The Early Adaptive Immune Response in the Pathophysiological Process of Pneumococcal Meningitis

Journal of Infectious Diseases

Volumn 215, Issue 1, 2017, Pages 150-158

  Ribes, Sandra ^a   Nessler, Stefan ^a   Heide, Ev Christin ^a   Malzahn, Dörthe ^a   Perske, Christina ^a   Brück, Wolfgang ^a   Nau, Roland ^a,b  

^a UNIVERSITY MEDICAL CENTER GÖTTINGEN   (Germany)

^b Sleep Laboratory   (Germany)

Author keywords

B cell; CD4+ T cell; Granulocyte; IL 1 ; Inflammatory response; Meningitis; Microglia; Natural killer T (NKT) cell; S. pneumoniae; T cell

Indexed keywords

CHEMOKINE; CXCL1 CHEMOKINE; CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 1BETA; RANTES; TUMOR NECROSIS FACTOR;

ADAPTIVE IMMUNITY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBIOTIC THERAPY; ANTIRETROVIRAL THERAPY; B LYMPHOCYTE; BACTERIAL CLEARANCE; BACTERIOLOGY; CELL PROLIFERATION; CLINICAL OUTCOME; COLONY FORMING UNIT; CONFERENCE PAPER; CONTROLLED STUDY; DISEASE EXACERBATION; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; GAMMA DELTA T LYMPHOCYTE; GRANULOCYTE; HISTOLOGY; IMMUNE RESPONSE; IMMUNOCOMPROMISED PATIENT; INFANT; INFLAMMATION; LIVER INJURY; LYMPHOCYTE FUNCTION; MENINGITIS; MICROGLIA; MICROSCOPY; MORTALITY RATE; MOUSE; NATURAL KILLER T CELL; NONHUMAN; PATHOGENESIS; PATHOPHYSIOLOGY; PNEUMOCOCCAL INFECTION; PNEUMOCOCCAL MENINGITIS; SURVIVAL TIME; T LYMPHOCYTE; ANIMAL; BIOSYNTHESIS; BRAIN; C57BL MOUSE; IMMUNOLOGY; KNOCKOUT MOUSE; MICROBIOLOGY; NATURAL KILLER CELL; SPLEEN; STREPTOCOCCUS PNEUMONIAE; ULTRASTRUCTURE;

ADAPTIVE IMMUNITY; ANIMALS; B-LYMPHOCYTES; BRAIN; CYTOKINES; INTERLEUKIN-1BETA; KILLER CELLS, NATURAL; MENINGITIS, PNEUMOCOCCAL; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICROGLIA; SPLEEN; STREPTOCOCCUS PNEUMONIAE; T-LYMPHOCYTES;

EID: 85021857545     PISSN: 00221899     EISSN: 15376613     Source Type: Journal    
DOI: 10.1093/INFDIS/JIW517     Document Type: Conference Paper

References (45)

1. Weisfelt M, van de Beek D, Spanjaard L, Reitsma JB, de Gans J. Clinical features, complications, and outcome in adults with pneumococcal meningitis: a prospective case series. Lancet Neurol 2006; 5:123–9.
2. Nau R, Soto A, Bruck W. Apoptosis of neurons in the dentate gyrus in humans suffering from bacterial meningitis. J Neuropathol Exp Neurol 1999; 58:265–74.
3. Nau R, Bruck W. Neuronal injury in bacterial meningitis: mechanisms and implications for therapy. Trends Neurosci 2002; 25:38–45.
4. Mariani MM, Kielian T. Microglia in infectious diseases of the central nervous system. J Neuroimmune Pharmacol 2009; 4:448–61.
5. Koedel U, Scheld WM, Pfister HW. Pathogenesis and pathophysiology of pneumococcal meningitis. Lancet Infect Dis 2002; 2:721–36.
6. Klein M, Obermaier B, Angele B, et al. Innate immunity to pneumococcal infection of the central nervous system depends on Toll-like receptor (TLR) 2 and TLR4. J Infect Dis 2008; 198:1028–36.
7. Mildner A, Djukic M, Garbe D, et al. Ly-6G+CCR2− myeloid cells rather than Ly-6ChighCCR2+ monocytes are required for the control of bacterial infection in the central nervous system. J Immunol 2008; 181:2713–22.
8. Alkhater SA. Approach to the child with recurrent infections. J Family Community Med 2009; 16:77–82.
9. Jordano Q, Falco V, Almirante B, et al. Invasive pneumococcal disease in patients infected with HIV: still a threat in the era of highly active antiretroviral therapy. Clin Infect Dis 2004; 38:1623–8.
10. Siemieniuk RA, Gregson DB, Gill MJ. The persisting burden of invasive pneumococcal disease in HIV patients: an observational cohort study. BMC Infect Dis 2011; 11:314.
11. Schatz DG, Oettinger MA, Baltimore D. The V(D)J recombination activating gene, RAG-1. Cell 1989; 59:1035–48.
12. Mombaerts P. Lymphocyte development and function in T-cell receptor and RAG-1 mutant mice. Int Rev Immunol 1995; 13:43–63.
13. Gerber J, Raivich G, Wellmer A, et al. A mouse model of Streptococcus pneumoniae meningitis mimicking several features of human disease. Acta Neuropathol 2001; 101:499–508.
14. Ribes S, Regen T, Meister T, et al. Resistance of the brain to Escherichia coli K1 infection depends on MyD88 signaling and the contribution of neutrophils and monocytes. Infect Immun 2013; 81:1810–9.
15. Hu W, Nessler S, Hemmer B, et al. Pharmacological prion protein silencing accelerates central nervous system autoimmune disease via T cell receptor signalling. Brain 2010; 133:375–88.
16. Malzahn D, Schillert A, Müller M, Bickeböller H. The longitudinal nonparametric test as a new tool to explore gene-gene and gene-time effects in cohorts. Genet Epidemiol 2010; 34:469–78.
17. Coutinho LG, Grandgirard D, Leib SL, Agnez-Lima LF. Cerebrospinal-fluid cytokine and chemokine profile in patients with pneumococcal and meningococcal meningitis. BMC Infect Dis 2013; 13:326.
18. Jaerve A, Muller HW. Chemokines in CNS injury and repair. Cell Tissue Res 2012; 349:229–48.
19. Ribes S, Abdullah MR, Saleh M, et al. Thioredoxins and methionine sulfoxide reductases in the pathophysiology of pneumococcal meningitis. J Infect Dis 2016; 214:953–61.
20. Ito D, Imai Y, Ohsawa K, Nakajima K, Fukuuchi Y, Kohsaka S. Microglia-specific localisation of a novel calcium binding protein, Iba1. Brain Res Mol Brain Res 1998; 57:1–9.
21. Karperien A, Ahammer H, Jelinek HF. Quantitating the subtleties of microglial morphology with fractal analysis. Front Cell Neurosci 2013; 7:3.
22. Yan J, Li S, Li S. The role of the liver in sepsis. Int Rev Immunol 2014; 33: 498–510.
23. Smith CJ, Emge JR, Berzins K, et al. Probiotics normalize the gut-brain-microbiota axis in immunodeficient mice. Am J Physiol Gastrointest Liver Physiol 2014; 307: G793–802.
24. Wilson EH, Weninger W, Hunter CA. Trafficking of immune cells in the central nervous system. J Clin Invest 2010; 120:1368–79.
25. Wolf SA, Steiner B, Akpinarli A, et al. CD4-positive T lymphocytes provide a neuroimmunological link in the control of adult hippocampal neurogenesis. J Immunol 2009; 182:3979–84.
26. Caccamo N, La Mendola C, Orlando V, et al. Differentiation, phenotype, and function of interleukin-17-producing human Vγ9Vδ2 T cells. Blood 2011; 118:129–38.
27. Raziuddin S, Mir NA, el-Awad Me-H, et al. Gamma delta T lymphocytes and proinflammatory cytokines in bacterial meningitis. J Allergy Clin Immunol 1994; 93:793–8.
28. Hoffmann O, Rung O, Held J, et al. Lymphocytes modulate innate immune responses and neuronal damage in experimental meningitis. Infect Immun 2015; 83:259–67.
29. Tunkel AR, Hartman BJ, Kaplan SL, et al. Practice guidelines for the management of bacterial meningitis. Clin Infect Dis 2004; 39:1267–84.
30. Ivanov S, Paget C, Trottein F. Role of non-conventional T lymphocytes in respiratory infections: the case of the pneumococcus. PLoS Pathog 2014; 10: e1004300.
31. Kawakami K, Yamamoto N, Kinjo Y, et al. Critical role of Valpha14+ natural killer T cells in the innate phase of host protection against Streptococcus pneumoniae infection. Eur J Immunol 2003; 33:3322–30.
32. Kadioglu A, Coward W, Colston MJ, Hewitt CR, Andrew PW. CD4-T-lymphocyte interactions with pneumolysin and pneumococci suggest a crucial protective role in the host response to pneumococcal infection. Infect Immun 2004; 72:2689–97.
33. LeMessurier K, Häcker H, Tuomanen E, Redecke V. Inhibition of T cells provides protection against early invasive pneumococcal disease. Infect Immun 2010; 78:5287–94.
34. Weber SE, Tian H, Pirofski LA. CD8+ cells enhance resistance to pulmonary serotype 3 Streptococcus pneumoniae infection in mice. J Immunol 2011; 186:432–42.
35. Kloss CU, Kreutzberg GW, Raivich G. Proliferation of ramified microglia on an astrocyte monolayer: characterization of stimulatory and inhibitory cytokines. J Neurosci Res 1997; 49:248–54.
36. Sutton CE, Lalor SJ, Sweeney CM, et al. Interleukin-1 and IL-23 induce innate IL-17 production from gammadelta T cells, amplifying Th17 responses and autoimmunity. Immunity 2009; 31:331–41.
37. Netea MG, Simon A, van de Veerdonk F, et al. IL-1beta processing in host defense: beyond the inflammasomes. PLoS Pathog 2010; 6:e1000661.
38. Ernst JD, Decazes JM, Sande MA. Experimental pneumococcal meningitis: role of leukocytes in pathogenesis. Infect Immun 1983; 41:275–9.
39. Brandt CT, Lundgren JD, Frimodt-Moller N, et al. Blocking of leukocyte accumulation in the cerebrospinal fluid augments bacteremia and increases lethality in experimental pneumococcal meningitis. J Neuroimmunol 2005; 166:126–31.
40. Kirby AC, Newton DJ, Carding SR, Kaye PM. Evidence for the involvement of lung-specific gammadelta T cell subsets in local responses to Streptococcus pneumoniae infection. Eur J Immunol 2007; 37:3404–13.
41. Chiavolini D, Pozzi G, Ricci S. Animal models of Streptococcus pneumoniae disease. Clin Microbiol Rev 2008; 21:666–85.
42. Saha SK, Naheed A, El Arifeen S, et al. Surveillance for invasive Streptococcus pneumoniae disease among hospitalized children in Bangladesh: antimicrobial susceptibility and serotype distribution. Clin Infect Dis 2009; 48(suppl 2):S75–81.
43. Saha SK, Al Emran HM, Hossain B, et al. Streptococcus pneumoniae serotype-2 childhood meningitis in Bangladesh: a newly recognized pneumococcal infection threat. PLoS One 2012; 7:e32134.
44. Pauza CD, Poonia B, Li H, Cairo C, Chaudhry S. Gammadelta T cells in HIV disease: past, present, and future. Front Immunol 2014; 5:687.
45. Andreu-Ballester JC, Tormo-Calandín C, Garcia-Ballesteros C, et al. Association of γδ T cells with disease severity and mortality in septic patients. Clin Vaccine Immunol 2013; 20:738–46.