION; SIGNAL TRANSDUCTION; ANIMAL; LUNG VENTILATION; MEDULLA OBLONGATA; PATHOPHYSIOLOGY; PHYSIOLOGY; SPRAGUE DAWLEY RAT;

ADENOSINE TRIPHOSPHATE; ANIMALS; ASTROCYTES; CALCIUM; HYPOXIA; MALE; MEDULLA OBLONGATA; PULMONARY VENTILATION; RATS, SPRAGUE-DAWLEY; RECEPTORS, PURINERGIC P2Y1;

EID: 85026347182     PISSN: 00223751     EISSN: 14697793     Source Type: Journal    
DOI: 10.1113/JP274727     Document Type: Article

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