The Role of Inflammation in β-cell Dedifferentiation

Scientific Reports

Volumn 7, Issue 1, 2017, Pages

  Nordmann, Thierry M ^a   Dror, Erez ^a   Schulze, Friederike ^a   Traub, Shuyang ^a   Berishvili, Ekaterine ^b   Barbieux, Charlotte ^b   Böni Schnetzler, Marianne ^a   Donath, Marc Y ^a  

^a UNIVERSITY HOSPITAL BASEL   (Switzerland)

^b GENEVA UNIVERSITY HOSPITALS   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFLAMMATORY AGENT; CYTOKINE; INSULIN;

ANIMAL; C57BL MOUSE; CELL CULTURE; CELL DEDIFFERENTIATION; COMPLICATION; DRUG EFFECT; EXPERIMENTAL DIABETES MELLITUS; HUMAN; INFLAMMATION; MALE; METABOLISM; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; PANCREAS ISLET BETA CELL; PATHOLOGY; PATHOPHYSIOLOGY;

ANIMALS; ANTI-INFLAMMATORY AGENTS; CELL DEDIFFERENTIATION; CELLS, CULTURED; CYTOKINES; DIABETES MELLITUS, EXPERIMENTAL; DIABETES MELLITUS, TYPE 2; HUMANS; INFLAMMATION; INSULIN; INSULIN-SECRETING CELLS; MALE; MICE; MICE, INBRED C57BL;

EID: 85025833616     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/s41598-017-06731-w     Document Type: Article

References (29)

1. Tabak, A. G. et al. Trajectories of glycaemia, insulin sensitivity, and insulin secretion before diagnosis of type 2 diabetes: an analysis from the Whitehall II study. Lancet 373, 2215-2221, doi:10.1016/S0140-6736(09)60619-X (2009).
2. Boni-Schnetzler, M. et al. Free fatty acids induce a proinflammatory response in islets via the abundantly expressed interleukin-1 receptor I. Endocrinology 150, 5218-5229, doi:10.1210/en.2009-0543 (2009).
3. Back, S. H. & Kaufman, R. J. Endoplasmic reticulum stress and type 2 diabetes. Annu Rev Biochem 81, 767-793, doi:10.1146/annurev-biochem-072909-095555 (2012).
4. Masters, S. L. et al. Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1beta in type 2 diabetes. Nat Immunol 11, 897-904, doi:10.1038/ni.1935 (2010).
5. Westwell-Roper, C. Y., Ehses, J. A. & Verchere, C. B. Resident macrophages mediate islet amyloid polypeptide-induced islet IL-1beta production and beta-cell dysfunction. Diabetes 63, 1698-1711, doi:10.2337/db13-0863 (2014).
6. Sauter, N. S. et al. Angiotensin II induces interleukin-1beta-mediated islet inflammation and beta-cell dysfunction independently of vasoconstrictive effects. Diabetes 64, 1273-1283, doi:10.2337/db14-1282 (2015).
7. Larsen, C. M. et al. Interleukin-1-receptor antagonist in type 2 diabetes mellitus. N Engl J Med 356, 1517-1526, doi:10.1056/NEJMoa065213 (2007).
8. Fleischman, A., Shoelson, S. E., Bernier, R. & Goldfine, A. B. Salsalate improves glycemia and inflammatory parameters in obese young adults. Diabetes Care 31, 289-294, doi:10.2337/dc07-1338 (2008).
9. Hotamisligil, G. S., Shargill, N. S. & Spiegelman, B. M. Adipose expression of tumor necrosis factor-alpha: direct role in obesitylinked insulin resistance. Science 259, 87-91 (1993).
10. Uysal, K. T., Wiesbrock, S. M., Marino, M. W. & Hotamisligil, G. S. Protection from obesity-induced insulin resistance in mice lacking TNF-alpha function. Nature 389, 610-614, doi:10.1038/39335 (1997).
11. Talchai, C., Xuan, S., Lin, H. V., Sussel, L. & Accili, D. Pancreatic beta cell dedifferentiation as a mechanism of diabetic beta cell failure. Cell 150, 1223-1234, doi:10.1016/j.cell.2012.07.029 (2012).
12. Guo, S. et al. Inactivation of specific beta cell transcription factors in type 2 diabetes. J Clin Invest 123, 3305-3316, doi:10.1172/JCI65390 (2013).
13. Zhang, T. et al. FoxO1 Plays an Important Role in Regulating beta-Cell Compensation for Insulin Resistance in Male Mice. Endocrinology 157, 1055-1070, doi:10.1210/en.2015-1852 (2016).
14. Wang, Z., York, N. W., Nichols, C. G. & Remedi, M. S. Pancreatic beta cell dedifferentiation in diabetes and redifferentiation following insulin therapy. Cell Metab 19, 872-882, doi:10.1016/j.cmet.2014.03.010 (2014).
15. Cardozo, A. K. et al. A comprehensive analysis of cytokine-induced and nuclear factor-kappa B-dependent genes in primary rat pancreatic beta-cells. J Biol Chem 276, 48879-48886, doi:10.1074/jbc.M108658200 (2001).
16. Ortis, F. et al. Cytokines interleukin-1beta and tumor necrosis factor-alpha regulate different transcriptional and alternative splicing networks in primary beta-cells. Diabetes 59, 358-374, doi:10.2337/db09-1159 (2010).
17. Ehses, J. A. et al. Increased number of islet-associated macrophages in type 2 diabetes. Diabetes 56, 2356-2370, doi:10.2337/db06-1650 (2007).
18. Richardson, S. J., Willcox, A., Bone, A. J., Foulis, A. K. & Morgan, N. G. Islet-associated macrophages in type 2 diabetes. Diabetologia 52, 1686-1688, doi:10.1007/s00125-009-1410-z (2009).
19. Bassilian, S. et al. Loss of regulation of lipogenesis in the Zucker diabetic rat. II. Changes in stearate and oleate synthesis. Am J Physiol Endocrinol Metab 282, E507-513, doi:10.1152/ajpendo.00211.2001 (2002).
20. Luo, J. et al. Nongenetic mouse models of non-insulin-dependent diabetes mellitus. Metabolism 47, 663-668 (1998).
21. Mu, J. et al. Chronic inhibition of dipeptidyl peptidase-4 with a sitagliptin analog preserves pancreatic beta-cell mass and function in a rodent model of type 2 diabetes. Diabetes 55, 1695-1704, doi:10.2337/db05-1602 (2006).
22. Butcher, M. J. et al. Association of proinflammatory cytokines and islet resident leucocytes with islet dysfunction in type 2 diabetes. Diabetologia 57, 491-501, doi:10.1007/s00125-013-3116-5 (2014).
23. Nieto-Vazquez, I., Fernandez-Veledo, S., de Alvaro, C. & Lorenzo, M. Dual role of interleukin-6 in regulating insulin sensitivity in murine skeletal muscle. Diabetes 57, 3211-3221, doi:10.2337/db07-1062 (2008).
24. Maedler, K. et al. Low concentration of interleukin-1beta induces FLICE-inhibitory protein-mediated beta-cell proliferation in human pancreatic islets. Diabetes 55, 2713-2722, doi:10.2337/db05-1430 (2006).
25. Rutti, S. et al. Low- and high-density lipoproteins modulate function, apoptosis, and proliferation of primary human and murine pancreatic beta-cells. Endocrinology 150, 4521-4530, doi:10.1210/en.2009-0252 (2009).
26. Tak, P. P. & Firestein, G. S. NF-kappaB: a key role in inflammatory diseases. J Clin Invest 107, 7-11, doi:10.1172/JCI11830 (2001).
27. Yuan, M. et al. Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of Ikkbeta. Science 293, 1673-1677, doi:10.1126/science.1061620 (2001).
28. Geiger, T. et al. Neutralization of interleukin-1 beta activity in vivo with a monoclonal antibody alleviates collagen-induced arthritis in DBA/1 mice and prevents the associated acute-phase response. Clin Exp Rheumatol 11, 515-522 (1993).
29. Herrero, L., Shapiro, H., Nayer, A., Lee, J. & Shoelson, S. E. Inflammation and adipose tissue macrophages in lipodystrophic mice. Proc Natl Acad Sci USA 107, 240-245, doi:10.1073/pnas.0905310107 (2010).