Redeploying β-Lactam Antibiotics as a Novel Antivirulence Strategy for the Treatment of Methicillin-Resistant Staphylococcus aureus Infections

Journal of Infectious Diseases

Volumn 215, Issue 1, 2017, Pages 80-87

  Waters, Elaine M ^a   Rudkin, Justine K ^c   Coughlan, Simone ^d   Clair, Geremy C ^g   Adkins, Joshua N ^g   Gore, Suzanna ^a   Xia, Guoqing ^b   Black, Nikki S ^c   Downing, Tim ^d,e   O'Neill, Eoghan ^f   Kadioglu, Aras ^a   O'Gara, James P ^c  

^a UNIVERSITY OF LIVERPOOL   (United Kingdom)

^b UNIVERSITY OF MANCHESTER   (United Kingdom)

^c Centre for Biodiversity Research   (Ireland)

^d NATIONAL UNIVERSITY OF IRELAND   (Ireland)

^e DUBLIN CITY UNIVERSITY   (Ireland)

^f Stroke and Hypertension Unit   (Ireland)

^g PACIFIC NORTHWEST NATIONAL LABORATORY   (United States)

Author keywords

antibiotic; attenuation; beta lactam; MRSA; virulence

Indexed keywords

ANTIINFECTIVE AGENT; BACTERIAL PROTEIN; OXACILLIN;

ANIMAL; DISEASE MODEL; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; HUMAN; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; MICROBIAL SENSITIVITY TEST; MICROBIOLOGY; MOUSE; PATHOGENICITY; PENICILLIN RESISTANCE; QUORUM SENSING; SEPSIS; STAPHYLOCOCCAL PNEUMONIA; STAPHYLOCOCCUS INFECTION; VIRULENCE;

ANIMALS; ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; DISEASE MODELS, ANIMAL; GENE EXPRESSION REGULATION, BACTERIAL; HUMANS; METHICILLIN RESISTANCE; METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS; MICE; MICROBIAL SENSITIVITY TESTS; OXACILLIN; PNEUMONIA, STAPHYLOCOCCAL; QUORUM SENSING; SEPSIS; STAPHYLOCOCCAL INFECTIONS; VIRULENCE;

EID: 85021792410     PISSN: 00221899     EISSN: 15376613     Source Type: Journal    
DOI: 10.1093/infdis/jiw461     Document Type: Article

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