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Volumn 5, Issue 1, 2015, Pages 81-89

The need to recognize the pulmonary circulation and the right ventricle as an integrated functional unit: Facts and hypotheses (2013 Grover conference series)

Author keywords

Apoptosis; Autophagy; Capillary density; Hibernation; Right ventricle phenotypes

Indexed keywords


EID: 85026338040     PISSN: 20458932     EISSN: 20458940     Source Type: Journal    
DOI: 10.1086/679702     Document Type: Article
Times cited : (25)

References (47)
  • 1
    • 0013862762 scopus 로고
    • Exercise performance of athletes at sea level and 3100 meters altitude
    • Grover RF, Reeves JT. Exercise performance of athletes at sea level and 3100 meters altitude. Med Thorac 1966;23 (3):129-143.
    • (1966) Med Thorac , vol.23 , Issue.3 , pp. 129-143
    • Grover, R.F.1    Reeves, J.T.2
  • 2
    • 0016165981 scopus 로고
    • Lung mast cell hyperplasia and pulmonary histamine-forming capacity in hypoxic rats
    • Kay JM, Waymire JC, Grover RF. Lung mast cell hyperplasia and pulmonary histamine-forming capacity in hypoxic rats. Am J Physiol 1974;226(1):178-184.
    • (1974) Am J Physiol , vol.226 , Issue.1 , pp. 178-184
    • Kay, J.M.1    Waymire, J.C.2    Grover, R.F.3
  • 3
    • 0019206486 scopus 로고
    • Cardiac output is decreased and hypoxic vasoconstriction is intact in chronically hypoxic sheep
    • Rounds SI, Moore LG, Voelkel NF, McMurtry IF, Reeves JT. Cardiac output is decreased and hypoxic vasoconstriction is intact in chronically hypoxic sheep. Proc Soc Exp Biol Med 1980;165(1):1-5.
    • (1980) Proc Soc Exp Biol Med , vol.165 , Issue.1 , pp. 1-5
    • Rounds, S.I.1    Moore, L.G.2    Voelkel, N.F.3    McMurtry, I.F.4    Reeves, J.T.5
  • 4
    • 0000124156 scopus 로고
    • Primary pulmonary hypertension
    • Moser KM, ed, New York: Marcel Dekker
    • Voelkel N, Reeves JT. Primary pulmonary hypertension. In: Moser KM, ed. Pulmonary vascular diseases. New York: Marcel Dekker, 1979:573-628.
    • (1979) Pulmonary Vascular Diseases , pp. 573-628
    • Voelkel, N.1    Reeves, J.T.2
  • 6
    • 33750560212 scopus 로고    scopus 로고
    • National Heart Lung and Blood Institute Working Group on Cellular and Molecular Mechanisms of Right Heart Failure. Right ventricular function and failure: Report of a National Heart, Lung, and Blood Institute Working Group on Cellular and Molecular Mechanisms of Right Heart Failure
    • Voelkel NF, Quaife RA, Leinwand LA, Barst RJ, McGoon MD, Meldrum DR, Dupuis J, et al.; National Heart Lung and Blood Institute Working Group on Cellular and Molecular Mechanisms of Right Heart Failure. Right ventricular function and failure: report of a National Heart, Lung, and Blood Institute Working Group on Cellular and Molecular Mechanisms of Right Heart Failure. Circulation 2006;114 (17):1883-1891.
    • (2006) Circulation , vol.114 , Issue.17 , pp. 1883-1891
    • Voelkel, N.F.1    Quaife, R.A.2    Leinwand, L.A.3    Barst, R.J.4    McGoon, M.D.5    Meldrum, D.R.6    Dupuis, J.7
  • 9
    • 84873647966 scopus 로고    scopus 로고
    • Metabolic gene remodeling and mitochondrial dysfunction in failing right ventricular hypertrophy secondary to pulmonary arterial hypertension
    • Gomez-Arroyo J, Mizuno S, Szczepanek K, Van Tassell B, Natarajan R, Remedios Dos CG, Drake JI, et al. Metabolic gene remodeling and mitochondrial dysfunction in failing right ventricular hypertrophy secondary to pulmonary arterial hypertension. Circ Heart Fail 2013;6(1):136-144.
    • (2013) Circ Heart Fail , vol.6 , Issue.1 , pp. 136-144
    • Gomez-Arroyo, J.1    Mizuno, S.2    Szczepanek, K.3    Van Tassell, B.4    Natarajan, R.5    Remedios Dos, C.G.6    Drake, J.I.7
  • 11
    • 84888636768 scopus 로고    scopus 로고
    • A metabolic remodeling in right ventricular hypertrophy is associated with decreased angiogenesis and a transition from a compensated to a decompensated state in pulmonary hypertension
    • Sutendra G, Dromparis P, Paulin R, Zervopoulos S, Haromy A, Nagendran J, Michelakis ED. A metabolic remodeling in right ventricular hypertrophy is associated with decreased angiogenesis and a transition from a compensated to a decompensated state in pulmonary hypertension. J Mol Med 2013;91(11):1315-1327.
    • (2013) J Mol Med , vol.91 , Issue.11 , pp. 1315-1327
    • Sutendra, G.1    Dromparis, P.2    Paulin, R.3    Zervopoulos, S.4    Haromy, A.5    Nagendran, J.6    Michelakis, E.D.7
  • 12
    • 84870906939 scopus 로고    scopus 로고
    • GRK2-mediated inhibition of adrenergic and dopaminergic signaling in right ventricular hypertrophy: Therapeutic implications in pulmonary hypertension
    • Piao L, Fang Y-H, Parikh KS, Ryan JJ, D’Souza KM, Theccanat T, Toth PT, et al. GRK2-mediated inhibition of adrenergic and dopaminergic signaling in right ventricular hypertrophy: therapeutic implications in pulmonary hypertension. Circulation 2012;126(24):2859-2869.
    • (2012) Circulation , vol.126 , Issue.24 , pp. 2859-2869
    • Piao, L.1    Fang, Y.-H.2    Parikh, K.S.3    Ryan, J.J.4    D’Souza, K.M.5    Theccanat, T.6    Toth, P.T.7
  • 13
    • 84887066953 scopus 로고    scopus 로고
    • Right ventricular diastolic impairment in patients with pulmonary arterial hypertension
    • Rain S, Handoko ML, Trip P, Gan CT-J, Westerhof N, Stienen GJ, Paulus WJ, et al. Right ventricular diastolic impairment in patients with pulmonary arterial hypertension. Circulation 2013;128(18):2016-2025.
    • (2013) Circulation , vol.128 , Issue.18 , pp. 2016-2025
    • Rain, S.1    Handoko, M.L.2    Trip, P.3    Gan, C.-J.4    Westerhof, N.5    Stienen, G.J.6    Paulus, W.J.7
  • 14
    • 75749133554 scopus 로고    scopus 로고
    • The inhibition of pyruvate dehydrogenase kinase improves impaired cardiac function and electrical remodeling in two models of right ventricular hypertrophy: Resuscitating the hibernating right ventricle
    • Piao L, Fang Y-H, Cadete VJJ, Wietholt C, Urboniene D, Toth PT, Marsboom G, et al. The inhibition of pyruvate dehydrogenase kinase improves impaired cardiac function and electrical remodeling in two models of right ventricular hypertrophy: resuscitating the hibernating right ventricle. J Mol Med 2010;88(1):47-60.
    • (2010) J Mol Med , vol.88 , Issue.1 , pp. 47-60
    • Piao, L.1    Fang, Y.-H.2    Cadete, V.3    Wietholt, C.4    Urboniene, D.5    Toth, P.T.6    Marsboom, G.7
  • 15
    • 38349138807 scopus 로고    scopus 로고
    • Transgenic system for conditional induction and rescue of chronic myocardial hibernation provides insights into genomic programs of hibernation
    • May D, Gilon D, Djonov V, Itin A, Lazarus A, Gordon O, Rosenberger C, Keshet E. Transgenic system for conditional induction and rescue of chronic myocardial hibernation provides insights into genomic programs of hibernation. Proc Natl Acad Sci USA 2008;105(1):282-287.
    • (2008) Proc Natl Acad Sci USA , vol.105 , Issue.1 , pp. 282-287
    • May, D.1    Gilon, D.2    Djonov, V.3    Itin, A.4    Lazarus, A.5    Gordon, O.6    Rosenberger, C.7    Keshet, E.8
  • 16
    • 62149104001 scopus 로고    scopus 로고
    • The right ventricle under pressure: Cellular and molecular mechanisms of right-heart failure in pulmonary hypertension
    • Bogaard HJ, Abe K, Vonk Noordegraaf A, Voelkel NF. The right ventricle under pressure: cellular and molecular mechanisms of right-heart failure in pulmonary hypertension. Chest 2009;135(3):794-804.
    • (2009) Chest , vol.135 , Issue.3 , pp. 794-804
    • Bogaard, H.J.1    Abe, K.2    Vonk Noordegraaf, A.3    Voelkel, N.F.4
  • 20
    • 84873660610 scopus 로고    scopus 로고
    • Autophagy in human health and disease
    • Choi AMK, Ryter SW, Levine B. Autophagy in human health and disease. N Engl J Med 2013;368(7):651-662.
    • (2013) N Engl J Med , vol.368 , Issue.7 , pp. 651-662
    • Choi, A.1    Ryter, S.W.2    Levine, B.3
  • 21
    • 77951915586 scopus 로고    scopus 로고
    • Autophagy during cardiac stress: Joys and frustrations of autophagy
    • Gottlieb RA, Mentzer RM. Autophagy during cardiac stress: joys and frustrations of autophagy. Annu Rev Physiol 2010; 72(1):45-59.
    • (2010) Annu Rev Physiol , vol.72 , Issue.1 , pp. 45-59
    • Gottlieb, R.A.1    Mentzer, R.M.2
  • 22
    • 34548188741 scopus 로고    scopus 로고
    • Self-eating and self-killing: Crosstalk between autophagy and apoptosis
    • Maiuri MC, Zalckvar E, Kimchi A, Kroemer G. Self-eating and self-killing: crosstalk between autophagy and apoptosis. Nat Rev Mol Cell Biol 2007;8(9):741-752.
    • (2007) Nat Rev Mol Cell Biol , vol.8 , Issue.9 , pp. 741-752
    • Maiuri, M.C.1    Zalckvar, E.2    Kimchi, A.3    Kroemer, G.4
  • 23
    • 84873034262 scopus 로고    scopus 로고
    • Proteotoxicity and cardiac dysfunction—Alzheimer’s disease of the heart?
    • Willis MS, Patterson C. Proteotoxicity and cardiac dysfunction—Alzheimer’s disease of the heart? N Engl J Med 2013; 368(5):455-464.
    • (2013) N Engl J Med , vol.368 , Issue.5 , pp. 455-464
    • Willis, M.S.1    Patterson, C.2
  • 24
    • 77955861146 scopus 로고    scopus 로고
    • Autophagy in health and disease. 5. Mitophagy as a way of life
    • Gottlieb RA, Carreira RS. Autophagy in health and disease. 5. Mitophagy as a way of life. Am J Physiol Cell Physiol 2010;299(2):C203-C210.
    • (2010) Am J Physiol Cell Physiol , vol.299 , Issue.2
    • Gottlieb, R.A.1    Carreira, R.S.2
  • 25
    • 35448981935 scopus 로고    scopus 로고
    • Autophagy: From phenomenology to molecular understanding in less than a decade
    • Klionsky DJ. Autophagy: from phenomenology to molecular understanding in less than a decade. Nat Rev Mol Cell Biol 2007;8(11):931-937.
    • (2007) Nat Rev Mol Cell Biol , vol.8 , Issue.11 , pp. 931-937
    • Klionsky, D.J.1
  • 26
    • 72549095406 scopus 로고    scopus 로고
    • Regulation mechanisms and signaling pathways of autophagy
    • He C, Klionsky DJ. Regulation mechanisms and signaling pathways of autophagy. Annu Rev Genet 2009;43:67-93.
    • (2009) Annu Rev Genet , vol.43 , pp. 67-93
    • He, C.1    Klionsky, D.J.2
  • 27
    • 84869499324 scopus 로고    scopus 로고
    • Targets, trafficking, and timing of cardiac autophagy
    • Rotter D, Rothermel BA. Targets, trafficking, and timing of cardiac autophagy. Pharmacol Res 2012;66(6):494-504.
    • (2012) Pharmacol Res , vol.66 , Issue.6 , pp. 494-504
    • Rotter, D.1    Rothermel, B.A.2
  • 28
    • 84863192578 scopus 로고    scopus 로고
    • Impaired autophagosome clearance contributes to cardiomyocyte death in ischemia/reperfusion injury
    • Ma X, Liu H, Foyil SR, Godar RJ, Weinheimer CJ, Hill JA, Diwan A. Impaired autophagosome clearance contributes to cardiomyocyte death in ischemia/reperfusion injury. Circulation 2012;125(25):3170-3181.
    • (2012) Circulation , vol.125 , Issue.25 , pp. 3170-3181
    • Ma, X.1    Liu, H.2    Foyil, S.R.3    Godar, R.J.4    Weinheimer, C.J.5    Hill, J.A.6    Diwan, A.7
  • 30
    • 84871211326 scopus 로고    scopus 로고
    • Pathobiology of pulmonary arterial hypertension and right ventricular failure
    • Voelkel NF, Gomez-Arroyo J, Abbate A, Bogaard HJ, Nicolls MR. Pathobiology of pulmonary arterial hypertension and right ventricular failure. Eur Respir J 2012;40(6): 1555-1565.
    • (2012) Eur Respir J , vol.40 , Issue.6 , pp. 1555-1565
    • Voelkel, N.F.1    Gomez-Arroyo, J.2    Abbate, A.3    Bogaard, H.J.4    Nicolls, M.R.5
  • 32
    • 0036149441 scopus 로고    scopus 로고
    • Severe pulmonary hypertension without right ventricular failure: The unique hearts of patients with Eisenmenger syndrome
    • Hopkins WE, Waggoner AD. Severe pulmonary hypertension without right ventricular failure: the unique hearts of patients with Eisenmenger syndrome. Am J Cardiol 2002; 89(1):34-38.
    • (2002) Am J Cardiol , vol.89 , Issue.1 , pp. 34-38
    • Hopkins, W.E.1    Waggoner, A.D.2
  • 35
    • 34948834742 scopus 로고    scopus 로고
    • Endothelial progenitor cell derived microvesicles activate an angiogenic program in endothelial cells by a horizontal transfer of mRNA
    • Deregibus MC, Cantaluppi V, Calogero R, Iacono Lo M, Tetta C, Biancone L, Bruno S, Bussolati B, Camussi G. Endothelial progenitor cell derived microvesicles activate an angiogenic program in endothelial cells by a horizontal transfer of mRNA. Blood 2007;110(7):2440-2448.
    • (2007) Blood , vol.110 , Issue.7 , pp. 2440-2448
    • Deregibus, M.C.1    Cantaluppi, V.2    Calogero, R.3    Iacono Lo, M.4    Tetta, C.5    Biancone, L.6    Bruno, S.7    Bussolati, B.8    Camussi, G.9
  • 36
    • 84881233752 scopus 로고    scopus 로고
    • Cardiac aging and rejuvenation—a sense of humors?
    • Rando TA, Finkel T. Cardiac aging and rejuvenation—a sense of humors? N Engl J Med 2013;369(6):575-576.
    • (2013) N Engl J Med , vol.369 , Issue.6 , pp. 575-576
    • Rando, T.A.1    Finkel, T.2
  • 37
    • 34547611337 scopus 로고    scopus 로고
    • Phosphodiesterase type 5 is highly expressed in the hypertrophied human right ventricle, and acute inhibition of phosphodiesterase type 5 improves contractility
    • Nagendran J, Archer SL, Soliman D, Gurtu V, Moudgil R, Haromy A, St Aubin C, et al. Phosphodiesterase type 5 is highly expressed in the hypertrophied human right ventricle, and acute inhibition of phosphodiesterase type 5 improves contractility. Circulation 2007;116(3):238-248.
    • (2007) Circulation , vol.116 , Issue.3 , pp. 238-248
    • Nagendran, J.1    Archer, S.L.2    Soliman, D.3    Gurtu, V.4    Moudgil, R.5    Haromy, A.6    St Aubin, C.7
  • 40
    • 84881240287 scopus 로고    scopus 로고
    • FK506 activates BMPR2, rescues endothelial dysfunction, and reverses pulmonary hypertension
    • Spiekerkoetter E, Tian X, Cai J, Hopper RK, Sudheendra D, Li CG, El-Bizri N, et al. FK506 activates BMPR2, rescues endothelial dysfunction, and reverses pulmonary hypertension. J Clin Invest 2013;123(8):3600-3613.
    • (2013) J Clin Invest , vol.123 , Issue.8 , pp. 3600-3613
    • Spiekerkoetter, E.1    Tian, X.2    Cai, J.3    Hopper, R.K.4    Sudheendra, D.5    Li, C.G.6    El-Bizri, N.7
  • 41
    • 85026341717 scopus 로고    scopus 로고
    • Inhaled iloprost improves right ventricular function in the Sugen5416/hypoxia model of severe pulmonary hypertension
    • September 26 (Epub ahead of print)
    • Syed A, Gomez-Arroyo J, Sakagami M, Farkas L, Farkas D, Al-Hussaini AA, Kraskauskas D. P. B, Voelkel NF. Inhaled iloprost improves right ventricular function in the Sugen5416/hypoxia model of severe pulmonary hypertension. Eur Respir J 2014, September 26 (Epub ahead of print).
    • (2014) Eur Respir J
    • Syed, A.1    Gomez-Arroyo, J.2    Sakagami, M.3    Farkas, L.4    Farkas, D.5    Al-Hussaini, A.A.6    Kraskauskas, D.7    Voelkel, N.F.8
  • 44
    • 84869758819 scopus 로고    scopus 로고
    • Cardiokines: Recent progress in elucidating the cardiac secretome
    • Shimano M, Ouchi N, Walsh K. Cardiokines: recent progress in elucidating the cardiac secretome. Circulation 2012; 126(21):e327-e332.
    • (2012) Circulation , vol.126 , Issue.21
    • Shimano, M.1    Ouchi, N.2    Walsh, K.3
  • 45
    • 70349776690 scopus 로고    scopus 로고
    • Comprehensive invasive and noninvasive approach to the right ventricle-pulmonary circulation unit: State of the art and clinical and research implications
    • Champion HC, Michelakis ED, Hassoun PM. Comprehensive invasive and noninvasive approach to the right ventricle-pulmonary circulation unit: state of the art and clinical and research implications. Circulation 2009;120 (11):992-1007.
    • (2009) Circulation , vol.120 , Issue.11 , pp. 992-1007
    • Champion, H.C.1    Michelakis, E.D.2    Hassoun, P.M.3
  • 46
    • 84878779757 scopus 로고    scopus 로고
    • Describing right ventricular function
    • Vonk Noordegraaf A, Westerhof N. Describing right ventricular function. Eur Respir J 2013;41(6):1419-1423.
    • (2013) Eur Respir J , vol.41 , Issue.6 , pp. 1419-1423
    • Vonk Noordegraaf, A.1    Westerhof, N.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.