Detection of iron restriction in anaemic and non-anaemic patients: New diagnostic approaches

European Journal of Haematology

Volumn 99, Issue 3, 2017, Pages 262-268

  Thomas, Lothar ^a   Thomas, Christian ^b  

^a GOETHE UNIVERSITY   (Germany)

^b JOHANNES GUTENBERG UNIVERSITY   (Germany)

Author keywords

anaemia; ferritin; iron restricted erythropoiesis; red cell indices; soluble transferrin receptor

Indexed keywords

BIOCHEMICAL MARKER; C REACTIVE PROTEIN; FERRITIN; HEMOGLOBIN; TRANSFERRIN; BIOLOGICAL MARKER; IRON; TRANSFERRIN RECEPTOR;

ADULT; AGED; ANALYTICAL PARAMETERS; ANEMIA; ARTICLE; CLINICAL EVALUATION; CONTROLLED STUDY; DIAGNOSTIC TEST ACCURACY STUDY; DYSERYTHROPOIESIS; ERYTHROCYTE PARAMETERS; EVALUATION STUDY; FEMALE; FERRITIN BLOOD LEVEL; HEMATOCRIT; HEMATOLOGICAL PARAMETERS; HEMOGLOBIN BLOOD LEVEL; HUMAN; IRON BLOOD LEVEL; IRON DEFICIENCY; IRON DEFICIENCY ANEMIA; IRON METABOLISM; IRON METABOLISM DISORDER; IRON RESTRICTED ERYTHROPOIESIS; IRON RESTRICTION; IRON RESTRICTION (DISEASE); IRON SEQUESTRATION SYNDROME; MAJOR CLINICAL STUDY; MALE; PREVALENCE; PRIORITY JOURNAL; REFERENCE VALUE; RETICULOCYTE COUNT; RETICULOCYTE HEMOGLOBIN CONTENT; RETICULOCYTE INDEX; SENSITIVITY AND SPECIFICITY; TRANSFERRIN BLOOD LEVEL; TRANSFERRIN SATURATION; BLOOD; ERYTHROPOIESIS; MEAN CORPUSCULAR VOLUME; METABOLISM; MIDDLE AGED; RECEIVER OPERATING CHARACTERISTIC; VERY ELDERLY; YOUNG ADULT;

ADULT; AGED; AGED, 80 AND OVER; ANEMIA; ANEMIA, IRON-DEFICIENCY; BIOMARKERS; ERYTHROCYTE INDICES; ERYTHROPOIESIS; FEMALE; FERRITINS; HUMANS; IRON; MALE; MIDDLE AGED; RECEPTORS, TRANSFERRIN; ROC CURVE; YOUNG ADULT;

EID: 85024493017     PISSN: 09024441     EISSN: 16000609     Source Type: Journal    
DOI: 10.1111/ejh.12914     Document Type: Article

References (28)

1. Goodnough LT, Nemeth E, Ganz T. Detection, evaluation, and management of iron-restricted erythropoiesis. Blood. 2010;116:4754-4761.
2. Macdougall IC, Cavill I, Hulme B, et al. Detection of functional iron deficiency during erythropoietin treatment: a new approach. BMJ. 1992;304:225-226.
3. KDIGO (Kidney Disease: Improving global outcomes). Anemia workgroup clinical practice guideline for anemia in chronic disease. Kidney Int Suppl. 2012;2:283-287.
4. Weiss G, Goodnough LT. Anemia of chronic disease. N Engl J Med. 2005;352:1011-1023.
5. Babitt JL, Lin HY. Mechanism of anemia in CKD. J Am Soc Nephrol. 2012;23:1631-1634.
6. Thomas WD, Hinchliffe RF, Briggs C, Macdougall IC, Littlewood T, Cavill I. Guideline for the laboratory diagnosis of functional iron deficiency. Br J Haematol. 2013;161:639-648.
7. Kassebaum NJ, Jasrasaria R, Naghavi M, et al. A systematic analysis of global anemia burden from 1990 to 2010. Blood. 2014;123:615-624.
8. McMurray JJ, Adamopoulos S, Anker SD, et al. ESC guidelines for the diagnosis and treatment of acute and chronic heart failure 2012 of the European Society of Cardiology. Eur J Heart Fail. 2012;14:803-869.
9. Munoz M, Ag Acheson, Auerbach M, et al. International consensus statement on the peri-operative management of anaemia and iron deficiency. Anaesthesia. 2017;72:233-247. https://doi.org/10.1111/anae.137773.
10. Baart AM, van Noord PAH, Vergouwe Y, et al. High prevalence of subclinical iron deficiency in whole blood donors not deferred for low hemoglobin. Transfusion. 2013;53:1670-1677.
11. Musallam KM, Tamim HM, Richards T, et al. Preoperative anemia and postoperative outcomes in non-cardiac surgery: a retrospective cohort study. Lancet. 2011;378:1396-1407.
12. Anker SD, Colet JC, Fillipatos G, et al. Ferric carboxymaltose in patients with heart failure and iron deficiency. N Engl J Med. 2009;361:2436-2448.
13. Punnonen K, Irjala K, Rajamäki A. Serum transferrin receptor and its ratio to serum ferritin in the diagnosis of iron deficiency. Blood. 1997;89:1052-1057.
14. Thomas C, Thomas L. Biochemical markers and hematologic indices in the diagnosis of functional iron deficiency. Clin Chem. 2002;48:1066-1076.
15. Kasper DC, Widness JA, Haiden N, et al. Characterization and differentiation of iron status in anemic very low birth weight infants using a diagnostic nomogram. Neonatology. 2009;95:164-171.
16. Enko D, Wallner F, von Goedecke A, Hirschmugl C, Auersperg V, Hallwachs-Baumann G. The impact of an algorithm-guided management of perioperative anemia in perioperative hemoglobin level and transfusion of major orthopedic surgery patients. Anemia. 2013;1:1-11. https://doi.org/doi.org/10.1155/2013/641876.
17. Leers MPG, Keuren JFW, Oosterhuis WP. The value of the Thomas-plot in the diagnostic workup of anemic patients referred by general practitioners. Int J Lab Hematol. 2010;32:572-581.
18. Enko D, Wagner H, Kriegshäuser G, et al. Hepcidin-25 vs. conventional clinical biomarkers in the diagnosis of functional iron deficiency. Eur J Haematol. 2015;95:507-513.
19. Vernet M, Doyen C. Assessment of iron status with a new fully automated assay for transferrin receptor in human serum. Clin Chem Lab Med. 2000;38:437-442.
20. Kolbe-Busch S, Lotz J, Hafner G, et al. Multicenter evaluation of a fully mechanized soluble transferrin receptor assay on the Hitachi and Cobas Integra analyzers. The determination of reference ranges. Clin Chem Lab Med. 2002;40:529-536.
21. MedCalc statistics for biomedical research. Mariakerke, Belgium, 2016.
22. The Commission of the European Communities. European Commission Directive 2004/33/EC. 2004.
23. Mast AE, Blinder MA, Gronowski AM, Chumley C, Scott MG. Clinical utility of the soluble transferrin receptor and comparison with serum ferritin in several populations. Clin Chem. 1998;44:45-51.
24. Cavill I. Iron status as measured by serum ferritin: the marker and its limitations. Am J Kidney Dis. 1999;34(Suppl. 2):S12-S17.
25. Feelders RA, Kuiper-Kramer EPA, van Eijk HG. Structure, function and clinical significance of transferrin receptors. Clin Chem Lab Med. 1999;37:1-10.
26. Markovic M, Majkic-Singh N, Ignjatovic S, Singh S. Reticulocyte haemoglobin content vs. soluble transferrin receptor and ferritin index in iron deficiency anaemia accompanied with inflammation. Int J Lab Hematol. 2007;29:341-346.
27. Bovy C, Tsobo C, Crapanzano L, et al. Factors determining the percentage of hypochromic red cells in hemodialysis patients. Kidney Int. 1999;56:1113-1119.
28. Brugnara C. Iron deficiency and erythropoiesis: new diagnostic approaches. Clin Chem. 2003;49:1573-1578.