The impact of oral probiotics on vaginal Group B Streptococcal colonisation rates in pregnant women: A pilot randomised control study

Women and Birth

Volumn 31, Issue 1, 2018, Pages 31-37

  Olsen, Paula ^a,b   Williamson, Moira ^a,c   Traynor, Victoria ^a   Georgiou, Chris ^a,d,e  

^a UNIVERSITY OF WOLLONGONG   (Australia)

^b SUTHERLAND HOSPITAL   (Australia)

^c CENTRAL QUEENSLAND UNIVERSITY   (Australia)

^d EASTERN HEALTH   (Australia)

^e MONASH UNIVERSITY   (Australia)

Author keywords

Bacterial Vaginosis; Group B Streptococcus; Lactobacillus; Pregnancy; Probiotics

Indexed keywords

PROBIOTIC AGENT;

ARTICLE; ASSOCIATION; BACTERIAL COLONIZATION; CLINICAL ARTICLE; COMMENSAL; CONTROLLED STUDY; DRUG USE; FEMALE; FOLLOW UP; GROUP B STREPTOCOCCAL INFECTION; HUMAN; INSTRUMENTAL DELIVERY; LACTOBACILLUS; MATERNAL HYPERTENSION; PAPULE; PILOT STUDY; PREGNANCY; PREGNANT WOMAN; PRENATAL CARE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; TELEPHONE INTERVIEW; VAGINA FLORA; ADULT; AUSTRALIA; DRUG EFFECT; ISOLATION AND PURIFICATION; MICROBIOLOGY; PREGNANCY COMPLICATION; PROCEDURES; RISK FACTOR; STREPTOCOCCUS AGALACTIAE; STREPTOCOCCUS INFECTION; VAGINA; YOUNG ADULT;

ADULT; AUSTRALIA; FEMALE; HUMANS; PILOT PROJECTS; PREGNANCY; PREGNANCY COMPLICATIONS, INFECTIOUS; PRENATAL CARE; PROBIOTICS; RISK FACTORS; STREPTOCOCCAL INFECTIONS; STREPTOCOCCUS AGALACTIAE; VAGINA; YOUNG ADULT;

EID: 85021263149     PISSN: 18715192     EISSN: 18781799     Source Type: Journal    
DOI: 10.1016/j.wombi.2017.06.012     Document Type: Article

References (56)

1. McIlwaine, K., Kneebone, K., Barkehall-Thomas, A., Wallace, E., Compliance with a risk factor-based intrapartum prophylaxis program for neonatal group B streptococcal disease. Aust N Z J Obstet Gynaecol 46 (2006), 199–201.
2. RANZCOG, Maternal Group B Streptococcus in pregnancy: screening and management (C-Obs 19). 2011, Royal Australian and New Zealand College of Obstetricians and Gynaecologists, Melbourne.
3. Centers for Disease Control and Prevention, Prevention of perinatal Group B streptococcal disease. Revised guidelines from CDC, 2010. Morb Mortal Wkly Rep 59 (2010), 1–32.
4. Colombo, D., Lew, J., Pedersen, C., Johnson, J., Fan-Harvard, P., Optimal timing of ampicillin administration to pregnant women for establishing bactericidal levels in the prophylaxis of Group B Streptococcus. Am J Obstet Gynecol 194 (2006), 466–470.
5. Ohlsson, A., Shah, V., Intrapartum antibiotics for known maternal Group B streptococcal colonization. Cochrane Database Syst Rev, 2013, CD007467, 10.1002/14651858 pub3 (Art. No. CD0074767).
6. Hassan, I.A., Onon, T.S., Weston, D., Isalska, B., Wall, K., Afshar, B., et al. A quantitative descriptive study of the prevalence of carriage (colonisation) of haemolytic streptococci groups A, B, C and G in pregnancy. Obstet Gynaecol 31 (2011), 207–209.
7. Jones, N., Oliver, K., Jones, Y., Haines, A., Crook, D., Carriage of group B streptococcus in pregnant women from Oxford, UK. J Clin Pathol 59 (2006), 363–366.
8. Matsubara, K., Kawai, M., Nakahata, T., Kato, F., Tsujahara, H., Yamakawa, M., et al. Procedures for prevention of perinatal group B streptococcal diseases: a multicenter questionnaire survey of hospitals in the Kyoto Neonatal Disease Study Group, Japan. J Infect Chemother 13 (2007), 59–62.
9. Valkenburg-van den Burg, A., Sprij, A., Oostuogel, P., Mutsaers, J., Renes, W., Rosendaal, F., et al. Prevalence of colonisation with Group B Streptococci in pregnant women of a multi-ethnic population in the Netherlands. Eur J Obstet Gynecol Reprod Biol 125 (2006), 178–183.
10. Reingold, A., Gershaman, K., Petit, S., Arnold, K., Perinatal Group B Streptococcal disease after universal screening recommendations—United States, 2003–2005. Morb Mortal Wkly Rep 56 (2007), 701–705.
11. Daley, A., Isaacs, D., Ten-year study on the effect of intrapartum antibiotic prophylaxis on early onset group B streptococcal and Escherichia coli neonatal sepsis in Australasia. Pediatr Infect Dis J 23 (2004), 630–634.
12. Baltimore, R.S., Consequences of prophylaxis for group B streptococcal infections of the neonate. Semin Perinatol 31 (2007), 33–38.
13. Cheng, P.J., Shaw, S.W., Lin, P.Y., Huang, S.Y., Soong, Y.K., Maternal anxiety about prenatal screening for group B streptococcus disease and impact of positive colonization results. Eur J Obstet Gynecol Reprod Biol 128 (2006), 29–33.
14. Dietert, R.R., The microbiome in early life: self-completion and microbiota protection as health priorities. Birth Defects Res B Dev Reprod Toxicol 101 (2014), 333–340.
15. Edwards, M., Issues of antimicrobial resistance in group B streptococcus in the era of intrapartum antibiotic prophylaxis. Semin Pediatr Infect Dis 17 (2006), 149–152.
16. Grimwood, K., Darlow, B.A., Gosling, A., Green, R., Lennon, D.R., Martin, D.R., et al. Early-onset neonatal group B streptococcal infections in New Zealand, 1998–1999. J Paediatr Child Health 38 (2002), 272–277.
17. Nylund, L., Satokari, R., Salminen, S., de Vos, W.M., Intestinal microbiota during early life-impact on health and disease. Proc Nutr Soc 73 (2014), 457–469.
18. Patten, D., Robinson, A., Vollman, A., Manning, S., Mucenski, M., Vidakovich, J., et al. Vaccination for Group B Streptococcus during pregnancy: attitudes and concerns for women and health care providers. Soc Sci Med 63 (2006), 347–358.
19. Rautava, S., Luoto, R., Salminen, S., Isolauri, E., Microbial contact during pregnancy, intestinal colonization and human disease. Nat Rev Gastroenterol Hepatol 9 (2012), 565–576.
20. Russel, A.R., Murch, S.H., Could peripartum antibiotics have delayed health consequences for the infant?. BJOG 113 (2006), 758–765.
21. Soto, A., Martin, V., Jimenez, E., Mader, I., Rodriguez, J.M., Fernandez, L., Lactobacilli and Bifidobacteria in human breast milk: influence of antibiotherapy and other host and clinical factors. J Pediatr Gastroenterol Nutr 59 (2014), 78–88.
22. Treven, P., Mrak, V., Bogovic, M., Horvat, S., Rogelj, I., Administration of probiotics Lactobacillus rhamnosus GG and Lactobacillus gasseri K7 during pregnancy and lactation changes mouse mesenteric lymph nodes and mammary gland microbiota. J Dairy Sci 98 (2015), 2114–2128.
23. Chen, K., Puopolo, K., Eichenwald, E., Onderdonk, A., Lieberman, E., No increase in rates of early-onset neonatal sepsis by antibiotic-resistant group B Streptococcus in the era of intrapartum antibiotic prophylaxis. Am J Obstet Gynecol 192 (2005), 1167–1171.
24. Glasgow, T., Young, P., Wallin, J., Kwok, C., Stoddard, G., Firth, S., et al. Association of intrapartum antibiotic exposure and late-onset serious bacterial infections in infants. Pediatrics 116 (2005), 696–702.
25. Altoparlak, U., Kadanali, A., Kadanali, S., Genital flora in pregnancy and its association with group B streptococcal colonization. Int J Gynecol Obstet 87 (2004), 245–246.
26. Donders, G., Bosmans, E., Dekeersmaecker, A., Vereecken, A., Van Bulck, B., Spitz, B., Pathogenesis of abnormal vaginal bacterial flora. Am J Obstet Gynecol 182 (2000), 872–878.
27. Kubota, T., Nojima, M., Itoh, S., Vaginal bacterial flora of pregnant women colonized with group B streptococcus. J Infect Chemother 8 (2002), 326–330.
28. Whitney, C.G., Daly, S., Limpongsanurak, S., Festin, M.R., Thinnn, K.K., Chipato, T., et al. The international infections in pregnancy study: group B streptococcal colonization in pregnant women. J Matern Fetal Neonatal Med 15 (2004), 267–274.
29. Morelli, L., Zonenenschain, B.S., Del Piano, M., Cognein, P., Utilization of the intestinal tract as a delivery system for urogenital probiotics. J Clin Gastroenterol 38 (2004), s107–s110.
30. Barrons, R., Tassone, D., Use of Lactobacillus probiotics for bacterial genitourinary infections in women: a review. Clin Ther 30 (2008), 453–468.
31. Lagenaur, L.A., Sanders-Beer, B.E., Brichacek, B., Pal, R., Liu, X., Liu, Y., et al. Prevention of vaginal HIV transmission in macaques by a live recombinant Lactobacillus. Mucosal Immunol 4 (2011), 648–657.
32. Rose, W.A. 2nd, McGowin, C.L., Spagnuolo, R.A., Eaves-Pyles, T.D., Popov, V.L., Pyles, R.B., Commensal bacteria modulate innate immune responses of vaginal epithelial cell multilayer culture. PLoS One, 7, 2012, e32728.
33. Lagenaur, L., Lee, P., Hamer, D., Sanders-Beer, B., Demonstration of vaginal colonization with GusA-expressing Lactobacillus jensenii following oral delivery in rhesus macaques. Res Microbiol 162 (2011), 1006–1010.
34. Allen, S., Jordan, S., Storey, M., Thornton, C., Gravenor, M., Garaiova, I., et al. Dietary supplementation with Lactobacilli and Bifidobacteria is well tolerated and not associated with adverse events during late pregnancy and early infancy. J Nutr 140 (2010), 483–488.
35. Dugoua, J.-J., Machado, M., Zhu, X., Chen, X., Koren, G., Einarson, T., Probiotic safety in pregnancy: a systematic review and meta-analysis of randomised controlled trial of Lactobacillus, Bifidobacterium and Saccharomyces spp. J Obstet Gynaecol Can 31 (2009), 542–552.
36. Anukam, K., Osazuwa, E., Osemene, G., Ehigiagbe, F., Bruce, A., Reid, G., Clinical study comparing probiotic Lactobacillus GR-1 and RC-14 with metronidazole vaginal gel to treat symptomatic bacterial vaginosis. Microb Infect 8 (2006), 2772–2776.
37. Krauss-Silva, L., Moreira, M.E., Alves, M.B., Braga, A., Camacho, K., Batista, M., et al. A randomised controlled trial of probiotics for the prevention of spontaneous preterm delivery associated with bacterial vaginosis: preliminary results. Trials 12 (2011), 239–250.
38. Martinez, R., Franceschini, S., Patta, M., Quintana, S., Gomes, B., De Martinis, E., et al. Improved cure of bacterial vaginosis with single dose of tinidazole (2 g), Lactobacillus rhamnosus GR-1, and Lactobacillus reuteri RC-14: a randomised, double-blind, placebo-controlled trial. Can J Microbiol 55 (2009), 133–138.
39. Reid, G., Charbonneau, D., Erb, J., Kochanowski, B., Beuerman, D., Doehner, R., et al. Oral use of Lactobacillus rhamnosus GR-1 and Lactobacillus fermentum RC-14 significantly alters vaginal flora: a randomised, placebo-controlled trial in 64 healthy women. FEMS Immunol Med Microbiol 35 (2003), 131–134.
40. Reid, G., Burton, J., Hammond, J., Bruce, A., Nucleic acid-based diagnosis of bacterial vaginosis and improved management using probiotic Lactobacilli. J Med Food 7 (2004), 223–228.
41. Reid, G., Bruce, A., Fraser, N., Heinemann, C., Owen, J., Henning, B., Oral probiotics can resolve urogenital infections. FEMS Immunol Med Microbiol 30 (2001), 49–52.
42. Ruiz, F., Gerbaldo, G., Garcia, M., Giordano, W., Pascual, L., Barberis, I., Synergistic effect between two bacteriocin-like inhibitory substances produced by Lactobacilli strains with inhibitory activity for Streptococcus agalactiae. Curr Microbiol 64 (2012), 349–356.
43. De Gregorio, P.R., Juarez, T., Leccese, T., Nader-Macias, M.E., Preventive effect of Lactobacillus reuteri CRL 1324 on Group B Streptococcus vaginal colonization in an experimental mouse model. J Appl Microbiol 118 (2015), 1034–1047.
44. Lamont, R.F., Sobel, J.D., Akins, R.A., Hassan, S.S., Chaiworapongsa, T., Kusanovic, J.P., et al. The vagina microbiome: new information about genital tract flora using molecular based techniques. BJOG 118 (2011), 533–549.
45. Ortiz, L., Ruiz, F., Pascual, L., Barberis, L., Effect of two probiotic strains of Lactobacillus on in vitro adherence of Listeria monocytogenes, Streptococcus agalactiae, and Staphylococcus aureus to vaginal epithelial cells. Curr Microbiol 68 (2014), 679–684.
46. Pham, M., Lemberg, D., Day, A., Probiotics: sorting the evidence from the myths. Med J Aust 188 (2008), 304–308.
47. Joint FAO/WHO Working Group on Drafting Guidelines for the Evaluation of Probiotics in Food. Guidelines for the evaluation of probiotics in food. London, Ontario, Canada 2002. Available at http://www.faorg/es/ESN/Probio/probio.htm.2002.
48. Bodaszewska-Lubas, M., Brzychczy-Wloch, M., Gosiewski, T., Heczko, P., Antibacterial activity of selected standard strains of lactic acid bacteria producing bacteriocins—pilot study. Postepy Hig Med Dosw 66 (2012), 787–794.
49. Hanson, L., VandeVusse, L., Duster, M., Warrack, S., Safdar, N., Feasibility of oral prenatal probiotics against maternal Group B Streptococcus vaginal and rectal colonisation. J Obstet Gynecol Neonatal Nurs 43 (2014), 294–304.
50. Ehrstrom, S., Daroczy, K., Rylander, E., Samuelsson, C., Johannesson, U., Anzen, B., et al. Lactic acid bacteria colonization and clinical outcome after probiotic supplementation in conventionally treated bacterial vaginosis and vulvovaginal candidiasis. Microb Infect 12 (2010), 691–699.
51. Marcone, V., Rocca, G., Lichtner, M., Calzolari, E., Long-term vaginal administration of Lactobacillus rhamnosus as a complementary approach to management of bacterial vaginosis. Int J Gynecol Obstet 11 (2010), 223–226.
52. Stojanovic, N., Plecas, D., Plesinac, S., Normal vaginal flora, disorders and application of probiotics in pregnancy. Arch Gynecol Obstet 286 (2012), 325–332.
53. Vitali, B., Cruciani, F., Baldassarre, M.E., Capursi, T., Spisni, E., Valerii, M.C., et al. Dietary supplementation with probiotics during late pregnancy: outcome on vaginal microbiota and cytokine secretion. BMC Microbiol, 12, 2012, 236 Available at http://www.biomedcentral.com/147-2180/12/236.
54. Wang, Y., Reifer, C., Miller, L., Efficacy of vaginal probiotic capsules for recurrent bacterial vaginosis: a double-blind, randomised, placebo-controlled study. Am J Obstet Gynecol, 203, 2010 120e1–e6.
55. Edwards, R., Novak-Weekley, S., Koty, P., Davis, T., Leeds, L., Jordan, J., Rapid Group B streptococci screening using a real-time polymerase chain reaction assay. Obstet Gynecol 111 (2008), 1335–1341.
56. Rautava, S., Early microbial contact, the breast milk microbiome and child health. J Dev Orig Health Dis 7 (2016), 5–14.