Modified carbapenem inactivation method for phenotypic detection of carbapenemase production among enterobacteriaceae

Journal of Clinical Microbiology

Volumn 55, Issue 8, 2017, Pages 2321-2333

  Pierce, Virginia M ^a,j   Simner, Patricia J ^b   Lonsway, David R ^c   Roe Carpenter, Darcie E ^d   Johnson, J Kristie ^e   Brasso, William B ^f   Bobenchik, April M ^g   Lockett, Zabrina C ^d   Charnot Katsikas, Angella ^h   Ferraro, Mary Jane ^a   Thomson, Richard B ⁱ   Jenkins, Stephen G ^j   Limbago, Brandi M ^c   Das, Sanchita ⁱ  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b DEPARTMENT OF PATHOLOGY   (United States)

^c NATIONAL CENTER FOR EMERGING AND ZOONOTIC INFECTIOUS DISEASES   (United States)

^d BECKMAN COULTER INC   (United States)

^e UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^f BD Diagnostic Systems   (United States)

^g Lifespan   (United States)

^h UNIVERSITY OF CHICAGO MEDICAL CENTER   (United States)

ⁱ NORTHSHORE UNIVERSITY HEALTHSYSTEM   (United States)

^j WEILL CORNELL MEDICAL COLLEGE   (United States)

more..

Author keywords

Antimicrobial susceptibility testing; Bacterial antibiotic resistance; Bacteriological techniques; Carbapenemase; Carbapenems; Enterobacteriaceae

Indexed keywords

CARBAPENEM; CARBAPENEMASE; BACTERIAL PROTEIN; BETA LACTAMASE; CARBAPENEM DERIVATIVE;

ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIUM ISOLATE; CONTROLLED STUDY; ENTEROBACTERIACEAE; ENZYME ASSAY; ENZYME SYNTHESIS; INCUBATION TIME; MEASUREMENT ACCURACY; MODIFIED CARBAPENEM INACTIVATION METHOD; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; RECEIVER OPERATING CHARACTERISTIC; REPRODUCIBILITY; SENSITIVITY AND SPECIFICITY; VALIDATION STUDY; CLINICAL TRIAL; ENZYMOLOGY; HUMAN; HYDROLYSIS; METABOLISM; MICROBIAL SENSITIVITY TEST; MULTICENTER STUDY; PROCEDURES;

BACTERIAL PROTEINS; BETA-LACTAMASES; CARBAPENEMS; ENTEROBACTERIACEAE; HUMANS; HYDROLYSIS; MICROBIAL SENSITIVITY TESTS; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY;

EID: 85026211707     PISSN: 00951137     EISSN: 1098660X     Source Type: Journal    
DOI: 10.1128/JCM.00193-17     Document Type: Article

References (38)

1. Nordmann P, Naas T, Poirel L. 2011. Global spread of carbapenemaseproducing Enterobacteriaceae. Emerg Infect Dis 17:1791-1798. https:// doi.org/10.3201/eid1710.110655.
2. Centers for Disease Control and Prevention. 2013. Vital signs: carbapenemresistant Enterobacteriaceae. MMWR Morb Mortal Wkly Rep 62:165-170.
3. Centers for Disease Control and Prevention. 2013. Antibiotic resistance threats in the United States, 2013. Centers for Disease Control and Prevention, Atlanta, GA. http://www.cdc.gov/drugresistance/threat-report-2013/.
4. World Health Organization. 2014. Antimicrobial resistance: global report on surveillance 2014. World Health Organization, Geneva, Switzerland. http://www.who.int/drugresistance/documents/surveillancereport/en/.
5. Vasoo S, Barreto JN, Tosh PK. 2015. Emerging issues in gram-negative bacterial resistance: an update for the practicing clinician. Mayo Clin Proc 90:395-403. https://doi.org/10.1016/j.mayocp.2014.12.002.
6. Peleg AY, Hooper DC. 2010. Hospital-acquired infections due to gramnegative bacteria. N Engl J Med 362:1804-1813. https://doi.org/10.1056/ NEJMra0904124.
7. Lutgring JD, Limbago BM. 2016. The problem of carbapenemaseproducing-carbapenem-resistant-Enterobacteriaceae detection. J Clin Microbiol 54:529-534. https://doi.org/10.1128/JCM.02771-15.
8. Clinical and Laboratory Standards Institute. 2016. Performance standards for antimicrobial susceptibility testing, 26th ed. CLSI supplement M100S. Clinical and Laboratory Standards Institute, Wayne, PA.
9. European Committee on Antimicrobial Susceptibility Testing. 2016. Breakpoint tables for interpretation of MICs and zone diameters, version 6.0. http://www.eucast.org/clinical-breakpoints/.
10. Centers for Disease Control and Prevention. 2015. Facility guidance for control of carbapenem-resistant Enterobactericeae (CRE): November 2015 update-CRE toolkit. Centers for Disease Control and Prevention, Atlanta, GA. http://www.cdc.gov/hai/organisms/cre/cre-toolkit/.
11. Boucher HW, Talbot GH, Benjamin DK, Jr, Bradley J, Guidos RJ, Jones RN, Murray BE, Bonomo RA, Gilbert D, Infectious Diseases Society of America. 2013. 10=20 Progress-development of new drugs active against gram-negative bacilli: an update from the Infectious Diseases Society of America. Clin Infect Dis 56:1685-1694. https://doi.org/10.1093/cid/cit152.
12. Tamma PD, Goodman KE, Harris AD, Tekle T, Roberts A, Taiwo A, Simner PJ. 2017. Comparing the outcomes of patients with carbapenemaseproducing and non-carbapenemase-producing carbapenem-resistant Enterobacteriaceae bacteremia. Clin Infect Dis 64:257-264. https://doi .org/10.1093/cid/ciw741.
13. Chea N, Bulens SN, Kongphet-Tran T, Lynfield R, Shaw KM, Vagnone PS, Kainer MA, Muleta DB, Wilson L, Vaeth E, Dumyati G, Concannon C, Phipps EC, Culbreath K, Janelle SJ, Bamberg WM, Guh AY, Limbago B, Kallen AJ. 2015. Improved phenotype-based definition for identifying carbapenemase producers among carbapenem-resistant Enterobacteriaceae. Emerg Infect Dis 21:1611-1616. https://doi.org/10.3201/eid2109.150198.
14. Tamma PD, Huang Y, Opene BN, Simner PJ. 2016. Determining the optimal carbapenem MIC that distinguishes carbapenemase-producing and non-carbapenemase-producing carbapenem-resistant Enterobacteriaceae. Antimicrob Agents Chemother 60:6425-6429. https://doi.org/ 10.1128/AAC.00838-16.
15. Centers for Disease Control and Prevention. 2015. FAQs about choosing and implementing a CRE definition. Centers for Disease Control and Prevention, Atlanta, GA. http://www.cdc.gov/hai/organisms/cre/definition.html.
16. Girlich D, Poirel L, Nordmann P. 2012. Value of the modified Hodge test for detection of emerging carbapenemases in Enterobacteriaceae. J Clin Microbiol 50:477-479. https://doi.org/10.1128/JCM.05247-11.
17. Anderson KF, Lonsway DR, Rasheed JK, Biddle J, Jensen B, McDougal LK, Carey RB, Thompson A, Stocker S, Limbago B, Patel JB. 2007. Evaluation of methods to identify the Klebsiella pneumoniae carbapenemase in Enterobacteriaceae. J Clin Microbiol 45:2723-2725. https://doi.org/10 .1128/JCM.00015-07.
18. Carvalhaes CG, Picao RC, Nicoletti AG, Xavier DE, Gales AC. 2010. Cloverleaf test (modified Hodge test) for detecting carbapenemase production in Klebsiella pneumoniae: be aware of false positive results. J Antimicrob Chemother 65:249-251. https://doi.org/10.1093/jac/dkp431.
19. Mochon AB, Garner OB, Hindler JA, Krogstad P, Ward KW, Lewinski MA, Rasheed JK, Anderson KF, Limbago BM, Humphries RM. 2011. New Delhi metallo-beta-lactamase (NDM-1)-producing Klebsiella pneumoniae: case report and laboratory detection strategies. J Clin Microbiol 49: 1667-1670. https://doi.org/10.1128/JCM.00183-11.
20. Papagiannitsis CC, Studentova V, Izdebski R, Oikonomou O, Pfeifer Y, Petinaki E, Hrabak J. 2015. Matrix-assisted laser desorption ionizationtime of flight mass spectrometry meropenem hydrolysis assay with NH4HCO3, a reliable tool for direct detection of carbapenemase activity. J Clin Microbiol 53:1731-1735. https://doi.org/10.1128/JCM .03094-14.
21. Tamma PD, Opene BNA, Gluck A, Chambers KK, Carroll KC, Simner PJ. 11 January 2017. A comparison of eleven phenotypic assays for the accurate detection of carbapenemase-producing Enterobacteriaceae. J Clin Microbiol. https://doi.org/10.1128/JCM.02338-16.
22. Poirel L, Potron A, Nordmann P. 2012. OXA-48-like carbapenemases: the phantom menace. J Antimicrob Chemother 67:1597-1606. https://doi .org/10.1093/jac/dks121.
23. Doyle D, Peirano G, Lascols C, Lloyd T, Church DL, Pitout JD. 2012. Laboratory detection of Enterobacteriaceae that produce carbapenemases. J Clin Microbiol 50:3877-3880. https://doi.org/10.1128/JCM .02117-12.
24. van der Zwaluw K, de Haan A, Pluister GN, Bootsma HJ, de Neeling AJ, Schouls LM. 2015. The carbapenem inactivation method (CIM), a simple and low-cost alternative for the Carba NP test to assess phenotypic carbapenemase activity in gram-negative rods. PLoS One 10:e0123690. https://doi.org/10.1371/journal.pone.0123690.
25. Tijet N, Patel SN, Melano RG. 2016. Detection of carbapenemase activity in Enterobacteriaceae: comparison of the carbapenem inactivation method versus the Carba NP test. J Antimicrob Chemother 71:274-276. https://doi.org/10.1093/jac/dkv283.
26. Yamada K, Kashiwa M, Arai K, Nagano N, Saito R. 2016. Comparison of the Modified-Hodge test, Carba NP test, and carbapenem inactivation method as screening methods for carbapenemase-producing Enterobacteriaceae. J Microbiol Methods 128:48-51. https://doi.org/10.1016/j .mimet.2016.06.019.
27. Aktas E, Malkocoglu G, Otlu B, Copur Cicek A, Kulah C, Comert F, Sandalli C, Gursoy NC, Erdemir D, Bulut ME. 30 August 2016. Evaluation of the carbapenem inactivation method for detection of carbapenemaseproducing Gram-negative bacteria in comparison with the RAPIDEC CARBA NP. Microb Drug Resist https://doi.org/10.1089/mdr.2016.0092.
28. Clinical and Laboratory Standards Institute. 2017. Performance standards for antimicrobial susceptibility testing, 27th ed. CLSI supplement M100. Clinical and Laboratory Standards Institute, Wayne, PA.
29. Centers for Disease Control and Prevention. 2015. Tracking CRE. Centers for Disease Control and Prevention, Atlanta, GA. https://www.cdc.gov/ hai/organisms/cre/TrackingCRE.html#CREmapKPC.
30. Pollett S, Miller S, Hindler J, Uslan D, Carvalho M, Humphries RM. 2014. Phenotypic and molecular characteristics of carbapenem-resistant Enterobacteriaceae in a health care system in Los Angeles, California, from 2011 to 2013. J Clin Microbiol 52:4003-4009. https://doi.org/10.1128/ JCM.01397-14.
31. Hemarajata P, Yang S, Hindler JA, Humphries RM. 2015. Development of a novel real-time PCR assay with high-resolution melt analysis to detect and differentiate OXA-48-like beta-lactamases in carbapenem-resistant Enterobacteriaceae. Antimicrob Agents Chemother 59:5574-5580. https://doi.org/10.1128/AAC.00425-15.
32. Yang S, Hemarajata P, Hindler J, Ward K, Adisetiyo H, Li F, Aldrovandi GM, Green NM, Russell D, Rubin Z, Humphries RM. 2016. Investigation of a suspected nosocomial transmission of blaKPC3-mediated carbapenemresistant Klebsiella pneumoniae by whole genome sequencing. Diagn Microbiol Infect Dis 84:337-342. https://doi.org/10.1016/j.diagmicrobio .2015.12.019.
33. Humphries RM, Yang S, Hemarajata P, Ward KW, Hindler JA, Miller SA, Gregson A. 2015. First report of ceftazidime-avibactam resistance in a KPC-3-expressing Klebsiella pneumoniae isolate. Antimicrob Agents Chemother 59:6605-6607. https://doi.org/10.1128/AAC.01165-15.
34. Yang S, Hemarajata P, Hindler J, Li F, Adisetiyo H, Aldrovandi GM, Sebra R, Kasarskis A, MacConnell D, Didelot X, Russell D, Rubin Z, Humphries RM. 1 April 2017. Evolution and transmission of carbapenem-resistant Klebsiella pneumoniae expressing the blaoxa-232 gene during an institutional outbreak associated with endoscopic retrograde cholangiopancreatography. Clin Infect Dis https://doi.org/10.1093/cid/ciw876.
35. de Man TJ, Limbago BM. 2016. SSTAR, a stand-alone easy-to-use antimicrobial resistance gene predictor. mSphere 1:e00050-15. https://doi .org/10.1128/mSphere.00050-15.
36. Zankari E, Hasman H, Cosentino S, Vestergaard M, Rasmussen S, Lund O, Aarestrup FM, Larsen MV. 2012. Identification of acquired antimicrobial resistance genes. J Antimicrob Chemother 67:2640-2644. https://doi .org/10.1093/jac/dks261.
37. Clinical and Laboratory Standards Institute. 2015. Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically; approved standard-tenth edition. CLSI document M07-A10. Clinical and Laboratory Standards Institute, Wayne, PA.
38. Clinical and Laboratory Standards Institute. 2015. Performance standards for antimicrobial disk susceptibility tests; approved standard-twelfth edition. CLSI document M02-A12. Clinical and Laboratory Standards Institute, Wayne, PA.