The response of the pulmonary circulation and right ventricle to exercise: Exercise-induced right ventricular dysfunction and structural remodeling in endurance athletes (2013 grover conference series)

Pulmonary Circulation

Volumn 4, Issue 3, 2014, Pages 407-416

  La Gerche, André ^a,b   Roberts, Timothy ^a   Claessen, Guido ^b  

^a UNIVERSITY OF MELBOURNE   (Australia)

^b UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

Athlete; Athlete s heart; Exercise; Exercise induced; Fibrosis; Pulmonary circulation; Right ventricle

Indexed keywords

EID: 85026338136     PISSN: 20458932     EISSN: 20458940     Source Type: Journal    
DOI: 10.1086/677355     Document Type: Review

References (55)

1. Prior DL, La Gerche A. The athlete’s heart. Heart 2012; 98:947-955.
2. La Gerche A, Taylor AJ, Prior DL. Athlete’s heart: the potential for multimodality imaging to address the critical remaining questions. JACC Cardiovasc Imaging 2009;2:350-363.
3. La Gerche A, Baggish AL, Knuuti J, et al. Cardiac imaging and stress testing asymptomatic athletes to identify those at risk of sudden cardiac death. JACC Cardiovasc Imaging 2013; 6:993-1007.
4. La Gerche A, Burns AT, Taylor AJ, MacIsaac AI, Heidbuchel H, Prior DL. Maximal oxygen consumption is best predicted by measures of cardiac size rather than function in healthy adults. Eur J Appl Physiol 2012;112:2139-2147.
5. Steding K, Engblom H, Buhre T, et al. Relation between cardiac dimensions and peak oxygen uptake. J Cardiovasc Magn Reson 2010;12:8.
6. Morganroth J, Maron BJ, Henry WL, Epstein SE. Comparative left ventricular dimensions in trained athletes. Ann Intern Med 1975;82:521-524.
7. Pluim BM, Zwinderman AH, van der Laarse A, van der Wall EE. The athlete’s heart: a meta-analysis of cardiac structure and function. Circulation 2000;101:336-344.
8. Spence AL, Naylor LH, Carter HH, et al. A prospective randomised longitudinal MRI study of left ventricular adaptation to endurance and resistance exercise training in humans. J Physiol 2011;589:5443-5452.
9. West JB, Watson RR, Fu Z. Major differences in the pulmonary circulation between birds and mammals. Respir Physiol Neurobiol 2007;157:382-390.
10. Lankhaar JW, Westerhof N, Faes TJ, et al. Pulmonary vascular resistance and compliance stay inversely related during treatment of pulmonary hypertension. Eur Heart J 2008;29: 1688-1695.
11. Slife DM, Latham RD, Sipkema P, Westerhof N. Pulmonary arterial compliance at rest and exercise in normal humans. Am J Physiol 1990;258: 1823-1828.
12. Reeves JT, Groves BM, Cymerman A, et al. Operation Everest II: cardiac filling pressures during cycle exercise at sea level. Respir Physiol 1990;80:147-154.
13. Buechel EV, Kaiser T, Jackson C, Schmitz A, Kellenberger CJ. Normal right-and left ventricular volumes and myocardial mass in children measured by steady state free precession cardiovascular magnetic resonance. J Cardiovasc Magn Reson 2009;11:19.
14. Faber MJ, Dalinghaus M, Lankhuizen IM, et al. Right and left ventricular function after chronic pulmonary artery banding in rats assessed with biventricular pressure-volume loops. Am J Physiol Heart Circ Physiol 2006;291:H1580-H1586.
15. Chin KM, Kim NH, Rubin LJ. The right ventricle in pulmonary hypertension. Coron Artery Dis 2005;16:13-18.
16. MacNee W. Pathophysiology of cor pulmonale in chronic obstructive pulmonary disease: part one. Am J Respir Crit Care Med 1994;150:833-852.
17. La Gerche A, Claessen G, Van de Bruaene A, et al. Cardiac MRI: a new gold standard for ventricular volume quantification during high-intensity exercise. Circ Cardiovasc Imaging 2013;6:329-338.
18. 2,max: what do we know, and what do we still need to know? J Physiol 2008;586:25-34.
19. Argiento P, Chesler N, Mulé M, et al. Exercise stress echocardiography for the study of the pulmonary circulation. Eur Respir J 2010;35:1273-1278.
20. Dawson CA. Role of pulmonary vasomotion in physiolog of the lung. Physiol Rev 1984;64:544-616.
21. McLaughlin VV, Langer A, Tan M, et al. Contemporary trends in the diagnosis and management of pulmonary arterial hypertension: an initiative to close the care gap. Chest 2013;143:324-332.
22. Jacobs KA, Kressler J, Stoutenberg M, Roos BA, Friedlander AL. Sildenafil has little influence on cardiovascular hemo-dynamics or 6-km time trial performance in trained men and women at simulated high altitude. High Alt Med Biol 2011;12:215-222.
23. Bidart CM, Abbas AE, Parish JM, Chaliki HP, Moreno CA, Lester SJ. The noninvasive evaluation of exercise-induced changes in pulmonary artery pressure and pulmonary vascular resistance. J Am Soc Echocardiogr 2007;20:270-275.
24. Argiento P, Chesler N, Mulé M, et al. Exercise stress echocardiography for the study of the pulmonary circulation. Eur Respir J 2010;35:1273-1278.
25. La Gerche A, Heidbuchel H, Burns AT, et al. Disproportionate exercise load and remodeling of the athlete’s right ventricle. Med Sci Sports Exerc 2011;43:974-981.
26. La Gerche A, MacIsaac AI, Burns AT, et al. Pulmonary transit of agitated contrast is associated with enhanced pulmonary vascular reserve and right ventricular function during exercise. J Appl Physiol 2010;109:1307-1317.
27. Lewis GD, Murphy RM, Shah RV, et al. Pulmonary vascular response patterns during exercise in left ventricular systolic dysfunction predict exercise capacity and outcomes. Circ Heart Fail 2011;4:276-285.
28. Kovacs G, Berghold A, Scheidl S, Olschewski H. Pulmonary arterial pressure during rest and exercise in healthy subjects: a systematic review. Eur Respir J 2009;34:888-894.
29. Stanek V, Jebavy P, Hurych J, Widimsky J. Central haemodynamics during supine exercise and pulmonary artery occlusion in normal subjects. Bull Physiopathol Respir (Nancy) 1973;9:1203-1217.
30. Gurtner HP, Walser P, Fassler B. Normal values for pulmonary haemodynamics at rest and during exercise in man. Prog Resp Res 1975;9:1203-1217.
31. Stanek V, Widimsky J, Degre S, Denolin H. The lesser circulation during exercise in healthy subjects. Prog Resp Res 1975;9:295-315.
32. Holverda S, Rietema H, Westerhof N, et al. Stroke volume increase to exercise in chronic obstructive pulmonary disease is limited by increased pulmonary artery pressure. Heart 2009;95:137-141.
33. Holverda S, Gan CT, Marcus JT, Postmus PE, Boonstra A, Vonk-Noordegraaf A. Impaired stroke volume response to exercise in pulmonary arterial hypertension. J Am Coll Cardiol 2006;47:1732-1733.
34. Shave R, George K, Whyte G, Hart E, Middleton N. Postexercise changes in left ventricular function: the evidence so far. Med Sci Sports Exerc 2008;40:1393-1399.
35. Trivax JE, Franklin BA, Goldstein JA, et al. Acute cardiac effects of marathon running. J Appl Physiol 2010;108:1148-1153.
36. Neilan TG, Yoerger DM, Douglas PS, et al. Persistent and reversible cardiac dysfunction among amateur marathon runners. Eur Heart J 2006;27:1079-1084.
37. Mousavi N, Czarnecki A, Kumar K, et al. Relation of biomarkers and cardiac magnetic resonance imaging after marathon running. Am J Cardiol 2009;103:1467-1472.
38. Douglas PS, O’Toole ML, Hiller WD, Reichek N. Different effects of prolonged exercise on the right and left ventricles. J Am Coll Cardiol 1990;15:64-69.
39. La Gerche A, Burns AT, Mooney DJ, et al. Exercise-induced right ventricular dysfunction and structural remodelling in endurance athletes. Eur Heart J 2012;33:998-1006.
40. La Gerche A, Connelly KA, Mooney DJ, MacIsaac AI, Prior DL. Biochemical and functional abnormalities of left and right ventricular function after ultra-endurance exercise. Heart 2008;94:860-866.
41. Oxborough D, Shave R, Warburton D, et al. Dilatation and dysfunction of the right ventricle immediately after ultraendurance exercise: exploratory insights from conventional two-dimensional and speckle tracking echocardiography. Circ Cardiovasc Imaging 2011;4:253-263.
42. Neilan TG, Januzzi JL, Lee-Lewandrowski E, et al. Myocardial injury and ventricular dysfunction related to training levels among nonelite participants in the Boston Marathon. Circulation 2006;114:2325-2333.
43. Marcus JT, Gan CT, Zwanenburg JJ, et al. Interventricular mechanical asynchrony in pulmonary arterial hypertension: left-to-right delay in peak shortening is related to right ventricular overload and left ventricular underfilling. J Am Coll Cardiol 2008;51:750-757.
44. Scharhag J, Schneider G, Urhausen A, Rochette V, Kramann B, Kindermann W. Athlete’s heart: right and left ventricular mass and function in male endurance athletes and untrained individuals determined by magnetic resonance imaging. J Am Coll Cardiol 2002;40:1856-1863.
45. Aaron CP, Tandri H, Barr RG, et al. Physical activity and right ventricular structure and function: the MESA-Right Ventricle Study. Am J Respir Crit Care Med 2011;183:396-404.
46. Modesti PA, Vanni S, Bertolozzi I, et al. Different growth factor activation in the right and left ventricles in experimental volume overload. Hypertension 2004;43:101-108.
47. Benito B, Gay-Jordi G, Serrano-Mollar A, et al. Cardiac arrhythmogenic remodeling in a rat model of long-term intensive exercise training. Circulation 2011;123:13-22.
48. Heidbuchel H, Hoogsteen J, Fagard R, et al. High prevalence of right ventricular involvement in endurance athletes with ventricular arrhythmias: role of an electrophysiologic study in risk stratification. Eur Heart J 2003;24:1473-1480.
49. Corrado D, Basso C, Rizzoli G, Schiavon M, Thiene G. Does sports activity enhance the risk of sudden death in adolescents and young adults? J Am Coll Cardiol 2003;42:1959-1963.
50. Maron BJ, Doerer JJ, Haas TS, Tierney DM, Mueller FO. Sudden deaths in young competitive athletes: analysis of 1866 deaths in the United States, 1980-2006. Circulation 2009;119: 1085-1092.
51. de Noronha SV, Sharma S, Papadakis M, Desai S, Whyte G, Sheppard MN. Aetiology of sudden cardiac death in athletes in the United Kingdom: a pathological study. Heart 2009; 95:1409-1414.
52. Wilson M, O’Hanlon R, Prasad S, et al. Diverse patterns of myocardial fibrosis in lifelong, veteran endurance athletes. J Appl Physiol 2011;110:1622-1626.
53. La Gerche A, Burns AT, Mooney DJ, et al. Exercise-induced right ventricular dysfunction and structural remodelling in endurance athletes. Eur Heart J 2012;33:1006.
54. Trivax JE, McCullough PA. Phidippides cardiomyopathy: a review and case illustration. Clin Cardiol 2012;35:69-73.
55. La Gerche A. Aetiology of structural and functional remodeling of the right ventricle in endurance athletes [doctoral thesis]. University of Melbourne, 2010.