Carrier-Mediated and Energy-Dependent Uptake and Efflux of Deoxynivalenol in Mammalian Cells

Scientific Reports

Volumn 7, Issue 1, 2017, Pages

  Li, Xiaoming ^a   Mu, Peiqiang ^a   Wen, Jikai ^a   Deng, Yiqun ^a  

^a SOUTH CHINA AGRICULTURAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

TRICHOTHECENE DERIVATIVE; VOMITOXIN;

ANIMAL; BIOLOGICAL MODEL; CACO-2 CELL LINE; CELL DEATH; DOG; DRUG EFFECT; ENERGY METABOLISM; HEP-G2 CELL LINE; HUMAN; MDCK CELL LINE; METABOLISM; TRANSPORT AT THE CELLULAR LEVEL;

ANIMALS; BIOLOGICAL TRANSPORT; CACO-2 CELLS; CELL DEATH; DOGS; ENERGY METABOLISM; HEP G2 CELLS; HUMANS; MADIN DARBY CANINE KIDNEY CELLS; MODELS, BIOLOGICAL; TRICHOTHECENES;

EID: 85025138919     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/s41598-017-06199-8     Document Type: Article

References (38)

1. Placinta, C., D'mello, J. & Macdonald, A. A review of worldwide contamination of cereal grains and animal feed with Fusarium mycotoxins. Anim Feed Ssi Tech 78, 21-37 (1999).
2. Organization, World Health. Selected mycotoxins: ochratoxins, trichothecenes, ergot. Environmental Health Criteria 105 (Geneva, 1990).
3. Scott, P. The natural occurrence of trichothecenes. Trichothecene mycotoxins: pathophysiologic effects (ed. Beasley, V. R.) 1-26 (Baco Raton, 1989).
4. International Agency for Research on Cancer. IARC Monographs of the evaluation of carcinogenic risks of Chemicals to human. Some Naturally-occuring Substances: Some Food items and Constituents, Heterocyclic Aromatic Amines and Mycotoxins. International Agency for Research on Cancer 56, 245-395 (Lyon, 1993).
5. Canady, R. et al. Deoxynivalenol. Safety evaluation of certain mycotoxins in food. Joint Expert Committee on Food Additives (JECFA). WHO Food Additives Series 47, 419-555 (Geneva, 2001).
6. Rotter, B. A. Invited review: Toxicology of deoxynivalenol (vomitoxin). J Toxicol Env Heal A 48, 1-34 (1996).
7. Pestka, J. J. & Smolinski, A. T. Deoxynivalenol: toxicology and potential effects on humans. J Toxicol Env Heal B 8, 39-69 (2005).
8. Pestka, J. J. Deoxynivalenol: mechanisms of action, human exposure, and toxicological relevance. Arch Toxicol 84, 663-679 (2010).
9. Maresca, M. From the gut to the brain: Journey and pathophysiological effects of the food-associated trichothecene mycotoxin deoxynivalenol. Toxins 5, 784-820 (2013).
10. Bensassi, F. et al. Involvement of mitochondria-mediated apoptosis in deoxynivalenol cytotoxicity. Food Chem Toxicol 50, 1680-1689 (2012).
11. Miller, J. D. & Ewen, M. A. Toxic effects of deoxynivalenol on ribosomes and tissues of the spring wheat cultivars Frontana and Casavant. Nat Toxins 5, 234-237 (1997).
12. Akbari, P. et al. Deoxynivalenol: a trigger for intestinal integrity breakdown. FASEB J 28, 2414-2429 (2014).
13. Awad, W. A. & Zentek, J. The feed contaminant deoxynivalenol affects the intestinal barrier permeability through inhibition of protein synthesis. Arch Toxicol 89, 961-965 (2015).
14. Behrens, M., Huwel, S., Galla, H. J. & Humpf, H. U. Blood-Brain Barrier Effects of the Fusarium Mycotoxins Deoxynivalenol, 3 Acetyldeoxynivalenol, and Moniliformin and Their Transfer to the Brain. PLoS One 10, e0143640 (2015).
15. Kadota, T. et al. Comparative study of deoxynivalenol, 3-acetyldeoxynivalenol, and 15-acetyldeoxynivalenol on intestinal transport and IL-8 secretion in the human cell line Caco-2. Toxicol in Vitro 27, 1888-1895 (2013).
16. Sergent, T. et al. Deoxynivalenol transport across human intestinal Caco-2 cells and its effects on cellular metabolism at realistic intestinal concentrations. Toxicol Lett 164, 167-176 (2006).
17. Videmann, B., Tep, J., Cavret, S. & Lecoeur, S. Epithelial transport of deoxynivalenol: involvement of human P-glycoprotein (ABCB1) and multidrug resistance-associated protein 2 (ABCC2). Food Chem Toxicol 45, 1938-1947 (2007).
18. Wang, X. et al. High risk of embryo-fetal toxicity: Placental transfer of T-2 toxin and its major metabolite HT-2 toxin in BeWo cells. Toxicol Sci 137, 168-178 (2014).
19. Dean, M., Hamon, Y. & Chimini, G. The human ATP-binding cassette (ABC) transporter superfamily. J Lipid Res 42, 1007-1017 (2001).
20. Tep, J. et al. Transepithelial transport of fusariotoxin nivalenol: mediation of secretion by ABC transporters. Toxicol Lett 170, 248-258 (2007).
21. Artursson, P., Palm, K. & Luthman, K. Caco-2 monolayers in experimental and theoretical predictions of drug transport. Adv Drug Deliver Re 46, 27-43 (2001).
22. Irvine, J. D. et al. MDCK (Madin-Darby canine kidney) cells: a tool for membrane permeability screening. J Pharm Sci 88, 28-33 (1999).
23. Lampl, T., Crum, J. A., Davis, T. A., Milligan, C. & Moore, V. D. G. Isolation and functional analysis of mitochondria from cultured cells and mouse tissue. J Vis Exp 97, e52076-e52076 (2015).
24. Abmayr, S. M., Carrozza, M. J. & Workman, J. L. Preparation of nuclear and cytoplasmic extracts from mammalian cells. Current protocols in pharmacology Chapter 12, Unit 12.1 (2006).
25. Yordanova, J., Rosso, O. A. & Kolev, V. A transient dominance of theta event-related brain potential component characterizes stimulus processing in an auditory oddball task. Clin Neurophysiol 114, 529-540 (2003).
26. Gouze, M. et al. Individual and combined effects of low oral doses of deoxynivalenol and nivalenol in mice. Cell Mol Biol 51, OL809-817 (2004).
27. Gottesman, M. M., Fojo, T. & Bates, S. E. Multidrug resistance in cancer: role of ATP-dependent transporters. Nat Rev Cancer 2, 48-58 (2002).
28. Minervini, F., Fornelli, F. & Flynn, K. Toxicity and apoptosis induced by the mycotoxins nivalenol, deoxynivalenol and fumonisin B 1 in a human erythroleukemia cell line. Toxicol in Vitro 18, 21-28 (2004).
29. Goyarts, T. & Dänicke, S. Bioavailability of the Fusarium toxin deoxynivalenol (DON) from naturally contaminated wheat for the pig. Toxicol Lett 163, 171-182 (2006).
30. Nielsen, J. K., Vikstrom, A. C., Turner, P. & Knudsen, L. E. Deoxynivalenol transport across the human placental barrier. Food Chem Toxicol 49, 2046-2052 (2011).
31. Frankič, T., Pajk, T., Rezar, V., Levart, A. & Salobir, J. The role of dietary nucleotides in reduction of DNA damage induced by T-2 toxin and deoxynivalenol in chicken leukocytes. Food Chem Toxicol 44, 1838-1844 (2006).
32. Cole, S. et al. Overexpression of a transporter gene in a multidrug-resistant human lung cancer cell line. Science 258, 1650-1650 (1992).
33. Nigam, S. K. What do drug transporters really do? Nat Rev Drug Discov 14, 29-44 (2015).
34. Visentin, M., Chang, M.-H., Romero, M. F., Zhao, R. & Goldman, I. D. Substrate-and pH-specific antifolate transport mediated by organic anion-transporting polypeptide 2B1 (OATP2B1-SLCO2B1). Mol Pharm 81, 134-142 (2012).
35. Bermejo, M. et al. PAMPA - a drug absorption in vitro model: 7 Comparing rat in situ, Caco-2, and PAMPA permeability of fluoroquinolones. Eur. J. Pharm. Sci 21, 429-441 (2004).
36. Kao, Y.-Y., Chen, Y.-C., Cheng, T.-J., Chiung, Y.-M. & Liu, P.-S. Zinc oxide nanoparticles interfere with zinc ion homeostasis to cause cytotoxicity. Toxicol Sci 125, 462-472 (2012).
37. Lison, D. et al. Nominal and effective dosimetry of silica nanoparticles in cytotoxicity assays. Toxicol Sci 104, 155-162 (2008).
38. Liu, F., Soares, M. J. & Audus, K. L. Permeability properties of monolayers of the human trophoblast cell line BeWo. Am J Physiol-Cell Ph 273, C1596-C1604 (1997).