Dysregulation of toll-like receptor-2 (TLR-2)-induced effects in monocytes from patients with atopic dermatitis: Impact of the TLR-2 R753Q polymorphism

Allergy: European Journal of Allergy and Clinical Immunology

Volumn 63, Issue 6, 2008, Pages 728-734

  Niebuhr, M ^a   Langnickel, J ^a   Draing, C ^b   Renz, H ^c   Kapp, A ^a   Werfel, T ^a  

^a HANNOVER MEDICAL SCHOOL   (Germany)

^b UNIVERSITY OF KONSTANZ   (Germany)

^c PHILIPPS UNIVERSITY MARBURG   (Germany)

Author keywords

Atopic dermatitis; Human; Lipoteichoic acid; Monocytes; Pam3Cys; Peptidoglycan; Toll like receptor 2

Indexed keywords

CYTOKINE; INTERLEUKIN 12; INTERLEUKIN 6; LIPOPEPTIDE; LIPOPROTEIN; LIPOTEICHOIC ACID; PAM3CYS; PEPTIDOGLYCAN; PROTEIN INHIBITOR; TOLL LIKE RECEPTOR 2;

ARTICLE; ATOPIC DERMATITIS; CELL STIMULATION; CONTROLLED STUDY; DISEASE PREDISPOSITION; DISEASE SEVERITY; DRUG INHIBITION; GENE CONTROL; GENE MUTATION; HUMAN; HUMAN CELL; INNATE IMMUNITY; MONOCYTE; PERIPHERAL BLOOD MONONUCLEAR CELL; PHENOTYPIC VARIATION; PREVALENCE; PRIORITY JOURNAL; PROTEIN FUNCTION; SINGLE NUCLEOTIDE POLYMORPHISM; STAPHYLOCOCCUS AUREUS; STAPHYLOCOCCUS INFECTION;

DERMATITIS, ATOPIC; HUMANS; INTERLEUKIN-12; INTERLEUKIN-6; LIGANDS; LIPOPOLYSACCHARIDES; MONOCYTES; PEPTIDOGLYCAN; POLYMORPHISM, SINGLE NUCLEOTIDE; STAPHYLOCOCCUS AUREUS; TEICHOIC ACIDS; TOLL-LIKE RECEPTOR 2;

EID: 42549101462     PISSN: 01054538     EISSN: 13989995     Source Type: Journal    
DOI: 10.1111/j.1398-9995.2008.01721.x     Document Type: Article

References (33)

1. Kapp A. Atopic dermatitis-the skin manifestation of atopy. Clin Exp Allergy 1995 25 : 210 219.
2. Werfel T, Kapp A. Environmental and other major provocation factors in atopic dermatitis. Allergy 1998 53 : 731 739.
3. Breuer K, Kapp A, Werfel T. Bacterial infections and atopic dermatitis. Allergy 2001 56 : 1034 1041.
4. Matsui K, Nishikawa A, Suto H, Tsuboi R, Ogawa H. et al. Comparative study of Staphylococcus aureus isolated from lesional and non-lesional skin of atopic dermatitis. Microbiol Immunol 2000 44 : 945 947.
5. Breuer K, Wittmann M, Bosche B, Kapp A, Werfel T. Severe atopic dermatitis is associated with sensitization to staphylococcal enterotoxin B (SEB). Allergy 2000 55 : 551 555.
6. Leung DYM, Harbeck R, Bina P, Reiser RF, Yang E, Norris DA et al. Presence of IgE antibodies to staphylococcal exotoxins on the skin of patients with atopic dermatitis. J Clin Invest 1993 92 : 1374 1380.
7. Skov L, Olsen JV, Giorno L, Schlievert PM, Baadsgaard O, Leung DY. Application of staphylococcal enterotoxin B on normal and atopic skin induces up-regulation of T-cells by a superantigen-mediated mechanism. J Allergy Clin Immunol 2000 105 : 820 826.
8. Mc Fadden JP, Noble WC, Camp RDR. Superantigenic exotoxin-secreting potential of staphylococci isolated from atopic eczematous skin. Br J Dermatol 1993 128 : 631 632.
9. Breuer K, Haussler S, Kapp A, Werfel T. Staphylococcus aureus: colonizing features and influence of an antibacterial treatment in adults with atopic dermatitis. Br J Dermatol 2002 147 : 55 61.
10. McGirt L, Beck L. Innate immune defects in atopic dermatitis. J Allergy Clin Immunol 2006 118 : 202 208.
11. Ong PY. Is/are pattern recognition receptor(s) for Staphylococcus aureus defective in atopic dermatitis? Dermatology 2006 212 : 19 22.
12. Schibli DJ, Hunter HN, Aseyev V, Starner TD, Wiencek JM, Mc Gray PB Jr. et al. The solution structures of the human β-defensins lead to a better understanding of the potent bactericidal activity of HBD-3 against S. aureus. J Biol Chem 2002 27 : 8279 8289.
13. Ong PY, Ohtake T, Brandt C, Strickland I, Boguniewicz M, Ganz T. Endogenous antimicrobial peptides and skin infections in atopic dermatitis. N Engl J Med 2002 347 : 1151 1160.
14. Takeuchi O, Hoshino K, Akira S. Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components. Immunity 1999 11 : 443 451.
15. Lorenz E, Mira JP, Cornish KL. A novel polymorphism in the toll-like receptor 2 gene and its potential association with staphylococcal infections. Infect Immunol 2000 68 : 6398 6401.
16. Ahmad-Nejad P, Mrabet-Dahbi S, Breuer K, Klotz M, Werfel T, Herz U et al. The toll-like receptor 2 R753Q polymorphism defines a subgroup of patients with atopic dermatitis having severe phenotype. J Allergy Clin Immunol 2004 113 : 565 567.
17. Morr M, Takeuchi O, Akira S, Simon M, Mühlradt PF. Differential recognition of structural details of bacterial lipopeptides by toll-like receptors. Eur J Immunol 2002 32 : 3337 3347.
18. Takcuchi O, Kawai T, Mühlradt PF, Morr M, Radolf JD, Zychlinsky A et al. Discrimination of bacterial lipoproteins by Toll-like receptor 6. Int Immunol 2001 13 : 933 940.
19. Girardin SE, Travassos LH, Herve M, Blanot D, Boneca IG, Philpott DJ et al. Peptidoglycan molecular requirements allowing detection by Nod1 and Nod2. J Biol Chem 2003 43 : 41702 41708.
20. Visser L, Melief M, van Riel D, van Meurs M, Sick EA, Inamura S et al. Phagocytes containing a disease-promoting toll-like receptor/Nod ligand are present in the brain during demyelinating disease in primates. Am J Pathol 2006 169 : 1671 1685.
21. Hasannejad H, Takahashi R, Kimishima M, Hayakawa K, Shiohara T. Selective impairment of toll-like receptor 2-mediated proinflammatory cytokine production by monocytes from patients with atopic dermatitis. J Allergy Clin Immunol 2007 120 : 69 75.
22. Hanifin JM, Rajka G. Diagnostic features of atopic dermatitis. Acta Derm Venereol (Stockh) 1980 92 (Suppl. 44 47
23. Morath S, Geyer A, Hartung T. Structure-function relationship of cytokine induction by lipoteichoic acid from Staphylococcus aureus. J Exp Med 2001 193 : 393 397.
24. Wittmann M, Larsson V, Schmidt P, Begemann G, Kapp A, Werfel T. Suppression of interleukin-12 production by human monocytes after preincubation with lipopolysaccharide. Blood 1999 94 : 1717 1726.
25. Weidinger S, Novak N, Klopp N, Baurecht H, Wagenpfeil S, Rummler L et al. Lack of association between toll-like receptor 2 and toll-like receptor 4 polymorphisms and atopic eczema. J Allergy Clin Immunol 2006 118 : 277 279.
26. Mrabet-Dahbi S, Dalpke A, Niebuhr M, Frey M, Draing C, Brand S et al. The toll-like receptor 2 R753Q mutation modifies cytokine production and toll-like receptor expression in atopic dermatitis. J Allerg Clin Immunol 2008, in press.
27. Germann T, Rude E. Interleukin-12. Int Arch Allergy Immunol 1995 108 : 103.
28. Trinchieri G. Interleukin-12 and its role in the generation of Th1 cells. Immunol Today 1993 14 : 335.
29. Balloy V, Si-Tahar M, Takeuchi O, Philippe B, Nahori MA, Tanguy M et al. Involvement of toll-like receptor 2 in experimental invasive pulmonary aspergillosis. Infect Immunol 2005 73 : 5420 5425.
30. Akdis C, Akdis M, Bieber T, Bindslev-Jensen C, Boguniewicz M, Eigenmann P et al. Diagnosis and treatment of atopic dermatitis in children and adults: European Academy of Allergology and Clinical Immunology/American Academy of Allergy, Asthma and Immunology/PRACTALL Consensus Report. J Allergy Clin Immunol 2006 118 : 152 169.
31. Schröder NWJ, Diterich I, Zinke A, Eckert J, Draing C, Baehr V et al. Heterozygous Arg753Gln Polymorphism of human TLR-2 impairs immune activation by Borrelia burgdorferi and protects from late stage of Lyme disease. J Immunol 2005 175 : 2534 2540.
32. Kadowaki N, Ho S, Antonenko S, Malefyt RW, Kastelein R, Bazan F et al. Subsets of human dendritic cell precursors express different toll-like receptors and respond to different microbial antigens. J Exp Med 2001 194 : 863 869.
33. Marsella R, Olivry T, Maeda S. Cellular and cytokine kinetics after epicutaneous allergen challenge (atopy patch testing) with house dust mites in high IgE beagles. Vet Dermatol 2006 17 : 111 120.