Sildenafil has little influence on cardiovascular hemodynamics or 6-km time trial performance in trained men and women at simulated high altitude

High Altitude Medicine and Biology

Volumn 12, Issue 3, 2011, Pages 215-222

  Jacobs, Kevin A ^a   Kressler, Jochen ^a   Stoutenberg, Mark ^a   Roos, Bernard A ^a,b,c   Friedlander, Anne L ^d  

^a UNIVERSITY OF MIAMI   (United States)

^b UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

^c VETERANS AFFAIRS MEDICAL CENTER   (United States)

^d STANFORD UNIVERSITY   (United States)

Author keywords

exertion; phosphodiesterase 5 inhibitor; simulated altitude; time trial; Viagra

Indexed keywords

OXYGEN; SILDENAFIL;

ADULT; AEROBIC CAPACITY; ALTITUDE; ARTERIAL OXYGEN SATURATION; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFECT; ENDURANCE TRAINING; EXERCISE; FEMALE; HEART HEMODYNAMICS; HEART OUTPUT; HEART RATE; HEART STROKE VOLUME; HUMAN; HYPOXIA; INGESTION; LUNG ARTERY PRESSURE; MALE; PERSONAL TRAINER; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SEA LEVEL;

ADULT; ALTITUDE; ANALYSIS OF VARIANCE; BLOOD PRESSURE; EXERCISE TEST; EXERCISE TOLERANCE; FEMALE; HEMODYNAMICS; HUMANS; MALE; OXYGEN; PIPERAZINES; PURINES; REGRESSION ANALYSIS; STROKE VOLUME; SULFONES; TIME FACTORS; VASODILATOR AGENTS; YOUNG ADULT;

EID: 80053493507     PISSN: 15270297     EISSN: 15578682     Source Type: Journal    
DOI: 10.1089/ham.2011.0011     Document Type: Article

References (33)

1. Bailey SJ, Fulford J, Vanhatalo A, Winyard PG, Blackwell JR, DiMenna FJ, Wilkerson DP, Benjamin N, and Jones AM. (2010). Dietary nitrate supplementation enhances muscle contractile efficiency during knee-extensor exercise in humans. J Appl Physiol 109:135-148.
2. Bailey SJ, Winyard P, Vanhatalo A, Blackwell JR, Dimenna FJ, Wilkerson DP, Tarr J, Benjamin N, and Jones AM. (2009). Dietary nitrate supplementation reduces the O2 cost of lowintensity exercise and enhances tolerance to high-intensity exercise in humans. J Appl Physiol 107:1144-1155.
3. Bartsch P, Maggiorini M, Mairbaurl H, Vock P, and Swenson ER. (2002). Pulmonary extravascular fluid accumulation in climbers. Lancet 360:571; author reply 571-572.
4. Boolell M, Allen MJ, Ballard SA, Gepi-Attee S, Muirhead GJ, Naylor AM, Osterloh IH, and Gingell C. (1996). Sildenafil: An orally active type 5 cyclic GMP-specific phosphodiesterase inhibitor for the treatment of penile erectile dysfunction. Int J Impot Res 8:47-52.
5. Boussuges A, Molenat F, Burnet H, Cauchy E, Gardette B, Sainty JM, Jammes Y, and Richalet JP. (2000). Operation Everest III (Comex '97): Modifications of cardiac function secondary to altitude-induced hypoxia. An echocardiographic and Doppler study. Am J Respir Crit Care Med 161:264-270. (Pubitemid 30055935)
6. Calbet JA, Boushel R, Radegran G, Sondergaard H, Wagner PD, and Saltin B. (2003). Determinants of maximal oxygen uptake in severe acute hypoxia. Am J Physiol Regul Integr Comp Physiol 284:R291-303. (Pubitemid 36120144)
7. Charloux A, Lonsdorfer-Wolf E, Richard R, Lampert E, Oswald-Mammosser M, Mettauer B, Geny B, and Lonsdorfer J. (2000). A new impedance cardiograph device for the non-invasive evaluation of cardiac output at rest and during exercise: Comparison with the "direct" Fick method. Eur J Appl Physiol 82:313-320. (Pubitemid 30599301)
8. Cisneros IE, Bettencourt J, Turner RJ, Zierke J, Parker D, and Quintana R. (2009). Effects of sildenafil on VO2max in trained women with moderate normobaric hypoxia. Med Sci Sports Exerc 41:S129.
9. Corbin JD, Beasley A, Blount MA, and Francis SH. (2005). High lung PDE5: A strong basis for treating pulmonary hypertension with PDE5 inhibitors. Biochem Biophys Res Commun 334:930-938. (Pubitemid 41033209)
10. Cremona G, Asnaghi R, Baderna P, Brunetto A, Brutsaert T, Cavallaro C, Clark TM, Cogo A, Donis R, Lanfranchi P et al. (2002). Pulmonary extravascular fluid accumulation in recreational climbers: A prospective study. Lancet 359:303-309. (Pubitemid 34119294)
11. Elliott PR and Atterbom HA. (1978). Comparison of exercise responses of males and females during acute exposure to hypobaria. Aviat Space Environ Med 49:415-418. (Pubitemid 8285994)
12. Faoro V, Lamotte M, Deboeck G, Pavelescu A, Huez S, Guenard H, Martinot J, and Naeije R. (2007). Effects of sildenafil on exercise capacity in hypoxic normal subjects. High Alt Med Biol 8:155-163. (Pubitemid 47001203)
13. Ghofrani HA, Osterloh IH, and Grimminger F. (2006). Sildenafil: from angina to erectile dysfunction to pulmonary hypertension and beyond. Nat Rev Drug Discov 5:689-702. (Pubitemid 44151606)
14. Ghofrani HA, Reichenberger F, Kohstall MG, Mrosek EH, Seeger T, Olschewski H, Seeger W, and Grimminger F. (2004). Sildenafil increased exercise capacity during hypoxia at low altitudes and at Mount Everest base camp: A randomized, double-blind, placebo-controlled crossover trial. Ann Intern Med 141:169-177.
15. Groves BM, Reeves JT, Sutton JR, Wagner PD, Cymerman A, Malconian MK, Rock PB, Young PM, Houston CS. (1987). Operation Everest II: Elevated high-altitude pulmonary resistance unresponsive to oxygen. J Appl Physiol 63:521-530. (Pubitemid 17161952)
16. Hackett PH, Rennie D, Levine HD. (1976). The incidence, importance, and prophylaxis of acute mountain sickness. Lancet 2:1149-1155.
17. Harris P and Heath D. (1977). The Human Pulmonary Circulation: Its Form and Function in Health and Disease. Churchill Livingston, Edinburgh.
18. Hopkins WG, Hawley JA, and Burke LM. (1999). Design and analysis of research on sport performance enhancement. Med Sci Sports Exerc 31:472-485. (Pubitemid 29136331)
19. Hsu AR, Barnholt KE, Grundmann NK, Lin JH, McCallum SW, and Friedlander AL. (2006). Sildenafil improves cardiac output and exercise performance during acute hypoxia, but not normoxia. J Appl Physiol 100:2031-2040. (Pubitemid 43845879)
20. Jeukendrup A, Saris WH, Brouns F, and Kester AD. (1996). A new validated endurance performance test. Med Sci Sports Exercise 28:266-270. (Pubitemid 26067700)
21. Kjaergaard J, Snyder EM, Hassager C, Olson TP, Oh JK, Johnson BD, and Frantz RP. (2007). Right ventricular function with hypoxic exercise: Effects of sildenafil. Eur J Appl Physiol 102:87-95. (Pubitemid 350090701)
22. Larsen FJ, Weitzberg E, Lundberg JO, and Ekblom B. (2007). Effects of dietary nitrate on oxygen cost during exercise. Acta Physiol (Oxf) 191:59-66. (Pubitemid 47221195)
23. Naeije R, Huez S, Lamotte M, Retailleau K, Neupane S, Abramowicz D, and Faoro V. (2010). Pulmonary artery pressure limits exercise capacity at high altitude. Eur Respir J. 36:1049-1055.
24. Nichols DJ, Muirhead GJ, and Harness JA. (2002). Pharmacokinetics of sildenafil after single oral doses in healthy male subjects: Absolute bioavailability, food effects and dose proportionality. Br J Clin Pharmacol 53 Suppl 1:5S-12S.
25. Paterson DJ, Pinnington H, Pearce AR, and Morton AR. (1987). Maximal exercise cardiorespiratory responses of men and women during acute exposure to hypoxia. Aviat Space Environ Med 58:243-247. (Pubitemid 17033241)
26. Ricart A, Maristany J, Fort N, Leal C, Pages T, and Viscor G. (2005). Effects of sildenafil on the human response to acute hypoxia and exercise. High Alt Med Biol 6:43-49. (Pubitemid 40533279)
27. Rice AJ, Thornton AT, Gore CJ, Scroop GC, Greville HW, Wagner H, Wagner PD, and Hopkins SR. (1999). Pulmonary gas exchange during exercise in highly trained cyclists with arterial hypoxemia. J Appl Physiol 87:1802-1812.
28. Richalet JP, Gratadour P, Robach P, Pham I, Dechaux M, Joncquiert-Latarjet A, Mollard P, Brugniaux J, and Cornolo J. (2005). Sildenafil inhibits altitude-induced hypoxemia and pulmonary hypertension. Am J Respir Crit Care Med 171:275-281.
29. Richard R, Lonsdorfer-Wolf E, Charloux A, Doutreleau S, Buchheit M, Oswald-Mammosser M, Lampert E, Mettauer B, Geny B, and Lonsdorfer J. (2001). Non-invasive cardiac output evaluation during a maximal progressive exercise test, using a new impedance cardiograph device. Eur J Appl Physiol 85:202-207. (Pubitemid 32755646)
30. Robergs RA, Quintana R, Parker DL, and Frankel CC. (1998). Multiple variables explain the variability in the decrement in VO2max during acute hypobaric hypoxia. Med Sci Sports Exerc 30:869-879. (Pubitemid 28262375)
31. Snyder EM, Olson TP, Johnson BD, and Frantz RP. (2008). Influence of sildenafil on lung diffusion during exposure to acute hypoxia at rest and during exercise in healthy humans. Eur J Appl Physiol 103:421-430.
32. Walker DK, Ackland MJ, James GC, Muirhead GJ, Rance DJ, Wastall P, and Wright PA. (1999). Pharmacokinetics and metabolism of sildenafil in mouse, rat, rabbit, dog and man. Xenobiotica 29:297-310. (Pubitemid 29140098)
33. Wu TY, Ding SQ, Liu JL, Yu MT, Jia JH, Chai ZC, Dai RC, Zhang SL, Li BY, Pan L, et al. (2007). Who should not go high: Chronic disease and work at altitude during construction of the Qinghai-Tibet railroad. High Alt Med Biol 8:88-107. (Pubitemid 47001196)