Chronic use of low-dose aspirin is not associated with lower bone mineral density in the general population

International Journal of Cardiology

Volumn 244, Issue , 2017, Pages 298-302

  Bonten, T N ^a   de Mutsert, R ^a   Rosendaal, F R ^a   Jukema, J W ^a   van der Bom, J G ^a,b   de Jongh, R T ^c   den Heijer, M ^a,c  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^b SANQUIN RESEARCH   (Netherlands)

^c VU UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Aspirin; Bone mineral density; Cardiovascular disease

Indexed keywords

ACETYLSALICYLIC ACID;

ADULT; AGED; ARTICLE; BODY COMPOSITION; BONE DENSITY; CARDIOVASCULAR DISEASE; COHORT ANALYSIS; COMORBIDITY; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; DEMOGRAPHY; DUAL ENERGY X RAY ABSORPTIOMETRY; FEMALE; FEMUR; HUMAN; LOW DRUG DOSE; MAJOR CLINICAL STUDY; MALE; POPULATION RESEARCH; POSTMENOPAUSE; PRIORITY JOURNAL; SECONDARY PREVENTION; VERTEBRA; CHEMICALLY INDUCED; DIAGNOSTIC IMAGING; DRUG ADMINISTRATION; DRUG EFFECTS; FRACTURE; HEALTH SURVEY; MIDDLE AGED; NETHERLANDS; PHOTON ABSORPTIOMETRY; PHYSIOLOGY; SPINE; TRENDS;

ABSORPTIOMETRY, PHOTON; AGED; ASPIRIN; BONE DENSITY; COHORT STUDIES; CROSS-SECTIONAL STUDIES; DRUG ADMINISTRATION SCHEDULE; FEMALE; FEMUR; FRACTURES, BONE; HUMANS; MALE; MIDDLE AGED; NETHERLANDS; POPULATION SURVEILLANCE; SPINE;

EID: 85021623504     PISSN: 01675273     EISSN: 18741754     Source Type: Journal    
DOI: 10.1016/j.ijcard.2017.06.089     Document Type: Article

References (35)

1. Mozaffarian, D., Benjamin, E.J., Go, A.S., Arnett, D.K., Blaha, M.J., Cushman, M., et al. Heart disease and stroke statistics—2015 update: a report from the American Heart Association. Circulation 131 (2015), e29–322.
2. Patrono, C., Bachmann, F., Baigent, C., Bode, C., De, C.R., Charbonnier, B., et al. Expert consensus document on the use of antiplatelet agents. The task force on the use of antiplatelet agents in patients with atherosclerotic cardiovascular disease of the European society of cardiology. Eur. Heart J. 25 (2004), 166–181.
3. Jorgensen, N.R., Grove, E.L., Schwarz, P., Vestergaard, P., Clopidogrel and the risk of osteoporotic fractures: a nationwide cohort study. J. Intern. Med. 272 (2012), 385–393.
4. Vestergaard, P., Steinberg, T.H., Schwarz, P., Jorgensen, N.R., Use of the oral platelet inhibitors dipyridamole and acetylsalicylic acid is associated with increased risk of fracture. Int. J. Cardiol. 160 (2012), 36–40.
5. Vestergaard, P., Hermann, P., Jensen, J.E.B., Eiken, P., Mosekilde, L., Effects of paracetamol, non-steroidal anti-inflammatory drugs, acetylsalicylic acid, and opioids on bone mineral density and risk of fracture: results of the Danish osteoporosis prevention study (DOPS). Osteoporos. Int. 23 (2012), 1255–1265.
6. Rachner, T.D., Khosla, S., Hofbauer, L.C., Osteoporosis: now and the future. Lancet 377 (2009), 1276–1287.
7. Cummings, S.R., Bates, D., Black, D.M., Clinical use of bone densitometry: scientific review. JAMA 288 (2002), 1889–1897.
8. Boutaud, O., Sosa, I.R., Amin, T., Oram, D., Adler, D., Hwang, H.S., et al. Inhibition of the biosynthesis of prostaglandin E2 by low-dose aspirin: implications for adenocarcinoma metastasis. Cancer Prev. Res. (Phila.) 9 (2016), 855–865.
9. Chin, K.Y., A review on the relationship between aspirin and bone health. J. Osteoporos., 2017, 2017, 3710959.
10. Blackwell, K.A., Raisz, L.G., Pilbeam, C.C., Prostaglandins in bone: bad cop, good cop?. Trends Endocrinol. Metab. 21 (2010), 294–301.
11. Grosser, N., Schroder, H., Aspirin protects endothelial cells from oxidant damage via the nitric oxide-cGMP pathway. Arterioscler. Thromb. Vasc. Biol. 23 (2003), 1345–1351.
12. Taubert, D., Berkels, R., Grosser, N., Schroder, H., Grundemann, D., Schomig, E., Aspirin induces nitric oxide release from vascular endothelium: a novel mechanism of action. Br. J. Pharmacol. 143 (2004), 159–165.
13. Armour, K.E., Van'T Hof, R.J., Grabowski, P.S., Reid, D.M., Ralston, S.H., Evidence for a pathogenic role of nitric oxide in inflammation-induced osteoporosis. J. Bone Miner. Res. 14 (1999), 2137–2142.
14. Bauer, D.C., Orwoll, E.S., Fox, K.M., Vogt, T.M., Lane, N.E., Hochberg, M.C., et al. Aspirin and NSAID use in older women: effect on bone mineral density and fracture risk. J. Bone Miner. Res. 11 (1996), 29–35.
15. Bleicher, K., Cumming, R.G., Naganathan, V., Seibel, M.J., Sambrook, P.N., Blyth, F.M., et al. Lifestyle factors, medications, and disease influence bone mineral density in older men: findings from the CHAMP study. Osteoporos. Int. 22 (2011), 2421–2437.
16. Morton, D.J., Barrett-Connor, E.L., Schneider, D.L., Nonsteroidal anti-inflammatory drugs and bone mineral density in older women: the rancho Bernardo study. J. Bone Miner. Res. 13 (1998), 1924–1931.
17. Carbone, L.D., Tylavsky, F.A., Cauley, J.A., Harris, T.B., Lang, T.F., Bauer, D.C., et al. Association between bone mineral density and the use of nonsteroidal anti-inflammatory drugs and aspirin: impact of cyclooxygenase selectivity. J. Bone Miner. Res. 18 (2003), 1795–1802.
18. de Mutsert, R.M., den Heijer, M., Rabelink, T.J., Smit, J.W., Romijn, J.A., Jukema, J.W., et al. The Netherlands Epidemiology of Obesity (NEO) study: study design and data collection. Eur. J. Epidemiol. 28 (2013), 513–523.
19. Buckley, K.A., Golding, S.L., Rice, J.M., Dillon, J.P., Gallagher, J.A., Release and interconversion of P2 receptor agonists by human osteoblast-like cells. FASEB J. 17 (2003), 1401–1410.
20. Suzawa, T., Miyaura, C., Inada, M., Maruyama, T., Sugimoto, Y., Ushikubi, F., et al. The role of prostaglandin E receptor subtypes (EP1, EP2, EP3, and EP4) in bone resorption: an analysis using specific agonists for the respective EPs. Endocrinology 141 (2000), 1554–1559.
21. Wendel-Vos, G.C., Schuit, A.J., Saris, W.H., Kromhout, D., Reproducibility and relative validity of the short questionnaire to assess health-enhancing physical activity. J. Clin. Epidemiol. 56 (2003), 1163–1169.
22. Verkleij-Hagoort, A.C., de Vries, J.H., Stegers, M.P., Lindemans, J., Ursem, N.T., Steegers-Theunissen, R.P., Validation of the assessment of folate and vitamin B12 intake in women of reproductive age: the method of triads. Eur. J. Clin. Nutr. 61 (2007), 610–615.
23. Levey, A.S., Bosch, J.P., Lewis, J.B., Greene, T., Rogers, N., Roth, D., A more accurate method to estimate glomerular filtration rate from serum creatinine: a new prediction equation. Modification of diet in renal disease study group. Ann. Intern. Med. 130 (1999), 461–470.
24. Altman, R., Alarcon, G., Appelrouth, D., Bloch, D., Borenstein, D., Brandt, K., et al. The American College of Rheumatology criteria for the classification and reporting of osteoarthritis of the hand. Arthritis Rheum. 33 (1990), 1601–1610.
25. Altman, R., Asch, E., Bloch, D., Bole, G., Borenstein, D., Brandt, K., et al. Development of criteria for the classification and reporting of osteoarthritis. Classification of osteoarthritis of the knee. Diagnostic and therapeutic criteria Committee of the American Rheumatism Association. Arthritis Rheum. 29 (1986), 1039–1049.
26. Korn, E.L., Graubard, B.I., Epidemiologic studies utilizing surveys: accounting for the sampling design. Am. J. Public Health 81 (1991), 1166–1173.
27. Lumley, T., Analysis of complex survey samples. J. Stat. Softw., 2004.
28. Centraal Buro voor de Statistiek (CBS), Uitkomsten Gezondheidsmonitor. https://www.cbs.nl/nl-nl/maatwerk/2013/37/uitkomsten-gezondheidsmonitor-2012, 2012 (accessed 03.04.2017).
29. Berard, A., Bravo, G., Gauthier, P., Meta-analysis of the effectiveness of physical activity for the prevention of bone loss in postmenopausal women. Osteoporos. Int. 7 (1997), 331–337.
30. Drake, M.T., Murad, M.H., Mauck, K.F., Lane, M.A., Undavalli, C., Elraiyah, T., et al. Clinical review. Risk factors for low bone mass-related fractures in men: a systematic review and meta-analysis. J. Clin. Endocrinol. Metab. 97 (2012), 1861–1870.
31. Pluijm, S.M.F., Visser, M., Smit, J.H., Popp-Snijders, C., Roos, J.C., Lips, P., Determinants of bone mineral density in older men and women: body composition as mediator. J. Bone Miner. Res. 16 (2001), 2142–2151.
32. Austin, P.C., Steyerberg, E.W., The number of subjects per variable required in linear regression analyses. J. Clin. Epidemiol. 68 (2015), 627–636.
33. Hollaender, R., Hartl, F., Krieg, M.A., Tyndall, A., Geuckel, C., Buitrago-Tellez, C., et al. Prospective evaluation of risk of vertebral fractures using quantitative ultrasound measurements and bone mineral density in a population-based sample of postmenopausal women: results of the Basel osteoporosis study. Ann. Rheum. Dis. 68 (2009), 391–396.
34. Naylor, K., Eastell, R., Bone turnover markers: use in osteoporosis. Nat. Rev. Rheumatol. 8 (2012), 379–389.
35. Rabar, S., Lau, R., O'Flynn, N., Li, L., Barry, P., Risk assessment of fragility fractures: summary of NICE guidance. BMJ, 345, 2012, e3698.