Proliferation of endogenous regulatory T cells improve the pathophysiology associated with placental ischaemia of pregnancy

American Journal of Reproductive Immunology

Volumn 78, Issue 5, 2017, Pages

  Ibrahim, Tarek ^a   Przybyl, Lukasz ^b   Harmon, Ashlyn C ^a   Amaral, Lorena M ^a   Faulkner, Jessica L ^a   Cornelius, Denise C ^a   Cunningham, Mark W ^a   Hünig, Thomas ^c   Herse, Florian ^b   Wallukat, Gerd ^d   Dechend, Ralf ^b,d   LaMarca, Babbette ^a  

^a UNIVERSITY OF MISSISSIPPI SCHOOL OF MEDICINE   (United States)

^b Experimental and Clinical Research Center   (Germany)

^c UNIVERSITY OF WÜRZBURG   (Germany)

^d HELIOS Clinic   (Germany)

Author keywords

inflammation; preeclampsia; regulatory T cells

Indexed keywords

ANGIOTENSIN II TYPE 1 RECEPTOR AUTOANTIBODY; AUTOANTIBODY; ENDOTHELIN 1; INTERLEUKIN 10; INTERLEUKIN 2; INTERLEUKIN 6; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG; CYTOKINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA; ARTICLE; BLOOD PRESSURE; CELL PROLIFERATION; CELL STIMULATION; FETUS GROWTH; FETUS WEIGHT; GESTATIONAL AGE; HYPERTENSION; INFLAMMATION; MEAN ARTERIAL PRESSURE; NONHUMAN; PATHOPHYSIOLOGY; PLACENTA; PREECLAMPSIA; PRIORITY JOURNAL; RAT; REGULATORY T LYMPHOCYTE; ANIMAL; CELL CULTURE; DISEASE MODEL; FEMALE; HUMAN; IMMUNOLOGY; ISCHEMIA; METABOLISM; PREGNANCY; SPRAGUE DAWLEY RAT;

ANIMALS; CELL PROLIFERATION; CELLS, CULTURED; CYTOKINES; DISEASE MODELS, ANIMAL; FEMALE; HUMANS; ISCHEMIA; PLACENTA; PRE-ECLAMPSIA; PREGNANCY; RATS; RATS, SPRAGUE-DAWLEY; T-LYMPHOCYTES, REGULATORY;

EID: 85021811298     PISSN: 10467408     EISSN: 16000897     Source Type: Journal    
DOI: 10.1111/aji.12724     Document Type: Article

References (32)

1. Uzan J, Carbonnel M, Piconne O, Asmar R, Ayoubi JM. Pre-eclampsia: pathophysiology, diagnosis, and management. Vasc Health Risk Manag. 2011;7:467-474.
2. Lamarca B. The role of immune activation in contributing to vascular dysfunction and the pathophysiology of hypertension during preeclampsia. Minerva Ginecol. 2010;62:105-120.
3. Pennington KA, Schlitt JM, Jackson DL, Schulz LC, Schust DJ. Preeclampsia: multiple approaches for a multifactorial disease. Dis Model Mech. 2012;5:9-18.
4. Lyall F, Robson SC, Bulmer JN. Spiral artery remodeling and trophoblast invasion in preeclampsia and fetal growth restriction: relationship to clinical outcome. Hypertension. 2013;62:1046-1054.
5. Roberts JM. Endothelial dysfunction in preeclampsia. Semin Reprod Endocrinol. 1998;16:5-15.
6. Amaral LM, Cornelius DC, Harmon A, Moseley J, Martin JN Jr, LaMarca B. 17-hydroxyprogesterone caproate significantly improves clinical characteristics of preeclampsia in the reduced uterine perfusion pressure rat model. Hypertension. 2015;65:225-231.
7. Gilbert JS, Ryan MJ, LaMarca BB, Sedeek M, Murphy SR, Granger JP. Pathophysiology of hypertension during preeclampsia: linking placental ischemia with endothelial dysfunction. Am J Physiol Heart Circ Physiol. 2008;294:H541-H550.
8. Harmon A, Cornelius D, Amaral L, et al. Il-10 supplementation increases tregs and decreases hypertension in the Rupp rat model of preeclampsia. Hypertension in pregnancy. 2015;34:291-306.
9. Santner-Nanan B, Peek MJ, Khanam R, Richarts L, Zhu E, Fazekas de St Groth B, Nanan R. Systemic increase in the ratio between FOXP3+ and IL-17-producing CD4+ t cells in healthy pregnancy but not in preeclampsia. J Immunol. 2009;183:7023-7030.
10. Duncombe G, Veldhuizen RA, Gratton RJ, Han VK, Richardson BS. Il-6 and tnfalpha across the umbilical circulation in term pregnancies: Relationship with labour events. Early Hum Dev. 2010;86:113-117.
11. Cornelius DC, Amaral LM, Harmon A, et al. An increased population of regulatory t cells improves the pathophysiology of placental ischemia in a rat model of preeclampsia. Am J Physiol Regul Integr Comp Physiol. 2015;309:R884-R891.
12. Przybyl L, Ibrahim T, Haase N, et al. Regulatory T cells ameliorate intrauterine growth retardation in a transgenic rat model for preeclampsia. Hypertension. 2015;65:1298-1306.
13. Novotny SR, Wallace K, Heath J, et al. Activating autoantibodies to the angiotensin ii type i receptor play an important role in mediating hypertension in response to adoptive transfer of CD4+ t lymphocytes from placental ischemic rats. Am J Physiol Regul Integr Comp Physiol. 2012;302:R1197-R1201.
14. Wallace K, Richards S, Dhillon P, et al. Cd4+ T-helper cells stimulated in response to placental ischemia mediate hypertension during pregnancy. Hypertension. 2011;57:949-955.
15. Cornelius DC, Hogg JP, Scott J, et al. Administration of interleukin-17 soluble receptor c suppresses th17 cells, oxidative stress, and hypertension in response to placental ischemia during pregnancy. Hypertension. 2013;62:1068-1073.
16. Alvarado C, Alcocer-Varela J, Llorente L, Richaud-Patin Y, Cerbon M, Alarcon-Segovia D. Effect of CD28 antibody on t cells from patients with systemic lupus erythematosus. J Autoimmun. 1994;7:763-773.
17. Laskowski IA, Pratschke J, Wilhelm MJ, et al. Anti-CD28 monoclonal antibody therapy prevents chronic rejection of renal allografts in rats. J Am Soc Nephrol. 2002;13:519-527.
18. Gogishvili T, Langenhorst D, Luhder F, et al. Rapid regulatory t-cell response prevents cytokine storm in CD28 superagonist treated mice. PLoS ONE. 2009;4:e4643.
19. Langenhorst D, Gogishvili T, Ribechini E, et al. Sequential induction of effector function, tissue migration and cell death during polyclonal activation of mouse regulatory T-cells. PLoS ONE. 2012;7:e50080.
20. Beyersdorf N, Hanke T, Kerkau T, Hunig T. Superagonistic anti-CD28 antibodies: potent activators of regulatory t cells for the therapy of autoimmune diseases. Ann Rheum Dis. 2005;64(Suppl 4):iv91-iv95.
21. Tabares P, Berr S, Romer PS, et al. Human regulatory t cells are selectively activated by low-dose application of the cd28 superagonist tgn1412/tab 08. Eur J Immunol. 2014;44:1225-1236.
22. Dechend R, Homuth V, Wallukat G, et al. At(1) receptor agonistic antibodies from preeclamptic patients cause vascular cells to express tissue factor. Circulation. 2000;101:2382-2387.
23. Dechend R, Homuth V, Wallukat G, et al. Agonistic antibodies directed at the angiotensin Ii, AT1 receptor in preeclampsia. J Soc Gynecol Investig. 2006;13:79-86.
24. LaMarca B, Parrish M, Ray LF, et al. Hypertension in response to autoantibodies to the angiotensin II type I receptor (at1-aa) in pregnant rats: role of endothelin-1. Hypertension. 2009;54:905-909.
25. LaMarca B, Wallace K, Herse F, et al. Hypertension in response to placental ischemia during pregnancy: role of B lymphocytes. Hypertension. 2011;57:865-871.
26. Parrish MR, Murphy SR, Rutland S, et al. The effect of immune factors, tumor necrosis factor-alpha, and agonistic autoantibodies to the angiotensin II type I receptor on soluble FMS-like tyrosine-1 and soluble endoglin production in response to hypertension during pregnancy. Am J Hypertens. 2010;23:911-916.
27. Parrish MR, Ryan MJ, Glover P, et al. Angiotensin II type 1 autoantibody induced hypertension during pregnancy is associated with renal endothelial dysfunction. Gend Med. 2011;8:184-188.
28. LaMarca BB, Cockrell K, Sullivan E, Bennett W, Granger JP. Role of endothelin in mediating tumor necrosis factor-induced hypertension in pregnant rats. Hypertension. 2005;46:82-86.
29. LaMarca BD, Gilbert J, Granger JP. Recent progress toward the understanding of the pathophysiology of hypertension during preeclampsia. Hypertension. 2008;51:982-988.
30. Parrish MR, Wallace K, Tam Tam KB, et al. Hypertension in response to AT1-AA: role of reactive oxygen species in pregnancy-induced hypertension. Am J Hypertens. 2011;24:835-840.
31. Park J, Kim M, Kang SG, et al. Short-chain fatty acids induce both effector and regulatory T cells by suppression of histone deacetylases and regulation of the MTOR-S6K pathway. Mucosal Immunol. 2015;8:80-93.
32. Schilderink R, Verseijden C, de Jonge WJ. Dietary inhibitors of histone deacetylases in intestinal immunity and homeostasis. Front Immunol. 2013;4:226.