Regulation of oxidized platelet lipidome: Implications for coronary artery disease

European Heart Journal

Volumn 38, Issue 25, 2017, Pages 1993-2005

  Chatterjee, Madhumita ^a   Rath, Dominik ^a   Schlotterbeck, Jörg ^a   Rheinlaender, Johannes ^a   Walker Allgaier, Britta ^a   Alnaggar, Nada ^a   Zdanyte, Monika ^a   Müller, Iris ^a   Borst, Oliver ^a   Geisler, Tobias ^a   Schäffer, Tilman E ^a   Lämmerhofer, Michael ^a   Gawaz, Meinrad ^a  

^a UNIVERSITY OF TÜBINGEN   (Germany)

Author keywords

Chemokines; Coronary artery disease; Lipidomics; Platelet; Thrombus

Indexed keywords

ALPHA2BBETA3 INTEGRIN; CERAMIDE; CHEMOKINE RECEPTOR CXCR4; CHEMOKINE RECEPTOR CXCR7; CHOLESTEROL ESTER; DIACYLGLYCEROL; INTEGRIN; LIPIDOME; LOW DENSITY LIPOPROTEIN CHOLESTEROL; REACTIVE OXYGEN METABOLITE; SPHINGOMYELIN; STROMAL CELL DERIVED FACTOR 1; THROMBIN; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; CHEMOKINE RECEPTOR CXCR; CXCL12 PROTEIN, HUMAN; CXCR7 PROTEIN, HUMAN; LOW DENSITY LIPOPROTEIN; OXIDIZED LOW DENSITY LIPOPROTEIN;

ACUTE CORONARY SYNDROME; ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; BLOOD CLOTTING; CARDIOVASCULAR RISK; CHOLESTEROL BLOOD LEVEL; CONFOCAL MICROSCOPY; CONTROLLED STUDY; CORONARY ANGIOGRAPHY; CORONARY ARTERY THROMBOSIS; DEGRANULATION; ELECTROSPRAY MASS SPECTROMETRY; EX VIVO STUDY; FEMALE; FLOW CYTOMETRY; HUMAN; IMMUNOFLUORESCENCE; IN VIVO STUDY; LIPID ANALYSIS; LIPID METABOLISM; LIPID OXIDATION; LIPID PEROXIDATION; LIPID TRANSPORT; LIPIDOMICS; MAJOR CLINICAL STUDY; MALE; MOLECULAR PATHOLOGY; MOUSE; NONHUMAN; PHOSPHOLIPID BLOOD LEVEL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; REGULATORY MECHANISM; THROMBOCYTE FUNCTION; TRIACYLGLYCEROL BLOOD LEVEL; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY; UPREGULATION; AGED; CASE CONTROL STUDY; CORONARY ARTERY DISEASE; METABOLISM; MIDDLE AGED; PHYSIOLOGY; THROMBOCYTE;

ACUTE CORONARY SYNDROME; AGED; BLOOD PLATELETS; CASE-CONTROL STUDIES; CHEMOKINE CXCL12; CORONARY ARTERY DISEASE; CORONARY THROMBOSIS; FEMALE; HUMANS; LIPID METABOLISM; LIPID PEROXIDATION; LIPOPROTEINS, LDL; MALE; MIDDLE AGED; REACTIVE OXYGEN SPECIES; RECEPTORS, CXCR; RECEPTORS, CXCR4;

EID: 85022321173     PISSN: 0195668X     EISSN: 15229645     Source Type: Journal    
DOI: 10.1093/eurheartj/ehx146     Document Type: Article

References (28)

1. Ruggeri ZM. Platelets in atherothrombosis. Nat Med 2002;8:1227-1234
2. Gawaz M, Langer H, May AE. Platelets in inflammation and atherogenesis. J Clin Invest 2005;115:3378-3384
3. Siegel-Axel D, Daub K, Seizer P, Lindemann S, Gawaz M. Platelet lipoprotein interplay: trigger of foam cell formation and driver of atherosclerosis. Cardiovasc Res 2008;78:8-17
4. Akkerman JW. From low-density lipoprotein to platelet activation. Int J Biochem Cell Biol 2008;40:2374-2378
5. Stellos K, Sauter R, Fahrleitner M, Grimm J, Stakos D, Emschermann F, Panagiota V, Gnerlich S, Perk A, Schönberger T, Bigalke B, Langer HF, Gawaz M. Binding of oxidized low-density lipoprotein on circulating platelets is increased in patients with acute coronary syndromes and induces platelet adhesion to vascular wall in vivo-brief report. Arterioscler Thromb Vasc Biol 2012;32:2017-2020
6. Podrez EA, Byzova TV, Febbraio M, Salomon RG, Ma Y, Valiyaveettil M, Poliakov E, Sun M, Finton PJ, Curtis BR, Chen J, Zhang R, Silverstein RL, Hazen SL. Platelet CD36 links hyperlipidemia, oxidant stress and a prothrombotic phenotype. Nat Med 2007;13:1086-1095
7. Magwenzi S, Woodward C, Wraith KS, Aburima A, Raslan Z, Jones H, McNeil C, Wheatcroft S, Yuldasheva N, Febbriao M, Kearney M, Naseem KM. Oxidized LDL activates blood platelets through CD36/NOX2-mediated inhibition of the cGMP/protein kinase G signaling cascade. Blood 2015;125:2693-2703
8. Tsimikas S, Bergmark C, Beyer RW, Patel R, Pattison J, Miller E, Juliano J, Witztum JL. Temporal increases in plasma markers of oxidized low-density lipoprotein strongly reflect the presence of acute coronary syndromes. J Am Coll Cardiol 2003;41:360-370
9. Segev A, Strauss BH, Witztum JL, Lau HK, Tsimikas S. Relationship of a comprehensive panel of plasma oxidized low-density lipoprotein markers to angiographic restenosis in patients undergoing percutaneous coronary intervention for stable angina. Am Heart J 2005;150:1007-1014
10. Laaksonen R, Ekroos K, Sysi-Aho M, Hilvo M, Vihervaara T, Kauhanen D, Suoniemi M, Hurme R, Marz W, Scharnagl H, Stojakovic T, Vlachopoulou E, Lokki ML, Nieminen MS, Klingenberg R, Matter CM, Hornemann T, Jüni P, Rodondi N, Raber L, Windecker S, Gencer B, Pedersen ER, Tell GS, Nygard O, Mach F, Sinisalo J, Lüscher TF. Plasma ceramides predict cardiovascular death in patients with stable coronary artery disease and acute coronary syndromes beyond LDL-cholesterol. Eur Heart J 2016;37:1967-1976
11. Chatterjee M, von Ungern-Sternberg SN, Seizer P, Schlegel F, Büttcher M, Sindhu NA, Müller S, Mack A, Gawaz M. Platelet-derived CXCL12 regulates monocyte function, survival, differentiation into macrophages and foam cells through differential involvement of CXCR4-CXCR7. Cell Death Dis 2015;6:e1989
12. Weber C. Platelets and chemokines in atherosclerosis: partners in crime. Circ Res 2005;96:612-616
13. Chatterjee M, Gawaz M. Platelet-derived CXCL12 (SDF-1a): basic mechanisms and clinical implications. J Thromb Haemost 2013;11:1954-1967
14. Rath D, Chatterjee M, Borst O, Müller K, Stellos K, Mack AF, Bongartz A, Bigalke B, Langer H, Schwab M, Gawaz M, Geisler T. Expression of SDF-1 receptors CXCR4 and CXCR7 on circulating platelets from patients with acute coronary syndrome and its association with left ventricular functional recovery. Eur Heart J 2014;35:386-394
15. Li X, Zhu M, Penfold ME, Koenen RR, Thiemann A, Heyll K, Akhtar S, Koyadan S, Wu Z, Gremse F, Kiessling F, van Zandvoort M, Schall TJ, Weber C, Schober A. Activation of CXCR7 limits atherosclerosis and improves hyperlipidemia by increasing cholesterol uptake in adipose tissue. Circulation 2014;129:1244-1253
16. Tsugawa H, Cajka T, Kind T, Ma Y, Higgins B, Ikeda K, Kanazawa M, Vander Gheynst J, Fiehn O, Arita M. MS-DIAL: data-independent MS/MS deconvolution for comprehensive metabolome analysis. Nat Methods 2015;12:523-526
17. Chatterjee M, Seizer P, Borst O, Schönberger T, Mack A, Geisler T, Langer HF, May AE, Vogel S, Lang F, Gawaz M. SDF-1a induces differential trafficking of CXCR4-CXCR7 involving cyclophilin A, CXCR7 ubiquitination and promotes platelet survival. FASEB J 2014;28:2864-2878
18. Carnevale R, Bartimoccia S, Nocella C, Di Santo S, Loffredo L, Illuminati G, Lombardi E, Boz V, Del Ben M, De Marco L, Pignatelli P, Violi F. LDL oxidation by platelets propagates platelet activation via an oxidative stress-mediated mechanism. Atherosclerosis 2014;237:108-116
19. Zhang Y, Bilbao A, Bruderer T, Luban J, Strambio-De-Castillia C, Lisacek F, Hopfgartner G, Varesio E. The use of variable Q1 isolation windows improves selectivity in LC-SWATH-MS acquisition. J Proteome Res 2015;14:4359-4371
20. Salomon G. Structural identification and cardiovascular activities of oxidized phospholipids. Circ Res 2012;111:930-946
21. Shah SH, Sun JL, Stevens RD, Bain JR, Muehlbauer MJ, Pieper KS, Haynes C, Hauser ER, Kraus WE, Granger CB, Newgard CB, Califf RM, Newby LK. Baseline metabolomic profiles predict cardiovascular events in patients at risk for coronary artery disease. Am Heart J 2012;163:844-850.e1
22. Walsh TG, Harper MT, Poole AW. SDF-1a is a novel autocrine activator of platelets operating through its receptor CXCR4. Cell Signal 2015:27:37-46
23. Kraus MJ, Seifert J, Strasser EF, Gawaz M, Schaffer TE, Rheinlaender J. Comparative morphology analysis of live blood platelets using scanning ion conductance and robotic dark-field microscopy. Platelets 2016;27:541-546
24. Park JY, Lee SH, Shin MJ, Hwang GS. Alteration in metabolic signature and lipid metabolism in patients with angina pectoris and myocardial infarction. PLoS One 2015;10:e0135228
25. Vorkas PA, Isaac G, Holmgren A, Want EJ, Shockcor JP, Holmes E, Henein MY. Perturbations in fatty acid metabolism and apoptosis are manifested in calcific coronary artery disease: An exploratory lipidomic study. Int J Cardiol 2015;197:192-199
26. Slatter DA, Aldrovandi M, O'Connor A, Allen SM, Brasher CJ, Murphy RC, Mecklemann S, Ravi S, Darley-Usmar V, O'Donnell VB. Mapping the human platelet lipidome reveals cytosolic phospholipase A2 as a regulator of mitochondrial bioenergetics during activation. Cell Metab 2016;23:930-944
27. O'Donnell VB, Murphy RC, Watson SP. Platelet lipidomics. modern day perspective on lipid discovery and characterization in platelets. Circ Res 2014;114:1185-1203
28. Stellos K, Ruf M, Sopova K, Kilias A, Rahmann A, Stamatelopoulos K, Jorbenadze R, Geisler T, Gawaz M, Bigalke B. Plasma levels of stromal cell-derived factor-1 in patients with coronary artery disease: effect of clinical presentation and cardiovascular risk factors. Atherosclerosis 2011;219:913-916.