Determinants of Antibiotic Tailoring in Pediatric Intensive Care: A National Survey∗

Pediatric Critical Care Medicine

Volumn 18, Issue 9, 2017, Pages e395-e405

  Fontela, Patricia S ^a   Quach, Caroline ^a,b   Karim, Mohammad E ^c   Willson, Douglas F ^d   Gilfoyle, Elaine ^e   McNally, James Dayre ^f   Gonzales, Milagros ^g   Papenburg, Jesse ^a   Reynolds, Steven ^c   Lacroix, Jacques ^b  

^a MCGILL UNIVERSITY   (Canada)

^b UNIVERSITÉ DE MONTRÉAL   (Canada)

^c UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^d VIRGINIA COMMONWEALTH UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e UNIVERSITY OF CALGARY   (Canada)

^f UNIVERSITY OF OTTAWA   (Canada)

^g RESEARCH INSTITUTE OF THE MCGILL UNIVERSITY HEALTH CENTRE   (Canada)

Author keywords

antibiotics; child; clinical reasoning; critical care; infection; procalcitonin; survey

Indexed keywords

ANTIBIOTIC AGENT; C REACTIVE PROTEIN; PROCALCITONIN; ANTIINFECTIVE AGENT;

ABDOMINAL INFECTION; ANTIBIOTIC THERAPY; ARTICLE; BACTERIAL INFECTION; BACTERIAL MENINGITIS; BACTERIAL PNEUMONIA; CANADA; CASE REPORT; CHILD; CLINICAL ARTICLE; CROSS-SECTIONAL STUDY; DISEASE SEVERITY; DRUG USE; ERYTHROCYTE SEDIMENTATION RATE; HOSPITAL INFECTION; HUMAN; LEUKOCYTE; MALE; PEDIATRIC INTENSIVE CARE UNIT; PLEURA EFFUSION; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SCHOOL CHILD; SEPSIS; ADOLESCENT; CLINICAL PRACTICE; FEMALE; HEALTH CARE SURVEY; INFANT; INTENSIVE CARE; NEWBORN; PRESCHOOL CHILD; PROCEDURES; STATISTICAL MODEL; STATISTICS AND NUMERICAL DATA;

ADOLESCENT; ANTI-BACTERIAL AGENTS; BACTERIAL INFECTIONS; CANADA; CHILD; CHILD, PRESCHOOL; CRITICAL CARE; CROSS-SECTIONAL STUDIES; FEMALE; HEALTH CARE SURVEYS; HUMANS; INFANT; INFANT, NEWBORN; INTENSIVE CARE UNITS, PEDIATRIC; LINEAR MODELS; MALE; PRACTICE PATTERNS, PHYSICIANS';

EID: 85021647451     PISSN: 15297535     EISSN: 19473893     Source Type: Journal    
DOI: 10.1097/PCC.0000000000001238     Document Type: Article

References (42)

1. Fischer JE, Ramser M, Fanconi S: Use of antibiotics in pediatric intensive care and potential savings. Intensive Care Med 2000; 26:959-966
2. Audry-Degardin E, Dubos F, Leteurtre S, et al: Evaluation of the antibiotic prescription in a paediatric intensive care unit. Arch Pediatr 2007; 14:157-163
3. Blinova E, Lau E, Bitnun A, et al: Point prevalence survey of antimicrobial utilization in the cardiac and pediatric critical care unit. Pediatr Crit Care Med 2013; 14:e280-e288
4. Ceyhan M, Yildirim I, Ecevit C, et al: Inappropriate antimicrobial use in Turkish pediatric hospitals: A multicenter point prevalence survey. Int J Infect Dis 2010; 14:e55-e61
5. Ciofi Degli Atti ML, Raponi M, Tozzi AE, et al: Point prevalence study of antibiotic use in a paediatric hospital in Italy. Eurosurveillance 2008; 13:12-15
6. Ding H, Yang Y, Chen Y, et al: Antimicrobial usage in paediatric intensive care units in China. Acta Paediatr 2008; 97:100-104
7. Ding H, Yang Y, Lu Q, et al: Five-year surveillance of antimicrobial use in Chinese Pediatric Intensive Care Units. J Trop Pediatr 2008; 54:238-242
8. Ferrer R, Artigas A, Suarez D, et al; Edusepsis Study Group: Effectiveness of treatments for severe sepsis: A prospective, multicenter, observational study. Am J Respir Crit Care Med 2009; 180:861-866
9. Ferrer R, Martin-Loeches I, Phillips G, et al: Empiric antibiotic treatment reduces mortality in severe sepsis and septic shock from the first hour: Results from a guideline-based performance improvement program. Crit Care Med 2014; 42:1749-1755
10. Gaieski DF, Mikkelsen ME, Band RA, et al: Impact of time to antibiotics on survival in patients with severe sepsis or septic shock in whom early goal-directed therapy was initiated in the emergency department. Crit Care Med 2010; 38:1045-1053
11. Kumar A, Roberts D, Wood KE, et al: Duration of hypotension before initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock. Crit Care Med 2006; 34:1589-1596
12. European Centre for Disease Prevention and Control (ECDC), European Medicines Agency (EMEA): ECDC/EMEA Joint Technical Report-The bacterial challenge: Time to react. Available at: http://ecdc.europa.eu/en/publications/Publications/0909-TER-The-Bacterial-Challenge-Time-To-React.pdf. Accessed June 23, 2017
13. Birnbaum D; Canadian Committee on Antibiotic Resistance: Antimicrobial resistance: A deadly burden no country can afford to ignore. Can Commun Dis Rep 2003; 29:157-164
14. World Health Organization (WHO): The Evolving Threat of Antimicrobial Resistance: Options for Action. Geneva, World Health Organization (WHO), 2012
15. Barlam TF, Cosgrove SE, Abbo LM, et al: Implementing an Antibiotic Stewardship Program: Guidelines by the Infectious Diseases Society of America and the Society for Healthcare Epidemiology of America. Clin Infect Dis 2016; 62:e51-e77
16. Dellinger RP, Levy MM, Rhodes A, et al; Surviving Sepsis Campaign Guidelines Committee including the Pediatric Subgroup: Surviving sepsis campaign: International guidelines for management of severe sepsis and septic shock: 2012. Crit Care Med 2013; 41:580-637
17. Le Saux N, Robinson J: Pneumonia in healthy Canadian children and youth: Practice points for management. Paediatr Child Health 2011; 16:417-424
18. Solomkin JS, Mazuski JE, Bradley JS, et al: Diagnosis and management of complicated intra-Abdominal infection in adults and children: Guidelines by the Surgical Infection Society and the Infectious Diseases Society of America. Clin Infect Dis 2010; 50:133-164
19. Tunkel AR, Hartman BJ, Kaplan SL, et al: Practice guidelines for the management of bacterial meningitis. Clin Infect Dis 2004; 39:1267-1284
20. Burns KE, Duffett M, Kho ME, et al; ACCADEMY Group: A guide for the design and conduct of self-Administered surveys of clinicians. CMAJ 2008; 179:245-252
21. Duffett M, Choong K, Vanniyasingam T, et al: Making decisions about medications in critically ill children: A survey of Canadian pediatric critical care clinicians. Pediatr Crit Care Med 2015; 16:21-28
22. Du Pont-Thibodeau G, Tucci M, Ducruet T, et al: Survey on stated transfusion practices in PICUs. Pediatr Crit Care Med 2014; 15:409-416
23. Newcombe RG: Two-sided confidence intervals for the single proportion: Comparison of seven methods. Stat Med 1998; 17:857-872
24. Hollander M, Wolfe DA: Nonparametric Statistical Methods. New York, John Wiley & Sons, 1973
25. Bauer DF: Constructing confidence sets using rank statistics. J Am Stat Assoc 1972; 67:687-690
26. Harrell F: Regression Modeling Strategies: With Applications to Linear Models, Logistic Regression, and Survival Analysis. Second Edition. New York, Springer, 2015
27. Akaike H: An information criterion (AIC). Math Sci 1976; 14:5-9
28. R Core Team: R: A Language and Environment for Statistical Computing. Vienna, Austria, R Foundation for Statistical Computing, 2016
29. Kim JH, Gallis HA: Observations on spiraling empiricism: Its causes, allure, and perils, with particular reference to antibiotic therapy. Am J Med 1989; 87:201-206
30. Aarts MA, Granton J, Cook DJ, et al: Empiric antimicrobial therapy in critical illness: Results of a surgical infection society survey. Surg Infect (Larchmt) 2007; 8:329-336
31. Aarts MA, Brun-Buisson C, Cook DJ, et al: Antibiotic management of suspected nosocomial ICU-Acquired infection: Does prolonged empiric therapy improve outcome? Intensive Care Med 2007; 33:1369-1378
32. Thomas Z, Bandali F, Sankaranarayanan J, et al; Critical Care Pharmacotherapy Trials Network: A multicenter evaluation of prolonged empiric antibiotic therapy in adult ICUs in the United States. Crit Care Med 2015; 43:2527-2534
33. Mandell LA, Wunderink RG, Anzueto A, et al; Infectious Diseases Society of America; American Thoracic Society: Infectious Diseases Society of America/American Thoracic Society consensus guidelines on the management of community-Acquired pneumonia in adults. Clin Infect Dis 2007; 44(Suppl 2):S27-S72
34. Mermel LA, Allon M, Bouza E, et al: Clinical practice guidelines for the diagnosis and management of intravascular catheter-related infection: 2009 Update by the Infectious Diseases Society of America. Clin Infect Dis 2009; 49:1-45
35. Bradley JS, Byington CL, Shah SS, et al; Pediatric Infectious Diseases Society and the Infectious Diseases Society of America: The management of community-Acquired pneumonia in infants and children older than 3 months of age: Clinical practice guidelines by the Pediatric Infectious Diseases Society and the Infectious Diseases Society of America. Clin Infect Dis 2011; 53:e25-e76
36. Mazuski JE, Sawyer RG, Nathens AB, et al; Therapeutic Agents Committee of the Surgical Infections Society: The Surgical Infection Society guidelines on antimicrobial therapy for intra-Abdominal infections: Evidence for the recommendations. Surg Infect (Larchmt) 2002; 3:175-233
37. Kalil AC, Metersky ML, Klompas M, et al: Executive summary: Management of adults with hospital-Acquired and ventilator-Associated pneumonia: 2016 clinical practice guidelines by the Infectious Diseases Society of America and the American Thoracic Society. Clin Infect Dis 2016; 63:575-582
38. Pugh R, Grant C, Cooke RP, Dempsey G: Short-course versus prolonged-course antibiotic therapy for hospital-Acquired pneumonia in critically ill adults. Cochrane Database Syst Rev 2015:Cd007577.
39. Bonsu BK, Harper MB: Differentiating acute bacterial meningitis from acute viral meningitis among children with cerebrospinal fluid pleocytosis: A multivariable regression model. Pediatr Infect Dis J 2004; 23:511-517
40. Jaeger F, Leroy J, Duchêne F, et al: Validation of a diagnosis model for differentiating bacterial from viral meningitis in infants and children under 3.5 years of age. Eur J Clin Microbiol Infect Dis 2000; 19:418-421
41. McKinney WP, Heudebert GR, Harper SA, et al: Validation of a clinical prediction rule for the differential diagnosis of acute meningitis. J Gen Intern Med 1994; 9:8-12
42. Spanos A, Harrell FE Jr, Durack DT: Differential diagnosis of acute meningitis. An analysis of the predictive value of initial observations. JAMA 1989; 262:2700-2707