Dynamics of Ebola RNA persistence in semen: A report from the postebogui cohort in Guinea

Clinical Infectious Diseases

Volumn 64, Issue 12, 2017, Pages 1788-1790

  Subtil, Fabien ^a,b,c   Delaunay, Charlotte ^a,b,c   Keita, Alpha Kabinet ^a   Sow, Mamadou Saliou ^d   Touré, Abdoulaye ^a,e   Leroy, Sandrine ^a   Msellati, Philippe ^a   Magassouba, N'Fally ^f   Baize, Sylvain ^g   Raoul, Hervé ^h   Ecochard, René ^b,c   Barry, Moumié ^d   Delaporte, Eric ^a   Etard, Jean François ^a,i  

^a UNIV MONTPELLIER   (France)

^b HOSPICES CIVILS DE LYON   (France)

^c LABORATOIRE DE BIOMÉTRIE ET BIOLOGIE EVOLUTIVE   (France)

^d University National Hospital Donka   (Guinea)

^e Université Gamal Abdel Nasser de Conakry   (Guinea)

^f Donka National Hospital   (Guinea)

^g UNIVERSITÉ LYON 1   (France)

^h INSERM   (France)

ⁱ INSTITUT DE RECHERCHE POUR LE DÉVELOPPEMENT   (France)

Author keywords

Ebola; Guinea; PCR.; semen; sexual transmission

Indexed keywords

VIRUS RNA;

ADOLESCENT; ADULT; AGED; ARTICLE; EBOLA HEMORRHAGIC FEVER; EBOLAVIRUS; FOLLOW UP; GUINEAN; HUMAN; MAJOR CLINICAL STUDY; MALE; MOLECULAR DYNAMICS; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEXUAL TRANSMISSION; SPERM; COHORT ANALYSIS; EPIDEMIC; GENETICS; GUINEA; ISOLATION AND PURIFICATION; MIDDLE AGED; NONPARAMETRIC TEST; PHYSIOLOGY; TRANSMISSION; VIROLOGY; YOUNG ADULT;

ADOLESCENT; ADULT; AGED; COHORT STUDIES; DISEASE OUTBREAKS; EBOLAVIRUS; GUINEA; HEMORRHAGIC FEVER, EBOLA; HUMANS; MALE; MIDDLE AGED; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, VIRAL; SEMEN; STATISTICS, NONPARAMETRIC; YOUNG ADULT;

EID: 85021169770     PISSN: 10584838     EISSN: 15376591     Source Type: Journal    
DOI: 10.1093/cid/cix210     Document Type: Article

References (11)

1. World Health Organization. Ebola virus disease. Situation summary. Latest available situation summary, 11 May 2016. Available at: http://apps.who.int/gho/data/view.ebola-sitrep.ebola-summary-latest?lang=en. Accessed 23 July 2016
2. Vetter P, Kaiser L, Schibler M, Ciglenecki I, Bausch DG. Sequelae of Ebola virus disease: the emergency within the emergency. Lancet Infect Dis 2016; 16: e82-91
3. World Health Organization. Clinical care for survivors of Ebola virus disease. Available at: http://www.who.int/csr/resources/publications/ebola/guidance-survivors/en/. Accessed 3 June 2016
4. Soka MJ, Choi MJ, Baller A, et al. Prevention of sexual transmission of Ebola in Liberia through a national semen testing and counselling programme for survivors: an analysis of Ebola virus RNA results and behavioural data. Lancet Glob Health 2016; 4: e736-43
5. Diallo B, Sissoko D, Loman NJ, et al. Resurgence of Ebola virus disease in Guinea linked to a survivor with virus persistence in seminal fluid for more than 500 days. Clin Infect Dis 2016; 63: 1356-6
6. Mate SE, Kugelman JR, Nyenswah TG, et al. Molecular evidence of sexual transmission of Ebola virus. N Engl J Med 2015; 373: 2448-54
7. Arias A, Watson SJ, Asogun D, et al. Rapid outbreak sequencing of Ebola virus in Sierra Leone identifies transmission chains linked to sporadic cases. Virus Evol 2016; 2: vew016
8. World Health Organization. Interim advice on the sexual transmission of the Ebola virus disease. Available at: http://www.who.int/reproductivehealth/topics/rtis/ebola-virus-semen/en/. Accessed 12 June 2016
9. Etard J-F, Sow MS, Leroy S, et al. Multidisciplinary assessment of post-Ebola sequelae in Guinea (Postebogui): an observational cohort study. Lancet Infect Dis 2017. doi: 10.1016/S1473-3099(16)30516-3
10. Vetter P, Fischer WA 2nd, Schibler M, Jacobs M, Bausch DG, Kaiser L. Ebola virus shedding and transmission: review of current evidence. J Infect Dis 2016; 214: 177-84
11. Eggo RM, Watson CH, Camacho A, Kucharski AJ, Funk S, Edmunds WJ. Duration of Ebola virus RNA persistence in semen of survivors: population-level estimates and projections. Euro Surveill 2015; 20. Available at: http://www.eurosurveillance. org/ViewArticle.aspx?ArticleId=21326. Accessed 20 October 2016