Studies on the antidiabetic activities of Momordica charantia fruit juice in streptozotocin-induced diabetic rats

Pharmaceutical Biology

Volumn 55, Issue 1, 2017, Pages 758-765

  Mahmoud, Mona Fouad ^a   El Ashry, Fatma El Zahraa Z ^a   El Maraghy, Nabila N ^a,b   Fahmy, Ahmed ^a  

^a Zagazig University   (Egypt)

^b Future University in Egypt   (Egypt)

Author keywords

Diabetes; Diaphragm; Insulin resistance

Indexed keywords

CHOLESTEROL; FRUCTOSAMINE; GLUCOSE; GLUTATHIONE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INSULIN; MALONALDEHYDE; MOMORDICA CHARANTIA EXTRACT; STREPTOZOCIN; TRIACYLGLYCEROL; ANTIDIABETIC AGENT; ANTIOXIDANT; PLANT EXTRACT;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIDIABETIC ACTIVITY; ARTICLE; CONTROLLED STUDY; DIAPHRAGM; GLUCOSE BLOOD LEVEL; GLUCOSE TRANSPORT; IN VITRO STUDY; IN VIVO STUDY; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; MALE; NONHUMAN; PANCREAS; PANCREAS ISLET CELL FUNCTION; RAT; STREPTOZOTOCIN-INDUCED DIABETES MELLITUS; ANIMAL; DIABETES MELLITUS, EXPERIMENTAL; FRUIT AND VEGETABLE JUICE; METABOLISM; MOMORDICA CHARANTIA; PATHOLOGY;

ANIMALS; ANTIOXIDANTS; DIABETES MELLITUS, EXPERIMENTAL; FRUIT AND VEGETABLE JUICES; HYPOGLYCEMIC AGENTS; MALE; MOMORDICA CHARANTIA; PANCREAS; PLANT EXTRACTS; RATS; STREPTOZOCIN;

EID: 85021851927     PISSN: 13880209     EISSN: 17445116     Source Type: Journal    
DOI: 10.1080/13880209.2016.1275026     Document Type: Article

References (46)

1. Ahmed I, Adeghate E, Sharma AK, Pallot DJ, Singh J. 1998. Effects of Momordica charantia fruit juice on islet morphology in the pancreas of the streptozotocin-diabetic rat. Diabetes Res Clin Pract. 40:145-151.
2. Ahmed I, Adeghate E, Cummings E, Sharma AK, Singh J. 2004. Beneficial effects and mechanism of action of Momordica charantia juice in the treatment of streptozotocin-induced diabetes mellitus in rat. Mol Cell Biochem. 261:63-70.
3. Armbruster DA. 1987. Fructosamine: structure, analysis, and clinical usefulness. Clin Chem. 33:2153-2163.
4. Beutler E, Dubon O, Kelly BM. 1963. Improved method for the determination of blood glutathione. J Lab Clin Med. 61:882-890.
5. Centers for Disease Control and Prevention. National diabetes fact sheet. 2007. General information and national estimates on diabetes in the United States, Atlanta, GA: U.S. Department of Health and Human Services.
6. Chaturvedi P. 2009. Bitter melon protects against lipid peroxidation caused by immobilization stress in albino rats. Int J Vitam Nutr Res. 79: 48-56.
7. Chen Q, Chan LL, Li ET. 2003. Bitter melon (Momordica charantia) reduces adiposity, lowers serum insulin and normalizes glucose tolerance in rats fed a high fat diet. J Nutr. 133:1088-1093.
8. Cummings E, Hundal HS, Wackerhage H, Hope M, Belle M, Adeghate E, Singh J. 2004. Momordica charantia fruit juice stimulates glucose and amino acid uptakes in L6 myotubes. Mol Cell Biochem. 261:99-104.
9. Day C, Cartwright T, Provost J, Bailey CJ. 1990. Hypoglycaemic effect of Momordica charantia extracts. Planta Med. 56:426-429.
10. Dhar P, Chattopadhyay K, Bhattacharyya D, Roychoudhury A, Biswas A, Ghosh S. 2006. Antioxidative effect of conjugated linolenic acid in diabetic and non-diabetic blood: an in vitro study. J Oleo Sci. 56:19-24.
11. Feldman H, Roadbard D. 1971. Mathematical theory of radioimmunoassay. In: Odell WD, Doughaday WH, editors, Principles of Competitive Protein-Binding Assays. Philadelphia: J.B. Lippincott Company. 158-203.
12. Fernandes NP, Lagishetty CV, Panda VS, Naik SR. 2007. An experimental evaluation of the antidiabetic and antilipidemic properties of a standardized Momordica charantia fruit extracts. BMC Complement Altern Med. 24:7-29.
13. Garau C, Cummings E, Phoenix DA, Singh J. 2003. Beneficial effect and mechanism of action of Momordica charantia in the treatment of diabetes mellitus: a mini review. Int J Diabetes Metab. 11:46-55.
14. Ghosh R, Sharatchandra KH, Rita S, Thokchom IS. 2004. Hypoglycemic activity of Ficus hispida (bark) in normal and diabetic albino rats. Indian J Pharmacol. 36:222-225.
15. Grodsky GM, Epstein GH, Fanska R, Karam JH. 1977. Pancreatic action of the sulfonylureas. Fed Proc. 36:1714-1719.
16. Hellman B, Lernmark A, Sehlin J, Taljedal IB. 1973. Pancreatic β-cell recognition of insulin secretagogues. Inhibitory effects of a membrane probe on the islet uptake and insulin-releasing action of glibenclamide. FEBS Lett. 34:347-349.
17. Joseph B, Jini D. 2013. Antidiabetic effects of Momordica charantia (bitter melon) and its medicinal potency. Asian Pacific J Trop Dis. 3:93-102.
18. Karunanayake EH, Tennekoon KH. 1993. Search of novel hypoglycemic agents from medicinal plants. In: Diabetes Mellitus and Its Complications, A.K. Sharma, editor. New Delhi, India: Macmillan India Ltd. p. 192-205.
19. Koebnick C, Garcia AL, Dagnelie PC, Strassner C, Lindeman J, Katz N, Leitzmann C, Hoffmann I. 2005. Long-term consumption of a raw food diet is associated with favorable serum LDL cholesterol and triglycerides but also with elevated plasma homocysteine and low serum HDL cholesterol in humans. J Nutr. 135:2372-2378.
20. Koracevic D, Koracevic G, Djordjevic G, Andrejevic S, Cosic V. 2001. Method for the measurement of antioxidant activity in human fluids. J Clin Pathol. 54:356-361.
21. Kumar DS, Sharathnath KV, Yogeswaran P, Harani A, Sudhakar K, Sudha P, Banji D. 2010. A medicinal potency of Momordica charantia. Int J Pharma Sci Rev Res. 1:018.
22. Matsui S, Yamane T, Takita T, Oishi Y, Kobayashi-Hattori K. 2013. The hypocholesterolemic activity of Momordica charantia fruit is mediated by the altered cholesterol- and bile acid-regulating gene expression in rat liver. Nutr Res. 33:580-585.
23. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. 1985. Homeostasis model assessment: insulin resistance and B-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia. 28:412-419.
24. Miura T, Itoh C, Iwamoto N, Kato M, Kawai M, Park SR, Suzuki I. 2001. Hypoglycemic activity of the fruit of the Momordica charantia in type 2 diabetic mice. J Nutr Sci Vitaminol. 47:340-344. (Tokyo)
25. Nerurkar VR. 2005. Microsomal triglyceride transfer protein gene expression and ApoB secretion are inhibited by bitter melon in HepG2 cells. J Nutr. 135:702-706.
26. Ng TB, Wong CM, Li WW, Yeung HW. 1986. Insulin-like molecules in Momordica charantia seeds. J Ethnopharmacol. 15:107-117.
27. Ohkawa H, Ohishi N, Yagi K. 1979. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem. 95:351-358.
28. Palaian AK, Chhetri M, Prabhu S, Rajan SP. 2005. Role of pharmacist in counseling diabetes patients. Internet J Pharmacol. 4:1-13.
29. Petlevski R, Hadzija M, Slijepcevic M, Juretic D. 2000. Effect of ‘antidiabetis’ herbal preparation on serum glucose and fructosamine in NOD mice. J Ethnopharmacol. 75:181-184.
30. Rang HP, Dale MM. 1991 The endocrine system. In: Pharmacology, 2nd ed. Harlow: Longman. Group Ltd. 6. p. 504-508
31. Rotshteyn Y, Zito SW. 2004. Application of modified in vitro screening procedure for identifying herbals possessing sulfonylurea-like activity. J Ethnopharmacol. 9:337-344.
32. Sarkar S, Pranava M, Marita R. 1996. Demonstration of the hypoglycemic action of Momordica charantia in a validated animal model of diabetes. Pharmacol Res. 33:1-4.
33. Sathishsekar D, Subramanian S. 2005. Beneficial effects of Momordica charantia seeds in the treatment of STZ-induced diabetes in experimental rats. Biol Pharm Bull. 28:978-983.
34. Schemer S. 1967. The blood morphology of laboratory animals, 3rd ed. Philadephia, USA: Davis-FA Company; 42.
35. Sharma AK, Ahmed I, Tadayyon M, Ponery AS, Aloamaka P, Absood G, Pallot DJ. 1995. The beneficial effects of Momordica charantia fruit juice on streptozotocin induced diabetes and hypertension in rats. Int J Diabetes. 4:29-38.
36. Shibib BA, Khan LA, Rahman R. 1993. Hypoglycaemic activity of Coccinia indica and Momordica charantia in diabetic rats: depression of the hepatic gluconeogenetic enzymes glucose-6-phosphatase and fructose-1,6-biphosphatase and elevation of both liver and red cell shunt enzyme glucose-6-phosphate dehydrogenase. Biochem J. 292:267-270.
37. Sitasawad SL, Shewade Y, Bhonde R. 2000. Role of bitter gourd fruit juice in STZ-induced diabetic state in vivo and in vitro. J Ethnopharmacol. 73:7-79.
38. Snedecor GW, Cochran WG. 1967 Statistical Methods. Ames, IA: Iowa State University Press, 6th ed, 593 pp.
39. Srivastava Y, Venkatakrishna-Bhatt H, Verma Y, Venkaiah K. 1993. Antidiabetic and adaptogenic properties of Momordica charantia extract: An experimental and clinical evaluation. Phytother Res. 7:285-289.
40. Tikkanen T, Tikkanen I, Rockell MD, Allen TJ, Johnston CI, Cooper ME, Burrell LM. 1998. Dual inhibition of neutral endopeptidase and angiotensin-converting enzyme in rats with hypertension and diabetes mellitus. Hypertension. 32:778-785.
41. Tiwari AK. 2007. A promising antidiabetic vegetable. Curr Sci. 92:12.
42. Virdi J, Sivakami S, Shahani S, Suthar AC, Banavalikar MM, Byanim MK. 2003. Antihyperglycemic effects of three extracts from Momordica charantia. J Ethnopharmacol. 88:107-111.
43. Wahren Ekberg K. 2007. Splanchnic regulation of glucose production. Annu Rev Nutr. 27:329-345.
44. Wong CM, Yeung HW, Ng TB. 1985. Screening of Trichosanthes kirilowii, Momordica charantia and Cucurbita maxima (family Cucurbitaceae) for compounds with antilipolytic activity. J Ethnopharmacol. 13:313-321.
45. Yadav UC, Moorthy K, Baquer NZ. 2005. Combined treatment of sodium orthovanadate and Momordica charantia fruit extract prevents alterations in lipid profile and lipogenic enzymes in alloxan diabetic rats. Mol Cell Biochem. 26:111-120.
46. Yibchok-Anun S, Adisakwattana S, Yao CY, Sangvanich P, Roengsumran S, Hsu WH. 2006. Slow acting protein extract from fruit pulp of Momordica charantia with insulin secretagogue and insulinomimetic activities. Biol Pharm Bull. 29:1126-1131.