Molecular evidence of sexual transmission of ebola virus

New England Journal of Medicine

Volumn 373, Issue 25, 2015, Pages 2448-2454

  Mate, S E ^a   Kugelman, J R ^a   Nyenswah, T G ^d   Ladner, J T ^a   Wiley, M R ^a   Cordier Lassalle, T ^e   Christie, A ^g   Schroth, G P ^h   Gross, S M ^h   Davies Wayne, G J ^e   Shinde, S A ⁱ   Murugan, R ^e   Sieh, S B ^d   Badio, M ^d   Fakoli, L ^f   Taweh, F ^f   De Wit, E ^j   Van Doremalen, N ^j   Munster, V J ^j   Pettitt, J ^c   Prieto, K ^a   Humrighouse, B W ^g   Stroher U ^g   DiClaro, J W ^k   Hensley, L E ^c   Schoepp, R J ^b   Safronetz, D ^j   Fair, J ^l   Kuhn, J H ^c   Blackley, D J ^g   Laney, A S ^g   Williams, D E ^g   Lo, T ^g   Gasasira, A ^e   Nichol, S T ^g   Formenty, P ^e   Kateh, F N ^d   DeCock, K M ^g   Bolay, F ^f   Sanchez Lockhart, M ^a   Palacios, G ^a   more..

^a UNITED STATES ARMY MEDICAL RESEARCH INSTITUTE OF INFECTIOUS DISEASES   (United States)

^b Diagnostic Systems Division   (United States)

^c NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^d MINISTRY OF HEALTH AND SOCIAL WELFARE   (Liberia)

^e WORLD HEALTH ORGANIZATION   (Switzerland)

^f Liberia Institute for Biomedical Research   (Liberia)

^g CENTERS FOR DISEASE CONTROL AND PREVENTION   (United States)

^h ILLUMINA INC   (United States)

ⁱ WHO   (India)

^j NATIONAL INSTITUTES OF HEALTH   (United States)

^k US Naval Medical Research Unit No 3 Egypt   (Egypt)

^l Foundation Merieux   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN G ANTIBODY; VIRUS RNA;

ARTICLE; BLOOD ANALYSIS; CONTACT EXAMINATION; EBOLA HEMORRHAGIC FEVER; HUMAN; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEMEN ANALYSIS; SEQUENCE ANALYSIS; SEXUAL TRANSMISSION; SURVIVOR; UNPROTECTED SEX; VIRUS GENOME; VIRUS TRANSMISSION; ADULT; BLOOD; CASE REPORT; COITUS; EBOLAVIRUS; FEMALE; GENETICS; ISOLATION AND PURIFICATION; LIBERIA; MALE; SPERM; TRANSMISSION; UNSAFE SEX; VIROLOGY;

ADULT; COITUS; EBOLAVIRUS; FEMALE; GENOME, VIRAL; HEMORRHAGIC FEVER, EBOLA; HUMANS; LIBERIA; MALE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, VIRAL; SEMEN; UNSAFE SEX;

EID: 84949460157     PISSN: 00284793     EISSN: 15334406     Source Type: Journal    
DOI: 10.1056/NEJMoa1509773     Document Type: Article

References (22)

1. Ebola situation reports. Geneva: World Health Organization, 2015 (http://apps.who.int/ebola/ebola-situation-reports).
2. Clark DV, Kibuuka H, Millard M, et al. Long-term sequelae after Ebola virus disease in Bundibugyo, Uganda: A retrospective cohort study. Lancet Infect Dis 2015; 15: 905-12.
3. Bausch DG, Towner JS, Dowell SF, et al. Assessment of the risk of Ebola virus transmission from bodily fluids and fomites. J Infect Dis 2007; 196: Suppl2: S142-S147.
4. Rodriguez LL, De Roo A, Guimard Y, et al. Persistence and genetic stability of Ebola virus during the outbreak in Kikwit, Democratic Republic of the Congo, 1995. J Infect Dis 1999; 179: Suppl 1: S170-S176.
5. Varkey JB, Shantha JG, Crozier I, et al. Persistence of Ebola virus in ocular fluid during convalescence. N Engl J Med 2015; 372: 2423-7.
6. Emond RT, Evans B, Bowen ET, Lloyd G. A case of Ebola virus infection. Br Med J 1977; 2: 541-4.
7. Martini GA, Schmidt HA. Spermatogenic transmission of the "Marburg virus": causes of "Marburg simian disease." Klin Wochenschr 1968; 46: 398-400. (In German.).
8. Possible sexual transmission of Ebola virus - Liberia, 2015. MMWR Morb Mortal Wkly Rep 2015; 64: 479-81.
9. World Health Organization. Ebola virus disease: factsheet N 103, August 2015 (http://www.who.int/mediacentre/factsheets/fs103/en/).
10. Rowe AK, Bertolli J, Khan AS, et al. Clinical, virologic, and immunologic follow- up of convalescent Ebola hemorrhagic fever patients and their household contacts, Kikwit, Democratic Republic of the Congo. J Infect Dis 1999; 179: Suppl1: S28-S35.
11. Cordier-Lassalle T. Summary of sector response model: A quality management system that led to Liberia's success in fighting Ebola. Geneva: World Health Organization, 2015 (http://www.who.int/csr/disease/ebola/sector-approach-liberia.pdf).
12. Kugelman JR, Wiley MR, Mate S, et al. Monitoring of Ebola virus Makona evolution through establishment of advanced genomic capability in Liberia. Emerg Infect Dis 2015; 21: 1135-43.
13. Baize S, Pannetier D, Oestereich L, et al. Emergence of Zaire Ebola virus disease in Guinea. N Engl J Med 2014; 371: 1418-25.
14. Carroll MW, Matthews DA, Hiscox JA, et al. Temporal and spatial analysis of the 2014-2015 Ebola virus outbreak in West Africa. Nature 2015; 524: 97-101.
15. Gire SK, Goba A, Andersen KG, et al. Genomic surveillance elucidates Ebola virus origin and transmission during the 2014 outbreak. Science 2014; 345: 1369-72.
16. Hoenen TS, Safronetz D, Groseth A, et al. Virology: mutation rate and genotype variation of Ebola virus from Mali case sequences. Science 2015; 348: 117-9.
17. Park DJ, Dudas G, Wohl S, et al. Ebola virus epidemiology, transmission, and evolution during seven months in Sierra Leone. Cell 2015; 161: 1516-26.
18. Simon-Loriere E, Faye O, Faye O, et al. Distinct lineages of Ebola virus in Guinea during the 2014 West African epidemic. Nature 2015; 524: 102-4.
19. Tong YG, Shi WF, Liu D, et al. Genetic diversity and evolutionary dynamics of Ebola virus in Sierra Leone. Nature 2015; 524: 93-6.
20. Kuhn JH, Andersen KG, Baize S, et al. Nomenclature- And database-compatible names for the two Ebola virus variants that emerged in Guinea and the Democratic Republic of the Congo in 2014. Viruses 2014; 6: 4760-99.
21. Nyenswah T, Fallah M, Sieh S, et al. Controlling the last known cluster of Ebola virus disease - Liberia, January-February 2015. MMWR Morb Mortal Wkly Rep 2015; 64: 500-4.
22. Richards GA, Murphy S, Jobson R, et al. Unexpected Ebola virus in a tertiary setting: clinical and epidemiologic aspects. Crit Care Med 2000; 28: 240-4.