Leukocyte Telomere Length and All-Cause, Cardiovascular Disease, and Cancer Mortality: Results from Individual-Participant-Data Meta-Analysis of 2 Large Prospective Cohort Studies

American Journal of Epidemiology

Volumn 185, Issue 12, 2017, Pages 1317-1326

  Mons, Ute ^a   Müezzinler, Aysel ^a,b   Schöttker, Ben ^a,b   Dieffenbach, Aida Karina ^a   Butterbach, Katja ^a   Schick, Matthias ^a   Peasey, Anne ^a   De Vivo, Immaculata ^c   Trichopoulou, Antonia ^d   Boffetta, Paolo ^e,f,h   Brenner, Hermann ^a,b,g  

^a GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^b UNIVERSITY OF HEIDELBERG   (Germany)

^c UNIVERSITY COLLEGE LONDON   (United Kingdom)

^d BRIGHAM AND WOMEN S HOSPITAL   (United States)

^e HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^f HELLENIC HEALTH FOUNDATION   (Greece)

^g UNIVERSITY OF ATHENS MEDICAL SCHOOL   (Greece)

^h MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

aging; all cause mortality; cancer mortality; cardiovascular disease mortality; cohort studies; leukocytes; telomere length

Indexed keywords

AGE STRUCTURE; AGING POPULATION; CANCER; CARDIOVASCULAR DISEASE; CELLS AND CELL COMPONENTS; CHROMOSOME; COHORT ANALYSIS; CONFIDENCE INTERVAL; HEALTH SURVEY; META-ANALYSIS; MORTALITY; PUBLIC HEALTH;

ADULT; BLOOD SAMPLING; CANCER MORTALITY; CARDIOVASCULAR DISEASE; CARDIOVASCULAR MORTALITY; COHORT ANALYSIS; FEMALE; FOLLOW UP; HUMAN; LEUKOCYTE; LEUKOCYTE TELOMERE LENGTH; MAJOR CLINICAL STUDY; MALE; META ANALYSIS (TOPIC); MIDDLE AGED; POLYMERASE CHAIN REACTION; PROSPECTIVE STUDY; QUANTITATIVE STUDY; REGISTERED NURSE; REVIEW; SYSTEMATIC REVIEW (TOPIC); TELOMERE LENGTH; UNITED STATES; AGE; AGED; CAUSE OF DEATH; EUROPE; META ANALYSIS; MORTALITY; NEOPLASM; PROPORTIONAL HAZARDS MODEL; TELOMERE; ULTRASTRUCTURE;

EUROPE; UNITED STATES;

ADULT; AGE FACTORS; AGED; CARDIOVASCULAR DISEASES; CAUSE OF DEATH; EUROPE; FEMALE; HUMANS; LEUKOCYTES; MALE; MIDDLE AGED; NEOPLASMS; PROPORTIONAL HAZARDS MODELS; PROSPECTIVE STUDIES; TELOMERE; UNITED STATES;

EID: 85021949906     PISSN: 00029262     EISSN: 14766256     Source Type: Journal    
DOI: 10.1093/aje/kww210     Document Type: Review

References (43)

1. Lansdorp PM, Verwoerd NP, van Rijke FM, et al. Heterogeneity in telomere length of human chromosomes. Hum Mol Genet. 1996;5(5):685-691
2. Martens UM, Zijlmans JM, Poon SS, et al. Short telomeres on human chromosome 17p. Nat Genet. 1998;18(1):76-80
3. Mather KA, Jorm AF, Parslow RA, et al. Is telomere length a biomarker of aging? A review. J Gerontol A Biol Sci Med Sci. 2011;66(2):202-213
4. Müezzinler A, Zaineddin AK, Brenner H. A systematic review of leukocyte telomere length and age in adults. Ageing Res Rev. 2013;12(2):509-519
5. Olovnikov AM. Principle of marginotomy in template synthesis of polynucleotides [in Russian]. Dokl Akad Nauk SSSR. 1971;201(6):1496-1499
6. Blackburn EH. Telomere states and cell fates. Nature. 2000; 408(6808):53-56
7. Brouilette S, Singh RK, Thompson JR, et al. White cell telomere length and risk of premature myocardial infarction. Arterioscler Thromb Vasc Biol. 2003;23(5):842-846
8. Farzaneh-Far R, Cawthon RM, Na B, et al. Prognostic value of leukocyte telomere length in patients with stable coronary artery disease: data from the Heart and Soul Study. Arterioscler Thromb Vasc Biol. 2008;28(7):1379-1384
9. Fitzpatrick AL, Kronmal RA, Gardner JP, et al. Leukocyte telomere length and cardiovascular disease in the Cardiovascular Health Study. Am J Epidemiol. 2007;165(1): 14-21
10. Weischer M, Bojesen SE, Cawthon RM, et al. Short telomere length, myocardial infarction, ischemic heart disease, and early death. Arterioscler Thromb Vasc Biol. 2012;32(3):822-829
11. Needham BL, Rehkopf D, Adler N, et al. Leukocyte telomere length and mortality in the National Health and Nutrition Examination Survey, 1999-2002. Epidemiology. 2015;26(4): 528-535
12. Svensson J, Karlsson MK, Ljunggren Ö, et al. Leukocyte telomere length is not associated with mortality in older men. Exp Gerontol. 2014;57:6-12
13. Fitzpatrick AL, Kronmal RA, Kimura M, et al. Leukocyte telomere length and mortality in the Cardiovascular Health Study. J Gerontol A Biol Sci Med Sci. 2011;66(4):421-429
14. Ma H, Zhou Z, Wei S, et al. Shortened telomere length is associated with increased risk of cancer: a meta-analysis. PLoS One. 2011;6(6):e20466
15. Prescott J, Wentzensen IM, Savage SA, et al. Epidemiologic evidence for a role of telomere dysfunction in cancer etiology. Mutat Res. 2012;730(1-2):75-84
16. Wentzensen IM, Mirabello L, Pfeiffer RM, et al. The association of telomere length and cancer: a meta-analysis. Cancer Epidemiol Biomarkers Prev. 2011;20(6):1238-1250
17. Willeit P, Willeit J, Kloss-Brandstätter A, et al. Fifteen-year follow-up of association between telomere length and incident cancer and cancer mortality. JAMA. 2011;306(1):42-44
18. Willeit P, Willeit J, Mayr A, et al. Telomere length and risk of incident cancer and cancer mortality. JAMA. 2010;304(1): 69-75
19. Fu X, Wan S, Hann HW, et al. Relative telomere length: a novel non-invasive biomarker for the risk of non-cirrhotic hepatocellular carcinoma in patients with chronic hepatitis B infection. Eur J Cancer. 2012;48(7):1014-1022
20. Han J, Qureshi AA, Prescott J, et al. A prospective study of telomere length and the risk of skin cancer. J Invest Dermatol. 2009;129(2):415-421
21. Lan Q, Cawthon R, Shen M, et al. A prospective study of telomere length measured by monochrome multiplex quantitative PCR and risk of non-Hodgkin lymphoma. Clin Cancer Res. 2009;15(23):7429-7433
22. Lynch SM, Major JM, Cawthon R, et al. A prospective analysis of telomere length and pancreatic cancer in the Alpha-Tocopherol, Beta-Carotene Cancer (ATBC) Prevention Study. Int J Cancer. 2013;133(11):2672-2680
23. Sanchez-Espiridion B, Chen M, Chang JY, et al. Telomere length in peripheral blood leukocytes and lung cancer risk: a large case-control study in Caucasians. Cancer Res. 2014; 74(9):2476-2486
24. Xie H, Wu X, Wang S, et al. Long telomeres in peripheral blood leukocytes are associated with an increased risk of soft tissue sarcoma. Cancer. 2013;119(10):1885-1891
25. Bendix L, Thinggaard M, Fenger M, et al. Longitudinal changes in leukocyte telomere length and mortality in humans. J Gerontol A Biol Sci Med Sci. 2014;69(2):231-239
26. Weischer M, Bojesen SE, Nordestgaard BG. Telomere shortening unrelated to smoking, body weight, physical activity, and alcohol intake: 4,576 general population individuals with repeat measurements 10 years apart. PLoS Genet. 2014;10(3):e1004191
27. Rode L, Nordestgaard BG, Bojesen SE. Peripheral blood leukocyte telomere length and mortality among 64,637 individuals from the general population. J Natl Cancer Inst. 2015;107(6):djv074
28. Boffetta P, Bobak M, Borsch-Supan A, et al. The Consortium on Health and Ageing: Network of Cohorts in Europe and the United States (CHANCES) project-design, population and data harmonization of a large-scale, international study. Eur J Epidemiol. 2014;29(12):929-936
29. Prescott J, DuM,Wong JY, et al. Paternal age at birth is associated with offspring leukocyte telomere length in the Nurses' Health Study. Hum Reprod. 2012;27(12): 3622-3631
30. Cawthon RM. Telomere measurement by quantitative PCR. Nucleic Acids Res. 2002;30(10):e47
31. Figueroa R, Lindenmaier H, Hergenhahn M, et al. Telomere erosion varies during in vitro aging of normal human fibroblasts from young and adult donors. Cancer Res. 2000; 60(11):2770-2774
32. Kimura M, Hjelmborg JV, Gardner JP, et al. Telomere length and mortality: a study of leukocytes in elderly Danish twins. Am J Epidemiol. 2008;167(7):799-806
33. Rehm J, Room R, Monteiro M, et al. Alcohol use. In: Ezzati M, Lopez AD, Rodgers A, et al., eds. Comparative Quantification of Health Risks: Global and Regional Burden of Disease Attribution to Selected Major Risk Factors. Geneva, Switzerland: World Health Organization; 2004: 959-1108
34. Normand SL. Meta-analysis: formulating, evaluating, combining, and reporting. Stat Med. 1999;18(3):321-359
35. Schwarzer G. Package 'meta': General Package for Meta-Analysis. Version 4.8-1. https://cran.r-project.org/web/ packages/meta/meta.pdf. Published March 17, 2015. Accessed April 11, 2017
36. Cassidy A, De Vivo I, Liu Y, et al. Associations between diet, lifestyle factors, and telomere length in women. Am J Clin Nutr. 2010;91(5):1273-1280
37. Müezzinler A, Mons U, Dieffenbach AK, et al. Smoking habits and leukocyte telomere length dynamics among older adults: results from the ESTHER cohort. Exp Gerontol. 2015;70: 18-25
38. Müezzinler A, Zaineddin AK, Brenner H. Body mass index and leukocyte telomere length in adults: a systematic review and meta-analysis. Obes Rev. 2014;15(3):192-201
39. Zhu H, Wang X, Gutin B, et al. Leukocyte telomere length in healthy Caucasian and African-American adolescents: relationships with race, sex, adiposity, adipokines, and physical activity. J Pediatr. 2011;158(2):215-220
40. von Zglinicki T. Role of oxidative stress in telomere length regulation and replicative senescence. Ann NY Acad Sci. 2000; 908:99-110
41. Cawthon RM, Smith KR, O'Brien E, et al. Association between telomere length in blood and mortality in people aged 60 years or older. Lancet. 2003;361(9355):393-395
42. Ehrlenbach S, Willeit P, Kiechl S, et al. Influences on the reduction of relative telomere length over 10 years in the population-based Bruneck Study: introduction of a well-controlled high-throughput assay. Int J Epidemiol. 2009; 38(6):1725-1734
43. Carty CL, Kooperberg C, Liu J, et al. Leukocyte telomere length and risks of incident coronary heart disease and mortality in a racially diverse population of postmenopausal women. Arterioscler Thromb Vasc Biol. 2015;35(10): 2225-2231