Update and new insights in encephalitis

Clinical Microbiology and Infection

Volumn 23, Issue 9, 2017, Pages 607-613

  Mailles, A ^a,b   Stahl, J P ^b,c   Bloch, K C ^d  

^a SANTÉ PUBLIQUE FRANCE   (France)

^b ESCMID Study Group on infections of the Brain   (France)

^c UNIV GRENOBLE ALPES   (France)

^d VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Autoimmunity; Bornavirus; Chikungunya; Ebola; Encephalitis; Guidelines; Lassa; Naegleria fowleri; Next generation sequencing; Zika

Indexed keywords

ACICLOVIR; DEXAMETHASONE;

AUTOIMMUNITY; BORNAVIRUS; BRAIN; CENTRAL NERVOUS SYSTEM; CENTRAL NERVOUS SYSTEM INFECTION; CHIKUNGUNYA; CHIKUNGUNYA VIRUS; EBOLA HEMORRHAGIC FEVER; EBOLAVIRUS; HEALTH HAZARD; HERPES SIMPLEX ENCEPHALITIS; HUMAN; LASSA FEVER; LASSA VIRUS; MONONEGAVIRALES INFECTION; MULTIPLEX POLYMERASE CHAIN REACTION; NAEGLERIA FOWLERI; NEXT GENERATION SEQUENCING; NONHUMAN; POWASSAN VIRUS; PRACTICE GUIDELINE; PRIMARY AMEBIC MENINGOENCEPHALITIS; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL (TOPIC); REVIEW; VARIEGATED SQUIRREL BORNAVIRUS 1; VIRUS ENCEPHALITIS; ZIKA FEVER; ZIKA VIRUS; INFECTIOUS ENCEPHALITIS; MOLECULAR DIAGNOSIS; RNA VIRUS;

CENTRAL NERVOUS SYSTEM PROTOZOAL INFECTIONS; HUMANS; INFECTIOUS ENCEPHALITIS; MOLECULAR DIAGNOSTIC TECHNIQUES; NAEGLERIA FOWLERI; PRACTICE GUIDELINES AS TOPIC; RNA VIRUSES;

EID: 85021235855     PISSN: 1198743X     EISSN: 14690691     Source Type: Journal    
DOI: 10.1016/j.cmi.2017.05.002     Document Type: Review

References (78)

1. Hoffmann, B., Tappe, D., Höper, D., Herden, C., Boldt, A., Mawrin, C., et al. A variegated squirrel bornavirus associated with fatal human encephalitis. N Engl J Med 373 (2015), 154–162.
2. Schlottau, K., Jenckel, M., van den Brand, J., Fast, C., Herden, C., Höper, D., et al. Variegated squirrel bornavirus 1 in squirrels, Germany and The Netherlands. Emerg Infect Dis 23 (2017), 477–481.
3. Ikerionwu, S.E., Sato, K., Katchy, K.C., Suseelan, A.A., Lassa fever—an autopsy report from the eastern part of Nigeria. J Trop Med Hyg 81 (1978), 134–136.
4. Grahn, A., Bråve, A., Lagging, M., Dotevall, L., Ekqvist, D., Hammarström, H., et al. Imported case of Lassa fever in Sweden with encephalopathy and sensorineural hearing deficit. Open Forum Infect Dis, 3, 2016 ofw198.
5. Bwaka, M.A., Bonnet, M.J., Calain, P., Colebunders, R., De Roo, A., Guimard, Y., et al. Ebola hemorrhagic fever in Kikwit, Democratic Republic of the Congo: clinical observations in 103 patients. J Infect Dis 179:Suppl. 1 (1999), S1–S7.
6. Ohuabunwo, C., Ameh, C., Oduyebo, O., Ahumibe, A., Mutiu, B., Olayinka, A., et al. Clinical profile and containment of the Ebola virus disease outbreak in two large West African cities, Nigeria, July–September. Int J Infect Dis 2016:53 (2014), 23–29.
7. Haaskjold, Y.L., Bolkan, H.A., KØ, Krogh, Jongopi, J., Lundeby, K.M., Mellesmo, S., et al. Clinical features of and risk factors for fatal Ebola virus disease, Moyamba District, Sierra Leone, December 2014–February 2015. Emerg Infect Dis 22 (2016), 1537–1544.
8. Kreuels, B., Wichmann, D., Emmerich, P., Schmidt-Chanasit, J., de Heer, G., Kluge, S., et al. A case of severe Ebola virus infection complicated by gram-negative septicemia. N Engl J Med 371 (2014), 2394–2401.
9. Sagui, E., Janvier, F., Baize, S., Foissaud, V., Koulibaly, F., Savini, H., et al. Severe Ebola virus infection with encephalopathy: evidence for direct virus involvement. Clin Infect Dis 61 (2015), 1627–1628.
10. Chertow, D.S., Nath, A., Suffredini, A.F., Danner, R.L., Reich, D.S., Bishop, R.J., et al. Severe meningoencephalitis in a case of Ebola virus disease: a case report. Ann Intern Med 165 (2016), 301–304.
11. Howlett, P., Brown, C., Helderman, T., Brooks, T., Lisk, D., Deen, G., et al. Ebola virus disease complicated by late-onset encephalitis and polyarthritis, Sierra Leone. Emerg Infect Dis 22 (2016), 150–152.
12. Uyeki, T.M., Mehta, A.K., Davey, R.T. Jr., Liddell, A.M., Wolf, T., Vetter, P., et al. Clinical management of Ebola virus disease in the United States and Europe. N Engl J Med 374 (2016), 636–646.
13. de Greslan, T., Billhot, M., Rousseau, C., Mac Nab, C., Karkowski, L., Cournac, J.M., et al. Ebola virus-related encephalitis. Clin Infect Dis 63 (2016), 1076–1078.
14. Bowen, L., Smith, B., Steinbach, S., Billioux, B., Summers, A., Azodi, S., et al. Survivors of Ebola virus disease have persistent neurological deficits. Neurology, 86(16), 2016 Supplement S53.00.
15. Qureshi, A.I., Chughtai, M., Loua, T.O., Kolie, J.P., Camara, H.F.S., Ishfaq, M.F., et al. Ebola virus disease survivors study in Guinea. Clin Infect Dis 61 (2015), 1035–1042.
16. Jacobs, M., Rodger, A., Bell, D.J., Bhagani, S., Cropley, I., Filipe, A., et al. Late Ebola virus relapse causing meningoencephalitis: a case report. Lancet 388:10043 (2016), 498–503.
17. Cauchemez, S., Besnard, M., Bompard, P., Dub, T., Guillemette-Artur, P., Eyrolle-Guignot, D., et al. Association between Zika virus and microcephaly in French Polynesia, 2013–15: a retrospective study. Lancet, 2016, 2125–2132.
18. Cao-Lormeau, V.M., Blake, A., Mons, S., Lastère, S., Roche, C., Vanhomwegen, J., et al. Guillain–Barré Syndrome outbreak associated with Zika virus infection in French Polynesia: a case–control study. Lancet 387:10027 (2016), 1531–1539.
19. Dirlikov, E., Major, C.G., Mayshack, M., Medina, N., Matos, D., Ryff, K.R., et al. Guillain–Barré syndrome during ongoing Zika virus transmission—Puerto Rico, January 1–July 31, 2016. MMWR Morb Mortal Wkly Rep 65 (2016), 910–914.
20. Carteaux, G., Maquart, M., Bedet, A., Contou, D., Brugières, P., Fourati, S., et al. Zika virus associated with meningoencephalitis. N Engl J Med 374 (2016), 1595–1596.
21. Soares, C.N., Brasil, P., Carrera, R.M., Sequeira, P., de Filippis, A.B., Borges, V.A., et al. Fatal encephalitis associated with Zika virus infection in an adult. J Clin Virol 83 (2016), 63–65.
22. Rozé, B., Najioullah, F., Signate, A., Apetse, K., Brouste, Y., Gourgoudou, S., et al. Zika virus detection in cerebrospinal fluid from two patients with encephalopathy, Martinique, February 2016. Euro Surveill, 21(16), 2016.
23. Niemeyer, B., Niemeyer, R., Borges, R., Marchiori, E., Acute disseminated encephalomyelitis following Zika virus infection. Eur Neurol 77 (2016), 45–46.
24. Mécharles, S., Herrmann, C., Poullain, P., Tran, T.H., Deschamps, N., Mathon, G., et al. Acute myelitis due to Zika virus infection. Lancet, 387(10026), 2016, 1481.
25. Barcellos, C., Xavier, D.R., Pavão, A.L., Boccolini, C.S., Pina, M.F., Pedroso, M., et al. Increased hospitalizations for neuropathies as indicators of Zika virus infection, according to Health Information System Data, Brazil. Emerg Infect Dis 22 (2016), 1894–1899.
26. Gérardin, P., Couderc, T., Bintner, M., Tournebize, P., Renouil, M., Lémant, J., et al. Chikungunya virus-associated encephalitis: a cohort study on La Réunion Island, 2005–2009. Neurology 86 (2016), 94–102.
27. Robin, S., Ramful, D., Le Seach', F., Jaffar-Bandjee, M.C., Rigou, G., Alessandri, J.L., Neurologic manifestations of pediatric chikungunya infection. J Child Neurol 23 (2008), 1028–1035.
28. Shaikh, N.J., Raut, C.G., Sinha, D.P., Manjunath, M.J., Detection of Chikungunya virus from a case of encephalitis, Bangalore, Karnataka State. Indian J Med Microbiol 33 (2015), 454–455.
29. Taraphdar, D., Roy, B.K., Chatterjee, S., Chikungunya virus infection amongst the acute encephalitis syndrome cases in West Bengal, India. Indian J Med Microbiol 33:Suppl. 15 (2015), 3–6.
30. Nelson, J., Waggoner, J.J., Sahoo, M.K., Grant, P.M., Pinsky, B.A., Encephalitis caused by Chikungunya virus in a traveler from the Kingdom of Tonga. J Clin Microbiol 52 (2014), 3459–3461.
31. Casolari, S., Briganti, E., Zanotti, M., Zauli, T., Nicoletti, L., Magurano, F., et al. A fatal case of encephalitis associated with Chikungunya virus infection. Scand J Infect Dis 40 (2008), 995–996.
32. Crosby, L., Perreau, C., Madeux, B., Cossic, J., Armand, C., Herrmann-Storke, C., et al. Severe manifestations of chikungunya virus in critically ill patients during the 2013–2014 Caribbean outbreak. Int J Infect Dis 48 (2016), 78–80.
33. Bandeira, A.C., Campos, G.S., Sardi, S.I., Rocha, V.F., Rocha, G.C., Neonatal encephalitis due to Chikungunya vertical transmission: first report in Brazil. IDCases 5 (2016), 57–59.
34. Hinten, S.R., Beckett, G.A., Gensheimer, K.F., Pritchard, E., Courtney, T.M., Sears, S.D., et al. Increased recognition of Powassan encephalitis in the United States, 1999–2005. Vector Borne Zoonotic Dis 8 (2008), 733–740.
35. Centers for Disease Control and Prevention (CDC), Outbreak of Powassan encephalitis—Maine and Vermont, 1999–2001. MMWR Morb Mortal Wkly Rep 50 (2001), 761–764.
36. Piantadosi, A., Rubin, D.B., McQuillen, D.P., Hsu, L., Lederer, P.A., Ashbaugh, C.D., et al. Emerging cases of Powassan virus encephalitis in New England: clinical presentation, imaging, and review of the literature. Clin Infect Dis 62 (2016), 707–713.
37. Hicar, M.D., Edwards, K., Bloch, K., Powassan virus infection presenting as acute disseminated encephalomyelitis in Tennessee. Pediatr Infect Dis J 30 (2011), 86–88.
38. Birge, J., Sonnesyn, S., Powassan virus encephalitis, Minnesota. USA Emerg Infect Dis 18 (2012), 1669–1671.
39. Nofchissey, R.A., Deardorff, E.R., Blevins, T.M., Anishchenko, M., Bosco-Lauth, A., Berl, E., et al. Seroprevalence of Powassan virus in New England deer, 1979–2010. Am J Trop Med Hyg 88 (2013), 1159–1162.
40. Capewell, L.G., Harris, A.M., Yoder, J.S., Cope, J.R., Eddy, B.A., Roy, S.L., et al. Diagnosis, clinical course, and treatment of primary amoebic meningoencephalitis in the United States, 1937–2013. J Pediatr Infect Dis Soc 4 (2015), e68–75.
41. Cope, J.R., Ali, I.K., Primary amebic meningoencephalitis: what have we learned in the last 5 years?. Curr Infect Dis Rep, 18, 2016, 31.
42. Cope, J.R., Ratard, R.C., Hill, V.R., Sokol, T., Causey, J.J., Yoder, J.S., et al. The first association of a primary amebic meningoencephalitis death with culturable Naegleria fowleri in tap water from a US treated public drinking water system. Clin Infect Dis 60 (2015), e36–42.
43. Yoder, J.S., Straif-Bourgeois, S., Roy, S.L., Moore, T.A., Visvesvara, G.S., Ratard, R.C., et al. Primary amebic meningoencephalitis deaths associated with sinus irrigation using contaminated tap water. Clin Infect Dis 55 (2012), e79–85.
44. Shakoor, S., Beg, M.A., Mahmood, S.F., Bandea, R., Sriram, R., Noman, F., et al. Primary amebic meningoencephalitis caused by Naegleria fowleri, Karachi, Pakistan. Emerg Infect Dis 17 (2011), 258–261.
45. Linam, W.M., Ahmed, M., Cope, J.R., Chu, C., Visvesvara, G.S., da Silva, A.J., et al. Successful treatment of an adolescent with Naegleria fowleri primary amebic meningoencephalitis. Pediatrics 135 (2015), e744–e748.
46. Cope, J.R., Conrad, D.A., Cohen, N., Cotilla, M., DaSilva, A., Jackson, J., et al. Use of the novel therapeutic agent miltefosine for the treatment of primary amebic meningoencephalitis: report of 1 fatal and 1 surviving case. Clin Infect Dis 62 (2016), 774–776.
47. Dalmau, J., Tüzün, E., Wu, H.Y., Masjuan, J., Rossi, J.E., Voloschin, A., et al. Paraneoplastic anti-N-methyl-d-aspartate receptor encephalitis associated with ovarian teratoma. Ann Neurol 61 (2007), 25–36.
48. Dalmau, J., Lancaster, E., Martinez-Hernandez, E., Rosenfeld, M.R., Balice-Gordon, R., Clinical experience and laboratory investigations in patients with anti-NMDAR encephalitis. Lancet Neurol 10 (2011), 63–74.
49. Salvucci, A., Devine, I.M., Hammond, D., Sheth, R.D., Pediatric anti-NMDA (N-methyl d-aspartate) receptor encephalitis. Pediatr Neurol 50 (2014), 507–510.
50. Gable, M.S., Sheriff, H., Dalmau, J., Tilley, D.H., Glaser, C.A., The frequency of autoimmune N-methyl-D-aspartate receptor encephalitis surpasses that of individual viral etiologies in young individuals enrolled in the California Encephalitis Project. Clin Infect Dis 54 (2012), 899–904.
51. Armangue, T., Leypoldt, F., Málaga, I., Raspall-Chaure, M., Marti, I., Nichter, C., et al. Herpes simplex virus encephalitis is a trigger of brain autoimmunity. Ann Neurol 75 (2014), 317–323.
52. Schein, F., Gagneux-Brunon, A., Antoine, J.C., Lavernhe, S., Pillet, S., Paul, S., et al. Anti-N-methyl-d-aspartate receptor encephalitis after Herpes simplex virus-associated encephalitis: an emerging disease with diagnosis and therapeutic challenges. Infection, 2016 [Epub ahead of print].
53. Westman, G., Studahl, M., Ahlm, C., Eriksson, B.M., Persson, B., Rönnelid, J., et al. N-methyl-d-aspartate receptor autoimmunity affects cognitive performance in herpes simplex encephalitis. Clin Microbiol Infect 22 (2016), 934–940.
54. Bradshaw, M.J., Pawate, S., Lennon, V.A., Bloch, K.C., Brown, K.M., Herpes simplex virus 1 encephalitis associated with voltage-gated calcium channel autoimmunity. Neurology 85 (2015), 2176–2177.
55. Schäbitz, W.R., Rogalewski, A., Hagemeister, C., Bien, C.G., VZV brainstem encephalitis triggers NMDA receptor immunoreaction. Neurology 83 (2014), 2309–2311.
56. Solís, N., Salazar, L., Hasbun, R., Anti-NMDA Receptor antibody encephalitis with concomitant detection of Varicella zoster virus. J Clin Virol 83 (2016), 26–28.
57. Xu, C.L., Liu, L., Zhao, W.Q., Li, J.M., Wang, R.J., Wang, S.H., et al. Anti-N-methyl-d-aspartate receptor encephalitis with serum anti-thyroid antibodies and IgM antibodies against Epstein–Barr virus viral capsid antigen: a case report and one year follow-up. BMC Neurol, 11, 2011, 149.
58. Baltagi, S.A., Shoykhet, M., Felmet, K., Kochanek, P.M., Bell, M.J., Neurological sequelae of 2009 influenza A (H1N1) in children: a case series observed during a pandemic. Pediatr Crit Care Med 11 (2010), 179–184.
59. Bloch, K.C., Glaser, C.A., Encephalitis surveillance through the emerging infections program, 1997–2010. Emerg Infect Dis 21 (2015), 1562–1567.
60. Venkatesan, A., Tunkel, A.R., Bloch, K.C., Lauring, A.S., Sejvar, J., Bitnun, A., et al. Case definitions, diagnostic algorithms, and priorities in encephalitis: consensus statement of the international encephalitis consortium. Clin Infect Dis 57 (2013), 1114–1128.
61. Guan, H., Shen, A., Lv, X., Yang, X., Ren, H., Zhao, Y., et al. Detection of virus in CSF from the cases with meningoencephalitis by next-generation sequencing. J Neurovirol 22 (2016), 240–245.
62. Salzberg, S.L., Breitwieser, F.P., Kumar, A., Hao, H., Burger, P., Rodriguez, F.J., et al. Next-generation sequencing in neuropathologic diagnosis of infections of the nervous system. Neurol Neuroimmunol Neuroinflamm, 3, 2016, e251.
63. Wilson, M.R., Naccache, S.N., Samayoa, E., Biagtan, M., Bashir, H., Yu, G., et al. Actionable diagnosis of neuroleptospirosis by next-generation sequencing. N Engl J Med 370 (2014), 2408–2417.
64. Yao, M., Zhou, J., Zhu, Y., Zhang, Y., Lv, X., Sun, R., et al. Detection of Listeria monocytogenes in CSF from three patients with meningoencephalitis by next-generation sequencing. J Clin Neurol 12 (2016), 446–451.
65. Mongkolrattanothai, K., Naccache, S.N., Bender, J.M., Samayoa, E., Pham, E., Yu, G., et al. Neurobrucellosis: unexpected answer from metagenomic next-generation sequencing. J Pediatr Infect Dis Soc, 2017, 10.1093/jpids/piw066 [Epub ahead of print].
66. Bukowska-Ośko, I., Perlejewski, K., Nakamura, S., Motooka, D., Stokowy, T., Kosińska, J., et al. Sensitivity of next-generation sequencing metagenomic analysis for detection of RNA and DNA viruses in cerebrospinal fluid: the confounding effect of background contamination. Adv Exp Med Biol 944 (2017), 53–62.
67. Pham, N.T., Ushijima, H., Thongprachum, A., Trinh, Q.D., Khamrin, P., Arakawa, C., et al. Multiplex PCR for the detection of 10 viruses causing encephalitis/encephalopathy and its application to clinical samples collected from Japanese children with suspected viral. Clin Lab 63 (2017), 91–100.
68. Shi, X., Wu, R., Shi, M., Zhou, L., Wu, M., Yang, Y., et al. Simultaneous detection of 13 viruses involved in meningoencephalitis using a newly developed multiplex PCR Mag-array system. Int J Infect Dis 49 (2016), 80–86.
69. Leber, A.L., Everhart, K., Balada-Llasat, J.M., Cullison, J., Daly, J., Holt, S., et al. Multicenter evaluation of BioFire filmarray meningitis/encephalitis panel for detection of bacteria, viruses, and yeast in cerebrospinal fluid specimens. J Clin Microbiol 54 (2016), 2251–2261.
70. Tunkel, A.R., Glaser, C.A., Bloch, K.C., Sejvar, J.J., Marra, C.M., Roos, K.L., et al. The management of encephalitis: clinical practice guidelines by the Infectious Diseases Society of America. Clin Infect Dis 47 (2008), 303–327.
71. Solomon, T., Michael, B.D., Smith, P.E., Sanderson, F., Davies, N.W., Hart, I.J., et al. Management of suspected viral encephalitis in adults—Association of British Neurologists and British Infection Association National Guidelines. J Infect 64 (2012), 347–373.
72. Kneen, R., Michael, B.D., Menson, E., Mehta, B., Easton, A., Hemingway, C., et al. Management of suspected viral encephalitis in children—Association of British Neurologists and British Paediatric Allergy Immunology and Infection Group national guidelines. J Infect 64 (2012), 449–477.
73. Sharma, S., Mishra, D., Aneja, S., Kumar, R., Jain, A., Vashishtha, V.M., Consensus guidelines on evaluation and management of suspected acute viral encephalitis in children in India. Indian Pediatr 49 (2012), 897–910.
74. Britton, P.N., Eastwood, K., Paterson, B., Durrheim, D.N., Dale, R.C., Cheng, A.C., et al. Consensus guidelines for the investigation and management of encephalitis in adults and children in Australia and New Zealand. Intern Med J 45 (2015), 563–576.
75. Stahl, J.P., Azouvi, P., Bruneel, F., De Broucker, T., Duval, X., Fantin, B., et al. Guidelines on the management of infectious encephalitis in adults. Med Mal Infect 47 (2017), 179–194.
76. Mailles, A., Stahl, J.P., Steering Committee and Investigators Group. Infectious encephalitis in France in 2007: a national prospective study. Clin Infect Dis 49 (2009), 1838–1847.
77. Granerod, J., Ambrose, H.E., Davies, N.W., Clewley, J.P., Walsh, A.L., Morgan, D., et al. Causes of encephalitis and differences in their clinical presentations in England: a multicentre, population-based prospective study. Lancet Infect Dis 10 (2010), 835–844.
78. Britton, P.N., Dale, R.C., Elliott, E., Festa, M., Macartney, K., Booy, R., et al. Pilot surveillance for childhood encephalitis in Australia using the Paediatric Active Enhanced Disease Surveillance (PAEDS) network. Epidemiol Infect 144 (2016), 2117–2127.