Detecting human coronary inflammation by imaging perivascular fat

Science Translational Medicine

Volumn 9, Issue 398, 2017, Pages

  Antonopoulos, Alexios S ^a   Sanna, Fabio ^a   Sabharwal, Nikant ^b   Thomas, Sheena ^a   Oikonomou, Evangelos K ^a   Herdman, Laura ^a   Margaritis, Marios ^a,c   Shirodaria, Cheerag ^b   Kampoli, Anna Maria ^a   Akoumianakis, Ioannis ^a   Petrou, Mario ^b   Sayeed, Rana ^b   Krasopoulos, George ^b   Psarros, Constantinos ^a   Ciccone, Patricia ^a   Brophy, Carl M ^a   Digby, Janet ^a   Kelion, Andrew ^b   Uberoi, Raman ^b   Anthony, Suzan ^b   Alexopoulos, Nikolaos ^d   Tousoulis, Dimitris ^d   Achenbach, Stephan ^e   Neubauer, Stefan ^a,c,f   Channon, Keith M ^a,c,f   Antoniades, Charalambos ^a,c,f   more..

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b OXFORD UNIVERSITY HOSPITALS NHS FOUNDATION TRUST   (United Kingdom)

^c KING'S COLLEGE LONDON   (United Kingdom)

^d UNIVERSITY OF ATHENS MEDICAL SCHOOL   (Greece)

^e UNIVERSITY HOSPITAL ERLANGEN   (Germany)

^f NIHR OXFORD BIOMEDICAL RESEARCH CENTRE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; FLUORODEOXYGLUCOSE F 18; CYTOKINE; LIPID;

ACUTE CORONARY SYNDROME; ARTICLE; ATHEROSCLEROTIC PLAQUE; CELL SIZE; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; CORONARY ARTERY DISEASE; CORONARY INFLAMMATION; DIAGNOSTIC IMAGING; DIAGNOSTIC TEST ACCURACY STUDY; EX VIVO STUDY; EXPLANT; HEART SURGERY; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; LIPID STORAGE; MAJOR CLINICAL STUDY; PARACRINE SIGNALING; PERIVASCULAR ADIPOSE TISSUE; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; PROADIPOCYTE; SENSITIVITY AND SPECIFICITY; THREE DIMENSIONAL IMAGING; VASCULITIS; ADIPOCYTE; ADIPOGENESIS; ADIPOSE TISSUE; CELL DIFFERENTIATION; CELL PROLIFERATION; CHEMISTRY; CORONARY BLOOD VESSEL; INFLAMMATION; METABOLISM; PATHOLOGY; PHENOTYPE; VASCULARIZATION; X-RAY COMPUTED TOMOGRAPHY;

ADIPOCYTES; ADIPOGENESIS; ADIPOSE TISSUE; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL SIZE; CORONARY VESSELS; CYTOKINES; HUMANS; IMAGING, THREE-DIMENSIONAL; INFLAMMATION; LIPIDS; PHENOTYPE; PLAQUE, ATHEROSCLEROTIC; TOMOGRAPHY, X-RAY COMPUTED;

EID: 85023780381     PISSN: 19466234     EISSN: 19466242     Source Type: Journal    
DOI: 10.1126/scitranslmed.aal2658     Document Type: Article

References (30)

1. R. Ross, Atherosclerosis-An inflammatory disease. N. Engl. J. Med. 340, 115-126 (1999).
2. R. Lee, M. Margaritis, K. M. Channon, C. Antoniades, Evaluating oxidative stress in human cardiovascular disease: Methodological aspects and considerations. Curr. Med. Chem. 19, 2504-2520 (2012).
3. M. Margaritis, A. S. Antonopoulos, J. Digby, R. Lee, S. Reilly, P. Coutinho, C. Shirodaria, R. Sayeed, M. Petrou, R. De Silva, S. Jalilzadeh, M. Demosthenous, C. Bakogiannis, D. Tousoulis, C. Stefanadis, R. P. Choudhury, B. Casadei, K. M. Channon, C. Antoniades, Interactions between vascular wall and perivascular adipose tissue reveal novel roles for adiponectin in the regulation of endothelial nitric oxide synthase function in human vessels. Circulation 127, 2209-2221 (2013).
4. T. Christen, Y. Sheikine, V. Z. Rocha, S. Hurwitz, A. B. Goldfine, M. Di Carli, P. Libby, Increased glucose uptake in visceral versus subcutaneous adipose tissue revealed by PET imaging. JACC Cardiovasc. Imaging 3, 843-851 (2010).
5. P. Greenland, L. LaBree, S. P. Azen, T. M. Doherty, R. C. Detrano, Coronary artery calcium score combined with Framingham score for risk prediction in asymptomatic individuals. JAMA 291, 210-215 (2004).
6. I. E. Hoefer, S. Steffens, M. Ala-Korpela, M. Bäck, L. Badimon, M.-L. Bochaton-Piallat, C. M. Boulanger, G. Caligiuri, S. Dimmeler, J. Egido, P. C. Evans, T. Guzik, B. R. Kwak, U. Landmesser, M. Mayr, C. Monaco, G. Pasterkamp, J. Tuñón, C. Weber; ESC Working Group Atherosclerosis and Vascular Biology, Novel methodologies for biomarker discovery in atherosclerosis. Eur. Heart J. 36, 2635-2642 (2015).
7. C. Antoniades, A. S. Antonopoulos, D. Tousoulis, C. Stefanadis, Adiponectin: From obesity to cardiovascular disease. Obes. Rev. 10, 269-279 (2009).
8. A. S. Antonopoulos, M. Margaritis, P. Coutinho, C. Shirodaria, C. Psarros, L. Herdman, F. Sanna, R. De Silva, M. Petrou, R. Sayeed, G. Krasopoulos, R. Lee, J. Digby, S. Reilly, C. Bakogiannis, D. Tousoulis, B. Kessler, B. Casadei, K. M. Channon, C. Antoniades, Adiponectin as a link between type 2 diabetes and vascular NADPH oxidase activity in the human arterial wall: The regulatory role of perivascular adipose tissue. Diabetes 64, 2207-2219 (2015).
9. J. M. Ntambi, K. Young-Cheul, Adipocyte differentiation and gene expression. J. Nutr. 130, 3122S-3126S (2000).
10. J. Bassols, F. J. Ortega, J. M. Moreno-Navarrete, B. Peral, W. Ricart, J.-M. Fernández-Real, Study of the proinflammatory role of human differentiated omental adipocytes. J. Cell. Biochem. 107, 1107-1117 (2009).
11. M. DiGirolamo, J. L. Owens, Water content of rat adipose tissue and isolated adipocytes in relation to cell size. Am. J. Physiol. 231, 1568-1572 (1976).
12. C. Farnier, S. Krief, M. Blache, F. Diot-Dupuy, G. Mory, P. Ferre, R. Bazin, Adipocyte functions are modulated by cell size change: Potential involvement of an integrin/ERK signalling pathway. Int. J. Obes. Relat. Metab. Disord. 27, 1178-1186 (2003).
13. M. Takaoka, H. Suzuki, S. Shioda, K. Sekikawa, Y. Saito, R. Nagai, M. Sata, Endovascular injury induces rapid phenotypic changes in perivascular adipose tissue. Arterioscler. Thromb. Vasc. Biol. 30, 1576-1582 (2010).
14. R. W. Grant, J. M. Stephens, Fat in flames: Influence of cytokines and pattern recognition receptors on adipocyte lipolysis. Am. J. Physiol. Endocrinol. Metab. 309, E205-E213 (2015).
15. M.-J. Lee, Y. Wu, S. K. Fried, A modified protocol to maximize differentiation of human preadipocytes and improve metabolic phenotypes. Obesity (Silver Spring) 20, 2334-2340 (2012).
16. N. Franck, K. G. Stenkula, A. Öst, T. Lindström, P. Strålfors, F. H. Nystrom, Insulininduced GLUT4 translocation to the plasma membrane is blunted in large compared with small primary fat cells isolated from the same individual. Diabetologia 50, 1716-1722 (2007).
17. M. R. Kazemi, C. M. McDonald, J. K. Shigenaga, C. Grunfeld, K. R. Feingold, Adipocyte fatty acid-binding protein expression and lipid accumulation are increased during activation of murine macrophages by toll-like receptor agonists. Arterioscler. Thromb. Vasc. Biol. 25, 1220-1224 (2005).
18. A. S. Antonopoulos, M. Margaritis, P. Coutinho, J. Digby, R. Patel, C. Psarros, N. Ntusi, T. D. Karamitsos, R. Lee, R. De Silva, M. Petrou, R. Sayeed, M. Demosthenous, C. Bakogiannis, P. B. Wordsworth, D. Tousoulis, S. Neubauer, K. M. Channon, C. Antoniades, Reciprocal effects of systemic inflammation and brain natriuretic peptide on adiponectin biosynthesis in adipose tissue of patients with ischemic heart disease. Arterioscler. Thromb. Vasc. Biol. 34, 2151-2159 (2014).
19. C. Bambace, A. Sepe, E. Zoico, M. Telesca, D. Olioso, S. Venturi, A. Rossi, F. Corzato, S. Faccioli, L. Cominacini, F. Santini, M. Zamboni, Inflammatory profile in subcutaneous and epicardial adipose tissue in men with and without diabetes. Heart Vessels 29, 42-48 (2014).
20. K. J. Rosenquist, A. Pedley, J. M. Massaro, K. E. Therkelsen, J. M. Murabito, U. Hoffmann, C. S. Fox, Visceral and subcutaneous fat quality and cardiometabolic risk. JACC Cardiovasc. Imaging 6, 762-771 (2013).
21. T. M. Abraham, A. Pedley, J. M. Massaro, U. Hoffmann, C. S. Fox, Association between visceral and subcutaneous adipose depots and incident cardiovascular disease risk factors. Circulation 132, 1639-1647 (2015).
22. D. Tousoulis, C. Psarros, M. Demosthenous, R. Patel, C. Antoniades, C. Stefanadis, Innate and adaptive inflammation as a therapeutic target in vascular disease: The emerging role of statins. J. Am. Coll. Cardiol. 63, 2491-2502 (2014).
23. A. S. Antonopoulos, M. Margaritis, R. Lee, K. Channon, C. Antoniades, Statins as antiinflammatory agents in atherogenesis: Molecular mechanisms and lessons from the recent clinical trials. Curr. Pharm. Des. 18, 1519-1530 (2012).
24. S. N. Verhagen, M. P. Buijsrogge, A. Vink, L. A. van Herwerden, Y. van der Graaf, F. L. J. Visseren, Secretion of adipocytokines by perivascular adipose tissue near stenotic and non-stenotic coronary artery segments in patients undergoing CABG. Atherosclerosis 233, 242-247 (2014).
25. S. N. Verhagen, F. L. J. Visseren, Perivascular adipose tissue as a cause of atherosclerosis. Atherosclerosis 214, 3-10 (2011).
26. P. Maurovich-Horvat, K. Kallianos, L.-C. Engel, J. Szymonifka, C. S. Fox, U. Hoffmann, Q. A. Truong, Influence of pericoronary adipose tissue on local coronary atherosclerosis as assessed by a novel MDCT volumetric method. Atherosclerosis 219, 151-157 (2011).
27. M. Konishi, S. Sugiyama, Y. Sato, S. Oshima, K. Sugamura, T. Nozaki, K. Ohba, J. Matsubara, H. Sumida, Y. Nagayoshi, K. Sakamoto, D. Utsunomiya, K. Awai, H. Jinnouchi, Y. Matsuzawa, Y. Yamashita, Y. Asada, K. Kimura, S. Umemura, H. Ogawa, Pericardial fat inflammation correlates with coronary artery disease. Atherosclerosis 213, 649-655 (2010).
28. M. S. Alam, R. Green, R. de Kemp, R. S. Beanlands, B. J. W. Chow, Epicardial adipose tissue thickness as a predictor of impaired microvascular function in patients with non-obstructive coronary artery disease. J. Nucl. Cardiol. 20, 804-812 (2013).
29. N. Alexopoulos, D. S. McLean, M. Janik, C. D. Arepalli, A. E. Stillman, P. Raggi, Epicardial adipose tissue and coronary artery plaque characteristics. Atherosclerosis 210, 150-154 (2010).
30. E. Henrichot, C. E. Juge-Aubry, A. Pernin, J.-C. Pache, V. Velebit, J.-M. Dayer, P. Meda, C. Chizzolini, C. A. Meier, Production of chemokines by perivascular adipose tissue: A role in the pathogenesis of atherosclerosis? Arterioscler. Thromb. Vasc. Biol. 25, 2594-2599 (2005).