Left ventricular ejection fraction recovery in patients with heart failure treated with intravenous iron: a pilot study

ESC Heart Failure

Volumn 3, Issue 4, 2016, Pages 293-298

  Núñez, Julio ^a   Monmeneu, José Vicente ^a   Mollar, Anna ^a   Núñez, Eduardo ^a   Bodí, Vicent ^a   Miñana, Gema ^a   García Blas, Sergio ^a   Santas, Enrique ^a   Agüero, Jaume ^b   Chorro, Francisco J ^a   Sanchis, Juan ^a   López Lereu, Maria Pilar ^a  

^a HOSPITAL CLÍNICO UNIVERSITARIO   (Spain)

^b CENTRO NACIONAL DE INVESTIGACIONES CARDIOVASCULARES CNIC   (Spain)

Author keywords

Intravenous iron; Iron deficiency; Left ventricular ejection fraction; Magnetic resonance imaging; Systolic heart failure; T2* sequence

Indexed keywords

EID: 85021363672     PISSN: None     EISSN: 20555822     Source Type: Journal    
DOI: 10.1002/ehf2.12101     Document Type: Article

References (15)

1. Anker SD, Comin Colet J, Filippatos G, Willenheimer R, Dickstein K, Drexler H, Lüscher TF, Bart B, Banasiak W, Niegowska J, Kirwan BA, Mori C, von Eisenhart RB, Pocock SJ, Poole-Wilson PA, Ponikowski P, Trial Investigators FAIR-HF. Ferric carboxymaltose in patients with heart failure and iron deficiency. N Engl J Med 2009; 361: 2436–48
2. Filippatos G, Farmakis D, Colet JC, Dickstein K, Lüscher TF, Willenheimer R, Parissis J, Gaudesius G, Mori C, von Eisenhart RB, Greenlaw N, Ford I, Ponikowski P, Anker SD. Intravenous ferric carboxymaltose in iron-deficient chronic heart failure patients with and without anaemia: a subanalysis of the FAIR-HF trial. Eur J Heart Fail 2013; 15: 1267–76
3. Dong F, Zhang X, Culver B, ChewHGJr KRO, Ren J. Dietary iron deficiency induces ventricular dilation, mitochondrial ultrastructural aberrations and cytochrome c release: involvement of nitric oxide synthase and protein tyrosine nitration. Clin Sci (London) 2005; 109: 277–286
4. Maeder MT, Khammy O, Remedios C, Kaye DM. Myocardial and systemic iron depletion in heart failure implications for anemia accompanying heart failure. J Am Coll Cardiol 2011; 58: 474–80
5. Toblli JE, Di Gennaro F, Rivas C. Changes in echocardiographic parameters in iron deficiency patients with heart failure and chronic kidney disease treated with intravenous iron. Heart Lung Circ 2015; 24: 686–95
6. McMurray J, Ponikowski P. Heart failure not enough pump iron? J Am Coll Cardiol 2011; 58: 481–2
7. Anderson LJ, Holden S, Davis B, Prescott E, Charrier CC, Bunce NH, Firmin DN, Wonke B, Porter J, Walker JM, Pennell DJ. Cardiovascular T2-star (T2*) magnetic resonance for the early diagnosis of myocardial iron overload. Eur Heart J 2001; 22: 2171–9
8. Carpenter JP, He T, Kirk P, Roughton M, Anderson LJ, de Noronha SV, Sheppard MN, Porter JB, Walker JM, Wood JC, Galanello R, Forni G, Catani G, Matta G, Fucharoen S, Fleming A, House MJ, Black G, Firmin DN, St Pierre TG, Pennell DJ. On T2* magnetic resonance and cardiac iron. Circulation 2011; 123: 1519–28
9. Nagao M, Matsuo Y, Kamitani T, Yonezawa M, Yamasaki Y, Kawanami S, Abe K, Mukai Y, Higo T, Yabuuchi H, Takemura A, Yoshiura T, Sunagawa K, Honda H. Quantification of myocardial iron deficiency in nonischemic heart failure by cardiac T2* magnetic resonance imaging. Am J Cardiol 2014; 113: 1024–30
10. Nagao M, Baba S, Yonezawa M, Yamasaki Y, Kamitani T, Isoda T, Kawanami S, Maruoka Y, Kitamura Y, Abe K, Higo T, Sunagawa K, Honda H. Prediction of adverse cardiac events in dilated cardiomyopathy using cardiac T2* MRI and MIBG scintigraphy. Int J Cardiovasc Imaging 2015; 31: 399–407
11. Cohen-Solal A, Leclercq C, Deray G, Lasocki S, Zambrowski JJ, Mebazaa A, de Groote P, Damy T, Galinier M. Iron deficiency: an emerging therapeutic target in heart failure. Heart 2014; 100: 1414–20
12. Sawicki KT, Chang HC, Ardehali H. Role of heme in cardiovascular physiology and disease. J Am Heart Assoc 2015; 4: e001138
13. Goldstein D, Felzen B, Youdim M, Lotan R, Binah O. Experimental iron deficiency in rats: mechanical and electrophysiological alterations in the cardiac muscle. Clin Sci (Lond) 1996; 91: 233–9
14. Dong F, Zhang X, Culver B, Chew HG Jr, Kelley RO, Ren J. Dietary iron deficiency induces ventricular dilation, mitochondrial ultrastructural aberrations and cytochrome c release: involvement of nitric oxide synthase and protein tyrosine nitration. Clin Sci (Lond) 2005; 109: 277–86
15. Hawwa N, Shrestha K, Hammadah M, Yeo PS, Fatica R, Tang WH. Reverse remodeling and prognosis following kidney transplantation in contemporary patients with cardiac dysfunction. J Am Coll Cardiol 2015; 66: 1779–87