메뉴 건너뛰기




Volumn 7, Issue 1, 2017, Pages

Evolution of the Pseudomonas aeruginosa mutational resistome in an international Cystic Fibrosis clone

Author keywords

[No Author keywords available]

Indexed keywords

PENICILLIN BINDING PROTEIN; POLYMYXIN; QUINOLONE DERIVATIVE;

EID: 85025116852     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/s41598-017-05621-5     Document Type: Article
Times cited : (114)

References (65)
  • 1
    • 84869219279 scopus 로고    scopus 로고
    • Adaptation of Pseudomonas aeruginosa to the cystic fibrosis airway: An evolutionary perspective
    • Folkesson, A. et al. Adaptation of Pseudomonas aeruginosa to the cystic fibrosis airway: An evolutionary perspective. Nat Rev Microbiol 10, 841-51 (2012).
    • (2012) Nat Rev Microbiol , vol.10 , pp. 841-851
    • Folkesson, A.1
  • 2
    • 84555178426 scopus 로고    scopus 로고
    • Intrinsic and environmental mutagenesis drive diversification and persistence of Pseudomonas aeruginosa in chronic lung infections
    • Rodríguez-Rojas, A., Oliver, A., Blázquez, J. Intrinsic and environmental mutagenesis drive diversification and persistence of Pseudomonas aeruginosa in chronic lung infections. J Infect Dis. 05, 121-7 (2012).
    • (2012) J Infect Dis , vol.5 , pp. 121-127
    • Rodríguez-Rojas, A.1    Oliver, A.2    Blázquez, J.3
  • 3
    • 78549263685 scopus 로고    scopus 로고
    • Adaptation of Pseudomonas aeruginosa during persistence in the cystic fibrosis lung
    • Hogardt, M., Heesemann, J. Adaptation of Pseudomonas aeruginosa during persistence in the cystic fibrosis lung. Int J Med Microbiol. 300, 557-62 (2010).
    • (2010) Int J Med Microbiol. , vol.300 , pp. 557-562
    • Hogardt, M.1    Heesemann, J.2
  • 6
    • 84899514356 scopus 로고    scopus 로고
    • Role of efflux pumps: MexAB-OprM and MexXY(-OprA), AmpC cephalosporinase and OprD porin in non-metallo-β-lactamase producing Pseudomonas aeruginosa isolated from cystic fibrosis and burn patients
    • Aghazadeh, M. et al. Role of efflux pumps: MexAB-OprM and MexXY(-OprA), AmpC cephalosporinase and OprD porin in non-metallo-β-lactamase producing Pseudomonas aeruginosa isolated from cystic fibrosis and burn patients. Infect Genet Evol. 24, 187-92 (2014).
    • (2014) Infect Genet Evol , vol.24 , pp. 187-192
    • Aghazadeh, M.1
  • 7
    • 19544386997 scopus 로고    scopus 로고
    • Occurrence of hypermutable Pseudomonas aeruginosa in cystic fibrosis patients is associated with the oxidative stress caused by chronic lung inflammation
    • Ciofu, O., Riis, B., Pressler, T., Poulsen, H. E., Høiby, N. Occurrence of hypermutable Pseudomonas aeruginosa in cystic fibrosis patients is associated with the oxidative stress caused by chronic lung inflammation. Antimicrob Agents Chemother. 49, 2276-82 (2005).
    • (2005) Antimicrob Agents Chemother. , vol.49 , pp. 2276-2282
    • Ciofu, O.1    Riis, B.2    Pressler, T.3    Poulsen, H.E.4    Høiby, N.5
  • 8
    • 77954729491 scopus 로고    scopus 로고
    • Mutators in cystic fibrosis chronic lung infection: Prevalence, mechanisms, and consequences for antimicrobial therapy
    • Oliver, A. Mutators in cystic fibrosis chronic lung infection: Prevalence, mechanisms, and consequences for antimicrobial therapy. Int J Med Microbiol. 300, 563-72 (2010).
    • (2010) Int J Med Microbiol. , vol.300 , pp. 563-572
    • Oliver, A.1
  • 9
    • 57349088170 scopus 로고    scopus 로고
    • Genetic adaptation of Pseudomonas aeruginosa to the airways of cystic fibrosis patients is catalyzed by hypermutation
    • Mena, A. et al. Genetic adaptation of Pseudomonas aeruginosa to the airways of cystic fibrosis patients is catalyzed by hypermutation. J Bacteriol. 190, 7910-7 (2008).
    • (2008) J Bacteriol , vol.190 , pp. 7910-7917
    • Mena, A.1
  • 10
    • 0034685940 scopus 로고    scopus 로고
    • High frequency of hypermutable Pseudomonas aeruginosa in cystic fibrosis lung infection
    • Oliver, A., Cantón, R., Campo, P., Baquero, F., Blázquez, J. High frequency of hypermutable Pseudomonas aeruginosa in cystic fibrosis lung infection. Science. 288, 1251-4 (2000).
    • (2000) Science , vol.288 , pp. 1251-1254
    • Oliver, A.1    Cantón, R.2    Campo, P.3    Baquero, F.4    Blázquez, J.5
  • 11
    • 0022576641 scopus 로고
    • An epidemic spread of multiresistant Pseudomonas aeruginosa in a cystic fibrosis centre
    • Pedersen, S. S., Koch, C., Hoiby, N., Rosendal, K. An epidemic spread of multiresistant Pseudomonas aeruginosa in a cystic fibrosis centre. J Antimicrob Chemother. 17, 505-516 (1986).
    • (1986) J Antimicrob Chemother , vol.17 , pp. 505-516
    • Pedersen, S.S.1    Koch, C.2    Hoiby, N.3    Rosendal, K.4
  • 12
    • 0030573808 scopus 로고    scopus 로고
    • Spread of beta-lactam-resistant Pseudomonas aeruginosa in a cystic fibrosis clinic
    • Cheng, K. et al. Spread of beta-lactam-resistant Pseudomonas aeruginosa in a cystic fibrosis clinic. Lancet. 348, 639-642 (1996).
    • (1996) Lancet , vol.348 , pp. 639-642
    • Cheng, K.1
  • 13
    • 0037951634 scopus 로고    scopus 로고
    • Evidence for spread of a clonal strain of Pseudomonas aeruginosa among cystic fibrosis clinics
    • Armstrong, D. et al. Evidence for spread of a clonal strain of Pseudomonas aeruginosa among cystic fibrosis clinics. J Clin Microbiol. 41, 2266-2267 (2003).
    • (2003) J Clin Microbiol. , vol.41 , pp. 2266-2267
    • Armstrong, D.1
  • 14
    • 84959309866 scopus 로고    scopus 로고
    • Pseudomonas aeruginosa evolutionary adaptation and diversification in cystic fibrosis chronic lung infections
    • Winstanley, C., O'Brien, S., Brockhurst, M. A. Pseudomonas aeruginosa evolutionary adaptation and diversification in cystic fibrosis chronic lung infections. Trends Microbiol. 24, 327-37 (2016).
    • (2016) Trends Microbiol. , vol.24 , pp. 327-337
    • Winstanley, C.1    O'Brien, S.2    Brockhurst, M.A.3
  • 15
    • 44449117336 scopus 로고    scopus 로고
    • Evolution of Pseudomonas aeruginosa pathogenicity: From acute to chronic infections
    • Baquero, F., Nombela, C., Cassell, G. H., Gutiérrez, J. A. (Eds ASM Press
    • Oliver, A., Mena, A., Macià, M. D. Evolution of Pseudomonas aeruginosa pathogenicity: From acute to chronic infections. In: Baquero, F., Nombela, C., Cassell, G. H., Gutiérrez, J. A. (Eds), Evolutionary Biology of Bacterial and Fungal Pathogens, ISBN 978-1-55581-414-4, 433-444, (ASM Press, 2008).
    • (2008) Evolutionary Biology of Bacterial and Fungal Pathogens , pp. 433-444
    • Oliver, A.1    Mena, A.2    MacIà, M.D.3
  • 16
    • 84881513008 scopus 로고    scopus 로고
    • Clonal dissemination, emergence of mutator lineages and antibiotic resistance evolution in Pseudomonas aeruginosa cystic fibrosis chronic lung infection
    • López-Causapé, C. et al. Clonal dissemination, emergence of mutator lineages and antibiotic resistance evolution in Pseudomonas aeruginosa cystic fibrosis chronic lung infection. PLoS One. 8, e71001, doi: 10.1371/journal.pone.0071001 (2013).
    • (2013) PLoS One , vol.8 , pp. 71001
    • López-Causapé, C.1
  • 17
    • 84859982559 scopus 로고    scopus 로고
    • Emergence of a mutL mutation causing multilocus sequence typing-pulsed-field gel electrophoresis discrepancy among Pseudomonas aeruginosa isolates from a cystic fibrosis patient
    • Garciá-Castillo, M. et al. Emergence of a mutL mutation causing multilocus sequence typing-pulsed-field gel electrophoresis discrepancy among Pseudomonas aeruginosa isolates from a cystic fibrosis patient. J Clin Microbiol. 50, 1777-8 (2012).
    • (2012) J Clin Microbiol , vol.50 , pp. 1777-1778
    • Garciá-Castillo, M.1
  • 18
    • 78650902004 scopus 로고    scopus 로고
    • Comparison of three molecular techniques for typing Pseudomonas aeruginosa isolates in sputum samples
    • Kidd, T. J., Grimwood, K., Ramsay, K. A., Rainey, P., Bell, S. C. Comparison of three molecular techniques for typing Pseudomonas aeruginosa isolates in sputum samples. J Clin Microbiol. 49, 263-268 (2011).
    • (2011) J Clin Microbiol , vol.49 , pp. 263-268
    • Kidd, T.J.1    Grimwood, K.2    Ramsay, K.A.3    Rainey, P.4    Bell, S.C.5
  • 19
    • 84946833974 scopus 로고    scopus 로고
    • Clinical utilization of genomics data produced by the international Pseudomonas aeruginosa consortium
    • Freschi, L. et al. Clinical utilization of genomics data produced by the international Pseudomonas aeruginosa consortium. Front Microbiol. 6, 1036 (2015).
    • (2015) Front Microbiol , vol.6 , pp. 1036
    • Freschi, L.1
  • 20
    • 84965190732 scopus 로고    scopus 로고
    • The Harvest suite for rapid core-genome alignment and visualization of thousands of intraspecific microbial genomes
    • Treangen, T. J., Ondov, B. D., Koren, S., Phillippy, A. M. The Harvest suite for rapid core-genome alignment and visualization of thousands of intraspecific microbial genomes. Genome Biol. 15, 524 (2014).
    • (2014) Genome Biol , vol.15 , pp. 524
    • Treangen, T.J.1    Ondov, B.D.2    Koren, S.3    Phillippy, A.M.4
  • 21
    • 84926620810 scopus 로고    scopus 로고
    • Divergent, coexisting Pseudomonas aeruginosa lineages in chronic cystic fibrosis lung infections
    • Williams, D. et al. Divergent, coexisting Pseudomonas aeruginosa lineages in chronic cystic fibrosis lung infections. Am J Respir Crit Care Med. 191, 775-785 (2015).
    • (2015) Am J Respir Crit Care Med. , vol.191 , pp. 775-785
    • Williams, D.1
  • 22
    • 84895531123 scopus 로고    scopus 로고
    • Comparative genomics of isolates of a Pseudomonas aeruginosa epidemic strain associated with chronic lung infections of cystic fibrosis patients
    • Jeukens, J. et al. Comparative genomics of isolates of a Pseudomonas aeruginosa epidemic strain associated with chronic lung infections of cystic fibrosis patients. PLoSOne. 9, e87611, doi: 10.1371/journal.pone.0087611 (2014).
    • (2014) PLoSOne , vol.9 , pp. e87611
    • Jeukens, J.1
  • 23
    • 79956307094 scopus 로고    scopus 로고
    • Evolutionary dynamics of bacteria in a human host environment
    • Yang, L. et al. Evolutionary dynamics of bacteria in a human host environment. Proc Natl Acad Sci USA. 108, 7481-6 (2011).
    • (2011) Proc Natl Acad Sci USA. , vol.108 , pp. 7481-7486
    • Yang, L.1
  • 24
    • 84908338190 scopus 로고    scopus 로고
    • Coexistence and within-host evolution of diversified lineages of hypermutable Pseudomonas aeruginosa in long-term cystic fibrosis infections
    • Feliziani, S. et al. Coexistence and within-host evolution of diversified lineages of hypermutable Pseudomonas aeruginosa in long-term cystic fibrosis infections. PLoS Genet. 10, e1004651, doi: 10.1371/journal.pgen.1004651 (2014).
    • (2014) PLoS Genet. , vol.10 , pp. e1004651
    • Feliziani, S.1
  • 25
    • 84884679783 scopus 로고    scopus 로고
    • Genome analysis of a transmissible lineage of Pseudomonas aeruginosa reveals pathoadaptive mutations and distinct evolutionary paths of hypermutators
    • Marvig, R. L., Johansen, H. K., Molin, S., Jelsbak, L. Genome analysis of a transmissible lineage of Pseudomonas aeruginosa reveals pathoadaptive mutations and distinct evolutionary paths of hypermutators. PLoS Genet. 9, e1003741, doi: 10.1371/journal.pgen.1003741 (2013).
    • (2013) PLoS Genet. , vol.9 , pp. e1003741
    • Marvig, R.L.1    Johansen, H.K.2    Molin, S.3    Jelsbak, L.4
  • 26
    • 79959841531 scopus 로고    scopus 로고
    • Microevolution of the major common Pseudomonas aeruginosa clones C and PA14 in cystic fibrosis lungs
    • Cramer, N. et al. Microevolution of the major common Pseudomonas aeruginosa clones C and PA14 in cystic fibrosis lungs. Environ Microbiol. 13, 1690-704 (2011).
    • (2011) Environ Microbiol , vol.13 , pp. 1690-1704
    • Cramer, N.1
  • 27
    • 84857646835 scopus 로고    scopus 로고
    • Multidrug-resistant, extensively drug-resistant and pandrug-resistant bacteria: An international expert proposal for interim standard definitions for acquired resistance
    • Magiorakos, A. P. et al. Multidrug-resistant, extensively drug-resistant and pandrug-resistant bacteria: An international expert proposal for interim standard definitions for acquired resistance. Clin Microbiol Infect. 18, 268-81 (2012).
    • (2012) Clin Microbiol Infect , vol.18 , pp. 268-281
    • Magiorakos, A.P.1
  • 28
    • 84867587461 scopus 로고    scopus 로고
    • Identification of acquired antimicrobial resistance genes
    • Zankari, E. et al. Identification of acquired antimicrobial resistance genes. J Antimicrob Chemother. 67, 2640-2644 (2012).
    • (2012) J Antimicrob Chemother. , vol.67 , pp. 2640-2644
    • Zankari, E.1
  • 29
    • 23044473638 scopus 로고    scopus 로고
    • Hypermutation is a key factor in development of multiple-antimicrobial resistance in Pseudomonas aeruginosa strains causing chronic lung infections
    • Maciá, M. D. et al. Hypermutation is a key factor in development of multiple-antimicrobial resistance in Pseudomonas aeruginosa strains causing chronic lung infections. Antimicrob Agents Chemother. 49, 3382-6 (2005).
    • (2005) Antimicrob Agents Chemother. , vol.49 , pp. 3382-3386
    • MacIá, M.D.1
  • 30
    • 79955530880 scopus 로고    scopus 로고
    • Overexpression of AmpC and efflux pumps in Pseudomonas aeruginosa isolates from bloodstream infections: Prevalence and impact on resistance in a Spanish multicenter study
    • Cabot, G. et al. Overexpression of AmpC and efflux pumps in Pseudomonas aeruginosa isolates from bloodstream infections: Prevalence and impact on resistance in a Spanish multicenter study. Antimicrob. Agents Chemother. 55, 1906-1911 (2011).
    • (2011) Antimicrob. Agents Chemother. , vol.55 , pp. 1906-1911
    • Cabot, G.1
  • 31
    • 63449128597 scopus 로고    scopus 로고
    • Beta-lactam resistance response triggered by inactivation of a nonessential penicillin-binding protein
    • Moyà, B. et al. Beta-lactam resistance response triggered by inactivation of a nonessential penicillin-binding protein. PLoS Pathog. 5, e1000353, doi: 10.1371/journal.ppat.1000353 (2009).
    • (2009) PLoS Pathog , vol.5 , pp. e1000353
    • Moyà, B.1
  • 32
    • 84946595400 scopus 로고    scopus 로고
    • Selective sweeps and parallel pathoadaptation drive Pseudomonas aeruginosa evolution in the cystic fibrosis lung
    • Diáz-Caballero, J. et al. Selective sweeps and parallel pathoadaptation drive Pseudomonas aeruginosa evolution in the cystic fibrosis lung. MBio. 6, e00981-15, doi: 10.1128/mBio.00981-15 (2015).
    • (2015) MBio , vol.6 , pp. e00981-e001015
    • Diáz-Caballero, J.1
  • 33
    • 84960192153 scopus 로고    scopus 로고
    • Evolution of Pseudomonas aeruginosa antimicrobial resistance and fitness under low and high mutation rates
    • Cabot, G. et al. Evolution of Pseudomonas aeruginosa antimicrobial resistance and fitness under low and high mutation rates. Antimicrob Agents Chemother. 60, 1767-1778 (2016).
    • (2016) Antimicrob Agents Chemother , vol.60 , pp. 1767-1778
    • Cabot, G.1
  • 34
    • 78650656571 scopus 로고    scopus 로고
    • Structural basis for effectiveness of siderophore-conjugated monocarbams against clinically relevant strains of Pseudomonas aeruginosa
    • Han, S. et al. Structural basis for effectiveness of siderophore-conjugated monocarbams against clinically relevant strains of Pseudomonas aeruginosa. Proc Natl Acad Sci USA 107, 22002-22007 (2010).
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 22002-22007
    • Han, S.1
  • 35
    • 84996565849 scopus 로고    scopus 로고
    • Deciphering the resistome of the widespread Pseudomonas aeruginosa sequence type 175 international high-risk clone through whole-genome sequencing
    • Cabot, G. et al. Deciphering the resistome of the widespread Pseudomonas aeruginosa sequence type 175 international high-risk clone through whole-genome sequencing. Antimicrob Agents Chemother. 60, 7415-7423 (2016).
    • (2016) Antimicrob Agents Chemother , vol.60 , pp. 7415-7423
    • Cabot, G.1
  • 36
    • 84920164355 scopus 로고    scopus 로고
    • The resistome of Pseudomonas aeruginosa in relationship to phenotypic susceptibility
    • Kos, V. N. et al. The resistome of Pseudomonas aeruginosa in relationship to phenotypic susceptibility. Antimicrob Agents Chemother. 59, 427-36 (2015).
    • (2015) Antimicrob Agents Chemother. , vol.59 , pp. 427-436
    • Kos, V.N.1
  • 37
    • 66149134410 scopus 로고    scopus 로고
    • Efflux unbalance in Pseudomonas aeruginosa isolates from cystic fibrosis patients
    • Vettoretti, L. et al. Efflux unbalance in Pseudomonas aeruginosa isolates from cystic fibrosis patients. Antimicrob Agents Chemother. 53, 1987-97 (2009).
    • (2009) Antimicrob Agents Chemother. , vol.53 , pp. 1987-1997
    • Vettoretti, L.1
  • 38
    • 12944262276 scopus 로고    scopus 로고
    • Aminoglycoside resistance in Pseudomonas aeruginosa
    • Poole, K. Aminoglycoside resistance in Pseudomonas aeruginosa. Antimicrob Agents Chemother. 49, 479-87 (2005).
    • (2005) Antimicrob Agents Chemother. , vol.49 , pp. 479-487
    • Poole, K.1
  • 39
    • 0037378945 scopus 로고    scopus 로고
    • MexXY-OprM efflux pump is necessary for adaptive resistance of Pseudomonas aeruginosa to aminoglycosides
    • Hocquet, D. et al. MexXY-OprM efflux pump is necessary for adaptive resistance of Pseudomonas aeruginosa to aminoglycosides. Antimicrob Agents Chemother. 47, 1371-5 (2003).
    • (2003) Antimicrob Agents Chemother , vol.47 , pp. 1371-1375
    • Hocquet, D.1
  • 40
    • 84977566041 scopus 로고    scopus 로고
    • Aminoglycoside resistance of Pseudomonas aeruginosa in cystic fibrosis results from convergent evolution in the mexZ gene
    • Prickett, M. H. et al. Aminoglycoside resistance of Pseudomonas aeruginosa in cystic fibrosis results from convergent evolution in the mexZ gene. Thorax. 72, 40-47 (2017).
    • (2017) Thorax , vol.72 , pp. 40-47
    • Prickett, M.H.1
  • 41
    • 2142697190 scopus 로고    scopus 로고
    • Role of the multidrug efflux system MexXY in the emergence of moderate resistance to aminoglycosides among Pseudomonas aeruginosa isolates from patients with cystic fibrosis
    • Vogne, C., Aires, J. R., Bailly, C., Hocquet, D., Plésiat, P. Role of the multidrug efflux system MexXY in the emergence of moderate resistance to aminoglycosides among Pseudomonas aeruginosa isolates from patients with cystic fibrosis. Antimicrob Agents Chemother. 48, 1676-80 (2004).
    • (2004) Antimicrob Agents Chemother. , vol.48 , pp. 1676-1680
    • Vogne, C.1    Aires, J.R.2    Bailly, C.3    Hocquet, D.4    Plésiat, P.5
  • 42
    • 84977126109 scopus 로고    scopus 로고
    • Dynamics of mutations during development of resistance by Pseudomonas aeruginosa against five antibiotics
    • Feng, Y., Jonker, M. J., Moustakas, I., Brul, S., Ter Kuile, B. H. Dynamics of mutations during development of resistance by Pseudomonas aeruginosa against five antibiotics. Antimicrob Agents Chemother. 60, 4229-36 (2016).
    • (2016) Antimicrob Agents Chemother , vol.60 , pp. 4229-4236
    • Feng, Y.1    Jonker, M.J.2    Moustakas, I.3    Brul, S.4    Ter Kuile, B.H.5
  • 43
    • 57049100540 scopus 로고    scopus 로고
    • Novel genetic determinants of low-level aminoglycoside resistance in Pseudomonas aeruginosa
    • Schurek, K. N. et al. Novel genetic determinants of low-level aminoglycoside resistance in Pseudomonas aeruginosa. Antimicrob. Agents Chemother. 52, 4213-4219 (2008).
    • (2008) Antimicrob. Agents Chemother. , vol.52 , pp. 4213-4219
    • Schurek, K.N.1
  • 44
    • 33847650484 scopus 로고    scopus 로고
    • Cumulative effects of several nonenzymatic mechanisms on the resistance of Pseudomonas aeruginosa to aminoglycosides
    • El'Garch, F., Jeannot, K., Hocquet, D., Llanes-Barakat, C., Plésiat, P. Cumulative effects of several nonenzymatic mechanisms on the resistance of Pseudomonas aeruginosa to aminoglycosides. Antimicrob Agents Chemother. 51, 1016-21 (2007).
    • (2007) Antimicrob Agents Chemother , vol.51 , pp. 1016-1021
    • El'Garch, F.1    Jeannot, K.2    Hocquet, D.3    Llanes-Barakat, C.4    Plésiat, P.5
  • 45
    • 84994850387 scopus 로고    scopus 로고
    • Molecular epidemiology of mutations in antimicrobial resistance loci of Pseudomonas aeruginosa isolates from airways of cystic fibrosis patients
    • Greipel, L. et al. Molecular epidemiology of mutations in antimicrobial resistance loci of Pseudomonas aeruginosa isolates from airways of cystic fibrosis patients. Antimicrob Agents Chemother. 60, 6726-6734 (2016).
    • (2016) Antimicrob Agents Chemother , vol.60 , pp. 6726-6734
    • Greipel, L.1
  • 46
    • 0242648332 scopus 로고    scopus 로고
    • Overexpression of the mexC-mexD-oprJ efflux operon in nfxB-type multidrug-resistant strains of Pseudomonas aeruginosa
    • Poole, K. et al. Overexpression of the mexC-mexD-oprJ efflux operon in nfxB-type multidrug-resistant strains of Pseudomonas aeruginosa. Mol Microbiol. 21, 713-724 (1996).
    • (1996) Mol Microbiol. , vol.21 , pp. 713-724
    • Poole, K.1
  • 47
    • 80052845657 scopus 로고    scopus 로고
    • Antagonistic interactions of Pseudomonas aeruginosa antibiotic resistance mechanisms in planktonic but not biofilm growth
    • Mulet, X. et al. Antagonistic interactions of Pseudomonas aeruginosa antibiotic resistance mechanisms in planktonic but not biofilm growth. Antimicrob Agents Chemother. 55, 4560-4568 (2011).
    • (2011) Antimicrob Agents Chemother. , vol.55 , pp. 4560-4568
    • Mulet, X.1
  • 48
    • 0032994202 scopus 로고    scopus 로고
    • Detection of gyrA mutations among 335 Pseudomonas aeruginosa strains isolated in Japan and their susceptibilities to fluoroquinolones
    • Takenouchi, T., Sakagawa, E., Sugawara, M. Detection of gyrA mutations among 335 Pseudomonas aeruginosa strains isolated in Japan and their susceptibilities to fluoroquinolones. Antimicrob Agents Chemother. 43, 406-9 (1999).
    • (1999) Antimicrob Agents Chemother. , vol.43 , pp. 406-409
    • Takenouchi, T.1    Sakagawa, E.2    Sugawara, M.3
  • 49
    • 84908463538 scopus 로고    scopus 로고
    • LpxC inhibitors as new antibacterial agents and tools for studying regulation of lipid A biosynthesis in Gram-negative pathogens
    • Tomaras, A. P. et al. LpxC inhibitors as new antibacterial agents and tools for studying regulation of lipid A biosynthesis in Gram-negative pathogens. MBio. 5, e01551-14, doi: 10.1128/mBio.01551-14 (2014).
    • (2014) MBio , vol.5 , pp. e01551-e01614
    • Tomaras, A.P.1
  • 50
    • 84876226990 scopus 로고    scopus 로고
    • Polymyxin resistance of Pseudomonas aeruginosa phoQ mutants is dependent on additional two-component regulatory systems
    • Gutu, A. D. et al. Polymyxin resistance of Pseudomonas aeruginosa phoQ mutants is dependent on additional two-component regulatory systems. Antimicrob Agents Chemother. 57, 2204-15 (2013).
    • (2013) Antimicrob Agents Chemother , vol.57 , pp. 2204-2215
    • Gutu, A.D.1
  • 51
    • 84869204668 scopus 로고    scopus 로고
    • The two-component system CprRS senses cationic peptides and triggers adaptive resistance in Pseudomonas aeruginosa independently of ParRS
    • Fernández, L. et al. The two-component system CprRS senses cationic peptides and triggers adaptive resistance in Pseudomonas aeruginosa independently of ParRS. Antimicrob Agents Chemother. 56, 6212-22 (2012).
    • (2012) Antimicrob Agents Chemother , vol.56 , pp. 6212-6222
    • Fernández, L.1
  • 52
    • 84863393429 scopus 로고    scopus 로고
    • PmrB mutations promote polymyxin resistance of Pseudomonas aeruginosa isolated from colistin-treated cystic fibrosis patients
    • Moskowitz, S. M. et al. PmrB mutations promote polymyxin resistance of Pseudomonas aeruginosa isolated from colistin-treated cystic fibrosis patients. Antimicrob Agents Chemother. 56, 1019-30 (2012).
    • (2012) Antimicrob Agents Chemother , vol.56 , pp. 1019-1030
    • Moskowitz, S.M.1
  • 53
    • 81555211920 scopus 로고    scopus 로고
    • PhoQ mutations promote lipid A modification and polymyxin resistance of Pseudomonas aeruginosa found in colistin-treated cystic fibrosis patients
    • Miller, A. K. et al. PhoQ mutations promote lipid A modification and polymyxin resistance of Pseudomonas aeruginosa found in colistin-treated cystic fibrosis patients. Antimicrob Agents Chemother. 55, 5761-9 (2011).
    • (2011) Antimicrob Agents Chemother , vol.55 , pp. 5761-5769
    • Miller, A.K.1
  • 54
    • 77955376940 scopus 로고    scopus 로고
    • Adaptive resistance to the last hope" antibiotics polymyxin B and colistin in Pseudomonas aeruginosa is mediated by the novel two-component regulatory system ParR-ParS
    • Fernández, L. et al. Adaptive resistance to the "last hope" antibiotics polymyxin B and colistin in Pseudomonas aeruginosa is mediated by the novel two-component regulatory system ParR-ParS. Antimicrob Agents Chemother. 54, 3372-82 (2010).
    • (2010) Antimicrob Agents Chemother , vol.54 , pp. 3372-3382
    • Fernández, L.1
  • 55
    • 84931330941 scopus 로고    scopus 로고
    • Development of colistin resistance in pmrA-, phoP-, parR-A nd cprR-inactivated mutants of Pseudomonas aeruginosa
    • Lee, J. Y. et al. Development of colistin resistance in pmrA-, phoP-, parR-A nd cprR-inactivated mutants of Pseudomonas aeruginosa. J Antimicrob Chemother. 69, 2966-71 (2014).
    • (2014) J Antimicrob Chemother , vol.69 , pp. 2966-2971
    • Lee, J.Y.1
  • 56
    • 71249110157 scopus 로고    scopus 로고
    • Alterations in two-component regulatory systems of phoPQ and pmrAB are associated with polymyxin B resistance in clinical isolates of Pseudomonas aeruginosa
    • Barrow, K., Kwon, D. H. Alterations in two-component regulatory systems of phoPQ and pmrAB are associated with polymyxin B resistance in clinical isolates of Pseudomonas aeruginosa. Antimicrob Agents Chemother. 53, 5150-4 (2009).
    • (2009) Antimicrob Agents Chemother. , vol.53 , pp. 5150-5154
    • Barrow, K.1    Kwon, D.H.2
  • 57
    • 33646458074 scopus 로고    scopus 로고
    • Stepwise upregulation of the Pseudomonas aeruginosa chromosomal cephalosporinase conferring high-level beta-lactam resistance involves three AmpD homologues
    • Juan, C., Moyá, B., Pérez, J. L., Oliver, A. Stepwise upregulation of the Pseudomonas aeruginosa chromosomal cephalosporinase conferring high-level beta-lactam resistance involves three AmpD homologues. Antimicrob Agents Chemother. 50, 1780-7 (2006).
    • (2006) Antimicrob Agents Chemother. , vol.50 , pp. 1780-1787
    • Juan, C.1    Moyá, B.2    Pérez, J.L.3    Oliver, A.4
  • 58
    • 85028139131 scopus 로고    scopus 로고
    • Convergent evolution and adaptation of Pseudomonas aeruginosa within patients with cystic fibrosis
    • Marvig, R. L., Sommer, L. M., Molin, S., Johansen, H. K. Convergent evolution and adaptation of Pseudomonas aeruginosa within patients with cystic fibrosis. Nat Genet. 47, 57-64 (2015).
    • (2015) Nat Genet. , vol.47 , pp. 57-64
    • Marvig, R.L.1    Sommer, L.M.2    Molin, S.3    Johansen, H.K.4
  • 59
    • 84859210032 scopus 로고    scopus 로고
    • Fast gapped-read alignment with Bowtie 2
    • Langmead, B., Salzberg, S. L. Fast gapped-read alignment with Bowtie 2. Nat Methods. 9, 357-9 (2012).
    • (2012) Nat Methods , vol.9 , pp. 357-359
    • Langmead, B.1    Salzberg, S.L.2
  • 60
    • 68549104404 scopus 로고    scopus 로고
    • The sequence alignment/map format and SAMtools
    • Li, H. et al. The Sequence Alignment/Map format and SAMtools. Bioinformatics. 25, 2078-9 (2009).
    • (2009) Bioinformatics , vol.25 , pp. 2078-2079
    • Li, H.1
  • 61
    • 79955483667 scopus 로고    scopus 로고
    • A framework for variation discovery and genotyping using next-generation DNA sequencing data
    • DePristo, M. A. A framework for variation discovery and genotyping using next-generation DNA sequencing data. Nat Genet. 43, 491-8 (2011).
    • (2011) Nat Genet. , vol.43 , pp. 491-498
    • DePristo, M.A.1
  • 62
    • 43149115851 scopus 로고    scopus 로고
    • Velvet: Algorithms for de novo short read assembly using de Bruijn graphs
    • Zerbino, D. R., Birney, E. Velvet: Algorithms for de novo short read assembly using de Bruijn graphs. Genome Res. 18, 821-9 (2008).
    • (2008) Genome Res. , vol.18 , pp. 821-829
    • Zerbino, D.R.1    Birney, E.2
  • 63
    • 2942538300 scopus 로고    scopus 로고
    • Versatile and open software for comparing large genomes
    • Kurtz, S. et al. Versatile and open software for comparing large genomes. Genome Biol. 5, R12 (2004).
    • (2004) Genome Biol. , vol.5 , pp. R12
    • Kurtz, S.1
  • 64
    • 84864530626 scopus 로고    scopus 로고
    • Bayesian phylogenetics with BEAUti and the BEAST 1.7
    • Drummond, A. J., Suchard, M. A., Xie, D., Rambaut, A. Bayesian phylogenetics with BEAUti and the BEAST 1.7. Mol Biol Evol 29, 1969-1973 (2012).
    • (2012) Mol Biol Evol , vol.29 , pp. 1969-1973
    • Drummond, A.J.1    Suchard, M.A.2    Xie, D.3    Rambaut, A.4
  • 65
    • 84862506964 scopus 로고    scopus 로고
    • A program for annotating and predicting the effects of single nucleotide polymorphisms SnpEff: SNPs in the genome of Drosophila melanogaster strain w1118; Iso-2; iso-3
    • Cingolani, P. et al. A program for annotating and predicting the effects of single nucleotide polymorphisms, SnpEff: SNPs in the genome of Drosophila melanogaster strain w1118; iso-2; iso-3. Fly (Austin). 6, 80-92 (2012).
    • (2012) Fly (Austin) , vol.6 , pp. 80-92
    • Cingolani, P.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.