CAT-tailing as a fail-safe mechanism for efficient degradation of stalled nascent polypeptides

Science

Volumn 357, Issue 6349, 2017, Pages

  Kostova, Kamena K ^a,b   Hickey, Kelsey L ^a   Osuna, Beatriz A ^a   Hussmann, Jeffrey A ^a   Frost, Adam ^a,c,d,e   Weinberg, David E ^a   Weissman, Jonathan S ^a,b,c,f  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^e CHAN ZUCKERBERG BIOHUB   (United States)

^f UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE; GREEN FLUORESCENT PROTEIN; LYSINE; POLYPEPTIDE; THREONINE; LTN1 PROTEIN, S CEREVISIAE; PEPTIDE; SACCHAROMYCES CEREVISIAE PROTEIN; UBIQUITIN; UBIQUITIN PROTEIN LIGASE;

AMINO ACID; CELL ORGANELLE; DEGRADATION; ENZYME; ENZYME ACTIVITY; PEPTIDE; YEAST;

ARTICLE; CARBOXY TERMINAL SEQUENCE; CRYOELECTRON MICROSCOPY; ENZYME DEGRADATION; MOLECULAR WEIGHT; NONHUMAN; PRIORITY JOURNAL; PROTEIN AGGREGATION; RIBOSOME; RING FINGER MOTIF; SACCHAROMYCES CEREVISIAE; STEREOSPECIFICITY; STOP CODON; UBIQUITINATION; CHEMISTRY; ENZYMOLOGY; METABOLISM; PROTEIN DEGRADATION; PROTEIN HOMEOSTASIS; TRANSCRIPTION ELONGATION;

SACCHAROMYCETALES;

ALANINE; LYSINE; PEPTIDES; PROTEOLYSIS; PROTEOSTASIS; RIBOSOMES; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; THREONINE; TRANSCRIPTION ELONGATION, GENETIC; UBIQUITIN; UBIQUITIN-PROTEIN LIGASES;

EID: 85026324537     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.aam7787     Document Type: Article

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