Anticancer effect of polyphyllin I in colorectal cancer cells through ROS-dependent autophagy and G2/M arrest mechanisms

Natural Product Research

Volumn 32, Issue 12, 2018, Pages 1489-1492

  Yu, Si ^a,b,c   Wang, Lijiao ^a,b,c   Cao, Zhixing ^a,b,c   Gong, Daoyin ^a,b,c   Liang, Qianyi ^a   Chen, Hanting ^a,b,c   Fu, Huizhu ^a   Wang, Wenwen ^a   Tang, Xue ^a,b,c   Xie, Zihao ^a,b,c   He, Yang ^a   Peng, Cheng ^a,b,c   Li, Yuzhi ^a,b,c  

^a CHENGDU UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

^b BEIJING UNIVERSITY OF POSTS AND TELECOMMUNICATIONS   (China)

^c Development and Utilization of Chinese Medicine Resources Co founded by Sichuan Province and MOST   (China)

Author keywords

Autophagy; G2 M arrest; Polyphyllin I; ROS

Indexed keywords

ANTINEOPLASTIC AGENT; CELL CYCLE PROTEIN; CYCLIN B1; POLYPHYLLIN I; PROTEIN P21; REACTIVE OXYGEN METABOLITE; SAPONIN; UNCLASSIFIED DRUG; DIOSGENIN; MTOR PROTEIN, HUMAN; PROTEIN KINASE B; TARGET OF RAPAMYCIN KINASE;

AKT SIGNALING; ANTINEOPLASTIC ACTIVITY; ARTICLE; AUTOPHAGY; CELL DEATH; CELL VIABILITY; COLORECTAL CANCER; CONFOCAL LASER SCANNING MICROSCOPY; DRUG CYTOTOXICITY; DRUG MECHANISM; FLOW CYTOMETRY; G2 PHASE CELL CYCLE CHECKPOINT; HCT 116 CELL LINE; HUMAN; HUMAN CELL; IC50; WESTERN BLOTTING; ANALOGS AND DERIVATIVES; CELL SURVIVAL; COLORECTAL TUMOR; CONFOCAL MICROSCOPY; DRUG EFFECT; METABOLISM; PATHOLOGY;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; AUTOPHAGY; CELL SURVIVAL; COLORECTAL NEOPLASMS; DIOSGENIN; FLOW CYTOMETRY; G2 PHASE CELL CYCLE CHECKPOINTS; HCT116 CELLS; HUMANS; MICROSCOPY, CONFOCAL; PROTO-ONCOGENE PROTEINS C-AKT; REACTIVE OXYGEN SPECIES; TOR SERINE-THREONINE KINASES;

EID: 85024387750     PISSN: 14786419     EISSN: 14786427     Source Type: Journal    
DOI: 10.1080/14786419.2017.1353512     Document Type: Article

References (17)

1. Arnold M, Sierra MS, Laversanne M, Soerjomataram I, Jemal A, Bray F. 2016. Global patterns and trends in colorectal cancer incidence and mortality. Gut, gutjnl-2015.
2. Blokhina O, Fagerstedt KV. 2010. Oxidative metabolism, ROS and NO under oxygen deprivation. Plant Physiol Biochem. 48(5):359-373.
3. Chang J, Wang H, Wang X, Zhao Y, Zhao D, Wang C, Li Y, Yang Z, Lu S, Zeng Q, et al. 2015. Molecular mechanisms of Polyphyllin I-induced apoptosis and reversal of the epithelial-mesenchymal transition in human osteosarcoma cells. J Ethnopharmacol. 170:117-127.
4. Gu L, Feng J, Xu H, Luo M, Su D. 2013. Polyphyllin I inhibits proliferation and metastasis of ovarian cancer cell line HO-8910PM in vitro. J Tradit Chin Med. 33(3):325-333.
5. He L, Nan MH, Oh HC, Kim YH, Jang JH, Erikson RL, Ahn JS, Kim BY. 2011. Asperlin induces G 2/M arrest through ROS generation and ATM pathway in human cervical carcinoma cells. Biochem Biophys Res Commun. 409(3):489-493.
6. Huo Y, Qiu WY, Pan Q, Yao YF, Xing K, Lou MF. 2009. Reactive oxygen species (ROS) are essential mediators in epidermal growth factor (EGF)-stimulated corneal epithelial cell proliferation, adhesion, migration, and wound healing. Exp Eye Res. 89(6):876-886.
7. Jing S, Wang Y, Li X, Man S, Gao W. 2017. Chemical constituents and antitumor activity from Paris polyphyllaSmith var. yunnanensis. Nat Prod Res. 31(6):660-666.
8. Ling Y, Fu Z, Zhang Q, Xu L, Liao L. 2015. Identification and structural elucidation of steroidal saponins from the root of Paris polyphylla by HPLC-ESI-QTOF-MS/MS. Nat Prod Res. 29(19):1798-1803.
9. Liu B, Wen X, Cheng Y. 2012. Survival or death: disequilibrating the oncogenic and tumor suppressive autophagy in cancer. Cell Death Dis. 4(5):e892.
10. Liu J, Chang F, Li F, Fu H, Wang J, Zhang S, Zhao J, Yin D. 2015. Palmitate promotes autophagy and apoptosis through ROS-dependent JNK and p38 MAPK. Biochem Biophys Res Commun. 463(3):262-267.
11. Nagesh R, Kumar KMK, Kumar MN, Patil RH, Kavya K, Babu RL, Ramesh GT, Sharma C. 2017. Aqueous areca nut extract induces oxidative stress in human lung epithelial A549 cells: Probable role of p21 in inducing cell death. Gene Rep. 103-111.
12. Prasad S, Gupta SC, Tyagi AK. 2016. Reactive oxygen species (ROS) and cancer: role of antioxidative nutraceuticals. Cancer Lett. 387:95-105.
13. Shi YM, Yang L, Geng YD, Zhang C, Kong LY. 2015. Polyphyllin I induced-apoptosis is enhanced by inhibition of autophagy in human hepatocellular carcinoma cells. Phytomed Int J Phytother & Phytopharmacol. 22(13):1139.
14. Sun ZL, Dong JL, Wu J. 2017. Juglanin induces apoptosis and autophagy in human breast cancer progression via ROS/JNK promotion. Biomed Pharmacother. 85:303-312.
15. Torre LA, Siegel RL, Ward EM, Jemal A. 2016. Global cancer incidence and mortality rates and trends-an update. Cancer Epidemiol Biomarkers Prev. 25(1):16.
16. Tsujimoto Y, Shimizu S. 2005. Another way to die: autophagic programmed cell death. Cell Death Differ. 12(2):1528-1534.
17. Xu C, Wang Q, Xu F, Bo Y. 2014. Effect of evodiagenine mediates photocytotoxicity on human breast cancer cells MDA-MB-231 through inhibition of PI3K/AKT/mTOR and activation of p38 pathways. Fitoterapia. 99:292-299.