Genetic influences of β-adrenoceptor polymorphisms on arterial functional changes and cardiac remodeling in hypertensive patients

Hypertension Research

Volumn 29, Issue 11, 2006, Pages 875-881

  Yuan, Ming ^a,b   Ohishi, Mitsuru ^a   Ito, Norihisa ^a   Sugimoto, Ken ^a   Takagi, Takashi ^a   Terai, Minako ^a   Katsuya, Tomohiro ^a   Rakugi, Hiromi ^a   Wu, Zonggui ^b   Ogihara, Toshio ^a  

^a OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b SECOND MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

adrenoreceptor; Arterial stiffness; Hypertensive complications; Polymorphisms

Indexed keywords

ALPHA ADRENERGIC RECEPTOR BLOCKING AGENT; ANGIOTENSIN RECEPTOR ANTAGONIST; ANTIHYPERTENSIVE AGENT; ARGININE; BETA 1 ADRENERGIC RECEPTOR; BETA 2 ADRENERGIC RECEPTOR; BETA 3 ADRENERGIC RECEPTOR; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CALCIUM CHANNEL BLOCKING AGENT; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; DIURETIC AGENT; GENOMIC DNA; GLUTAMIC ACID; GLUTAMINE; GLYCERYL TRINITRATE; GLYCINE; SERINE; TRYPTOPHAN;

ADULT; AGED; AMINO ACID SUBSTITUTION; ARTERY DISEASE; ARTICLE; CARDIOMEGALY; CARDIOVASCULAR RISK; ECHOCARDIOGRAPHY; ELECTROCARDIOGRAPHY; ESSENTIAL HYPERTENSION; FEMALE; GENETIC ASSOCIATION; HEART LEFT VENTRICLE HYPERTROPHY; HEART VENTRICLE REMODELING; HUMAN; HYPEREMIA; MAJOR CLINICAL STUDY; MALE; OBSERVATIONAL STUDY; PATHOGENESIS; POLYMERASE CHAIN REACTION; PULSE WAVE; RISK FACTOR; SINGLE NUCLEOTIDE POLYMORPHISM; THORAX RADIOGRAPHY;

AGED; AMINO ACID SUBSTITUTION; CROSS-SECTIONAL STUDIES; FEMALE; HUMANS; HYPERTENSION; HYPERTROPHY, LEFT VENTRICULAR; JAPAN; MALE; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTORS, ADRENERGIC, BETA; RISK FACTORS; VASODILATION;

EID: 33846117517     PISSN: 09169636     EISSN: 13484214     Source Type: Journal    
DOI: 10.1291/hypres.29.875     Document Type: Article

References (36)

1. Walston J, Lowe A, Silver K, et al: The beta3-adrenergic receptor in the obesity and diabetes prone rhesus monkey is very similar to human and contains arginine at codon 64. Gene 1997; 188: 207-213.
2. Naga Prasad SV, Nienaber J, Rockman HA: Beta-adrenergic axis and heart disease. Trends Genet 2001; 17: S44-S49.
3. Johnson M: The beta-adrenoceptor. Am J Respir Crit Care Med 1998; 158: S146-S153.
4. Krum H: Sympathetic activation and the role of beta-blockers in chronic heart failure. Aust N Z J Med 1999; 29: 418-427.
5. Bohm M, Flesch M, Schnabel P: Beta-adrenergic signal transduction in the failing and hypertrophied myocardium. J Mol Med 1997; 75: 842-848.
6. Scarpace PJ, Tumer N, Mader SL: Beta-adrenergic function in aging. Basic mechanisms and clinical implications. Drugs Aging 1991; 1: 116-129.
7. Feldman RD: Adrenergic receptor polymorphisms and cardiac function (and dysfunction): a failure to communicate? Circulation 2001; 103: 1042-1043.
8. Dzimiri N: Regulation of beta-adrenoceptor signaling in cardiac function and disease. Pharmacol Rev 1999; 51: 465-501.
9. Diamond J, Phillips R: Hypertensive heart disease. Hypertens Res 2005; 28: 191-202.
10. Imanishi R, Seto S, Toda G, et al: High brachial-ankle pulse wave velocity is an independent predictor of the presence of coronary artery disease in men. Hypertens Res 2004; 27: 71-78.
11. Nitta K, Akiba T, Uchida K, et al: Left ventricular hypertrophy is associated with arterial stiffness and vascular calcification in hemodialysis patients. Hypertens Res 2004; 27: 47-52.
12. Erickson RP, Graves PE: Genetic variation in beta-adrenergic receptors and their relationship to susceptibility for asthma and therapeutic response. Drug Metab Dispos 2001; 29:557-561.
13. Johnson JA, Terra SG: Beta-adrenergic receptor polymorphisms: cardiovascular disease associations and pharmacogenetics. Pharm Res 2002; 19: 1779-1787.
14. Iwai C, Akita H, Kanazawa K, et al: Arg389Gly polymorphism of the human betal-adrenergic receptor in patients with nonfatal acute myocardial infarction. Am Heart J 2003; 146: 106-109.
15. Shioji K, Kokubo Y, Mannami T, et al: Association between hypertension and the α-adducin, β1-adrenoreceptor, and G-protein β3 subunit genes in the Japanese population; the Suita study. Hypertens Res 2004; 27: 31-37.
16. Svetkey LP, Timmons PZ, Emovon O, Anderson NB, Preis L, Chen YT: Association of hypertension with beta2- and alpha2c10-adrenergic receptor genotype. Hypertension 1996; 27: 1210-1215.
17. Fujisawa T, Ikegami H, Yamato E, et al: Association of Trp64Arg mutation of the beta3-adrenergic-receptor with NIDDM and body weight gain. Diabetologia 1996; 39: 349-352.
18. Fujisawa T, Ikegami H, Yamato E, et al: Trp64Arg mutation of beta3-adrenergic receptor in essential hypertension: insulin resistance and the adrenergic system. Am J Hypertens 1997; 10: 101-105.
19. Katsuya T, Baba S, Ishikawa K, et al: Epsilon 4 allele of apolipoprotein E gene associates with lower blood pressure in young Japanese subjects: the Suita Study. J Hypertens 2002; 20: 2017-2021.
20. Ranade K, Jorgenson E, Shen WH, et al: A polymorphism in the beta1 adrenergic receptor is associated with resting heart rate. Am J Hum Genet 2002; 70: 935-942.
21. Komai N, Ohishi M, Morishita R, et al: Serum hepatocyte growth factor concentration is correlated with the forearm vasodilator response in hypertensive patients. Am J Hypertens 2002; 15: 499-506.
22. Komai N, Ohishi M, Moriguchi A, et al: Low-dose doxazosin improved aortic stiffness and endothelial dysfunction as measured by noninvasive evaluation. Hypertens Res 2002; 25: 5-10.
23. Asmar R, Rudnichi A, Blacher J, London GM, Safar ME: Pulse pressure and aortic pulse wave are markers of cardiovascular risk in hypertensive populations. Am J Hypertens 2001; 14: 91-97.
24. Ouchi N, Ohishi M, Kihara S, et al: Association of hypoadiponectinemia with impaired vasoreactivity. Hypertension 2003; 43: 231-234.
25. Sokolow M, Lyon T: The ventricular complex in left ventricular hypertrophy as obtained by unipolar precordial and limb leads. Am Heart J 1949; 37: 161-186.
26. Devereux R, Alonso D, Lutas E, et al: Echocardiographic assessment of left ventricular hypertrophy: comparison to necropsy findings. Am J Cardiol 1986; 57: 450-458.
27. Bengtsson K, Melander O, Orho-Melander M, et al: Polymorphism in the β1-adrenergic receptor gene and hypertension. Circulation 2001; 104: 187-190.
28. Yoshida N, Nishimaki Y, Sugiyama M, et al: SNP genotyping in the β2-adrenergic receptor by electronic microchip assay, DHPLC, and direct sequencing. J Hum Genet 2002; 47: 500-503.
29. Chang TJ, Tsai MH, Jiang YD, et al: The Arg16Gly polymorphism of human beta2-adrenoreceptor is associated with type 2 diabetes in Taiwanese people. Clin Endocrinol (Oxf) 2002; 57: 685-690.
30. Okumura K, Matsui H, Ogawa Y, et al: The polymorphism of the beta3-adrenergic receptor gene is associated with reduced low-density lipoprotein particle size. Metabolism 2003; 52: 356-361.
31. Karlsson J, Lind L, Hallberg P, et al: Beta1adrenergic receptor gene polymorphisms and response to beta1adrenergic receptor blockade in patients with essential hypertension. Clin Cardiol 2004; 27: 347-350.
32. Mason DA, Moore JD, Green SA, Liggett SB: A gain-of-function polymorphism in a G-protein coupling domain of the human beta1-adrenergic receptor. J Biol Chem 1999; 274: 12670-12674.
33. Masuo K, Katsuya T, Kawaguchi H, et al: Rebound weight gain as associated with high plasma norepinephrine levels that are mediated through polymorphisms in the beta2-adrenoceptor. Am J Hypertens 2005; 18: 1508-1516.
34. Eisenach J, Schroeder D, Pike T, et al: Dietary sodium restriction and β2-adrenergic receptor polymorphism modulate cardiovascular function in humans. J Physiol 2006; 574: 955-965.
35. Hojlund K, Christiansen C, Bjornsbo K, et al: Energy expenditure, body composition and insulin response to glucose in male twins discordant for the Trp64Arg polymorphism of the beta3-adrenergic receptor gene. Diabetes Obes Metab 2006; 8: 322-330.
36. Kuusela T, Jartti T, Tahvanainen K, Kaila T: Effects of terbutaline on peripheral vascular resistance and arterial compliance. J Cardiovasc Pharmacol 2004; 44: 74-81.