Human Metapneumovirus Infection in Chronic Obstructive Pulmonary Disease: Impact of Glucocorticosteroids and Interferon

Journal of Infectious Diseases

Volumn 215, Issue 10, 2017, Pages 1536-1545

  Kan O, Keiko ^a,b,c,g   Ramirez, Ruben ^d   Macdonald, Martin I ^a   Rolph, Michael ^e   Rudd, Penny A ^e   Spann, Kirsten M ^f   Mahalingam, Suresh ^e   Bardin, Philip G ^a,b,c   Thomas, Belinda J ^a,b,c  

^a MONASH MEDICAL CENTRE   (Australia)

^b HUDSON INSTITUTE OF MEDICAL RESEARCH   (Australia)

^c MONASH UNIVERSITY   (Australia)

^d UNIVERSITY OF CANBERRA   (Australia)

^e GRIFFITH UNIVERSITY   (Australia)

^f QUEENSLAND UNIVERSITY OF TECHNOLOGY   (Australia)

^g KYUSHU UNIVERSITY   (Japan)

Author keywords

apoptosis; glucocorticosteroids; human metapneumovirus; human primary bronchial epithelial cells; innate immune response.; interferon

Indexed keywords

BETA INTERFERON; GAMMA INTERFERON INDUCIBLE PROTEIN 10; INTERFERON; MIFEPRISTONE; RANTES; GAMMA INTERFERON; GLUCOCORTICOID;

AGED; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CHRONIC OBSTRUCTIVE LUNG DISEASE; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE EXACERBATION; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN METAPNEUMOVIRUS; HUMAN METAPNEUMOVIRUS INFECTION; IFNB GENE; IN VITRO STUDY; IP10 GENE; ISG56 GENE; LIMIT OF DETECTION; LIMIT OF QUANTITATION; LUNG ALVEOLUS EPITHELIUM CELL; MAJOR CLINICAL STUDY; MOUSE; NONHUMAN; PRIMARY BRONCHIAL EPITHELIAL CELL; PRIORITY JOURNAL; RANTES GENE; VIRUS GENE; VIRUS PATHOGENESIS; VIRUS REPLICATION; ANIMAL; ASTHMA; BAGG ALBINO MOUSE; BIOLOGICAL MODEL; BRONCHUS; CELL CULTURE; CYTOLOGY; DRUG EFFECTS; EPITHELIUM CELL; METAPNEUMOVIRUS; PARAMYXOVIRUS INFECTION; RESPIRATORY MUCOSA; VIROLOGY;

ANIMALS; APOPTOSIS; ASTHMA; BRONCHI; CELLS, CULTURED; EPITHELIAL CELLS; GLUCOCORTICOIDS; HUMANS; INTERFERON-GAMMA; METAPNEUMOVIRUS; MICE; MICE, INBRED BALB C; MODELS, BIOLOGICAL; PARAMYXOVIRIDAE INFECTIONS; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; RESPIRATORY MUCOSA; VIRUS REPLICATION;

EID: 85021842706     PISSN: 00221899     EISSN: 15376613     Source Type: Journal    
DOI: 10.1093/infdis/jix167     Document Type: Article

References (34)

1. van den Hoogen BG, de Jong JC, Groen J, et al. A newly discovered human pneumovirus isolated from young children with respiratory tract disease. Nat Med 2001; 7:719-24.
2. Wen SC, Williams JV. New approaches for immunization and therapy against human metapneumovirus. Clin Vaccine Immunol 2015; 22:858-66.
3. Martinello RA, Esper F, Weibel C, Ferguson D, Landry ML, Kahn JS. Human metapneumovirus and exacerbations of chronic obstructive pulmonary disease. J Infect 2006; 53:248-54.
4. Rohde G, Borg I, Arinir U, et al. Relevance of human metapneumovirus in exacerbations of COPD. Respir Res 2005; 6:150.
5. Vicente D, Montes M, Cilla G, Perez-Trallero E. Human metapneumovirus and chronic obstructive pulmonary disease. Emerg Infect Dis 2004; 10:1338-9.
6. Zwaans WA, Mallia P, van Winden ME, Rohde GG. The relevance of respiratory viral infections in the exacerbations of chronic obstructive pulmonary disease-a systematic review. J Clin Virol 2014; 61:181-8.
7. Kuiken T, van den Hoogen BG, van Riel DA, et al. Experimental human metapneumovirus infection of cynomolgus macaques (Macaca fascicularis) results in virus replication in ciliated epithelial cells and pneumocytes with associated lesions throughout the respiratory tract. Am J Pathol 2004; 164:1893-900.
8. Boivin G, De Serres G, Hamelin ME, et al. An outbreak of severe respiratory tract infection due to human metapneumovirus in a long-term care facility. Clin Infect Dis 2007; 44:1152-8.
9. Bao X, Liu T, Spetch L, Kolli D, Garofalo RP, Casola A. Airway epithelial cell response to human metapneumovirus infection. Virology 2007; 368:91-101.
10. Hsu AC, Starkey MR, Hanish I, et al. Targeting PI3K-p110 suppresses influenza virus infection in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2015; 191:1012-23.
11. Wark PA, Johnston SL, Bucchieri F, et al. Asthmatic bronchial epithelial cells have a deficient innate immune response to infection with rhinovirus. J Exp Med 2005; 201:937-47.
12. McKeever T, Harrison TW, Hubbard R, Shaw D. Inhaled corticosteroids and the risk of pneumonia in people with asthma: A case-control study. Chest 2013; 144:1788-94.
13. Suissa S, Patenaude V, Lapi F, Ernst P. Inhaled corticosteroids in COPD and the risk of serious pneumonia. Thorax 2013; 68:1029-36.
14. Ducharme FM, Lemire C, Noya FJ, et al. Preemptive use of high-dose fluticasone for virus-induced wheezing in young children. N Engl J Med 2009; 360:339-53.
15. Price D, Yawn B, Brusselle G, Rossi A. Risk-to-benefit ratio of inhaled corticosteroids in patients with COPD. Prim Care Respir J 2013; 22:92-100.
16. Thomas BJ, Porritt RA, Hertzog PJ, Bardin PG, Tate MD. Glucocorticosteroids enhance replication of respiratory viruses: effect of adjuvant interferon. Sci Rep 2014; 4:7176.
17. Herd KA, Nelson M, Mahalingam S, Tindle RW. Pulmonary infection of mice with human metapneumovirus induces local cytotoxic T-cell and immunoregulatory cytokine responses similar to those seen with human respiratory syncytial virus. J Gen Virol 2010; 91:1302-10.
18. Spann KM, Baturcam E, Schagen J, et al. Viral and host factors determine innate immune responses in airway epithelial cells from children with wheeze and atopy. Thorax 2014; 69:918-25.
19. Foster MW, Gerhardt G, Robitaille L, et al. Targeted proteomics of human metapneumovirus in clinical samples and viral cultures. Anal Chem 2015; 87:10247-54.
20. Thomas BJ, Lindsay M, Dagher H, et al. Transforming growth factor-enhances rhinovirus infection by diminishing early innate responses. Am J Respir Cell Mol Biol 2009; 41:339-47.
21. Herd KA, Mahalingam S, Mackay IM, Nissen M, Sloots TP, Tindle RW. Cytotoxic T-lymphocyte epitope vaccination protects against human metapneumovirus infection and disease in mice. J Virol 2006; 80:2034-44.
22. Edwards MR, Haas J, Panettieri RA Jr, Johnson M, Johnston SL. Corticosteroids and 2 agonists differentially regulate rhinovirus-induced interleukin-6 via distinct cis-acting elements. J Biol Chem 2007; 282:15366-75.
23. Edwards MR, Johnson MW, Johnston SL. Combination therapy: synergistic suppression of virus-induced chemokines in airway epithelial cells. Am J Respir Cell Mol Biol 2006; 34:616-24.
24. Gruver-Yates AL, Cidlowski JA. Tissue-specific actions of glucocorticoids on apoptosis: A double-edged sword. Cells 2013; 2:202-23.
25. Glasauer A, Sena LA, Diebold LP, Mazar AP, Chandel NS. Targeting SOD1 reduces experimental non-small-cell lung cancer. J Clin Invest 2014; 124:117-28.
26. Levy DE, Marie IJ, Durbin JE. Induction and function of type I and III interferon in response to viral infection. Curr Opin Virol 2011; 1:476-86.
27. Clark TW, Medina MJ, Batham S, Curran MD, Parmar S, Nicholson KG. C-reactive protein level and microbial aetiology in patients hospitalised with acute exacerbation of COPD. Eur Respir J 2015; 45:76-86.
28. Sumino KC, Agapov E, Pierce RA, et al. Detection of severe human metapneumovirus infection by real-time polymerase chain reaction and histopathological assessment. J Infect Dis 2005; 192:1052-60.
29. Bao X, Kolli D, Liu T, Shan Y, Garofalo RP, Casola A. Human metapneumovirus small hydrophobic protein inhibits NF-B transcriptional activity. J Virol 2008; 82:8224-9.
30. Reddel HK, Bateman ED, Becker A, et al. A summary of the new GINA strategy: A roadmap to asthma control. Eur Respir J 2015; 46:622-39.
31. Baturcam E, Snape N, Yeo TH, et al. Human metapneumovirus impairs apoptosis of nasal epithelial cells in asthma via HSP70. J Innate Immun 2017; 9:52-64.
32. Benedict CA, Norris PS, Ware CF. To kill or be killed: viral evasion of apoptosis. Nat Immunol 2002; 3:1013-8.
33. Kaczmarek A, Vandenabeele P, Krysko DV. Necroptosis: The release of damage-associated molecular patterns and its physiological relevance. Immunity 2013; 38:209-23.
34. Djukanovi R, Harrison T, Johnston SL, et al; INTERCIA Study Group. The effect of inhaled IFN-on worsening of asthma symptoms caused by viral infections: A randomized trial. Am J Respir Crit Care Med 2014; 190:145-54.