Local protein kinase A action proceeds through intact holoenzymes

Science

Volumn 356, Issue 6344, 2017, Pages 1288-1293

  Smith, F Donelson ^a   Esseltine, Jessica L ^a,d   Nygren, Patrick J ^a   Veesler, David ^a   Byrne, Dominic P ^b   Vonderach, Matthias ^b   Strashnov, Ilya ^c   Eyers, Claire E ^b   Eyers, Patrick A ^b   Langeberg, Lorene K ^a   Scott, John D ^a  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF LIVERPOOL   (United Kingdom)

^c UNIVERSITY OF MANCHESTER   (United Kingdom)

^d WESTERN UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; FORSKOLIN; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; HOLOENZYME; ISOBUTYLMETHYLXANTHINE; ISOPRENALINE; ROLIPRAM; CYCLIC AMP DEPENDENT PROTEIN KINASE ANCHORING PROTEIN; HYBRID PROTEIN; PROTEIN BINDING;

CATALYSIS; CATALYST; CYTOPLASM; ENZYME; ENZYME ACTIVITY; HORMONE; PROTEIN;

APOPTOSIS; ARTICLE; CELL LYSATE; CRISPR CAS SYSTEM; ENZYME ACTIVITY; FLUORESCENCE RESONANCE ENERGY TRANSFER; GENE EDITING; GENETIC BACKGROUND; HEK293 CELL LINE; HUMAN; IMMUNOBLOTTING; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; ANIMAL; CHEMISTRY; ELECTRON MICROSCOPY; ENZYMOLOGY; GENETICS; METABOLISM; MITOCHONDRION; MOUSE; PHOSPHORYLATION; PROTEIN STABILITY; SIGNAL TRANSDUCTION; TUMOR CELL LINE;

A KINASE ANCHOR PROTEINS; ANIMALS; CELL LINE, TUMOR; CYCLIC AMP; CYCLIC AMP-DEPENDENT PROTEIN KINASES; HOLOENZYMES; HUMANS; MICE; MICROSCOPY, ELECTRON; MITOCHONDRIA; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN STABILITY; RECOMBINANT FUSION PROTEINS; SIGNAL TRANSDUCTION;

EID: 85021306691     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.aaj1669     Document Type: Article

References (32)

1. D. A. Walsh, J. P. Perkins, E. G. Krebs, J. Biol. Chem. 243, 3763-3765 (1968).
2. R. L. Potter, S. S. Taylor, J. Biol. Chem. 254, 2413-2418 (1979).
3. D. R. Knighton et al., Science 253, 407-414 (1991).
4. L. K. Langeberg, J. D. Scott, Nat. Rev. Mol. Cell Biol. 16, 232-244 (2015).
5. S. H. Scheres, J. Struct. Biol. 180, 519-530 (2012).
6. F. D. Smith et al., eLife 2, e01319 (2013).
7. A. J. Heck, Nat. Methods 5, 927-933 (2008).
8. M. G. Gold et al., Proc. Natl. Acad. Sci. U.S.A. 108, 6426-6431 (2011).
9. D. P. Byrne et al., Biochem. J. 473, 3159-3175 (2016).
10. M. Zaccolo, T. Pozzan, Science 295, 1711-1715 (2002).
11. P. J. Silver, Am. J. Cardiol. 63, 2A-8A (1989).
12. S. L. Jin, T. Bushnik, L. Lan, M. Conti, J. Biol. Chem. 273, 19672-19678 (1998).
13. J. Zhang, R. E. Campbell, A. Y. Ting, R. Y. Tsien, Nat. Rev. Mol. Cell Biol. 3, 906-918 (2002).
14. L. M. DiPilato, J. Zhang, Mol. Biosyst. 5, 832-837 (2009).
15. O. Söderberg et al., Genet. Eng. (N.Y.) 28, 85-93 (2007).
16. K. J. Herbst, M. D. Allen, J. Zhang, Mol. Cell. Biol. 31, 4063-4075 (2011).
17. S. S. Taylor, R. Ilouz, P. Zhang, A. P. Kornev, Nat. Rev. Mol. Cell Biol. 13, 646-658 (2012).
18. D. J. Morgan et al., Proc. Natl. Acad. Sci. U.S.A. 105, 20740-20745 (2008).
19. M. S. Lopez, J. I. Kliegman, K. M. Shokat, Methods Enzymol. 548, 189-213 (2014).
20. H. Harada et al., Mol. Cell 3, 413-422 (1999).
21. J. M. Lizcano, N. Morrice, P. Cohen, Biochem. J. 349, 547-557 (2000).
22. Y. Tan, M. R. Demeter, H. Ruan, M. J. Comb, J. Biol. Chem. 275, 25865-25869 (2000).
23. K. Virdee, P. A. Parone, A. M. Tolkovsky, Curr. Biol. 10, R883 (2000).
24. E. H. Cheng, T. V. Sheiko, J. K. Fisher, W. J. Craigen, S. J. Korsmeyer, Science 301, 513-517 (2003).
25. G. Manning, D. B. Whyte, R. Martinez, T. Hunter, S. Sudarsanam, Science 298, 1912-1934 (2002).
26. J. D. Scott, C. W. Dessauer, K. Taskén, Annu. Rev. Pharmacol. Toxicol. 53, 187-210 (2013).
27. N. Hoshi, L. K. Langeberg, C. M. Gould, A. C. Newton, J. D. Scott, Mol. Cell 37, 541-550 (2010).
28. N. Hoshi, L. K. Langeberg, J. D. Scott, Nat. Cell Biol. 7, 1066-1073 (2005).
29. H. Hehnly et al., eLife 4, e09384 (2015).
30. B. Lygren et al., EMBO Rep. 8, 1061-1067 (2007).
31. J. C. Chrivia et al., Nature 365, 855-859 (1993).
32. M. Hagiwara et al., Mol. Cell. Biol. 13, 4852-4859 (1993).