Aerobic fitness associates with mnemonic discrimination as a mediator of physical activity effects: Evidence for memory flexibility in young adults /631/378/1595/1554 /631/378/1595/1554 /631/378/1595/1554 /631/378/1595/1554 /631/477/2811 /141 article

Scientific Reports

Volumn 7, Issue 1, 2017, Pages

  Suwabe, Kazuya ^a   Hyodo, Kazuki ^a,b   Byun, Kyeongho ^a,d   Ochi, Genta ^a   Fukuie, Takemune ^a   Shimizu, Takeshi ^a   Kato, Morimasa ^c   Yassa, Michael A ^a,d   Soya, Hideaki ^a  

^a UNIVERSITY OF TSUKUBA   (Japan)

^b PHYSICAL FITNESS RESEARCH INSTITUTE   (Japan)

^c YAMAGATA UNIVERSITY   (Japan)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; CROSS-SECTIONAL STUDY; DENTATE GYRUS; ENDURANCE; EXERCISE; FEMALE; HIPPOCAMPUS; HUMAN; MAJOR CLINICAL STUDY; MALE; MEDIATOR; MEMORY; PHYSICAL ACTIVITY; THEORETICAL MODEL; YOUNG ADULT; CARDIORESPIRATORY FITNESS; LIFESTYLE; NERVE CELL PLASTICITY; PHYSIOLOGY;

CARDIORESPIRATORY FITNESS; CROSS-SECTIONAL STUDIES; DENTATE GYRUS; EXERCISE; FEMALE; HUMANS; LIFE STYLE; MALE; MEMORY; NEURONAL PLASTICITY; PHYSICAL FUNCTIONAL PERFORMANCE; YOUNG ADULT;

EID: 85023164709     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/s41598-017-04850-y     Document Type: Article

References (48)

1. Hillman, C. H., Erickson, K. I. & Kramer, A. F. Be smart, exercise your heart: exercise effects on brain and cognition. Nat. Rev. Neurosci. 9, 58-65 (2008).
2. Voss, M. W., Vivar, C., Kramer, A. F. & van Praag, H. Bridging animal and human models of exercise-induced brain plasticity. Trends Cogn. Sci. 17, 525-544 (2013).
3. Chaddock, L. et al. A neuroimaging investigation of the association between aerobic fitness, hippocampal volume, and memory performance in preadolescent children. Brain Res. 1358, 172-183 (2010).
4. Erickson, K. I. et al. Aerobic fitness is associated with hippocampal volume in elderly humans. Hippocampus 19, 1030-1039 (2009).
5. van Praag, H., Kempermann, G. & Gage, F. H. Running increases cell proliferation and neurogenesis in the adult mouse dentate gyrus. Nat. Neurosci. 2, 266-270 (1999).
6. van Praag, H., Shubert, T., Zhao, C. & Gage, F. H. Exercise enhances learning and hippocampal neurogenesis in aged mice. J. Neurosci. 25, 8680-8685 (2005).
7. Lee, M. C. et al. Voluntary resistance running induces increased hippocampal neurogenesis in rats comparable to load-free running. Neurosci. Lett. 537, 6-10 (2013).
8. Okamoto, M. et al. Mild exercise increases dihydrotestosterone in hippocampus providing evidence for androgenic mediation of neurogenesis. Proc. Natl. Acad. Sci. USA 109, 13100-13105 (2012).
9. Inoue, K. et al. Long-term mild, rather than intense, exercise enhances adult hippocampal neurogenesis and greatly changes the transcriptomic profile of the hippocampus. PLoS One 10, e0128720 (2015).
10. Pereira, A. C. et al. An in vivo correlate of exercise-induced neurogenesis in the adult dentate gyrus. Proc. Natl. Acad. Sci. USA 104, 5638-5643 (2007).
11. Leutgeb, J. K., Leutgeb, S., Moser, M.-B. & Moser, E. I. Pattern separation in the dentate gyrus and CA3 of the hippocampus. Science 315, 961-966 (2007).
12. Yassa, M. A. & Stark, C. E. L. Pattern separation in the hippocampus. Trends Neurosci. 34, 515-525 (2011).
13. Leal, S. L. & Yassa, M. A. Neurocognitive aging and the hippocampus across species. Trends Neurosci. 38, 800-812 (2015).
14. Fogelholm, M. et al. International physical activity questionnaire: Validity against fitness. Med. Sci. Sports Exerc. 38, 753-760 (2006).
15. Stark, S. M., Yassa, M. A., Lacy, J. W. & Stark, C. E. L. A task to assess behavioral pattern separation (BPS) in humans: Data from healthy aging and mild cognitive impairment. Neuropsychologia 51, 2442-2449 (2013).
16. Yassa, M. A. et al. Pattern separation deficits associated with increased hippocampal CA3 and dentate gyrus activity in nondemented older adults. Hippocampus 21, 968-979 (2011).
17. Reagh, Z. M. et al. Spatial discrimination deficits as a function of mnemonic interference in aged adults with and without memory impairment. Hippocampus 24, 303-314 (2014).
18. Yassa, M. A., Mattfeld, A. T., Stark, S. M. & Stark, C. E. L. Age-related memory deficits linked to circuit-specific disruptions in the hippocampus. Proc. Natl. Acad. Sci. USA 108, 8873-8878 (2011).
19. Craig, C. L. et al. International physical activity questionnaire: 12-Country reliability and validity. Med. Sci. Sports Exerc. 35, 1381-1395 (2003).
20. Van Holle, V., De Bourdeaudhuij, I., Deforche, B., Van Cauwenberg, J. & Van Dyck, D. Assessment of physical activity in older Belgian adults: validity and reliability of an adapted interview version of the long International Physical Activity Questionnaire (IPAQ-L). BMC Public Health 15(433), doi:10.1186/s12889-015-1785-3 (2015).
21. Skinner, E. I. & Fernandes, M. A. Neural correlates of recollection and familiarity: A review of neuroimaging and patient data. Neuropsychologia 45, 2163-2179 (2007).
22. Kirwan, B. et al. Pattern separation deficits following damage to the hippocampus. Neuropsychologia 50, 2408-2414 (2012).
23. Beck, A., Steer, R. & Brown, G. Manual for the Beck Depression Inventory-II. Psychological Corporation (1996).
24. Déry, N. et al. Adult hippocampal neurogenesis reduces memory interference in humans: Opposing effects of aerobic exercise and depression. Front. Neurosci. 7(66), doi:10.3389/fnins.2013.00066 (2013).
25. Leal, S. L., Tighe, S. K. & Yassa, M. A. Asymmetric effects of emotion on mnemonic interference. Neurobiol. Learn. Mem. 111, 41-48 (2014).
26. Faul, F., Erdfelder, E., Lang, A.-G. & Buchner, A. G Power 3: A flexible statistical power analysis program for the social, behavioral, and biomedical sciences. Behav. Res. Methods 39, 175-191 (2007).
27. Cohen, J. A power primer. Psychol. Psychol. Bull. 112, 155-159 (1992).
28. Baron, R. M. & Kenny, D. A. The moderator-mediator variable distinction in social psychological research: conceptual, strategic, and statistical considerations. J. Pers. Soc. Psychol. 51, 1173-1182 (1986).
29. Hayes, A. F. Introduction to Mediation, Moderation, and Conditional Process Analysis A Regression-Based Approach (Guilford Press, 2013).
30. Wilson, I. A., Gallagher, M., Eichenbaum, H. & Tanila, H. Neurocognitive aging: prior memories hinder new hippocampal encoding. Trends Neurosci. 29, 662-670 (2006).
31. Chaddock, L., Hillman, C. H., Buck, S. M. & Cohen, N. J. Aerobic fitness and executive control of relational memory in preadolescent children. Med Sci Sport. Exerc 43, 344-349 (2010).
32. Baym, C. L. et al. Aerobic fitness predicts relational memory but not item memory performance in healthy young adults. J. Cogn. Neurosci. 26, 2645-2652 (2014).
33. Hayes, S. M. et al. Physical Activity Is Positively Associated with Episodic Memory in Aging. J. Int. Neuropsychol. Soc. 21, 780-790 (2015).
34. Aberg, M. A. I. et al. Cardiovascular fitness is associated with cognition in young adulthood. Proc. Natl. Acad. Sci. USA 106, 20906-20911 (2009).
35. Etnier, J. L. et al. The influence of physical fitness and exercise upon cognitive functioning: A meta-analysis. Journal of Sport and Exercise Psychology 19, 249-277 (1997).
36. Creer, D. J., Romberg, C., Saksida, L. M., van Praag, H. & Bussey, T. J. Running enhances spatial pattern separation in mice. Proc. Natl. Acad. Sci. USA 107, 2367-2372 (2010).
37. Manganas, L. N. et al. Magnetic resonance spectroscopy identifies neural progenitor cells in the live human brain. Science 318, 980-985 (2007).
38. Friedman, S. D. Comment on "Magnetic resonance spectroscopy identifies neural progenitor cells in the live human brain". Science 321, 640c (2008).
39. Hoch, J. C., Maciejewski, M. W. & Gryk, M. R. Comment on "Magnetic resonance spectroscopy identifies neural progenitor cells in the live human brain". Science 321, 640b (2008).
40. Jansen, J. F. A., Gearhart, J. D. & Bulte, J. W. M. Comment on "Magnetic resonance spectroscopy identifies neural progenitor cells in the live human brain". Science 321, 640d (2008).
41. Dong, Z., Dreher, W., Leibfritz, D. & Peterson, B. S. Challenges of Using MR Spectroscopy to Detect Neural Progenitor Cells In Vivo. Am. J. Neuroradiol. 30, 1096-1101 (2009).
42. Ramm, P. et al. A nuclear magnetic resonance biomarker for neural progenitor cells: is it all neurogenesis Stem Cells 27, 420-423 (2009).
43. Yassa, M. A., Muftuler, L. T. & Stark, C. E. L. Ultrahigh-resolution microstructural diffusion tensor imaging reveals perforant path degradation in aged humans in vivo. Proc. Natl. Acad. Sci. USA 107, 12687-12691 (2010).
44. Hyodo, K. et al. The association between aerobic fitness and cognitive function in older men mediated by frontal lateralization. Neuroimage 125, 291-300 (2016).
45. Prakash, R. S. et al. Cardiorespiratory fitness and attentional control in the aging brain. Front. Hum. Neurosci. 4(229), doi:10.3389/ fnhum.2010.00229 (2011).
46. Voelcker-Rehage, C., Godde, B. & Staudinger, U. M. Physical and motor fitness are both related to cognition in old age. Eur. J. Neurosci. 31, 167-176 (2010).
47. Pidgeon, L. M. & Morcom, A. M. Cortical pattern separation and item-specific memory encoding. Neuropsychologia 85, 256-271 (2016).
48. Suwabe, K. et al. Acute moderate exercise improves mnemonic discrimination in young adults. Hippocampus 27, 229-234 (2017).