메뉴 건너뛰기




Volumn 7, Issue 11, 2012, Pages

Sequential Induction of Effector Function, Tissue Migration and Cell Death during Polyclonal Activation of Mouse Regulatory T-Cells

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE RECEPTOR CCR5; CHEMOKINE RECEPTOR CCR7; INTERLEUKIN 10; TRANSCRIPTION FACTOR FOXP3;

EID: 84870589141     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0050080     Document Type: Article
Times cited : (16)

References (44)
  • 1
    • 16844365788 scopus 로고    scopus 로고
    • Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-self
    • Sakaguchi S, (2005) Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-self. Nat Immunol 6: 345-352.
    • (2005) Nat Immunol , vol.6 , pp. 345-352
    • Sakaguchi, S.1
  • 2
    • 39449126502 scopus 로고    scopus 로고
    • The Foxp3+ regulatory T cell: a jack of all trades, master of regulation
    • Tang Q, Bluestone JA, (2008) The Foxp3+ regulatory T cell: a jack of all trades, master of regulation. Nat Immunol 9: 239-244.
    • (2008) Nat Immunol , vol.9 , pp. 239-244
    • Tang, Q.1    Bluestone, J.A.2
  • 3
    • 14944386649 scopus 로고    scopus 로고
    • CD25+ CD4+ T cells compete with naive CD4+ T cells for IL-2 and exploit it for the induction of IL-10 production
    • Barthlott T, Moncrieffe H, Veldhoen M, Atkins CJ, Christensen J, et al. (2005) CD25+ CD4+ T cells compete with naive CD4+ T cells for IL-2 and exploit it for the induction of IL-10 production. Int Immunol 17: 279-288.
    • (2005) Int Immunol , vol.17 , pp. 279-288
    • Barthlott, T.1    Moncrieffe, H.2    Veldhoen, M.3    Atkins, C.J.4    Christensen, J.5
  • 4
    • 4644369302 scopus 로고    scopus 로고
    • Interleukin-2 is essential for CD4+CD25+ regulatory T cell function
    • de la Rosa M, Rutz S, Dorninger H, Scheffold A, (2004) Interleukin-2 is essential for CD4+CD25+ regulatory T cell function. Eur J Immunol 34: 2480-2488.
    • (2004) Eur J Immunol , vol.34 , pp. 2480-2488
    • de la Rosa, M.1    Rutz, S.2    Dorninger, H.3    Scheffold, A.4
  • 5
    • 7144259082 scopus 로고    scopus 로고
    • Regulatory CD4 T cells: expression of IL-2R alpha chain, resistance to clonal deletion and IL-2 dependency
    • Papiernik M, de Moraes ML, Pontoux C, Vasseur F, Penit C, (1998) Regulatory CD4 T cells: expression of IL-2R alpha chain, resistance to clonal deletion and IL-2 dependency. Int Immunol 10: 371-378.
    • (1998) Int Immunol , vol.10 , pp. 371-378
    • Papiernik, M.1    de Moraes, M.L.2    Pontoux, C.3    Vasseur, F.4    Penit, C.5
  • 6
    • 0027521572 scopus 로고
    • Interleukin-10-deficient mice develop chronic enterocolitis
    • Kühn R, Löhler J, Rennick D, Rajewsky K, Müller W, (1993) Interleukin-10-deficient mice develop chronic enterocolitis. Cell 75: 263-274.
    • (1993) Cell , vol.75 , pp. 263-274
    • Kühn, R.1    Löhler, J.2    Rennick, D.3    Rajewsky, K.4    Müller, W.5
  • 7
    • 34548131112 scopus 로고    scopus 로고
    • Regulatory T cells expressing interleukin 10 develop from Foxp3+ and Foxp3- precursor cells in the absence of interleukin 10
    • Maynard CL, Harrington LE, Janowski KM, Oliver JR, Zindl CL, et al. (2007) Regulatory T cells expressing interleukin 10 develop from Foxp3+ and Foxp3- precursor cells in the absence of interleukin 10. Nat Immunol 8: 931-941.
    • (2007) Nat Immunol , vol.8 , pp. 931-941
    • Maynard, C.L.1    Harrington, L.E.2    Janowski, K.M.3    Oliver, J.R.4    Zindl, C.L.5
  • 8
    • 0031821875 scopus 로고    scopus 로고
    • CD4+CD25+ immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production
    • Thornton AM, Shevach EM, (1998) CD4+CD25+ immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production. J Exp Med 188: 287-296.
    • (1998) J Exp Med , vol.188 , pp. 287-296
    • Thornton, A.M.1    Shevach, E.M.2
  • 9
    • 41549159660 scopus 로고    scopus 로고
    • Regulatory T cell-derived interleukin-10 limits inflammation at environmental interfaces
    • Rubtsov YP, Rasmussen JP, Chi EY, Fontenot J, Castelli L, et al. (2008) Regulatory T cell-derived interleukin-10 limits inflammation at environmental interfaces. Immunity 28: 546-558.
    • (2008) Immunity , vol.28 , pp. 546-558
    • Rubtsov, Y.P.1    Rasmussen, J.P.2    Chi, E.Y.3    Fontenot, J.4    Castelli, L.5
  • 10
    • 27144524938 scopus 로고    scopus 로고
    • Migration matters: regulatory T-cell compartmentalization determines suppressive activity in vivo
    • Siegmund K, Feuerer M, Siewert C, Ghani S, Haubold U, et al. (2005) Migration matters: regulatory T-cell compartmentalization determines suppressive activity in vivo. Blood 106: 3097-3104.
    • (2005) Blood , vol.106 , pp. 3097-3104
    • Siegmund, K.1    Feuerer, M.2    Siewert, C.3    Ghani, S.4    Haubold, U.5
  • 11
    • 27744528888 scopus 로고    scopus 로고
    • Homing to suppress: address codes for Treg migration
    • Huehn J, Hamann A, (2005) Homing to suppress: address codes for Treg migration. Trends Immunol 26: 632-636.
    • (2005) Trends Immunol , vol.26 , pp. 632-636
    • Huehn, J.1    Hamann, A.2
  • 12
    • 10744221289 scopus 로고    scopus 로고
    • Developmental stage, phenotype, and migration distinguish naive- and effector/memory-like CD4+ regulatory T cells
    • Huehn J, Siegmund K, Lehmann JC, Siewert C, Haubold U, et al. (2004) Developmental stage, phenotype, and migration distinguish naive- and effector/memory-like CD4+ regulatory T cells. J Exp Med 199: 303-313.
    • (2004) J Exp Med , vol.199 , pp. 303-313
    • Huehn, J.1    Siegmund, K.2    Lehmann, J.C.3    Siewert, C.4    Haubold, U.5
  • 13
    • 61949334905 scopus 로고    scopus 로고
    • Regulatory T cells sequentially migrate from inflamed tissues to draining lymph nodes to suppress the alloimmune response
    • Zhang N, Schroppel B, Lal G, Jakubzick C, Mao X, et al. (2009) Regulatory T cells sequentially migrate from inflamed tissues to draining lymph nodes to suppress the alloimmune response. Immunity 30: 458-469.
    • (2009) Immunity , vol.30 , pp. 458-469
    • Zhang, N.1    Schroppel, B.2    Lal, G.3    Jakubzick, C.4    Mao, X.5
  • 14
    • 41149124867 scopus 로고    scopus 로고
    • The control of CD4+CD25+Foxp3+ regulatory T cell survival
    • Pandiyan P, Lenardo MJ, (2008) The control of CD4+CD25+Foxp3+ regulatory T cell survival. Biol Direct 3: 6.
    • (2008) Biol Direct , vol.3 , pp. 6
    • Pandiyan, P.1    Lenardo, M.J.2
  • 15
    • 84872445287 scopus 로고    scopus 로고
    • Cell-intrinsic and -extrinsic control of Treg-cell homeostasis and function revealed by induced CD28 deletion
    • doi:10.1002/eji.201242824
    • Gogishvili T, Lühder F, Goebbels S, Beer-Hammer S, Pfeffer K, et al. (2012) Cell-intrinsic and-extrinsic control of Treg-cell homeostasis and function revealed by induced CD28 deletion. Eur J Immunol doi: 10.1002/eji.201242824.
    • (2012) Eur J Immunol
    • Gogishvili, T.1    Lühder, F.2    Goebbels, S.3    Beer-Hammer, S.4    Pfeffer, K.5
  • 16
    • 27944455288 scopus 로고    scopus 로고
    • Sequential development of interleukin 2-dependent effector and regulatory T cells in response to endogenous systemic antigen
    • Knoechel B, Lohr J, Kahn E, Bluestone JA, Abbas AK, (2005) Sequential development of interleukin 2-dependent effector and regulatory T cells in response to endogenous systemic antigen. J Exp Med 202: 1375-1386.
    • (2005) J Exp Med , vol.202 , pp. 1375-1386
    • Knoechel, B.1    Lohr, J.2    Kahn, E.3    Bluestone, J.A.4    Abbas, A.K.5
  • 17
    • 23744517125 scopus 로고    scopus 로고
    • Selective targeting of regulatory T cells with CD28 superagonists allows effective therapy of experimental autoimmune encephalomyelitis
    • Beyersdorf N, Gaupp S, Balbach K, Schmidt J, Toyka KV, et al. (2005) Selective targeting of regulatory T cells with CD28 superagonists allows effective therapy of experimental autoimmune encephalomyelitis. J Exp Med 202: 445-455.
    • (2005) J Exp Med , vol.202 , pp. 445-455
    • Beyersdorf, N.1    Gaupp, S.2    Balbach, K.3    Schmidt, J.4    Toyka, K.V.5
  • 18
    • 0037352740 scopus 로고    scopus 로고
    • Efficient expansion of regulatory T cells in vitro and in vivo with a CD28 superagonist
    • Lin CH, Hünig T, (2003) Efficient expansion of regulatory T cells in vitro and in vivo with a CD28 superagonist. Eur J Immunol 33: 626-638.
    • (2003) Eur J Immunol , vol.33 , pp. 626-638
    • Lin, C.H.1    Hünig, T.2
  • 19
    • 84864279250 scopus 로고    scopus 로고
    • Rapid regulatory T-cell response prevents cytokine storm in CD28 superagonist treated mice
    • Gogishvili T, Langenhorst D, Lühder F, Elias F, Elflein K, et al. (2009) Rapid regulatory T-cell response prevents cytokine storm in CD28 superagonist treated mice. PLoS One 4: e4643.
    • (2009) PLoS One , vol.4
    • Gogishvili, T.1    Langenhorst, D.2    Lühder, F.3    Elias, F.4    Elflein, K.5
  • 20
    • 50949124542 scopus 로고    scopus 로고
    • Experimental expansion of the regulatory T cell population increases resistance to African trypanosomiasis
    • Guilliams M, Bosschaerts T, Herin M, Hünig T, Loi P, et al. (2008) Experimental expansion of the regulatory T cell population increases resistance to African trypanosomiasis. J Infect Dis 198: 781-791.
    • (2008) J Infect Dis , vol.198 , pp. 781-791
    • Guilliams, M.1    Bosschaerts, T.2    Herin, M.3    Hünig, T.4    Loi, P.5
  • 21
    • 77953639101 scopus 로고    scopus 로고
    • Regulatory T cells protect from local and systemic bone destruction in arthritis
    • Zaiss MM, Frey B, Hess A, Zwerina J, Luther J, et al. (2010) Regulatory T cells protect from local and systemic bone destruction in arthritis. J Immunol 184: 7238-7246.
    • (2010) J Immunol , vol.184 , pp. 7238-7246
    • Zaiss, M.M.1    Frey, B.2    Hess, A.3    Zwerina, J.4    Luther, J.5
  • 22
    • 34548488466 scopus 로고    scopus 로고
    • Manipulation of regulatory T-cell number and function with CD28-specific monoclonal antibodies
    • Hünig T, (2007) Manipulation of regulatory T-cell number and function with CD28-specific monoclonal antibodies. Adv Immunol 95: 111-148.
    • (2007) Adv Immunol , vol.95 , pp. 111-148
    • Hünig, T.1
  • 23
    • 0031034123 scopus 로고    scopus 로고
    • CD28-mediated induction of proliferation in resting T cells in vitro and in vivo without engagement of the T cell receptor: evidence for functionally distinct forms of CD28
    • Tacke M, Hanke G, Hanke T, Hünig T, (1997) CD28-mediated induction of proliferation in resting T cells in vitro and in vivo without engagement of the T cell receptor: evidence for functionally distinct forms of CD28. Eur J Immunol 27: 239-247.
    • (1997) Eur J Immunol , vol.27 , pp. 239-247
    • Tacke, M.1    Hanke, G.2    Hanke, T.3    Hünig, T.4
  • 24
    • 33846526236 scopus 로고    scopus 로고
    • Mitogenic CD28 signals require the exchange factor Vav1 to enhance TCR signaling at the SLP-76-Vav-Itk signalosome
    • Dennehy KM, Elias F, Na SY, Fischer KD, Hünig T, et al. (2007) Mitogenic CD28 signals require the exchange factor Vav1 to enhance TCR signaling at the SLP-76-Vav-Itk signalosome. J Immunol 178: 1363-1371.
    • (2007) J Immunol , vol.178 , pp. 1363-1371
    • Dennehy, K.M.1    Elias, F.2    Na, S.Y.3    Fischer, K.D.4    Hünig, T.5
  • 25
    • 33646468938 scopus 로고    scopus 로고
    • Cutting edge: monovalency of CD28 maintains the antigen dependence of T cell costimulatory responses
    • Dennehy KM, Elias F, Zeder-Lutz G, Ding X, Altschuh D, et al. (2006) Cutting edge: monovalency of CD28 maintains the antigen dependence of T cell costimulatory responses. J Immunol 176: 5725-5729.
    • (2006) J Immunol , vol.176 , pp. 5725-5729
    • Dennehy, K.M.1    Elias, F.2    Zeder-Lutz, G.3    Ding, X.4    Altschuh, D.5
  • 26
    • 33846423147 scopus 로고    scopus 로고
    • Selective depletion of Foxp3+ regulatory T cells induces a scurfy-like disease
    • Lahl K, Loddenkemper C, Drouin C, Freyer J, Arnason J, et al. (2007) Selective depletion of Foxp3+ regulatory T cells induces a scurfy-like disease. J Exp Med 204: 57-63.
    • (2007) J Exp Med , vol.204 , pp. 57-63
    • Lahl, K.1    Loddenkemper, C.2    Drouin, C.3    Freyer, J.4    Arnason, J.5
  • 27
    • 79955529454 scopus 로고    scopus 로고
    • Trans-endocytosis of CD80 and CD86: a molecular basis for the cell-extrinsic function of CTLA-4
    • Qureshi OS, Zheng Y, Nakamura K, Attridge K, Manzotti C, et al. (2011) Trans-endocytosis of CD80 and CD86: a molecular basis for the cell-extrinsic function of CTLA-4. Science 332: 600-603.
    • (2011) Science , vol.332 , pp. 600-603
    • Qureshi, O.S.1    Zheng, Y.2    Nakamura, K.3    Attridge, K.4    Manzotti, C.5
  • 28
    • 79954629814 scopus 로고    scopus 로고
    • The effects of Foxp3-expressing regulatory T cells expanded with CD28 superagonist antibody in DSS-induced mice colitis
    • Chen J, Xie L, Toyama S, Hünig T, Takahara S, et al. (2011) The effects of Foxp3-expressing regulatory T cells expanded with CD28 superagonist antibody in DSS-induced mice colitis. Int Immunopharmacol 11: 610-617.
    • (2011) Int Immunopharmacol , vol.11 , pp. 610-617
    • Chen, J.1    Xie, L.2    Toyama, S.3    Hünig, T.4    Takahara, S.5
  • 29
  • 30
    • 33947427950 scopus 로고    scopus 로고
    • Identification of a chemokine network that recruits FoxP3(+) regulatory T cells into chronically inflamed intestine
    • Kang SG, Piniecki RJ, Hogenesch H, Lim HW, Wiebke E, et al. (2007) Identification of a chemokine network that recruits FoxP3(+) regulatory T cells into chronically inflamed intestine. Gastroenterology 132: 966-981.
    • (2007) Gastroenterology , vol.132 , pp. 966-981
    • Kang, S.G.1    Piniecki, R.J.2    Hogenesch, H.3    Lim, H.W.4    Wiebke, E.5
  • 31
    • 15944425718 scopus 로고    scopus 로고
    • CCR6 expression defines regulatory effector/memory-like cells within the CD25(+)CD4+ T-cell subset
    • Kleinewietfeld M, Puentes F, Borsellino G, Battistini L, Rotzschke O, et al. (2005) CCR6 expression defines regulatory effector/memory-like cells within the CD25(+)CD4+ T-cell subset. Blood 105: 2877-2886.
    • (2005) Blood , vol.105 , pp. 2877-2886
    • Kleinewietfeld, M.1    Puentes, F.2    Borsellino, G.3    Battistini, L.4    Rotzschke, O.5
  • 32
    • 3042711375 scopus 로고    scopus 로고
    • Links between apoptosis, proliferation and the cell cycle
    • Alenzi FQ, (2004) Links between apoptosis, proliferation and the cell cycle. Br J Biomed Sci 61: 99-102.
    • (2004) Br J Biomed Sci , vol.61 , pp. 99-102
    • Alenzi, F.Q.1
  • 33
    • 0037100384 scopus 로고    scopus 로고
    • Modulation of Fas-dependent apoptosis: a dynamic process controlling both the persistence and death of CD4 regulatory T cells and effector T cells
    • Banz A, Pontoux C, Papiernik M, (2002) Modulation of Fas-dependent apoptosis: a dynamic process controlling both the persistence and death of CD4 regulatory T cells and effector T cells. J Immunol 169: 750-757.
    • (2002) J Immunol , vol.169 , pp. 750-757
    • Banz, A.1    Pontoux, C.2    Papiernik, M.3
  • 34
    • 33751175422 scopus 로고    scopus 로고
    • Naive regulatory T cells: a novel subpopulation defined by resistance toward CD95L-mediated cell death
    • Fritzsching B, Oberle N, Pauly E, Geffers R, Buer J, et al. (2006) Naive regulatory T cells: a novel subpopulation defined by resistance toward CD95L-mediated cell death. Blood 108: 3371-3378.
    • (2006) Blood , vol.108 , pp. 3371-3378
    • Fritzsching, B.1    Oberle, N.2    Pauly, E.3    Geffers, R.4    Buer, J.5
  • 35
    • 34447643405 scopus 로고    scopus 로고
    • Control of immune responses by antigen-specific regulatory T cells expressing the folate receptor
    • Yamaguchi T, Hirota K, Nagahama K, Ohkawa K, Takahashi T, et al. (2007) Control of immune responses by antigen-specific regulatory T cells expressing the folate receptor. Immunity 27: 145-159.
    • (2007) Immunity , vol.27 , pp. 145-159
    • Yamaguchi, T.1    Hirota, K.2    Nagahama, K.3    Ohkawa, K.4    Takahashi, T.5
  • 36
    • 33751544158 scopus 로고    scopus 로고
    • Interleukin-10 induces apoptosis in developing mast cells and macrophages
    • Bailey DP, Kashyap M, Bouton LA, Murray PJ, Ryan JJ, (2006) Interleukin-10 induces apoptosis in developing mast cells and macrophages. J Leukoc Biol 80: 581-589.
    • (2006) J Leukoc Biol , vol.80 , pp. 581-589
    • Bailey, D.P.1    Kashyap, M.2    Bouton, L.A.3    Murray, P.J.4    Ryan, J.J.5
  • 37
    • 27744575802 scopus 로고    scopus 로고
    • The abnormal apoptosis of T cell subsets and possible involvement of IL-10 in systemic lupus erythematosus
    • Wang H, Xu J, Ji X, Yang X, Sun K, et al. (2005) The abnormal apoptosis of T cell subsets and possible involvement of IL-10 in systemic lupus erythematosus. Cell Immunol 235: 117-121.
    • (2005) Cell Immunol , vol.235 , pp. 117-121
    • Wang, H.1    Xu, J.2    Ji, X.3    Yang, X.4    Sun, K.5
  • 38
  • 39
    • 84255160968 scopus 로고    scopus 로고
    • Preculture of PBMC at high cell density increases sensitivity of T-cell responses, revealing cytokine release by CD28 superagonist TGN1412
    • Römer PS, Berr S, Avota E, Na SY, Battaglia M, et al. (2011) Preculture of PBMC at high cell density increases sensitivity of T-cell responses, revealing cytokine release by CD28 superagonist TGN1412. Blood.
    • (2011) Blood
    • Römer, P.S.1    Berr, S.2    Avota, E.3    Na, S.Y.4    Battaglia, M.5
  • 40
    • 77956304908 scopus 로고    scopus 로고
    • Monoclonal antibody TGN1412 trial failure explained by species differences in CD28 expression on CD4+ effector memory T-cells
    • Eastwood D, Findlay L, Poole S, Bird C, Wadhwa M, et al. (2010) Monoclonal antibody TGN1412 trial failure explained by species differences in CD28 expression on CD4+ effector memory T-cells. Br J Pharmacol 161: 512-526.
    • (2010) Br J Pharmacol , vol.161 , pp. 512-526
    • Eastwood, D.1    Findlay, L.2    Poole, S.3    Bird, C.4    Wadhwa, M.5
  • 41
    • 0034903945 scopus 로고    scopus 로고
    • Anticardiolipin antibody assay: a methodological analysis for a better consensus in routine determinations-a cooperative project of the European Antiphospholipid Forum
    • Tincani A, Allegri F, Sanmarco M, Cinquini M, Taglietti M, et al. (2001) Anticardiolipin antibody assay: a methodological analysis for a better consensus in routine determinations-a cooperative project of the European Antiphospholipid Forum. Thromb Haemost 86: 575-583.
    • (2001) Thromb Haemost , vol.86 , pp. 575-583
    • Tincani, A.1    Allegri, F.2    Sanmarco, M.3    Cinquini, M.4    Taglietti, M.5
  • 42
    • 11244346557 scopus 로고    scopus 로고
    • Variance stabilization applied to microarray data calibration and to the quantification of differential expression
    • Huber W, von Heydebreck A, Sultmann H, Poustka A, Vingron M, (2002) Variance stabilization applied to microarray data calibration and to the quantification of differential expression. Bioinformatics 18 Suppl 1: S96-104.
    • (2002) Bioinformatics , vol.18 , Issue.SUPPL. 1
    • Huber, W.1    von Heydebreck, A.2    Sultmann, H.3    Poustka, A.4    Vingron, M.5
  • 43
    • 33644872577 scopus 로고    scopus 로고
    • Limma: linear models for microarray data
    • In: Gentelman R, Carey V, Dudoit S, Irizarry R, Huber W (Eds), New York: Springer
    • Smyth GK (2005). Limma: linear models for microarray data. In: Gentelman R, Carey V, Dudoit S, Irizarry R, Huber W (Eds) Bioinformatics and Computational Biology Solutions using R and Bioconductor. New York: Springer.
    • (2005) Bioinformatics and Computational Biology Solutions using R and Bioconductor
    • Smyth, G.K.1
  • 44
    • 0024267975 scopus 로고
    • Growth and metastasis of human tumors in nude mice following tumor-cell inoculation into a vascularized polyurethane sponge matrix
    • Thiede K, Momburg F, Zangemeister U, Schlag P, Schirrmacher V, (1988) Growth and metastasis of human tumors in nude mice following tumor-cell inoculation into a vascularized polyurethane sponge matrix. Int J Cancer 42: 939-945.
    • (1988) Int J Cancer , vol.42 , pp. 939-945
    • Thiede, K.1    Momburg, F.2    Zangemeister, U.3    Schlag, P.4    Schirrmacher, V.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.