The hypocholesterolemic activity of Momordica charantia fruit is mediated by the altered cholesterol- and bile acid-regulating gene expression in rat liver

Nutrition Research

Volumn 33, Issue 7, 2013, Pages 580-585

  Matsui, Sho ^a   Yamane, Takumi ^a   Takita, Toshichika ^a   Oishi, Yuichi ^a   Kobayashi Hattori, Kazuo ^a  

^a TOKYO UNIVERSITY OF AGRICULTURE   (Japan)

Author keywords

Bile acids; Bitter gourd fruit; Cholesterol; Cholesterol 7 hydroxylase; Rat; Small heterodimer partner

Indexed keywords

BILE ACID; CHOLESTEROL; CHOLESTEROL 7ALPHA MONOOXYGENASE; FARNESOID X RECEPTOR; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LIVER RECEPTOR HOMOLOG 1; LOW DENSITY LIPOPROTEIN CHOLESTEROL; MESSENGER RNA; PROTEIN TYROSINE PHOSPHATASE SHP; REGULATOR PROTEIN; SMALL HETERODIMER PARTNER; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BILE ACID METABOLISM; CHOLESTEROL BLOOD LEVEL; CHOLESTEROL DIET; CONTROLLED STUDY; DOWN REGULATION; GENE EXPRESSION; MALE; MOMORDICA CHARANTIA; MOUSE; NONHUMAN; PRIORITY JOURNAL; UPREGULATION;

ABCG5; ABCG8; ATP-BINDING CASSETTE SUBFAMILY G MEMBER 5; ATP-BINDING CASSETTE SUBFAMILY G MEMBER 8; BGF; BILE ACIDS; BITTER GOURD FRUIT; CHOLESTEROL; CHOLESTEROL 7Α-HYDROXYLASE; CHOLESTEROL-7Α-HYDROXYLASE; CYP7A1; FARNESOID X RECEPTOR; FXR; HC; HDL-C; HIGH CHOLESTEROL; HIGH-DENSITY LIPOPROTEIN CHOLESTEROL; HMGR; HYDROXYMETHYLGLUTARYL-COENZYME A REDUCTASE; LDL-C; LIVER RECEPTOR HOMOLOGUE-1; LIVER X RECEPTOR Α; LOW-DENSITY LIPOPROTEIN CHOLESTEROL; LRH-1; LXRΑ; MESSENGER RNA; MRNA; NF; NORMAL FAT; PCR; POLYMERASE CHAIN REACTION; RAT; SHP; SMALL HETERODIMER PARTNER; TBA; TC; TOTAL BILE ACID; TOTAL CHOLESTEROL;

ANIMALS; ANTICHOLESTEREMIC AGENTS; BILE ACIDS AND SALTS; CHOLESTEROL; FECES; FRUIT; GENE EXPRESSION; GENE EXPRESSION REGULATION; HYPERCHOLESTEROLEMIA; INTESTINAL ABSORPTION; LIVER; MALE; MOMORDICA CHARANTIA; PHYTOTHERAPY; PLANT PREPARATIONS; RATS; RATS, WISTAR; RNA, MESSENGER;

MOMORDICA CHARANTIA; RATTUS; RATTUS NORVEGICUS;

EID: 84879889072     PISSN: 02715317     EISSN: 18790739     Source Type: Journal    
DOI: 10.1016/j.nutres.2013.05.002     Document Type: Article

References (23)

1. Guilbert J.J. The World Health Report 2002-reducing risks, promoting healthy life. Educ Health (Abingdon) 2003, 16:230.
2. Teramoto T., Sasaki J., Ueshima H., Egusa G., Kinoshita M., Shimamoto K., et al. Executive summary of Japan Atherosclerosis Society (JAS) guideline for diagnosis and prevention of atherosclerotic cardiovascular diseases for Japanese. J Atheroscler Thromb 2007, 14:45-50.
3. Yusuf S., Anand S. Cost of prevention. The case of lipid lowering. Circulation 1996, 93:1774-1776.
4. Chen Z.Y., Jiao R., Ma K.Y. Cholesterol-lowering nutraceuticals and functional foods. J Agric Food Chem 2008, 56:8761-8773.
5. Jayasooriya A.P., Sakono M., Yukizaki C., Kawano M., Yamamoto K., Fukuda N. Effects of Momordica charantia powder on serum glucose levels and various lipid parameters in rats fed with cholesterol-free and cholesterol-enriched diets. J Ethnopharmacol 2000, 72:331-336.
6. Ahmed I., Lakhani M.S., Gillett M., John A., Raza H. Hypotriglyceridemic and hypocholesterolemic effects of anti-diabetic Momordica charantia (Karela) fruit extract in streptozotocin-induced diabetic rats. Diabetes Res Clin Pract 2001, 51:155-161.
7. Keller A.C., Ma J., Kavalier A., He K., Brillantes A.M., Kennelly E.J. Saponins from the traditional medicinal plant Momordica charantia stimulate insulin secretion in vitro. Phytomedicine 2011, 19:32-37.
8. Pandak W.M., Schwarz C., Hylemon P.B., Mallonee D., Valerie K., Heuman D.M., et al. Effects of CYP7A1 overexpression on cholesterol and bile acid homeostasis. Am J Physiol Gastrointest Liver Physiol 2001, 281:878-889.
9. Sievanen E. Exploitation of bile acid transport systems in prodrug design. Molecules 2007, 12:1859-1889.
10. Gupta S., Pandak W.M., Hylemon P.B. LXRα is the dominant regulator of CYP7A1 transcription. Biochem Biophys Res Commun 2002, 293:338-343.
11. Goodwin B., Jones S.A., Price R.R., Watson M.A., McKee D.D., Moore L.B., et al. A regulatory cascade of the nuclear receptors FXR, SHP-1, and LRH-1 represses bile acid biosynthesis. Mol Cell 2000, 6:517-526.
12. American Institute of Nutrition Report of the American Institute of Nutrition ad hoc committee on standards for nutritional studies. J Nutr 1977, 107:1340-1348.
13. Udagawa H., Kitaoka C., Sakamoto T., Kobayashi-Hattori K., Oishi Y., Arai S., et al. Increase of serum cholesterol levels by heat-moisture-treated high-amylose cornstarch in rats fed a high-cholesterol diet. Lipids 2008, 43:695-702.
14. Folch J., Lees M., Sloane S.G.H. A simple method for the isolation and purification of total lipids from animal tissues. J Biol Chem 1957, 226:497-509.
15. Onoyama I., Suzuki A., Matsumoto A., Tomita K., Katagiri H., Oike Y., et al. Fbxw7 regulates lipid metabolism and cell fate decisions in the mouse liver. J Clin Invest 2011, 121:342-354.
16. Chomczynski P., Sacchi N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 1987, 162:156-159.
17. Yamane T., Kobayashi-Hattori K., Oishi Y., Takita T. High-fat diet reduces levels of type I tropocollagen and hyaluronan in rat skin. Mol Nutr Food Res 2010, 54:53-61.
18. Wang Y.M., Zhang B., Xue Y., Li Z.J., Wang J.F., Xue C.H., et al. The mechanism of dietary cholesterol effects on lipids metabolism in rats. Lipids Health Dis 2010, 9:4.
19. Yazdanparast R., Bahramika S. Evaluation of the effect of Anethum graveolens L. crude extracts on serum lipids and lipoproteins profiles in hypercholesterolaemic rats. DARU J Pharm Sci 2008, 16:88-94.
20. Istvan E.S. Structural mechanism for statin inhibition of 3-hydroxy-3-methylglutaryl coenzyme A reductase. Am Heart J 2002, 144:27-32.
21. Freeman L.A., Kennedy A., Wu J., Bark S., Remaley A.T., Santamarina-Fojo S., et al. The orphan nuclear receptor LRH-1 activates the ABCG5/ABCG8 intergenic promoter. J Lipid Res 2004, 45:1197-1206.
22. Remaley A.T., Bark S., Walts A.D., Freeman L., Shulenin S., Annilo T., et al. Comparative genome analysis of potential regulatory elements in the ABCG5-ABCG8 gene cluster. Biochem Biophys Res Commun 2002, 295:276-282.
23. Yu L., Li-Hawkins J., Hammer R.E., Berge K.E., Horton J.D., Cohen J.C., et al. Overexpression of ABCG5 and ABCG8 promotes biliary cholesterol secretion and reduces fractional absorption of dietary cholesterol. J Clin Invest 2002, 110:671-680.