A metagenomic analysis provides a culture-independent pathogen detection for atopic dermatitis

Allergy, Asthma and Immunology Research

Volumn 9, Issue 5, 2017, Pages 453-461

  Kim, Min Hye ^a   Rho, Mina ^b   Choi, Jun Pyo ^c   Choi, Hyun Il ^d   Park, Han Ki ^e   Song, Woo Jung ^f   Min, Taek Ki ^g   Cho, Sang Heon ^f   Cho, Young Joo ^a   Kim, Yoon Keun ^h   Yang, Sanghwa ^h   Pyun, Bok Yang ^g  

^a Ewha Womans University School of Medicine   (South Korea)

^b Hanyang University   (South Korea)

^c University of Ulsan College of Medicine   (South Korea)

^d Pohang University of Science and Technology (POSTECH)   (South Korea)

^e Ajou University Medical CentSuwon   (South Korea)

^f Seoul National University College of Medicine   (South Korea)

^g Soonchunhyang University College of Medicine   (South Korea)

^h MD Healthcare Inc   (South Korea)

Author keywords

Atopic dermatitis; Extracellular vesicle; Metagenomic analysis

Indexed keywords

BACTERIUM ANTIBODY; C REACTIVE PROTEIN; GENOMIC DNA; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G;

ACHROMOBACTER; ACINETOBACTER; ALCALIGENACEAE; ARTICLE; ATOPIC DERMATITIS; BACTERIUM; BACTERIUM CULTURE; BETAPROTEOBACTERIA; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; EOSINOPHIL COUNT; EXOSOME; FEMALE; HUMAN; IMMUNOGLOBULIN BLOOD LEVEL; LACTOBACILLALES; LACTOBACILLUS; LACTOCOCCUS; LEUCONOSTOC; LEUKOCYTE COUNT; MALE; METAGENOMICS; METHYLOBACTERIACEAE; METHYLOBACTERIUM; MICROBIAL COMMUNITY; MICROBIAL DIVERSITY; MICROORGANISM DETECTION; NEXT GENERATION SEQUENCING; PHAEOSPIRILLUM; PRESCHOOL CHILD; PSEUDOMONAS; PYROSEQUENCING; RHIZOBIALES; RHODOCOCCUS; SEDIMINIBACTERIUM; STAPHYLOCOCCUS AUREUS; STREPTOCOCCUS; XANTHOMONADACEAE;

EID: 85021833135     PISSN: 20927355     EISSN: 20927363     Source Type: Journal    
DOI: 10.4168/aair.2017.9.5.453     Document Type: Article

References (27)

1. Sabin BR, Peters N, Peters AT. Chapter 20: atopic dermatitis. Allergy Asthma Proc 2012;33 Suppl 1:S67-9
2. Lee JH, Son SW, Cho SH. A comprehensive review of the treatment of atopic eczema. Allergy Asthma Immunol Res 2016;8:181-90
3. Leung DY, Boguniewicz M, Howell MD, Nomura I, Hamid QA. New insights into atopic dermatitis. J Clin Invest 2004;113:651-7
4. Pyun BY. Natural history and risk factors of atopic dermatitis in chil dren. Allergy Asthma Immunol Res 2015;7:101-5
5. Bieber T. Atopic dermatitis. N Engl J Med 2008;358:1483-94
6. Ahn K. The prevalence of atopic dermatitis in Korean children. Allergy Asthma Immunol Res 2016;8:1-2
7. Lee JH, Han KD, Kim KM, Park YG, Lee JY, Park YM. Prevalence of atopic dermatitis in Korean children based on data from the 2008-2011 Korean National Health and Nutrition Examination Survey. Allergy Asthma Immunol Res 2016;8:79-83
8. Niebuhr M, Langnickel J, Draing C, Renz H, Kapp A, Werfel T. Dysregulation of toll-like receptor-2 (TLR-2)-induced effects in monocytes from patients with atopic dermatitis: impact of the TLR-2 R753Q polymorphism. Allergy 2008;63:728-34
9. Wollenberg A, Feichtner K. Atopic dermatitis and skin allergies-update and outlook. Allergy 2013;68:1509-19
10. Kong HH, Oh J, Deming C, Conlan S, Grice EA, Beatson MA, et al. Temporal shifts in the skin microbiome associated with disease flares and treatment in children with atopic dermatitis. Genome Res 2012;22:850-9
11. Breuer K, Wittmann M, Bösche B, Kapp A, Werfel T. Severe atopic dermatitis is associated with sensitization to staphylococcal enterotoxin B (SEB). Allergy 2000;55:551-5
12. Chen YE, Tsao H. The skin microbiome: current perspectives and future challenges. J Am Acad Dermatol 2013;69:143-55
13. Human Microbiome Project Consortium. Structure, function and diversity of the healthy human microbiome. Nature 2012;486:207-14
14. EL Andaloussi S, Mäger I, Breakefield XO, Wood MJ. Extracellular vesicles: biology and emerging therapeutic opportunities. Nat Rev Drug Discov 2013;12:347-57
15. Pyun BY. Extracellular vesicle: an unknown environmental factor for causing airway disease. Allergy Asthma Immunol Res 2016;8: 179-80
16. Shin TS, Kim JH, Kim YS, Jeon SG, Zhu Z, Gho YS, et al. Extracellular vesicles are key intercellular mediators in the development of immune dysfunction to allergens in the airways. Allergy 2010;65: 1256-65
17. Hong SW, Kim MR, Lee EY, Kim JH, Kim YS, Jeon SG, et al. Extracellular vesicles derived from Staphylococcus aureus induce atopic dermatitis-like skin inflammation. Allergy 2011;66:351-9
18. Hong SW, Choi EB, Min TK, Kim JH, Kim MH, Jeon SG, et al. An important role of a-hemolysin in extracellular vesicles on the development of atopic dermatitis induced by Staphylococcus aureus. PLoS One 2014;9:e100499
19. Hanifin JM, Rajka G. Diagnostic features of atopic dermatitis. Acta Derm Venereol Suppl (Stockh) 1980;92:44-7
20. Severity scoring of atopic dermatitis: the SCORAD index. Consensus Report of the European Task Force on Atopic Dermatitis. Dermatology 1993;186:23-31
21. Edgar RC. Search and clustering orders of magnitude faster than BLAST. Bioinformatics 2010;26:2460-1
22. Caporaso JG, Kuczynski J, Stombaugh J, Bittinger K, Bushman FD, Costello EK, et al. QIIME allows analysis of high-throughput community sequencing data. Nat Methods 2010;7:335-6
23. Drago L, De Grandi R, Altomare G, Pigatto P, Rossi O, Toscano M. Skin microbiota of first cousins affected by psoriasis and atopic dermatitis. Clin Mol Allergy 2016;14:2
24. Seite S, Flores GE, Henley JB, Martin R, Zelenkova H, Aguilar L, et al. Microbiome of affected and unaffected skin of patients with atopic dermatitis before and after emollient treatment. J Drugs Dermatol 2014;13:1365-72
25. Choi Y, Park H, Park HS, Kim YK. Extracellular vesicles, a key mediator to link environmental microbiota to airway immunity. Allergy Asthma Immunol Res 2017;9:101-6
26. Kim JH, Lee J, Park J, Gho YS. Gram-negative and gram-positive bacterial extracellular vesicles. Semin Cell Dev Biol 2015;40:97-104
27. Campos JH, Soares RP, Ribeiro K, Andrade AC, Batista WL, Torrecilhas AC. Extracellular vesicles: role in inflammatory responses and potential uses in vaccination in cancer and infectious diseases. J Immunol Res 2015;2015:832057